review article | Q7318358 |
scholarly article | Q13442814 |
P50 | author | Jon Clardy | Q16106217 |
Geng-min Lin | Q57002569 | ||
Eric J N Helfrich | Q85923388 | ||
P2093 | author name string | Christopher A Voigt | |
P2860 | cites work | Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia | Q24607361 |
Scalable enantioselective total synthesis of taxanes | Q24624169 | ||
Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli | Q24630359 | ||
Cannabidiol: pharmacology and potential therapeutic role in epilepsy and other neuropsychiatric disorders | Q26823267 | ||
Structure of Epi-Isozizaene Synthase from Streptomyces coelicolor A3(2), a Platform for New Terpenoid Cyclization Templates , | Q27659507 | ||
Reprogramming the Chemodiversity of Terpenoid Cyclization by Remolding the Active Site Contour of epi -Isozizaene Synthase | Q27681677 | ||
Induced-fit mechanism in class I terpene cyclases | Q27690639 | ||
Engineering a mevalonate pathway in Escherichia coli for production of terpenoids | Q28207854 | ||
Enzymatic assembly of DNA molecules up to several hundred kilobases | Q28241142 | ||
Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in Pacific yew | Q28276543 | ||
Biochemistry and molecular genetics of the biosynthesis of the earthy odorant methylisoborneol in Streptomyces coelicolor | Q28504081 | ||
Metabolic engineering of Escherichia coli for limonene and perillyl alcohol production | Q44567066 | ||
Cannabidiol-transdermal delivery and anti-inflammatory effect in a murine model | Q44673550 | ||
Type II thioesterase restores activity of a NRPS module stalled with an aminoacyl-S-enzyme that cannot be elongated. | Q45059780 | ||
Cloning and heterologous expression of the cyclooctatin biosynthetic gene cluster afford a diterpene cyclase and two p450 hydroxylases. | Q45918702 | ||
Organic chemistry: Synthetic lessons from nature. | Q45974048 | ||
Total synthesis of eudesmane terpenes by site-selective C-H oxidations. | Q46013534 | ||
Engineering Escherichia coli for production of functionalized terpenoids using plant P450s | Q46094196 | ||
A novel semi-biosynthetic route for artemisinin production using engineered substrate-promiscuous P450(BM3). | Q46094956 | ||
Development of a Terpenoid-Production Platform in Streptomyces reveromyceticus SN-593. | Q46289101 | ||
Efficient synthesis of functional isoprenoids from acetoacetate through metabolic pathway-engineered Escherichia coli | Q46330709 | ||
Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene | Q46384890 | ||
A single terpene synthase is responsible for a wide variety of sesquiterpenes in Sorangium cellulosum Soce56. | Q46584438 | ||
Oxaziridine-mediated catalytic hydroxylation of unactivated 3 degrees C-H bonds using hydrogen peroxide | Q46785325 | ||
Towards industrial production of isoprenoids in Escherichia coli: lessons learned from CRISPR-Cas9 based optimization of a chromosomally integrated mevalonate pathway. | Q47218805 | ||
Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes. | Q47716925 | ||
Cellular Assays for Ferredoxins: A Strategy for Understanding Electron Flow through Protein Carriers That Link Metabolic Pathways. | Q48052131 | ||
Biosynthesis of the terpene phenalinolactone in Streptomyces sp. Tü6071: analysis of the gene cluster and generation of derivatives | Q48090865 | ||
Structural Insights into the CotB2-Catalyzed Cyclization of Geranylgeranyl Diphosphate to the Diterpene Cyclooctat-9-en-7-ol | Q48208149 | ||
Mechanistic Investigations of Two Bacterial Diterpene Cyclases: Spiroviolene Synthase and Tsukubadiene Synthase | Q48289278 | ||
Spata-13,17-diene Synthase-An Enzyme with Sesqui-, Di-, and Sesterterpene Synthase Activity from Streptomyces xinghaiensis | Q48325175 | ||
Two Diterpene Synthases for Spiroalbatene and Cembrene A from Allokutzneria albata. | Q49609544 | ||
