Inositol and antioxidant supplementation: Safety and efficacy in pregnancy

scientific article published on 10 April 2019

Inositol and antioxidant supplementation: Safety and efficacy in pregnancy is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.1002/DMRR.3154
P932PMC publication ID6617769
P698PubMed publication ID30889626

P50authorMaria Pompea Antonia BaldassarreQ60322617
Agostino ConsoliQ91035578
Ines BucciQ92481682
Gloria FormosoQ48329432
P2093author name stringFederica Ginestra
Maria Assunta Carlucci
P2860cites workIn vivo chiro-inositol metabolism in the rat: a defect in chiro-inositol synthesis from myo-inositol and an increased incorporation of chiro-[3H]inositol into phospholipid in the Goto-Kakizaki (G.K) rat.Q54131435
Urinary chiro-inositol excretion is an index marker of insulin sensitivity in Japanese type II diabetes.Q54189909
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The antioxidant alpha-lipoic acid enhances insulin-stimulated glucose metabolism in insulin-resistant rat skeletal muscle.Q55066548
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Lipoic acid reduces glycemia and increases muscle GLUT4 content in streptozotocin-diabetic ratsQ73515749
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chiro-inositol deficiency and insulin resistance: a comparison of the chiro-inositol- and the myo-inositol-containing insulin mediators isolated from urine, hemodialysate, and muscle of control and type II diabetic subjectsQ30454061
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Inositol safety: clinical evidences.Q34028175
myo-Inositol supplementation and onset of gestational diabetes mellitus in pregnant women with a family history of type 2 diabetes: a prospective, randomized, placebo-controlled studyQ34035221
Differential effects of lipoic acid stereoisomers on glucose metabolism in insulin-resistant skeletal muscleQ34065020
Alpha-lipoic acid inhibits thrombin-induced fetal membrane weakening in vitroQ34154820
Inositols prevent and reverse endothelial dysfunction in diabetic rat and rabbit vasculature metabolically and by scavenging superoxide.Q34248342
Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acidQ34301299
α-Lipoic acid protects diabetic apolipoprotein E-deficient mice from nephropathyQ34440949
Resveratrol prevents embryonic oxidative stress and apoptosis associated with diabetic embryopathy and improves glucose and lipid profile of diabetic dam.Q35022230
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Increased inositol phosphoglycan P-type in the second trimester in pregnant women with type 2 and gestational diabetes mellitus.Q45984509
Effect of dietary myo-inositol supplementation in pregnancy on the incidence of maternal gestational diabetes mellitus and fetal outcomes: a randomized controlled trialQ46085298
Alpha-lipoic acid reduces congenital malformations in the offspring of diabetic miceQ46109430
Urinary Excretion of Myo-Inositol and D-Chiro-Inositol in Early Pregnancy Is Enhanced in Gravidas With Gestational Diabetes MellitusQ46421990
Switching from pathogenetic treatment with alpha-lipoic acid to gabapentin and other analgesics in painful diabetic neuropathy: a real-world study in outpatientsQ46651876
Safety studies on epigallocatechin gallate (EGCG) preparations. Part 3: teratogenicity and reproductive toxicity studies in ratsQ46892599
Urinary excretion of inositol phosphoglycan P-type in gestational diabetes mellitusQ46935436
Inositol phosphoglycan putative insulin mediator in human amniotic fluid.Q46955898
Safety of synthetic trans-resveratrol as a novel food pursuant to Regulation (EC) No 258/97Q47157595
Nutritional and Acquired Deficiencies in Inositol Bioavailability. Correlations with Metabolic DisordersQ47162682
An open-label pilot trial of alpha-lipoic acid for weight loss in patients with schizophrenia without diabetesQ47249844
Effects of alpha-lipoic Acid on body weight in obese subjectsQ47399374
Can trans resveratrol plus d-chiro-inositol and myo-inositol improve maternal metabolic profile in overweight pregnant patients?Q47768063
Myo-inositol may prevent gestational diabetes onset in overweight women: a randomized, controlled trialQ47932349
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Abnormalities in myo-inositol metabolism associated with type 2 diabetes in mice fed a high-fat diet: benefits of a dietary myo-inositol supplementationQ48801302
Myo-inositol transport into endothelial cells derived from nervous system microvesselsQ49054165
Myo-inositol lowers the risk of developing gestational diabetic mellitus in pregnancies: A systematic review and meta-analysis of randomized controlled trials with trial sequential analysisQ50080683
Green tea extract reduces blood pressure, inflammatory biomarkers, and oxidative stress and improves parameters associated with insulin resistance in obese, hypertensive patients.Q50494276
Finding the best therapeutic approach for PCOS: the importance of inositol(s) bioavailability.Q50525517
