m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer

scientific article published on 01 March 2020

m6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/J.CCELL.2020.02.004
P932PMC publication ID7141420
P698PubMed publication ID32183948

P2093author name stringJianjun Chen
Huilin Huang
Hengyou Weng
P2860cites workN6-methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTOQ24293481
Perturbation of m6A writers reveals two distinct classes of mRNA methylation at internal and 5' sitesQ24300072
ALKBH5 is a mammalian RNA demethylase that impacts RNA metabolism and mouse fertilityQ24304362
N6-methyladenosine-dependent regulation of messenger RNA stabilityQ24310545
Oxidative demethylation of 3-methylthymine and 3-methyluracil in single-stranded DNA and RNA by mouse and human FTOQ24310886
A METTL3-METTL14 complex mediates mammalian nuclear RNA N6-adenosine methylationQ24311871
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferaseQ24315962
Mammalian WTAP is a regulatory subunit of the RNA N6-methyladenosine methyltransferaseQ24318728
N(6)-methyladenosine-dependent RNA structural switches regulate RNA-protein interactionsQ24320088
Topology of the human and mouse m6A RNA methylomes revealed by m6A-seqQ24320240
N6-methyladenosine marks primary microRNAs for processingQ24323516
N(6)-methyladenosine Modulates Messenger RNA Translation EfficiencyQ24337939
Induction of sporulation in Saccharomyces cerevisiae leads to the formation of N6-methyladenosine in mRNA: a potential mechanism for the activity of the IME4 geneQ24537653
VIRMA mediates preferential m6A mRNA methylation in 3'UTR and near stop codon and associates with alternative polyadenylation.Q52366303
The SMAD2/3 interactome reveals that TGFβ controls m6A mRNA methylation in pluripotency.Q52371608
Identification of methylated nucleosides in messenger RNA from Novikoff hepatoma cellsQ24563918
Comprehensive analysis of mRNA methylation reveals enrichment in 3' UTRs and near stop codonsQ24598126
Methylation of nuclear simian virus 40 RNAsQ24634149
Structural basis of N(6)-adenosine methylation by the METTL3-METTL14 complexQ27709350
5' UTR m(6)A Promotes Cap-Independent TranslationQ28114851
Nuclear m(6)A Reader YTHDC1 Regulates mRNA SplicingQ28114974
Structural Basis for Cooperative Function of Mettl3 and Mettl14 MethyltransferasesQ28117995
Dynamic m(6)A mRNA methylation directs translational control of heat shock responseQ28118495
HNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing EventsQ28118781
The methylated constituents of L cell messenger RNA: evidence for an unusual cluster at the 5' terminusQ28202411
Modified nucleosides and bizarre 5'-termini in mouse myeloma mRNAQ28210505
5′-Terminal structures of poly(A)+ cytoplasmic messenger RNA and of poly(A)+ and poly(A)− heterogeneous nuclear RNA of cells of the dipteran Drosophila melanogasterQ28237586
Localization of N6-methyladenosine in the Rous sarcoma virus genomeQ28252257
Stem cells. m6A mRNA methylation facilitates resolution of naïve pluripotency toward differentiationQ28511267
Important Role of FTO in the Survival of Rare Panresistant Triple-Negative Inflammatory Breast Cancer Cells Facing a Severe Metabolic ChallengeQ28552551
N6-methyladenosine modification destabilizes developmental regulators in embryonic stem cellsQ28585513
Cytoplasmic m6A reader YTHDF3 promotes mRNA translationQ29465772
YTHDF3 facilitates translation and decay of N6-methyladenosine-modified RNA.Q29465801
Methyltransferase-like protein 16 binds the 3'-terminal triple helix of MALAT1 long noncoding RNA.Q32884496
The U6 snRNA m6A Methyltransferase METTL16 Regulates SAM Synthetase Intron RetentionQ32884542
N6-methyladenosine alters RNA structure to regulate binding of a low-complexity proteinQ33741052
Probing N6-methyladenosine RNA modification status at single nucleotide resolution in mRNA and long noncoding RNAQ34378909
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesisQ34448805
N(6)-methyladenosine in mRNA disrupts tRNA selection and translation-elongation dynamicsQ34508439
