A Snu114-GTP-Prp8 module forms a relay station for efficient splicing in yeast

scientific article published on 20 March 2020

A Snu114-GTP-Prp8 module forms a relay station for efficient splicing in yeast is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/NAR/GKAA182
P932PMC publication ID7192624
P698PubMed publication ID32196113

P50authorBernhard LollQ28322901
Markus C WahlQ30502739
P2093author name stringClaudia Alings
Eva Absmeier
Florian Heyd
Junqiao Jia
Marco Preußner
Oleg M Ganichkin
P2860cites workThe human U5-220kD protein (hPrp8) forms a stable RNA-free complex with several U5-specific proteins, including an RNA unwindase, a homologue of ribosomal elongation factor EF-2, and a novel WD-40 proteinQ22003972
The crystal structure of the exon junction complex reveals how it maintains a stable grip on mRNAQ24300447
Structural basis for functional cooperation between tandem helicase cassettes in Brr2-mediated remodeling of the spliceosomeQ24300527
An evolutionarily conserved U5 snRNP-specific protein is a GTP-binding factor closely related to the ribosomal translocase EF-2.Q24318957
Prp8 protein: at the heart of the spliceosomeQ24537373
RNA helicases in splicingQ27000261
Structures of the human pre-catalytic spliceosome and its precursor spliceosomeQ57470604
MultiBac: Baculovirus-Mediated Multigene DNA Cargo Delivery in Insect and Mammalian CellsQ64103530
Structures of the fully assembled Saccharomyces cerevisiae spliceosome before activationQ68712889
Structures of the human spliceosomes before and after release of the ligated exonQ91387193
Structures of the Catalytically Activated Yeast Spliceosome Reveal the Mechanism of BranchingQ92419392
Mechanism of 5' splice site transfer for human spliceosome activationQ93039523
Two crystal structures demonstrate large conformational changes in the eukaryotic ribosomal translocaseQ27640976
Mechanism for Aar2p function as a U5 snRNP assembly factorQ27670833
Crystal structure of Prp8 reveals active site cavity of the spliceosomeQ27676016
Structural basis for dual roles of Aar2p in U5 snRNP assemblyQ27676636
Structure of a yeast spliceosome at 3.6-angstrom resolutionQ27701867
Structure of a yeast activated spliceosome at 3.5 Å resolutionQ27721209
Structure of a yeast catalytic step I spliceosome at 3.4 Å resolutionQ27721261
XDSQ27860472
Coot: model-building tools for molecular graphicsQ27860505
Towards automated crystallographic structure refinement with phenix.refineQ27860678
Linking Crystallographic Model and Data QualityQ27860887
Assembly of Snu114 into U5 snRNP requires Prp8 and a functional GTPase domainQ27932833
Genetic analysis reveals a role for the C terminus of the Saccharomyces cerevisiae GTPase Snu114 during spliceosome activationQ27935130
prp8 mutations that cause human retinitis pigmentosa lead to a U5 snRNP maturation defect in yeastQ27935241
The yeast U5 snRNP coisolated with the U1 snRNP has an unexpected protein composition and includes the splicing factor Aar2pQ27935715
Prp8 retinitis pigmentosa mutants cause defects in the transition between the catalytic steps of splicingQ27937907
Mechanical devices of the spliceosome: motors, clocks, springs, and thingsQ27938081
The spliceosome: design principles of a dynamic RNP machineQ28131809
Spliceosomal UsnRNP biogenesis, structure and functionQ28188106
Structure of the exon junction core complex with a trapped DEAD-box ATPase bound to RNAQ28259974
Spliceosome Structure and FunctionQ29392298
Occurrence of protein disulfide bonds in different domains of life: a comparison of proteins from the Protein Data BankQ30729945
GTPases mechanisms and functions of translation factors on the ribosomeQ33999568
Conformational changes of elongation factor G on the ribosome during tRNA translocationQ34978694
MolProbity for the masses-of dataQ35701346
Activation of GTP hydrolysis in mRNA-tRNA translocation by elongation factor G.Q35729265
Evidence for disulfide bonds in SR Protein Kinase 1 (SRPK1) that are required for activity and nuclear localizationQ36271734
The EF-G-like GTPase Snu114p regulates spliceosome dynamics mediated by Brr2p, a DExD/H box ATPaseQ37183473
Visualization of elongation factor G on the Escherichia coli 70S ribosome: the mechanism of translocationQ37382075
Physical and genetic interactions of yeast Cwc21p, an ortholog of human SRm300/SRRM2, suggest a role at the catalytic center of the spliceosomeQ37426593
Structure-function relationships of the G domain, a canonical switch motifQ37889983
Alternative splicing: a pivotal step between eukaryotic transcription and translationQ38079475
Cryo-EM structure of the yeast U4/U6.U5 tri-snRNP at 3.7 Å resolutionQ38584680
The large N-terminal region of the Brr2 RNA helicase guides productive spliceosome activationQ41310559
Roles of PRP8 protein in the assembly of splicing complexesQ41533943
Cryo-EM structure of a human spliceosome activated for step 2 of splicingQ41599367
Structure of a yeast step II catalytically activated spliceosomeQ41599632
Large-scale movement of elongation factor G and extensive conformational change of the ribosome during translocationQ41632068
The ribosomal translocase homologue Snu114p is involved in unwinding U4/U6 RNA during activation of the spliceosomeQ42724676
Mutagenesis Suggests Several Roles of Snu114p in Pre-mRNA SplicingQ44433316
Structure of the yeast spliceosomal postcatalytic P complex.Q46132698
Cryo-electron microscopy snapshots of the spliceosome: structural insights into a dynamic ribonucleoprotein machine.Q47183843
Structure of a human catalytic step I spliceosomeQ47231251
Mechanistic insights into precursor messenger RNA splicing by the spliceosomeQ47738832
Structure of an Intron Lariat Spliceosome from Saccharomyces cerevisiaeQ47789779
Structure and Conformational Dynamics of the Human Spliceosomal Bact Complex.Q52390145
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesImageQuantQ112270642
P577publication date2020-03-20
P1433published inNucleic Acids ResearchQ135122
P1476titleA Snu114-GTP-Prp8 module forms a relay station for efficient splicing in yeast

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