Bacterial Production of Pinene by a Laboratory-Evolved Pinene-Synthase. | Q51309583 | ||
In vitro reconstitution of mevalonate pathway and targeted engineering of farnesene overproduction in Escherichia coli. | Q51756116 | ||
The Clinical Development of Paclitaxel: A Successful Collaboration of Academia, Industry and the National Cancer Institute. | Q52203194 | ||
Bricks and blueprints: methods and standards for DNA assembly. | Q53206635 | ||
Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases. | Q53244079 | ||
An improved technique for the rapid chemical characterisation of bacterial terpene cyclases. | Q54294297 | ||
A methyltransferase initiates terpene cyclization in teleocidin B biosynthesis. | Q54340218 | ||
Gibberellin Biosynthesis in Plants and Fungi: A Case of Convergent Evolution? | Q56288317 | ||
Predictive, structure-based model of amino acid recognition by nonribosomal peptide synthetase adenylation domains | Q56901837 | ||
Generation of a cluster-free Streptomyces albus chassis strains for improved heterologous expression of secondary metabolite clusters | Q57994911 | ||
Lessons and revelations from biomimetic syntheses | Q58195179 | ||
Towards a comprehensive understanding of the structural dynamics of a bacterial diterpene synthase during catalysis | Q58199055 | ||
The antiSMASH database version 2: a comprehensive resource on secondary metabolite biosynthetic gene clusters | Q58611630 | ||
A Toolbox for Diverse Oxyfunctionalisation of Monoterpenes | Q58695586 | ||
Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners | Q58716400 | ||
Bacterial Synthesis of Diverse Indole Terpene Alkaloids by an Unparalleled Cyclization Sequence | Q61774168 | ||
Uncoupled activation and cyclization in catmint reductive terpenoid biosynthesis. | Q64990657 | ||
Catalytic oxidations of steroid substrates by artificial cytochrome p-450 enzymes | Q74483451 | ||
Structures and Biosynthesis of Corvol Ethers-Sesquiterpenes from the ActinomyceteKitasatospora setae | Q78231024 | ||
One pathway, many products | Q80494454 | ||
Biosynthesis of ambiguine indole alkaloids in cyanobacterium Fischerella ambigua | Q86628067 | ||
Two Bacterial Diterpene Synthases from Allokutzneria albata Produce Bonnadiene, Phomopsene, and Allokutznerene | Q88664059 | ||
Two-step pathway for isoprenoid synthesis | Q90744851 | ||
Heterologous expression of bacterial natural product biosynthetic pathways | Q90939885 | ||
Sodorifen Biosynthesis in the Rhizobacterium Serratia plymuthica Involves Methylation and Cyclization of MEP-Derived Farnesyl Pyrophosphate by a SAM-Dependent C-Methyltransferase | Q91077609 | ||
antiSMASH 5.0: updates to the secondary metabolite genome mining pipeline | Q91588102 | ||
Automated structure prediction of trans-acyltransferase polyketide synthase products | Q91904872 | ||
Complete biosynthesis of cannabinoids and their unnatural analogues in yeast | Q91987015 | ||
Bacterial Diterpene Biosynthesis | Q92650594 | ||
Combinatorial biosynthesis and the basis for substrate promiscuity in class I diterpene synthases | Q92907808 | ||
Escherichia coli "Marionette" strains with 12 highly optimized small-molecule sensors | Q93382220 | ||
Catalytic C–H functionalization by metal carbenoid and nitrenoid insertion | Q29308505 | ||
Artemisinin-A Gift from Traditional Chinese Medicine to the World (Nobel Lecture). | Q30248633 | ||
Alteration of the substrate specificity of a modular polyketide synthase acyltransferase domain through site-specific mutations. | Q30329267 | ||
Natural products--a simple model to explain chemical diversity | Q30980990 | ||
Rational design of a minimal and highly enriched CYP102A1 mutant library with improved regio-, stereo- and chemoselectivity | Q33409906 | ||
Golden gate shuffling: a one-pot DNA shuffling method based on type IIs restriction enzymes | Q33444742 | ||