Effect of alpha-lipoic acid on blood glucose, insulin resistance and glutathione peroxidase of type 2 diabetic patients.Q51027693
Myo-inositol, D-chiro-inositol, folic acid and manganese in second trimester of pregnancy: a preliminary investigationQ53101945
Centella asiatica and lipoic acid, or a combination thereof, inhibit monocyte adhesion to endothelial cells from umbilical cords of gestational diabetic women.Q53487033
Are oxidative stress-activated signaling pathways mediators of insulin resistance and beta-cell dysfunction?Q35034481
Increased endothelial inflammation, sTie-2 and arginase activity in umbilical cords obtained from gestational diabetic mothersQ35078422
New Insights on Oxidative Stress and Diabetic Complications May Lead to a “Causal” Antioxidant TherapyQ35115544
Efficacy and safety of antioxidant treatment with α-lipoic acid over 4 years in diabetic polyneuropathy: the NATHAN 1 trialQ35179957
Diabetes and alpha lipoic Acid.Q35564911
Effect of α-lipoic acid and exercise training on cardiovascular disease risk in obesity with impaired glucose tolerance.Q35707591
Transplacental supply of mannose and inositol in uncomplicated pregnancies using stable isotopesQ36069734
Myo-Inositol Safety in Pregnancy: From Preimplantation Development to Newborn Animals.Q36152232
Ambient glucose and aldose reductase-induced myo-inositol depletion modulate basal and carbachol-stimulated inositol phospholipid metabolism and diacylglycerol accumulation in human retinal pigment epithelial cells in cultureQ36608285
D-chiro-inositol metabolism in diabetes mellitusQ36626417
Effect of treating streptozotocin-induced diabetic rats with sorbinil, myo-inositol or aminoguanidine on endoneurial blood flow, motor nerve conduction velocity and vascular function of epineurial arterioles of the sciatic nerveQ36782199
Metabolic changes in pregnancyQ36992758
The use of green tea polyphenols for treating residual albuminuria in diabetic nephropathy: A double-blind randomised clinical trialQ37019265
Alpha-lipoic acid inhibits tumor necrosis factor-induced remodeling and weakening of human fetal membranesQ37170671
The Effectiveness of Myo-Inositol and D-Chiro Inositol Treatment in Type 2 Diabetes.Q37363630
Oxidative stress in diabetes: implications for vascular and other complicationsQ37375332
Safety and pharmacokinetics of multiple dose myo-inositol in preterm infantsQ37544118
Diabetes and obesity in pregnancyQ37830151
The putative metabolic role of d-chiro inositol phosphoglycan in human pregnancy and preeclampsiaQ38130381
Peripheral neuropathy in obstetrics: efficacy and safety of α-lipoic acid supplementation.Q38260441
Metabolic effects of resveratrol: addressing the controversies.Q38303686
Antidiabetic activity of resveratrol, a known SIRT1 activator in a genetic model for type-2 diabetesQ38342570
Inositol transport proteinsQ38394774
Alpha-lipoic acid inhibits adipocyte differentiation by regulating pro-adipogenic transcription factors via mitogen-activated protein kinase pathwaysQ38520024
The influence of D-chiro-inositol and D-myo-inositol in pregnant women with glucose intoleranceQ38626565
Protective role of epigallocatechin-3-gallate in health and disease: A perspectiveQ38742626
Dietary supplementation with myo-inositol in women during pregnancy for treating gestational diabetes.Q38823728
Immunomodulatory activities of alpha lipoic acid with a special focus on its efficacy in preventing miscarriageQ38854377
Pharmacodynamics and pharmacokinetics of inositol(s) in health and diseaseQ38879505
Epigallocatechin-3-O-gallate (EGCG) protects the insulin sensitivity in rat L6 muscle cells exposed to dexamethasone conditionQ39788941
Sodium- and energy-dependent uptake of myo-inositol by rabbit peripheral nerve. Competitive inhibition by glucose and lack of an insulin effectQ40681688
Stimulation of glucose uptake by the natural coenzyme alpha-lipoic acid/thioctic acid: participation of elements of the insulin signaling pathwayQ41149722
Myo-inositol Supplementation for Prevention of Gestational Diabetes in Obese Pregnant Women: A Randomized Controlled TrialQ41515750
Elevated D-glucose induces insulin insensitivity in human umbilical endothelial cells isolated from gestational diabetic pregnanciesQ42451377
Safety of oral alpha-lipoic acid treatment in pregnant women: a retrospective observational studyQ42696763
Effects of lipoic acid on AMPK and adiponectin in adipose tissue of low- and high-fat-fed ratsQ42717684
Engagement of the insulin-sensitive pathway in the stimulation of glucose transport by alpha-lipoic acid in 3T3-L1 adipocytesQ42803223
Alpha-lipoic acid supplementation: a tool for obesity therapy?Q43101323
P275copyright licenseCreative Commons Attribution-NonCommercial-NoDerivativesQ6937225
P433issue5
P921main subjectgestational diabetesQ126691
antioxidantQ133948
P304page(s)e3154
P577publication date2019-04-10
2019-07-01
P1433published inDiabetes - Metabolism: Research and ReviewsQ15750056
P1476titleInositol and antioxidant supplementation: Safety and efficacy in pregnancy
P478volume35

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