Immunogenicity of somatic mutations in human gastrointestinal cancers.

scientific article published on 29 October 2015

Immunogenicity of somatic mutations in human gastrointestinal cancers. is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1126/SCIENCE.AAD1253
P932PMC publication ID7445892
P698PubMed publication ID26516200

P50authorSteven RosenbergQ2347448
Alena GrosQ38801343
Yong-Chen LuQ42199992
P2093author name stringSatyajit Ray
Paul F Robbins
Yong F Li
Zhili Zheng
John R Wunderlich
Jared J Gartner
Simon Turcotte
Eric Tran
Mojgan Ahmadzadeh
Robert P Somerville
P2860cites workCancer genome landscapesQ22242276
Mutational heterogeneity in cancer and the search for new cancer-associated genesQ24606956
Safety, activity, and immune correlates of anti-PD-1 antibody in cancerQ24633070
Nivolumab plus ipilimumab in advanced melanomaQ27852310
Safety and Tumor Responses with Lambrolizumab (Anti–PD-1) in MelanomaQ27860650
Intratumor Heterogeneity and Branched Evolution Revealed by Multiregion SequencingQ27860948
Improved Survival with Ipilimumab in Patients with Metastatic MelanomaQ27861062
PD-1 Blockade in Tumors with Mismatch-Repair DeficiencyQ28262647
Frequent mutations of chromatin remodeling gene ARID1A in ovarian clear cell carcinomaQ28292742
NetMHCpan, a method for quantitative predictions of peptide binding to any HLA-A and -B locus protein of known sequenceQ28469279
Cancer immunology. Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancerQ29615679
Genetic basis for clinical response to CTLA-4 blockade in melanomaQ29620594
Nivolumab and ipilimumab versus ipilimumab in untreated melanomaQ29620657
Ras history: The saga continuesQ30404024
Mining exomic sequencing data to identify mutated antigens recognized by adoptively transferred tumor-reactive T cellsQ30621114
Inference of high resolution HLA types using genome-wide RNA or DNA sequencing readsQ33669140
Efficient identification of mutated cancer antigens recognized by T cells associated with durable tumor regressions.Q33851742
Adoptive cell transfer as personalized immunotherapy for human cancerQ34043643
Mutated PPP1R3B is recognized by T cells used to treat a melanoma patient who experienced a durable complete tumor regression.Q34729631
Identification of PHLPP1 as a tumor suppressor reveals the role of feedback activation in PTEN-mutant prostate cancer progressionQ35223274
API5 confers tumoral immune escape through FGF2-dependent cell survival pathwayQ35386974
Simplified method of the growth of human tumor infiltrating lymphocytes in gas-permeable flasks to numbers needed for patient treatmentQ35860034
NetMHCpan, a method for MHC class I binding prediction beyond humansQ35869130
Intratumor heterogeneity in human glioblastoma reflects cancer evolutionary dynamics.Q36673354
NetMHCIIpan-3.0, a common pan-specific MHC class II prediction method including all three human MHC class II isotypes, HLA-DR, HLA-DP and HLA-DQ.Q37257313
PD-1 identifies the patient-specific CD8⁺ tumor-reactive repertoire infiltrating human tumorsQ37726682
KRAS: feeding pancreatic cancer proliferationQ38175666
Messenger RNA-electroporated dendritic cells presenting MAGE-A3 simultaneously in HLA class I and class II molecules.Q41914021
A ras-mutated peptide targeted by CTL infiltrating a human melanoma lesionQ42674919
Tumor exome analysis reveals neoantigen-specific T-cell reactivity in an ipilimumab-responsive melanomaQ42874163
CD4(+) T-cell recognition of mutated B-RAF in melanoma patients harboring the V599E mutationQ48010177
Frequency of KRAS, BRAF, and NRAS mutations in colorectal cancer.Q54614277
Cancer immunotherapy based on mutation-specific CD4+ T cells in a patient with epithelial cancerQ57152489
Cytotoxic CD4+ and CD8+ T lymphocytes, generated by mutant p21-ras (12Val) peptide vaccination of a patient, recognize 12Val-dependent nested epitopes present within the vaccine peptide and kill autologous tumour cells carrying this mutationQ73734358
P433issue6266
P407language of work or nameEnglishQ1860
P304page(s)1387-1390
P577publication date2015-10-29
P1433published inScienceQ192864
P1476titleImmunogenicity of somatic mutations in human gastrointestinal cancers
P478volume350

Reverse relations

cites work (P2860)
Q39136403'Final common pathway' of human cancer immunotherapy: targeting random somatic mutations.