Adenylation enzyme characterization using gamma -(18)O(4)-ATP pyrophosphate exchange | Q33455175 | ||
Combining metabolic and protein engineering of a terpenoid biosynthetic pathway for overproduction and selectivity control | Q33636362 | ||
Vanadium bromoperoxidase-catalyzed biosynthesis of halogenated marine natural products | Q33983136 | ||
Cannabidiol--recent advances | Q34005880 | ||
Chrysanthemyl diphosphate synthase. The relationship among chain elongation, branching, and cyclopropanation reactions in the isoprenoid biosynthetic pathway | Q34202541 | ||
Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia | Q34235776 | ||
Mechanism and stereochemistry of the germacradienol/germacrene D synthase of Streptomyces coelicolor A3(2). | Q34302494 | ||
Large-scale de novo DNA synthesis: technologies and applications | Q34417984 | ||
Taxol: biosynthesis, molecular genetics, and biotechnological applications | Q34427992 | ||
The specificity-conferring code of adenylation domains in nonribosomal peptide synthetases | Q34504359 | ||
Geosmin biosynthesis. Streptomyces coelicolor germacradienol/germacrene D synthase converts farnesyl diphosphate to geosmin | Q34540208 | ||
Structural biology and chemistry of the terpenoid cyclases | Q34555232 | ||
Assembly-line enzymology for polyketide and nonribosomal Peptide antibiotics: logic, machinery, and mechanisms. | Q34555236 | ||
Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin | Q34635129 | ||
A predictably selective aliphatic C-H oxidation reaction for complex molecule synthesis | Q34708270 | ||
Geosmin biosynthesis. Mechanism of the fragmentation-rearrangement in the conversion of germacradienol to geosmin | Q34728064 | ||
Unearthing the roots of the terpenome | Q34745950 | ||
Enhancing Terpene yield from sugars via novel routes to 1-deoxy-d-xylulose 5-phosphate. | Q34747813 | ||
Engineered Streptomyces platensis strains that overproduce antibiotics platensimycin and platencin. | Q34928039 | ||
Terpene synthases are widely distributed in bacteria. | Q35031386 | ||
Cytochrome P450: taming a wild type enzyme | Q35054396 | ||
Dioxygen activation at mononuclear nonheme iron active sites: enzymes, models, and intermediates | Q35660894 | ||
Metabolic and evolutionary origin of actin-binding polyketides from diverse organisms | Q35734767 | ||
Minimum Information about a Biosynthetic Gene cluster. | Q35748739 | ||
Polyketide proofreading by an acyltransferase-like enzyme | Q36104031 | ||
Structure and chemistry of cytochrome P450. | Q36154632 | ||
Combinatory optimization of chromosomal integrated mevalonate pathway for β-carotene production in Escherichia coli | Q36209182 | ||
Biosynthetic Origin of the Ether Ring in Platensimycin. | Q36223066 | ||
Terpenoid synthase structures: a so far incomplete view of complex catalysis | Q36252953 | ||
Cytochrome P450 systems--biological variations of electron transport chains. | Q36595344 | ||
Probing the promiscuity of ent-kaurene oxidases via combinatorial biosynthesis | Q36658872 | ||
Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis in Escherichia coli | Q36742753 | ||
A cDNA clone for taxadiene synthase, the diterpene cyclase that catalyzes the committed step of taxol biosynthesis | Q36798017 | ||
Modern synthetic efforts toward biologically active terpenes | Q36852237 | ||
The function of terpene natural products in the natural world | Q36852242 | ||
Evolving biosynthetic tangos negotiate mechanistic landscapes | Q37244299 | ||
A cytochrome P450 serves as an unexpected terpene cyclase during fungal meroterpenoid biosynthesis | Q37412377 | ||
The biosynthetic logic of polyketide diversity | Q37513922 | ||
Elucidation of gibberellin biosynthesis in bacteria reveals convergent evolution | Q37540252 | ||
