Robust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague

scientific article published on 12 August 2019

Robust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.VACCINE.2019.07.103
P932PMC publication ID6773249
P698PubMed publication ID31416643

P50authorMatthew LawrenzQ33295608
Lalit BatraQ91610229
P2093author name stringEsma S Yolcu
Haval Shirwan
Amanda R Pulsifer
William Bowen
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Yersinia pestis YopE contains a dominant CD8 T cell epitope that confers protection in a mouse model of pneumonic plagueQ35091255
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Costimulation as a platform for the development of vaccines: a peptide-based vaccine containing a novel form of 4-1BB ligand eradicates established tumorsQ37370587
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Novel CTL epitopes identified through a Y. pestis proteome-wide analysis in the search for vaccine candidates against plagueQ38671761
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Multiple antigen peptide containing B and T cell epitopes of F1 antigen of Yersinia pestis showed enhanced Th1 immune response in murine modelQ41400297
Cell-mediated immune response to epitopic MAP (multiple antigen peptide) construct of LcrV antigen of Yersinia pestis in murine modelQ41406576
Evaluation of CD4+/CD8+ T-cell expression and IFN-γ, perforin secretion for B-T constructs of F1 and V antigens of Yersinia pestis.Q41422910
Recombinant (F1+V) vaccine protects cynomolgus macaques against pneumonic plague.Q41428963
Cell-mediated immune response and Th/Th cytokine profile of B-T constructs of F1 and V antigen of Yersinia pestisQ41434326
CpG oligodeoxynucleotides augment the murine immune response to the Yersinia pestis F1-V vaccine in bubonic and pneumonic models of plague.Q41438984
Antibodies and cytokines independently protect against pneumonic plague.Q41441607
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Vaccination with live Yersinia pestis primes CD4 and CD8 T cells that synergistically protect against lethal pulmonary Y. pestis infectionQ41451306
Immunogenicity of the rF1+rV vaccine for plague with identification of potential immune correlatesQ41451391
Gamma interferon, tumor necrosis factor alpha, and nitric oxide synthase 2, key elements of cellular immunity, perform critical protective functions during humoral defense against lethal pulmonary Yersinia pestis infectionQ41453869
Developing subunit immunogens using B and T cell epitopes and their constructs derived from the F1 antigen ofYersinia pestisusing novel delivery vehiclesQ41465431
A single dose sub-unit vaccine protects against pneumonic plagueQ41478002
An IgG1 titre to the F1 and V antigens correlates with protection against plague in the mouse modelQ41483141
Protection against experimental bubonic and pneumonic plague by a recombinant capsular F1-V antigen fusion protein vaccineQ41485426
A sub-unit vaccine elicits IgG in serum, spleen cell cultures and bronchial washings and protects immunized animals against pneumonic plagueQ41488013
A comparison of Plague vaccine, USP and EV76 vaccine induced protection against Yersinia pestis in a murine modelQ41493178
Membrane-bound Fas ligand only is essential for Fas-induced apoptosisQ42093656
SA-4-1BBL and monophosphoryl lipid A constitute an efficacious combination adjuvant for cancer vaccinesQ42186082
Expression and function of 4-1BB during CD4 versus CD8 T cell responses in vivoQ48020828
PlagueQ56706594
A brief history of biological weapons programmes and the use of animal pathogens as biological warfare agentsQ64360772
PlagueQ75331478
Ex vivo expansion of CD4+CD25+FoxP3+ T regulatory cells based on synergy between IL-2 and 4-1BB signalingQ79912637
P433issue38
P921main subjectYersinia pestisQ153875
P304page(s)5708-5716
P577publication date2019-08-12
P1433published inVaccineQ7907941
P1476titleRobust Th1 cellular and humoral responses generated by the Yersinia pestis rF1-V subunit vaccine formulated to contain an agonist of the CD137 pathway do not translate into increased protection against pneumonic plague
P478volume37

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cites work (P2860)
Q89698047The Impact of Age and Sex on Mouse Models of Melioidosis
Q91808007The Use of Analgesics during Vaccination with a Live Attenuated Yersinia pestis Vaccine Alters the Resulting Immune Response in Mice

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