Q53600744'Genotype/immunotype' correlations in resected NSCLC.
Q45718710'Hotspots' of Antigen Presentation Revealed by Human Leukocyte Antigen Ligandomics for Neoantigen Prioritization
Q541396654-1BB Agonist Focuses CD8+ Tumor-Infiltrating T-Cell Growth into a Distinct Repertoire Capable of Tumor Recognition in Pancreatic Cancer.
Q468638194-1BB-Enhanced Expansion of CD8+ TIL from Triple-Negative Breast Cancer Unveils Mutation-Specific CD8+ T Cells
Q58790788A dormant TIL phenotype defines non-small cell lung carcinomas sensitive to immune checkpoint blockers
Q95319497A guide to cancer immunotherapy: from T cell basic science to clinical practice
Q58696044A neoepitope derived from a novel human germline APC gene mutation in familial adenomatous polyposis shows selective immunogenicity
Q90648467Actively personalized vaccination trial for newly diagnosed glioblastoma
Q90677024Adaptive Immunity and the Tumor Microenvironment
Q90479566Adoptive Cell Therapy Targeting Neoantigens: A Frontier for Cancer Research
Q90398709Adoptive Cell Therapy-Harnessing Antigen-Specific T Cells to Target Solid Tumours
Q89823519Adoptive Cell Therapy: A Novel and Potential Immunotherapy for Glioblastoma
Q38783946Advances in personalized cancer immunotherapy.
Q45875006An Efficient Single-Cell RNA-Seq Approach to Identify Neoantigen-Specific T Cell Receptors.
Q64070843Antigen Targets for the Development of Immunotherapies in Leukemia
Q64118726Antigen delivery targeted to tumor-associated macrophages overcomes tumor immune resistance
Q93052202Apparent Lack of BRAF V600E Derived HLA Class I Presented Neoantigens Hampers Neoplastic Cell Targeting by CD8+ T Cells in Langerhans Cell Histiocytosis
Q60047537CAR T Cell Therapy of Non-hematopoietic Malignancies: Detours on the Road to Clinical Success
Q58606449CART Immunotherapy: Development, Success, and Translation to Malignant Gliomas and Other Solid Tumors
Q37029731CD40 Stimulation Obviates Innate Sensors and Drives T Cell Immunity in Cancer
Q41808474CD74 and intratumoral immune response in breast cancer
Q36889067Cancer immunotherapy targeting neoantigens
Q64931054Cancer immunotherapy: broadening the scope of targetable tumours.
Q60933076Cancer research in the era of immunogenomics
Q49260236Cancer vaccine: learning lessons from immune checkpoint inhibitors
Q33806351Cervical Cancer Neoantigen Landscape and Immune Activity is Associated with Human Papillomavirus Master Regulators
Q90254063Challenges towards the realization of individualized cancer vaccines
Q38854579Characterization of an Immunogenic Mutation in a Patient with Metastatic Triple-Negative Breast Cancer.
Q57180053Chromosome Y-encoded antigens associate with acute graft-versus-host disease in sex-mismatched stem cell transplant
Q39092611Coevolution of Leukemia and Host Immune Cells in Chronic Lymphocytic Leukemia
Q64122192Combined Analysis of Antigen Presentation and T-cell Recognition Reveals Restricted Immune Responses in Melanoma
Q38698210Combining Local Immunotoxins Targeting Mesothelin with CTLA-4 Blockade Synergistically Eradicates Murine Cancer by Promoting Anticancer Immunity
Q91341294Comparing and contrasting predictive biomarkers for immunotherapy and targeted therapy of NSCLC
Q53740080Composite biomarkers defined by multiparametric immunofluorescence analysis identify ALK-positive adenocarcinoma as a potential target for immunotherapy.