Hypoxia induces the breast cancer stem cell phenotype by HIF-dependent and ALKBH5-mediated m⁶A-demethylation of NANOG mRNA.Q34519307
The m(6)A Methyltransferase METTL3 Promotes Translation in Human Cancer CellsQ34523745
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5Q34883200
WTAP is a novel oncogenic protein in acute myeloid leukemiaQ35206435
Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptomeQ35804751
Nature and nurture - lessons from chemical carcinogenesisQ36014330
Insulin-like growth factor 2 mRNA-binding proteins (IGF2BPs): post-transcriptional drivers of cancer progression?Q37002361
YTHDF2 destabilizes m(6)A-containing RNA through direct recruitment of the CCR4-NOT deadenylase complexQ37222906
IMPs: an RNA-binding protein family that provides a link between stem cell maintenance in normal development and cancerQ37507920
Post-transcriptional gene regulation by mRNA modifications.Q37515917
m6ASNP: a tool for annotating genetic variants by m6A function.Q52607196
N6-Methyladenosine modification of lincRNA 1281 is critically required for mESC differentiation potential.Q52660655
N6-methyladenosine mediates the cellular proliferation and apoptosis via microRNAs in arsenite-transformed cells.Q53175872
Deregulation of UBE2C-mediated autophagy repression aggravates NSCLC progression.Q55089347
N-methyladenosine contributes to cellular phenotype in a genetically-defined model of breast cancer progressionQ56396035
A dynamic N-methyladenosine methylome regulates intrinsic and acquired resistance to tyrosine kinase inhibitorsQ57293800
Cross-talk among writers, readers, and erasers of mA regulates cancer growth and progressionQ57298223
IGF2BP1 promotes SRF-dependent transcription in cancer in a m6A- and miRNA-dependent mannerQ58106106
Methylation of Structured RNA by the mA Writer METTL16 Is Essential for Mouse Embryonic DevelopmentQ58709961
mRNA circularization by METTL3-eIF3h enhances translation and promotes oncogenesisQ59082106
RNA mA modification enzymes shape innate responses to DNA by regulating interferon βQ59350385
The role of the fat mass and obesity-associated protein in the proliferation of pancreatic cancer cellsQ61812189
Impaired autophagic degradation of lncRNA ARHGAP5-AS1 promotes chemoresistance in gastric cancerQ64053337
KIAA1429 regulates the migration and invasion of hepatocellular carcinoma by altering m6A modification of ID2 mRNAQ64064227
RNA mA methylation regulates the epithelial mesenchymal transition of cancer cells and translation of SnailQ64065752
Changes of N6-methyladenosine modulators promote breast cancer progressionQ64070357
METTL3 Promotes the Proliferation and Mobility of Gastric Cancer CellsQ64072434
Excessive miR-25-3p maturation via N-methyladenosine stimulated by cigarette smoke promotes pancreatic cancer progressionQ64097541
Mettl3-mediated mRNA mA methylation promotes dendritic cell activationQ64097754
RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3Q64108135
ALKBH5 inhibited autophagy of epithelial ovarian cancer through miR-7 and BCL-2Q64113805
YTHDF1 Regulates Tumorigenicity and Cancer Stem Cell-Like Activity in Human Colorectal CarcinomaQ64245310
Structural insights into FTO's catalytic mechanism for the demethylation of multiple RNA substratesQ64272565
Targeting the RNA m6A Reader YTHDF2 Selectively Compromises Cancer Stem Cells in Acute Myeloid LeukemiaQ64460020
m6A mRNA demethylase FTO regulates melanoma tumorigenicity and response to anti-PD-1 blockade.Q64893136
EBV epitranscriptome reprogramming by METTL14 is critical for viral-associated tumorigenesis.Q64971530
m6A modification controls the innate immune response to infection by targeting type I interferonsQ67200928
Histone H3 trimethylation at lysine 36 guides m6A RNA modification co-transcriptionallyQ68692501
Single-base mapping of m6A by an antibody-independent methodQ68693705
Characterization and partial purification of mRNA N6-adenosine methyltransferase from HeLa cell nuclei. Internal mRNA methylation requires a multisubunit complexQ72037221