Evolution of metabolic diversity: insights from microbial polyketide synthases | Q37556893 | ||
Semisynthesis of Taxol. | Q37569874 | ||
Streptomyces and Saccharopolyspora hosts for heterologous expression of secondary metabolite gene clusters | Q37751993 | ||
Two rings in them all: The labdane-related diterpenoids | Q37796616 | ||
Bacterial diterpene synthases: new opportunities for mechanistic enzymology and engineered biosynthesis. | Q37996675 | ||
Terpenoid biosynthesis off the beaten track: unconventional cyclases and their impact on biomimetic synthesis | Q38285498 | ||
Cytochromes P450 for terpene functionalisation and metabolic engineering. | Q38337948 | ||
Terpene hydroxylation with microbial cytochrome P450 monooxygenases | Q38355668 | ||
Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function. | Q38429569 | ||
Expanding the Landscape of Diterpene Structural Diversity through Stereochemically Controlled Combinatorial Biosynthesis | Q38495747 | ||
Discovery of microbial natural products by activation of silent biosynthetic gene clusters | Q38539563 | ||
Bacterial terpene cyclases | Q38632052 | ||
Navigating the Chiral Pool in the Total Synthesis of Complex Terpene Natural Products. | Q38745582 | ||
Progress in terpene synthesis strategies through engineering of Saccharomyces cerevisiae | Q38828293 | ||
Conformational Analysis, Thermal Rearrangement, and EI-MS Fragmentation Mechanism of (1(10)E,4E,6S,7R)-Germacradien-6-ol by (13)C-Labeling Experiments | Q40549126 | ||
Principal component analysis of proteomics (PCAP) as a tool to direct metabolic engineering. | Q41632673 | ||
The Cytochrome P450-Catalyzed Oxidative Rearrangement in the Final Step of Pentalenolactone Biosynthesis: Substrate Structure Determines Mechanism | Q41674537 | ||
Isoprenoid biosynthesis: manifold chemistry catalyzed by similar enzymes | Q41728431 | ||
Engineering Streptomyces coelicolor for heterologous expression of secondary metabolite gene clusters. | Q41761257 | ||
Characterization of a silent sesquiterpenoid biosynthetic pathway in Streptomyces avermitilis controlling epi-isozizaene albaflavenone biosynthesis and isolation of a new oxidized epi-isozizaene metabolite. | Q42198206 | ||
A synthetic biochemistry platform for cell free production of monoterpenes from glucose | Q42223455 | ||
Extreme promiscuity of a bacterial and a plant diterpene synthase enables combinatorial biosynthesis | Q42576984 | ||
Identification and characterization of bacterial diterpene cyclases that synthesize the cembrane skeleton. | Q42713044 | ||
antiSMASH: rapid identification, annotation and analysis of secondary metabolite biosynthesis gene clusters in bacterial and fungal genome sequences | Q42779012 | ||
Total synthesis: towards artificial terpene cyclases. | Q43008353 | ||
Enantioselective synthesis of (-)-englerins A and B. | Q43026163 | ||
Asymmetric, protecting-group-free total synthesis of (-)-englerin A. | Q43026168 | ||
Biosynthesis of the sesquiterpene antibiotic albaflavenone in Streptomyces coelicolor. Mechanism and stereochemistry of the enzymatic formation of epi-isozizaene | Q43118352 | ||
Engineering dynamic pathway regulation using stress-response promoters. | Q43654854 | ||
Vanadium haloperoxidase-catalyzed bromination and cyclization of terpenes | Q44375538 | ||
P304 | page(s) | 2889-2906 | |
P577 | publication date | 2019-11-29 | |
P1433 | published in | Beilstein Journal of Organic Chemistry | Q2894008 |
P1476 | title | Bacterial terpene biosynthesis: challenges and opportunities for pathway engineering | |
P478 | volume | 15 |
Q96294741 | 2-Hydroxysorangiadenosine: Structure and Biosynthesis of a Myxobacterial Sesquiterpene-Nucleoside |
Q110171252 | Discovery and Biosynthesis of a Structurally Dynamic Antibacterial Diterpenoid |
Q94468541 | Exploring novel bacterial terpene synthases |
Search more.