Q38885361Computational genomics tools for dissecting tumour-immune cell interactions
Q55034685Concepts Collide: Genomic, Immune, and Microbial Influences on the Tumor Microenvironment and Response to Cancer Therapy.
Q90194707Conceptual Development of Immunotherapeutic Approaches to Gastrointestinal Cancer
Q99237757Crosstalk Between the MSI Status and Tumor Microenvironment in Colorectal Cancer
Q38780728Current status and future prospects of peptide-based cancer vaccines
Q26745516Current status and perspectives in translational biomarker research for PD-1/PD-L1 immune checkpoint blockade therapy
Q92284774Deciphering CD4+ T cell specificity using novel MHC-TCR chimeric receptors
Q90580775Deep learning using tumor HLA peptide mass spectrometry datasets improves neoantigen identification
Q39243064Dendritic Cell Strategies for Eliciting Mutation-Derived Tumor Antigen Responses in Patients.
Q91782530Determinants for Neoantigen Identification
Q90576547Developing neoantigen-targeted T cell-based treatments for solid tumors
Q40178906Development of an epitope panel for consistent identification of antigen-specific T-cells in humans
Q47716902Differential binding affinity of mutated peptides for MHC class I is a predictor of survival in advanced lung cancer and melanoma
Q42143897Direct identification of clinically relevant neoepitopes presented on native human melanoma tissue by mass spectrometry
Q40062688Effect of Modified Vaccinia Ankara-5T4 and Low-Dose Cyclophosphamide on Antitumor Immunity in Metastatic Colorectal Cancer: A Randomized Clinical Trial.
Q51275962Emerging biomarkers for PD-1 pathway cancer therapy.
Q36340870Emerging role of mutations in epigenetic regulators including MLL2 derived from The Cancer Genome Atlas for cervical cancer
Q57029270Enhanced detection of neoantigen-reactive T cells targeting unique and shared oncogenes for personalized cancer immunotherapy
Q92782148Enhanced efficacy and limited systemic cytokine exposure with membrane-anchored interleukin-12 T-cell therapy in murine tumor models
Q59812766Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance
Q37147632Future perspectives in cancer immunotherapy
Q90618258Gene editing and CRISPR in the clinic: current and future perspectives
Q37430859Gene expression and pathway analysis of CTNNB1 in cancer and stem cells
Q38774775Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease.
Q52587406Genomic Features of Response to Combination Immunotherapy in Patients with Advanced Non-Small-Cell Lung Cancer.
Q36730827Genomic and Transcriptomic Features of Response to Anti-PD-1 Therapy in Metastatic Melanoma
Q92179996Genomic correlates of response to immune checkpoint blockade
Q91956657Genomics-Guided Immunotherapy for Precision Medicine in Cancer
Q38806243Harnessing the immune system for the treatment of melanoma: current status and future prospects.
Q38390185Human Leukocyte Antigen (HLA) Peptides Derived from Tumor Antigens Induced by Inhibition of DNA Methylation for Development of Drug-facilitated Immunotherapy.
Q47152763Hypothesis: Induction of biomarkers for detection of colonic neoplasms
Q47133741Identification and Characterization of Neoantigens As Well As Respective Immune Responses in Cancer Patients
Q36194803Identification and isolation of antigen-specific cytotoxic T lymphocytes with an automated microraft sorting system.
Q42078847Identification of a tumor-reactive T-cell repertoire in the immune infiltrate of patients with resectable pancreatic ductal adenocarcinoma
Q61445099Identification of candidate neoantigens produced by fusion transcripts in human osteosarcomas
Q47736099Identification of essential genes for cancer immunotherapy.
Q62050532Identifying neoantigens for use in immunotherapy
Q90027962Immune Profiling of Cancer Patients Treated with Immunotherapy: Advances and Challenges
Q91451443Immune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma
Q89655603Immune engineering: from systems immunology to engineering immunity
Q57118558Immune recognition of somatic mutations leading to complete durable regression in metastatic breast cancer
Q39057617Immune targets and neoantigens for cancer immunotherapy and precision medicine
Q39144327Immune-Mediated Therapies for Liver Cancer.