Anti-tumour immunity controlled through mRNA m6A methylation and YTHDF1 in dendritic cellsQ75719938
m6A demethylase FTO facilitates tumor progression in lung squamous cell carcinoma by regulating MZF1 expressionQ88905968
YTH domain family 2 promotes lung cancer cell growth by facilitating 6-phosphogluconate dehydrogenase mRNA translationQ90025594
N6-Methyladenosine Modulates Nonsense-Mediated mRNA Decay in Human GlioblastomaQ90147906
DART-seq: an antibody-free method for global m6A detectionQ90243294
N6-Methyladenosine methyltransferase ZCCHC4 mediates ribosomal RNA methylationQ90371346
ALKBH5 Inhibits Pancreatic Cancer Motility by Decreasing Long Non-Coding RNA KCNK15-AS1 MethylationQ90386634
METTL3-mediated m6A modification of HDGF mRNA promotes gastric cancer progression and has prognostic significanceQ90465747
The RNA m6A methyltransferase METTL3 promotes pancreatic cancer cell proliferation and invasionQ90670508
METTL3-mediated N6-methyladenosine modification is critical for epithelial-mesenchymal transition and metastasis of gastric cancerQ90676584
An N6-methyladenosine at the transited codon 273 of p53 pre-mRNA promotes the expression of R273H mutant protein and drug resistance of cancer cellsQ90714266
Long noncoding RNA GAS5 inhibits progression of colorectal cancer by interacting with and triggering YAP phosphorylation and degradation and is negatively regulated by the m6A reader YTHDF3Q90751756
Critical Enzymatic Functions of FTO in Obesity and CancerQ90930461
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progressionQ90950201
ALKBH5-m6A-FOXM1 signaling axis promotes proliferation and invasion of lung adenocarcinoma cells under intermittent hypoxiaQ91068102
The m6A methyltransferase METTL3 promotes bladder cancer progression via AFF4/NF-κB/MYC signaling networkQ91117885
m6A mRNA methylation regulates AKT activity to promote the proliferation and tumorigenicity of endometrial cancerQ91185402
YTHDF2 reduction fuels inflammation and vascular abnormalization in hepatocellular carcinomaQ91310549
Differential m6A, m6Am, and m1A Demethylation Mediated by FTO in the Cell Nucleus and CytoplasmQ91346488
Mettl14 inhibits bladder TIC self-renewal and bladder tumorigenesis through N6-methyladenosine of Notch1Q91419120
RNA m6A methyltransferase METTL3 regulates invasiveness of melanoma cells by matrix metallopeptidase 2Q91574116
METTL3 promotes ovarian carcinoma growth and invasion through the regulation of AXL translation and epithelial to mesenchymal transitionQ91698979
IGF2BP2 regulates DANCR by serving as an N6-methyladenosine readerQ91718565
RNA m6A Methyltransferase METTL3 Promotes The Growth Of Prostate Cancer By Regulating Hedgehog PathwayQ91737536
ALKBH5 promotes invasion and metastasis of gastric cancer by decreasing methylation of the lncRNA NEAT1Q91759465
The Biogenesis and Precise Control of RNA m6A MethylationQ91763924
m6A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasisQ91819611
RNA modifications modulate gene expression during developmentQ91823437
Dynamic m6A mRNA methylation reveals the role of METTL3-m6A-CDCP1 signaling axis in chemical carcinogenesisQ91844964
The m6A eraser FTO facilitates proliferation and migration of human cervical cancer cellsQ91893522
METTL14 Suppresses CRC Progression via Regulating N6-Methyladenosine-Dependent Primary miR-375 ProcessingQ91991150
The human 18S rRNA m6A methyltransferase METTL5 is stabilized by TRMT112Q92061186
KIAA1429 contributes to liver cancer progression through N6-methyladenosine-dependent post-transcriptional modification of GATA3Q92128551
Roles and Regulation of Long Noncoding RNAs in Hepatocellular CarcinomaQ92133179
RNA N 6-Methyladenosine Modification in Normal and Malignant HematopoiesisQ92140582
m6A mRNA methylation regulates CTNNB1 to promote the proliferation of hepatoblastomaQ92212631
m6A demethylase ALKBH5 inhibits pancreatic cancer tumorigenesis by decreasing WIF-1 RNA methylation and mediating Wnt signalingQ92450835
