Decorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes

scientific article published on 30 April 2020

Decorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes is …
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scholarly articleQ13442814

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P356DOI10.1371/JOURNAL.PONE.0232321
P932PMC publication ID7192450
P698PubMed publication ID32353084

P50authorMengying WangQ93065953
P2093author name stringHui Wang
Ying Zhang
Meng Zhang
Yinan Liu
Zhengzheng Li
Yiping Feng
Jinghong Chen
P2860cites workIntegrin ligands at a glanceQ24600618
Expression of alpha and beta subunits of the integrin superfamily in articular cartilage from macroscopically normal and osteoarthritic human femoral headsQ24675261
Regional assessment of articular cartilage gene expression and small proteoglycan metabolism in an animal model of osteoarthritisQ24817141
NADPH-oxidase-driven oxygen radical production determines chondrocyte death and partly regulates metalloproteinase-mediated cartilage matrix degradation during interferon-gamma-stimulated immune complex arthritisQ24817170
Biological interplay between proteoglycans and their innate immune receptors in inflammationQ27005610
The role of changes in extracellular matrix of cartilage in the presence of inflammation on the pathology of osteoarthritisQ27011498
Pivotal role for decorin in angiogenesisQ28085303
Decorin binds to a narrow region of the epidermal growth factor (EGF) receptor, partially overlapping but distinct from the EGF-binding epitopeQ28213528
Localization of a binding site for the proteoglycan decorin on collagen XIV (undulin)Q28245922
Signaling by the matrix proteoglycan decorin controls inflammation and cancer through PDCD4 and MicroRNA-21Q28253084
Binding of the proteoglycan decorin to collagen type VIQ28284759
Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growthQ28508542
Immunolocalization of proteoglycans in Meckel's cartilage of the ratQ28567129
Integrin connections map: to infinity and beyondQ30309413
Demineralized bone matrix gelatin as scaffold for osteochondral tissue engineeringQ30438937
Assembly of Fibronectin Extracellular MatrixQ30538938
Biglycan and decorin bind close to the n-terminal region of the collagen VI triple helixQ30659690
Tumour necrosis factor-alpha interacts with biglycan and decorinQ30864778
Overexpression of decorin induces apoptosis and cell growth arrest in cultured rat mesangial cells in vitroQ33339680
In vitro cartilage tissue engineering using cancellous bone matrix gelatin as a biodegradable scaffoldQ33600940
Laminin-binding integrins and their tetraspanin partners as potential antimetastatic targetsQ33610587
Interclass small leucine-rich repeat proteoglycan interactions regulate collagen fibrillogenesis and corneal stromal assemblyQ33690533
Decorin regulates assembly of collagen fibrils and acquisition of biomechanical properties during tendon developmentQ34499890
Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily membersQ34504056
Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseasesQ34816873
BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development.Q35388963
Deficiency of NADPH Oxidase Components p47phox and gp91phox Caused Granulomatous Synovitis and Increased Connective Tissue Destruction in Experimental Arthritis ModelsQ35792117
A comparative evaluation of the small leucine-rich proteoglycans of pathological human intervertebral discsQ35888109
Decorin-TGFβ axis in hepatic fibrosis and cirrhosisQ35956255
Decorin: a guardian from the matrixQ36131541
Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragilityQ36258506
Decorin is an autophagy-inducible proteoglycan and is required for proper in vivo autophagyQ36322642
Integrins and chondrocyte-matrix interactions in articular cartilageQ36425948
Regulation of MAPKs by growth factors and receptor tyrosine kinasesQ36738312
Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissuesQ36955365
Integrin-mediated signalling through the MAP-kinase pathway.Q37076237
Structure and function of the human Gly1619Arg polymorphism of M6P/IGF2R domain 11 implicated in IGF2 dependent growthQ37136974
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs.Q37271877
Decorin and its galactosaminoglycan chain: extracellular regulator of cellular function?Q37272650
Genetic and cell biological analysis of integrin outside-in signaling.Q37400411
The regulatory roles of small leucine-rich proteoglycans in extracellular matrix assemblyQ38075193
Role of integrins and their ligands in osteoarthritic cartilageQ38254774
Decorin interacting network: A comprehensive analysis of decorin-binding partners and their versatile functions.Q38969810
Decorin is a novel VEGFR-2-binding antagonist for the human extravillous trophoblastQ39527514
Active ERK/MAP kinase is targeted to newly forming cell-matrix adhesions by integrin engagement and v-SrcQ39922817
Decorin enhances the proliferation and differentiation of myogenic cells through suppressing myostatin activity.Q40029833
Decorin protein core inhibits in vivo cancer growth and metabolism by hindering epidermal growth factor receptor function and triggering apoptosis via caspase-3 activationQ40256606
Osteoarthritis in the human knee: a dynamic process of cartilage matrix degradation, synthesis and reorganization.Q40888639
Growth/differentiation factor 15 promotes EGFR signalling, and regulates proliferation and migration in the hippocampus of neonatal and young adult miceQ41968735
Decorin inhibition of PDGF-stimulated vascular smooth muscle cell function: potential mechanism for inhibition of intimal hyperplasia after balloon angioplastyQ42792245
Genetic variation in the type 2 insulin-like growth factor receptor gene and disparity in childhood heightQ47368305
Fibrillogenesis of collagen types I, II, and III with small leucine-rich proteoglycans decorin and biglycan.Q51147366
Forced exercise-induced osteoarthritis is attenuated in mice lacking the small leucine-rich proteoglycan decorin.Q51268179
Decorin, a novel player in the insulin-like growth factor system.Q52767194
PDGF regulates chondrocyte proliferation through activation of the GIT1- and PLCγ1-mediated ERK1/2 signaling pathway.Q53023888
Changes in the integrins expression are related with the osteoarthritis severity in an experimental animal model in ratsQ57663560
Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilageQ71692768
Contents and distributions of the proteoglycans decorin and biglycan in normal and osteoarthritic human articular cartilageQ71730143
Characterization of the interactions of type XII collagen with two small proteoglycans from fetal bovine tendon, decorin and fibromodulinQ71940033
Light and electron microscopical immunohistochemical localization of the small proteoglycan core proteins decorin and biglycan in human knee joint cartilageQ72645130
Elevated levels of synovial fluid antibodies reactive with the small proteoglycans biglycan and decorin in patients with rheumatoid arthritis or other joint diseasesQ73155116
The small proteoglycans decorin and biglycan in human articular cartilage of late-stage osteoarthritisQ74612779
Decorin binds fibrinogen in a Zn2+-dependent interactionQ78969609
Small Leucine-Rich Proteoglycans in Skin Wound HealingQ89736179
Decorin Regulates the Aggrecan Network Integrity and Biomechanical Functions of Cartilage Extracellular MatrixQ90254321
Small Leucine Rich Proteoglycans (decorin, biglycan and lumican) in cancerQ90984631
Fibroblast growth factors in skeletal developmentQ92560050
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P4510describes a project that usesedgeRQ113334690
P433issue4
P304page(s)e0232321
P577publication date2020-04-30
P1433published inPLOS OneQ564954
P1476titleDecorin knockdown affects the gene expression profile of adhesion, growth and extracellular matrix metabolism in C-28/I2 chondrocytes
P478volume15

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