Q90215738Immunogenic neoantigens derived from gene fusions stimulate T cell responses
Q37481401Immunogenicity of self tumor associated proteins is enhanced through protein truncation
Q49483662Immunopharmacogenomics towards personalized cancer immunotherapy targeting neoantigens
Q41127026Immunoscore in mismatch repair-proficient and -deficient colon cancer.
Q41012572Immunotherapy Expands and Maintains the Function of High-Affinity Tumor-Infiltrating CD8 T Cells In Situ
Q67201060Immunotherapy for Glioblastoma: Adoptive T-cell Strategies
Q92626003Immunotherapy in colorectal cancer: Available clinical evidence, challenges and novel approaches
Q50034111Immunotherapy of cancer with checkpoint inhibitors : Not only in malignant melanoma
Q47729557Immunotherapy of cancer: targeting cancer during active disease or during dormancy?
Q94475664In Silico analyses of host immunity and stroma provide prognostic factors in early stage pancreatic ductal adenocarcinoma (PDAC)
Q92126199Induction of neoantigen-reactive T cells from healthy donors
Q38864070Inflammation as a driver and vulnerability of KRAS mediated oncogenesis
Q89965765Insights Into Lung Cancer Immune-Based Biology, Prevention, and Treatment
Q37548587Ionic immune suppression within the tumour microenvironment limits T cell effector function.
Q47279363Is It Possible to Develop Cancer Vaccines to Neoantigens, What Are the Major Challenges, and How Can These Be Overcome? Neoantigens: Nothing New in Spite of the Name
Q42348082Is Tolerance Broken in Autoimmunity?
Q38797183Isolation of T-Cell Receptors Specifically Reactive with Mutated Tumor-Associated Antigens from Tumor-Infiltrating Lymphocytes Based on CD137 Expression.
Q89730893KRAS as a druggable target in NSCLC: Rising like a phoenix after decades of development failures
Q40242985Landscape of immunogenic tumor antigens in successful immunotherapy of virally induced epithelial cancer
Q52372679Lessons learned from the blockade of immune checkpoints in cancer immunotherapy.
Q64279278Level of neo-epitope predecessor and mutation type determine T cell activation of MHC binding peptides
Q36021163Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines.
Q90228169Low and variable tumor reactivity of the intratumoral TCR repertoire in human cancers
Q45459148Lung Cancer Subtypes Generate Unique Immune Responses
Q91671018Machine Learning for Cancer Immunotherapies Based on Epitope Recognition by T Cell Receptors
Q47947510Mapping the human T cell repertoire to recurrent driver mutations in MYD88 and EZH2 in lymphoma
Q38740015Mass spectrometric analysis of the HLA class I peptidome of melanoma cell lines as a promising tool for the identification of putative tumor-associated HLA epitopes
Q52382940Maturation of tertiary lymphoid structures and recurrence of stage II and III colorectal cancer.
Q34522172Mechanism-driven biomarkers to guide immune checkpoint blockade in cancer therapy
Q61124550Memory T cells targeting oncogenic mutations detected in peripheral blood of epithelial cancer patients
Q47153393Mesothelin as a novel biomarker and immunotherapeutic target in human glioblastoma
Q46056233Metastasectomy for Tumor-Infiltrating Lymphocytes: An Emerging Operative Indication in Surgical Oncology
Q47292249Molecular Biomarkers of Primary and Acquired Resistance to T-Cell-Mediated Immunotherapy in Cancer: Landscape, Clinical Implications, and Future Directions.