The m6A-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca2+ influx modulating ERK1/2 phosphorylation and MMP9 signaling pathwayQ92497567
M6A-mediated upregulation of LINC00958 increases lipogenesis and acts as a nanotherapeutic target in hepatocellular carcinomaQ92501485
MiR-4429 prevented gastric cancer progression through targeting METTL3 to inhibit m6A-caused stabilization of SEC62Q92505912
The m6A demethylase FTO promotes the growth of lung cancer cells by regulating the m6A level of USP7 mRNAQ92578561
N6-methyladenosine modification of ITGA6 mRNA promotes the development and progression of bladder cancerQ92600798
Oncogenic Role of an Epigenetic Reader of m6A RNA Modification: YTHDF1 in Merkel Cell CarcinomaQ92702124
N 6-methyladenosine of chromosome-associated regulatory RNA regulates chromatin state and transcriptionQ92711302
WTAP facilitates progression of hepatocellular carcinoma via m6A-HuR-dependent epigenetic silencing of ETS1Q92787270
Regulation of Co-transcriptional Pre-mRNA Splicing by m6A through the Low-Complexity Protein hnRNPGQ92844891
DDX3 modulates cisplatin resistance in OSCC through ALKBH5-mediated m6A-demethylation of FOXM1 and NANOGQ92892994
N6-methyladenosine METTL3 promotes the breast cancer progression via targeting Bcl-2Q92902790
METTL3 promote tumor proliferation of bladder cancer by accelerating pri-miR221/222 maturation in m6A-dependent mannerQ92956393
METTL3 facilitates tumor progression via an m6A-IGF2BP2-dependent mechanism in colorectal carcinomaQ92966476
Dysregulated N6-methyladenosine methylation writer METTL3 contributes to the proliferation and migration of gastric cancerQ92977417
N6-Methylation of Adenosine of FZD10 mRNA Contributes to PARP Inhibitor ResistanceQ92985610
YTHDF2 suppresses cell proliferation and growth via destabilizing the EGFR mRNA in hepatocellular carcinomaQ93037855
N6-Methyladenosine Modification Controls Circular RNA ImmunityQ93045003
Reduced m6A modification predicts malignant phenotypes and augmented Wnt/PI3K-Akt signaling in gastric cancerQ93056827
The m6A methyltransferase METTL3 promotes osteosarcoma progression by regulating the m6A level of LEF1Q93113487
Small-Molecule Targeting of Oncogenic FTO Demethylase in Acute Myeloid LeukemiaQ93129281
Deciphering the "m6A Code" via Antibody-Independent Quantitative ProfilingQ93137733
Upregulated METTL3 promotes metastasis of colorectal Cancer via miR-1246/SPRED2/MAPK signaling pathwayQ93157333
Long noncoding RNA GAS5-AS1 suppresses growth and metastasis of cervical cancer by increasing GAS5 stabilityQ93187503
Hypoxia-inducible factors regulate pluripotency factor expression by ZNF217- and ALKBH5-mediated modulation of RNA methylation in breast cancer cellsQ37662078
The role of the oncofetal IGF2 mRNA-binding protein 3 (IGF2BP3) in cancerQ38234648
m(6)A mRNA methylation controls T cell homeostasis by targeting the IL-7/STAT5/SOCS pathwaysQ38632272
m6A Demethylase ALKBH5 Maintains Tumorigenicity of Glioblastoma Stem-like Cells by Sustaining FOXM1 Expression and Cell Proliferation ProgramQ38710467
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.Q38712170
m(6)A RNA methylation is regulated by microRNAs and promotes reprogramming to pluripotencyQ39038754
Dynamic RNA Modifications in Gene Expression RegulationQ39378718
RNA helicase YTHDC2 promotes cancer metastasis via the enhancement of the efficiency by which HIF-1α mRNA is translated.Q39508782
‘Cap’ structures in maize poly(A)-containing RNAQ40243572
METTL14 suppresses the metastatic potential of hepatocellular carcinoma by modulating N6 -methyladenosine-dependent primary MicroRNA processingQ40520642
Extensive translation of circular RNAs driven by N6-methyladenosineQ41083717
Structural insights into the molecular mechanism of the m(6)A writer complexQ41093229
Partial purification of a 6-methyladenine mRNA methyltransferase which modifies internal adenine residuesQ41784805
Ythdc2 is an N6-methyladenosine binding protein that regulates mammalian spermatogenesisQ41791644
