Induction of brain-infiltrating T-bet-expressing B cells in multiple sclerosis

scientific article published on 19 June 2019

Induction of brain-infiltrating T-bet-expressing B cells in multiple sclerosis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1002/ANA.25508
P932PMC publication ID6771938
P698PubMed publication ID31136008

P50authorJamie van LangelaarQ88370936
Malou JanssenQ116784956
P2093author name stringRogier Q Hintzen
Helga E de Vries
S Marieke van Ham
Marvin M van Luijn
Annet F Wierenga-Wolf
Peter-Paul A Unger
Marie-José Melief
Liza Rijvers
Theodora A Siepman
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Pharmacological inhibition of TLR9 activation blocks autoantibody production in human B cells from SLE patients.Q51039778
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Toll-like receptor stimulation as a third signal required for activation of human naive B cells.Q53632191
IL-21 drives expansion and plasma cell differentiation of autoreactive CD11chiT-bet+ B cells in SLE.Q54223580
T helper 17.1 cells associate with multiple sclerosis disease activity: perspectives for early interventionQ56582190
Abnormal B-cell cytokine responses a trigger of T-cell-mediated disease in MS?Q57041523
Memory B Cells Activate Brain-Homing, Autoreactive CD4 T Cells in Multiple SclerosisQ58709181
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EBNA1-specific T cells from patients with multiple sclerosis cross react with myelin antigens and co-produce IFN-gamma and IL-2Q24657388
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B Cells in the Multiple Sclerosis Central Nervous System: Trafficking and Contribution to CNS-Compartmentalized InflammationQ26770852
Salmonella as a model for non-cognate Th1 cell stimulationQ28082931
B-cell depletion with rituximab in relapsing-remitting multiple sclerosisQ28268626
T-bet regulates IgG class switching and pathogenic autoantibody productionQ28588979
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T-bet+ B cells are induced by human viral infections and dominate the HIV gp140 responseQ33578985
Altered B cell signalling in autoimmunityQ33924642
Immunoglobulin class-switched B cells form an active immune axis between CNS and periphery in multiple sclerosis.Q34251673
The lymphoid chemokine, CXCL13, is dispensable for the initial recruitment of B cells to the acutely inflamed central nervous systemQ35104199
TLR7 and TLR9 trigger distinct neuroinflammatory responses in the CNSQ35168231
B cells populating the multiple sclerosis brain mature in the draining cervical lymph nodesQ35298764
Investigating the Antigen Specificity of Multiple Sclerosis Central Nervous System-Derived ImmunoglobulinsQ36330016
CCR5(+) and CXCR3(+) T cells are increased in multiple sclerosis and their ligands MIP-1alpha and IP-10 are expressed in demyelinating brain lesionsQ36384816
B cell exchange across the blood-brain barrier in multiple sclerosisQ36498036
B cell IFN-γ receptor signaling promotes autoimmune germinal centers via cell-intrinsic induction of BCL-6.Q36863150
Specific peripheral B cell tolerance defects in patients with multiple sclerosisQ36890946
Natalizumab treatment leads to an increase in circulating CXCR3-expressing B cellsQ37365081
B cells expressing the transcription factor T-bet drive lupus-like autoimmunityQ37730634
Phenotypic and functional characterization of T cells in white matter lesions of multiple sclerosis patients.Q38720773
Cutting Edge: B Cell-Intrinsic T-bet Expression Is Required To Control Chronic Viral InfectionQ39588420
Determination of IgG subgroups in cerebrospinal fluid of multiple sclerosis patients and othersQ39716173
B cell receptor-mediated internalization of salmonella: a novel pathway for autonomous B cell activation and antibody production.Q39843083
Massive intracerebral Epstein-Barr virus reactivation in lethal multiple sclerosis relapse after natalizumab withdrawal.Q40205114
c-Myb Regulates the T-Bet-Dependent Differentiation Program in B Cells to Coordinate Antibody ResponsesQ40236309
Blood-brain barrier-specific properties of a human adult brain endothelial cell lineQ40377619
A TLR9-dependent checkpoint governs B cell responses to DNA-containing antigensQ42290162
CCR6-dependent positioning of memory B cells is essential for their ability to mount a recall response to antigen.Q43089413
P433issue2
P304page(s)264-278
P577publication date2019-06-19
P1433published inAnnals of NeurologyQ564414
P1476titleInduction of brain-infiltrating T-bet-expressing B cells in multiple sclerosis
P478volume86

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cites work (P2860)
Q95840980B and T Cells Driving Multiple Sclerosis: Identity, Mechanisms and Potential Triggers
Q101351073The association of Epstein-Barr virus infection with CXCR3+ B-cell development in multiple sclerosis impact of immunotherapies

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