Q38380080Monitoring immune responses in the tumor microenvironment
Q64079285Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma
Q37109573Mutanome and expression of immune response genes in microsatellite stable colon cancer
Q90067743Mutated RAS: Targeting the "Untargetable" with T Cells
Q42777878Mutational Analysis of Gene Fusions Predicts Novel MHC Class I-Restricted T cell Epitopes & Immune Signatures in a Subset of Prostate Cancer
Q92137757Neoantigen identification strategies enable personalized immunotherapy in refractory solid tumors
Q38761397Neoantigen landscape dynamics during human melanoma-T cell interactions
Q97644519Neoantigen-Specific Adoptive Cell Therapies for Cancer: Making T-Cell Products More Personal
Q26738693Neoantigen-based cancer immunotherapy
Q92332582Neoantigen-specific immunity in low mutation burden colorectal cancers of the consensus molecular subtype 4
Q58086853Neoepitope targets of tumour-infiltrating lymphocytes from patients with pancreatic cancer
Q49711158New Chimeric Antigen Receptor Design for Solid Tumors
Q89456690Next-generation sequencing technologies accelerate advances in T-cell therapy for cancer
Q46512368Novel and shared neoantigen derived from histone 3 variant H3.3K27M mutation for glioma T cell therapy
Q38812269Opportunities and challenges for TCR mimic antibodies in cancer therapy
Q26738680Optimized tumor cryptic peptides: the basis for universal neo-antigen-like tumor vaccines
Q61448030Pancreatic cancer microenvironment: a current dilemma
Q92504704Pancreatic ductal adenocarcinoma: biological hallmarks, current status, and future perspectives of combined modality treatment approaches
Q48156858Patient HLA class I genotype influences cancer response to checkpoint blockade immunotherapy
Q93052152Pediatric patients with acute lymphoblastic leukemia generate abundant and functional neoantigen-specific CD8+ T cell responses
Q37059928Personalized Oncology Meets Immunology: The Path toward Precision Immunotherapy
Q50906889Personalized RNA mutanome vaccines mobilize poly-specific therapeutic immunity against cancer.
Q64988012Personalized cancer neoantigen vaccines come of age.
Q59136533Personalized identification of tumor-associated immunogenic neoepitopes in hepatocellular carcinoma in complete remission after sorafenib treatment
Q99551753Point mutation screening of tumor neoantigens and peptide-induced specific cytotoxic T lymphocytes using The Cancer Genome Atlas database
Q47701712Precision Immuno-Oncology: Prospects of Individualized Immunotherapy for Pancreatic Cancer
Q92830570Precision Medicine-Enabled Cancer Immunotherapy
Q38810911Precision medicine in pediatric oncology: Lessons learned and next steps
Q90704104Predicting HLA class II antigen presentation through integrated deep learning
Q31148562Prediction and prioritization of neoantigens: integration of RNA sequencing data with whole-exome sequencing.
Q61698755Principles of adoptive T cell therapy in cancer
Q57191808Prognostic Factors for Checkpoint Inhibitor Based Immunotherapy: An Update With New Evidences
Q94503515Prognostic value of CD73 expression in resected colorectal cancer liver metastasis
Q98771735Progress in Neoantigen Targeted Cancer Immunotherapies
Q33913077Progressive hypoventilation due to mixed CD8+ and CD4+ lymphocytic polymyositis following tremelimumab - durvalumab treatment
Q34507561Prospects for gene-engineered T cell immunotherapy for solid cancers.
Q52691915Quiescent Tissue Stem Cells Evade Immune Surveillance.
Q58698657RNA editing derived epitopes function as cancer antigens to elicit immune responses
Q40788906Rapid tumor regression in an Asian lung cancer patient following personalized neo-epitope peptide vaccination
Q37593573Reactivation of dormant anti-tumor immunity - a clinical perspective of therapeutic immune checkpoint modulation
Q38819745Recent advances in immuno-oncology and its application to urological cancers
Q28067217Recent advances in understanding antitumor immunity
Q90086342Recent insights into the biology of pancreatic cancer
Q90688967Recognition of human gastrointestinal cancer neoantigens by circulating PD-1+ lymphocytes
Q99237818Recombinant KRAS G12D Protein Vaccines Elicit Significant Anti-Tumor Effects in Mouse CT26 Tumor Models
Q26738301Regulation of CTNNB1 signaling in gastric cancer and stem cells
Q53850924Rekindling cancer vaccines.
Q90704110Robust prediction of HLA class II epitopes by deep motif deconvolution of immunopeptidomes
Q39304787Safety of Intra-Arterial Injection With Tumor-Activated T Cells to the Rabbit Brain Evaluated by MRI and SPECT/CT.
Q42654278Selection of Shared and Neoantigen-Reactive T Cells for Adoptive Cell Therapy Based on CD137 Separation
Q93104450Single-Cell Transcriptome Analysis Reveals Gene Signatures Associated with T-cell Persistence Following Adoptive Cell Therapy
Q41635793Socializing Individualized T-Cell Cancer Immunotherapy
Q37043492Stable, Nonviral Expression of Mutated Tumor Neoantigen-specific T-cell Receptors Using the Sleeping Beauty Transposon/Transposase System.
