Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models

scientific article published on 01 January 2020

Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1136/JITC-2019-000210
P932PMC publication ID7057422
P698PubMed publication ID31959727

P50authorSteven RosenbergQ2347448
John DaviesQ59917096
P2093author name stringLing Zhang
Nicholas P Restifo
Carylinda Serna
Richard A Morgan
Zhiya Yu
Christian S Hinrichs
P2860cites workRegulated intratumoral expression of IL-12 using a RheoSwitch Therapeutic System® (RTS®) gene switch as gene therapy for the treatment of glioma.Q54213332
Engineered T cells targeting E7 mediate regression of human papillomavirus cancers in a murine model.Q55086081
Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancerQ57118558
Recombinant IL-12 administration induces tumor regression in association with IFN-gamma productionQ72686394
Bioactive murine and human interleukin-12 fusion proteins which retain antitumor activity in vivoQ73077128
Effects of single-dose interleukin-12 exposure on interleukin-12-associated toxicity and interferon-gamma productionQ73774733
Intratumoral injection of IL-12 plasmid DNA--results of a phase I/IB clinical trialQ80448479
Intratumoral injection of DNA encoding human interleukin 12 into patients with metastatic melanoma: clinical efficacyQ81386256
Intratumoral recombinant human interleukin-12 administration in head and neck squamous cell carcinoma patients modifies locoregional lymph node architecture and induces natural killer cell infiltration in the primary tumorQ81498369
The power and pitfalls of IL-12Q84067446
A Phase II Study of Tumor-infiltrating Lymphocyte Therapy for Human Papillomavirus-associated Epithelial CancersQ90287047
Durable complete responses in heavily pretreated patients with metastatic melanoma using T-cell transfer immunotherapyQ24596055
Interleukin-12 and the regulation of innate resistance and adaptive immunityQ29614602
Tumor-specific CD8+ T cells expressing interleukin-12 eradicate established cancers in lymphodepleted hostsQ34109953
Improving adoptive T cell therapy by targeting and controlling IL-12 expression to the tumor environmentQ34757266
The B7-1 cytoplasmic tail enhances intracellular transport and mammalian cell surface display of chimeric proteins in the absence of a linear ER export motifQ35000777
A pilot trial using lymphocytes genetically engineered with an NY-ESO-1-reactive T-cell receptor: long-term follow-up and correlates with responseQ35182795
Complete regression of metastatic cervical cancer after treatment with human papillomavirus-targeted tumor-infiltrating T cells.Q35563824
IL-12 triggers a programmatic change in dysfunctional myeloid-derived cells within mouse tumors.Q35578622
Tumor-infiltrating lymphocytes genetically engineered with an inducible gene encoding interleukin-12 for the immunotherapy of metastatic melanomaQ35613148
Cancer immunotherapy using a membrane-bound interleukin-12 with B7-1 transmembrane and cytoplasmic domains.Q35939476
Evaluation of γ-retroviral vectors that mediate the inducible expression of IL-12 for clinical applicationQ35982211
Tumor regression and autoimmunity after reversal of a functionally tolerant state of self-reactive CD8+ T cells.Q36371632
Immunotherapy of cancer by IL-12-based cytokine combinationsQ36724827
Molecular Pathways: Breaking the Epithelial Cancer Barrier for Chimeric Antigen Receptor and T-cell Receptor Gene TherapyQ36928580
Collapse of the tumor stroma is triggered by IL-12 induction of Fas.Q36984473
IL-12 delivered intratumorally by multilamellar liposomes reactivates memory T cells in human tumor microenvironmentsQ37219974
Adoptively transferred effector cells derived from naive rather than central memory CD8+ T cells mediate superior antitumor immunity.Q37389018
Exploiting the curative potential of adoptive T-cell therapy for cancerQ37576033
Of CARs and TRUCKs: chimeric antigen receptor (CAR) T cells engineered with an inducible cytokine to modulate the tumor stromaQ38170498
Immunogenicity of somatic mutations in human gastrointestinal cancers.Q38823554
Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancerQ40242985
Phase I study of the intratumoral administration of recombinant canarypox viruses expressing B7.1 and interleukin 12 in patients with metastatic melanomaQ40507124
Re-designing Interleukin-12 to enhance its safety and potential as an anti-tumor immunotherapeutic agent.Q45874251
The Dark Side of IFN-γ: Its Role in Promoting Cancer ImmunoevasionQ48337458
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue1
P407language of work or nameEnglishQ1860
P577publication date2020-01-01
P1433published inJournal for Immunotherapy of CancerQ27725163
P1476titleEnhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models
P478volume8

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