Synthesis of a FTO inhibitor with anticonvulsant activity.Q42040042
m6A-dependent maternal mRNA clearance facilitates zebrafish maternal-to-zygotic transitionQ42130806
Coordination of m(6)A mRNA Methylation and Gene Transcription by ZFP217 Regulates Pluripotency and ReprogrammingQ42134417
YTHDC1 mediates nuclear export of N6-methyladenosine methylated mRNAs.Q42380468
The N6-methyladenosine (m6A)-forming enzyme METTL3 controls myeloid differentiation of normal hematopoietic and leukemia cells.Q45067620
Genome-Wide Maps of m6A circRNAs Identify Widespread and Cell-Type-Specific Methylation Patterns that Are Distinct from mRNAs.Q46834664
m6A modulates haematopoietic stem and progenitor cell specificationQ47073270
N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3'-end processingQ47128487
m6AVar: a database of functional variants involved in m6A modificationQ47159279
METTL14 Inhibits Hematopoietic Stem/Progenitor Differentiation and Promotes Leukemogenesis via mRNA m6A ModificationQ47207720
FTO regulates the chemo-radiotherapy resistance of cervical squamous cell carcinoma (CSCC) by targeting β-catenin through mRNA demethylationQ47217954
R-2HG Exhibits Anti-tumor Activity by Targeting FTO/m6A/MYC/CEBPA Signaling.Q47284426
The M6A methyltransferase METTL3: acting as a tumor suppressor in renal cell carcinomaQ47314607
Promoter-bound METTL3 maintains myeloid leukaemia by m6A-dependent translation control.Q47352505
HBXIP-elevated methyltransferase METTL3 promotes the progression of breast cancer via inhibiting tumor suppressor let-7g.Q47365935
RNA N6-methyladenosine methyltransferase METTL3 promotes liver cancer progression through YTHDF2 dependent post-transcriptional silencing of SOCS2.Q47368330
YTH domain family 2 orchestrates epithelial-mesenchymal transition/proliferation dichotomy in pancreatic cancer cellsQ47405466
Role of N6-methyladenosine modification in cancerQ47567064
m6A RNA Methylation Regulates the Self-Renewal and Tumorigenesis of Glioblastoma Stem Cells.Q47583443
Essential role of METTL3-mediated m6A modification in glioma stem-like cells maintenance and radioresistanceQ47602761
Human METTL16 is a N6-methyladenosine (m6A) methyltransferase that targets pre-mRNAs and various non-coding RNAs.Q47626728
Chronic Cigarette Smoke-Induced Epigenomic Changes Precede Sensitization of Bronchial Epithelial Cells to Single-Step Transformation by KRAS Mutations.Q47816766
Knockdown of YTH N6-methyladenosine RNA binding protein 2 (YTHDF2) inhibits proliferation and promotes apoptosis in MGC-803 gastric cancer cellsQ49573889
The epitranscriptome m6A writer METTL3 promotes chemo- and radioresistance in pancreatic cancer cellsQ49974458
Overexpression of YTHDF1 is associated with poor prognosis in patients with hepatocellular carcinomaQ50034633
Downregulation of N6-methyladenosine binding YTHDF2 protein mediated by miR-493-3p suppresses prostate cancer by elevating N6-methyladenosine levelsQ50105616
Smoke-Induced Changes to the Epigenome Provide Fertile Ground for Oncogenic MutationQ50131602
Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancerQ50322294
Recognition of RNA N6-methyladenosine by IGF2BP proteins enhances mRNA stability and translation.Q50422081
MicroRNA-145 Modulates N6-Methyladenosine Levels by Targeting the 3'-Untranslated mRNA Region of the N6-Methyladenosine Binding YTH Domain Family 2 Protein.Q51180526
FTO Plays an Oncogenic Role in Acute Myeloid Leukemia as a N6-Methyladenosine RNA Demethylase.Q51236778
RNA N6-methyladenosine modification in cancers: current status and perspectives.Q52311777
Zc3h13 Regulates Nuclear RNA m6A Methylation and Mouse Embryonic Stem Cell Self-Renewal.Q52352943
Zc3h13/Flacc is required for adenosine methylation by bridging the mRNA-binding factor Rbm15/Spenito to the m6A machinery component Wtap/Fl(2)d.Q52357020
P433issue3
P304page(s)270-288
P577publication date2020-03-01
P1433published inCancer CellQ280018
P1476titlem6A Modification in Coding and Non-coding RNAs: Roles and Therapeutic Implications in Cancer
P478volume37