Q92242813Stem Cell Plasticity and Dormancy in the Development of Cancer Therapy Resistance
Q30252919Stimulating CD27 to quantitatively and qualitatively shape adaptive immunity to cancer
Q47335259Strategies for Bispecific Single Chain Antibody in Cancer Immunotherapy
Q52691832Strategies for Increasing Pancreatic Tumor Immunogenicity.
Q90629190Survival after checkpoint inhibitors for metastatic acral, mucosal and uveal melanoma
Q38992976T Cell Genesis: In Vitro Veritas Est?
Q92245345T cell receptor-based cancer immunotherapy: Emerging efficacy and pathways of resistance
Q30832820T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.
Q88938409T-cell Responses to TP53 "Hotspot" Mutations and Unique Neoantigens Expressed by Human Ovarian Cancers
Q55518760TCRmodel: high resolution modeling of T cell receptors from sequence.
Q50130464Targeting Neoantigens in Glioblastoma: An Overview of Cancer Immunogenomics and Translational Implications.
Q37223669Targeting neoantigens for cancer immunotherapy
Q39149196Targeting neoantigens to augment antitumour immunity
Q34677333Targeting of cancer neoantigens with donor-derived T cell receptor repertoires
Q97519028The Connection Between Minor H Antigens and Neoantigens and the Missing Link in Their Prediction
Q64075706The Discovery of Biomarkers in Cancer Immunotherapy
Q39152114The Heterocellular Emergence of Colorectal Cancer
Q89080863The Mutation-Associated Neoantigen Functional Expansion of Specific T Cells (MANAFEST) Assay: A Sensitive Platform for Monitoring Antitumor Immunity
Q90677037The Paradox of Cancer Immune Exclusion: Immune Oncology Next Frontier
Q41673084The Potential and Challenges of Exploiting the Vast But Dynamic Neoepitope Landscape for Immunotherapy
Q49307766The Potential of Donor T-Cell Repertoires in Neoantigen-Targeted Cancer Immunotherapy
Q38753386The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer
Q91933780The Spatial and Genomic Hierarchy of Tumor Ecosystems Revealed by Single-Cell Technologies
Q36129950The Value of Online Algorithms to Predict T-Cell Ligands Created by Genetic Variants
Q98771269The Ways of Isolating Neoantigen-Specific T Cells
Q38833922The case for immune-based approaches in biliary tract carcinoma
Q91520697The evolving landscape of biomarkers for checkpoint inhibitor immunotherapy
Q54967177Towards a better cancer precision medicine: systems biology meets immunotherapy.
Q96641056Towards new horizons: characterization, classification and implications of the tumour antigenic repertoire
Q47789519Towards personalized, tumour-specific, therapeutic vaccines for cancer.
Q99633734Transcriptional and immunohistological assessment of immune infiltration in pancreatic cancer
Q39280840Treating Hepatobiliary Cancer: The Immunologic Approach
Q93157712Tumor neoantigens: from basic research to clinical applications
Q101166677Tumor-infiltrating lymphocytes in the immunotherapy era
Q92523541Unique Neoantigens Arise from Somatic Mutations in Patients with Gastrointestinal Cancers
Q38787035Unmasking targets of antitumor immunity via high-throughput antigen profiling
Q40048119Unveiling the Peptide Motifs of HLA-C and HLA-G from Naturally Presented Peptides and Generation of Binding Prediction Matrices
Q36905613Use of HLA peptidomics and whole exome sequencing to identify human immunogenic neo-antigens.
Q91517668Ushering in Integrated T Cell Repertoire Profiling in Cancer
Q93081824Uveal Versus Cutaneous Melanoma; Same Origin, Very Distinct Tumor Types
Q100761752Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers
Q39013357mRNA Cancer Vaccines
Q64068516α-PD-1 therapy elevates Treg/Th balance and increases tumor cell pSmad3 that are both targeted by α-TGFβ antibody to promote durable rejection and immunity in squamous cell carcinomas