Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues

scientific article published on 14 July 2008

Fragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1186/AR2453
P932PMC publication ID2575625
P698PubMed publication ID18620607
P5875ResearchGate publication ID5231175

P50authorChristopher B LittleQ58048957
James MelroseQ58824586
Bruce CatersonQ42663796
Clare E. HughesQ46565033
P2093author name stringPeter J Roughley
Emily S Fuller
Briedgeen Kerr
Margaret M Smith
P2860cites workNon-proteoglycan forms of biglycan increase with age in human articular cartilageQ24528167
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Functions of lumican and fibromodulin: lessons from knockout miceQ28207266
Fibromodulin-null mice have abnormal collagen fibrils, tissue organization, and altered lumican deposition in tendonQ28593977
Degradation of decorin by matrix metalloproteinases: identification of the cleavage sites, kinetic analyses and transforming growth factor-beta1 releaseQ28611028
Cartilage proteoglycans: structure and potential functionsQ30419749
Age-related changes in the proteoglycans of human skin. Specific cleavage of decorin to yield a major catabolic fragment in adult skinQ31134336
Changes in leucine-rich repeat proteoglycans during maturation of the bovine growth plateQ32062846
Cleavage of fibromodulin in cartilage explants involves removal of the N-terminal tyrosine sulfate-rich region by proteolysis at a site that is sensitive to matrix metalloproteinase-13.Q33195733
Differential expression of the keratan sulphate proteoglycan, keratocan, during chick corneal embryogenesisQ33298730
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Differential expression of lumican and fibromodulin regulate collagen fibrillogenesis in developing mouse tendonsQ33925247
Influence of Decorin and Biglycan on Mechanical Properties of Multiple Tendons in Knockout MiceQ61771860
The pathology of the degenerate meniscus lesionQ67312557
Presence of small proteoglycan fragments in normal and arthritic human cartilageQ67569111
Large and small proteoglycans of osteoarthritic and rheumatoid articular cartilageQ71692768
Changes in the expression of decorin and biglycan in human articular cartilage with age and regulation by TGF-betaQ72132111
Age-related changes in fibromodulin and lumican in human intervertebral discsQ72994903
Modulation of keratan sulfate synthesis on lumican by the action of cytokines on human articular chondrocytesQ73073315
Keratocan-deficient mice display alterations in corneal structureQ73193137
Changes in messenger RNA and protein levels of proteoglycans and link protein in human osteoarthritic cartilage samplesQ73414170
Age-related changes in the synthesis and mRNA expression of decorin and aggrecan in human meniscus and articular cartilageQ73441871
Early changes in lapine menisci during osteoarthritis development: Part I: cellular and matrix alterationsQ73441884
A syndrome of joint laxity and impaired tendon integrity in lumican- and fibromodulin-deficient miceQ74380543
Abnormal collagen fibrils in tendons of biglycan/fibromodulin-deficient mice lead to gait impairment, ectopic ossification, and osteoarthritisQ78014904
Cyclic compression of cartilage/bone explants in vitro leads to physical weakening, mechanical breakdown of collagen and release of matrix fragmentsQ78629113
SLRP interaction can protect collagen fibrils from cleavage by collagenasesQ80275065
Mice deficient in biglycan and fibromodulin as a model for temporomandibular joint osteoarthritisQ83150420
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Changes with age in the structure of fibromodulin in human articular cartilageQ34405082
Mice deficient in small leucine-rich proteoglycans: novel in vivo models for osteoporosis, osteoarthritis, Ehlers-Danlos syndrome, muscular dystrophy, and corneal diseasesQ34816873
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Burden of major musculoskeletal conditions.Q35622610
Molecular markers of cartilage breakdown and synovitis at baseline as predictors of structural progression of hip osteoarthritis. The ECHODIAH CohortQ35636920
MMPs and ADAMTSs: functional studiesQ36251025
Targeted disruption of decorin leads to abnormal collagen fibril morphology and skin fragilityQ36258506
Biglycan and fibromodulin fragmentation correlates with temporal and spatial annular remodelling in experimentally injured ovine intervertebral discsQ36274812
Osteoarthritis: socioeconomic problemsQ36277774
In vitro, ex vivo, and in vivo methodological approaches for studying therapeutic targets of osteoporosis and degenerative joint diseases: how biomarkers can assist?Q36320642
Matrix metalloproteinases (MMPs) in health and disease: an overviewQ36348231
Use of biochemical markers to study and follow patients with osteoarthritisQ36413086
Usurped SLRPs: novel arthritis biomarkers exposed by catabolism of small leucine-rich proteoglycans?Q36430826
Biologic markers and disc degenerationQ36440814
The burden of musculoskeletal disease--a global perspectiveQ36446201
Biomarkers in spondyloarthritisQ36535219
The structure and function of cartilage proteoglycans.Q36669213
Pathology of the meniscusQ38141457
The ultrastructure and biochemistry of meniscal cartilageQ38141491
Direct and indirect markers of cartilage metabolism in synovial fluid obtained from dogs with hip dysplasia and correlation with clinical and radiographic variablesQ40335867
Altered proteolytic activities of ADAMTS-4 expressed by C-terminal processingQ40609440
Age-related changes in the structure of the keratan sulphate chains attached to fibromodulin isolated from articular cartilageQ41819202
Presence of pro-forms of decorin and biglycan in human articular cartilageQ41891631
Degradation of small leucine-rich repeat proteoglycans by matrix metalloprotease-13: identification of a new biglycan cleavage siteQ42010980
Identification and characterization of glycanated and non-glycanated forms of biglycan and decorin in the human intervertebral discQ42809150
Resistance of small leucine-rich repeat proteoglycans to proteolytic degradation during interleukin-1-stimulated cartilage catabolismQ42993459
Ocular and scleral alterations in gene-targeted lumican-fibromodulin double-null miceQ44453099
Serum cartilage oligomeric matrix protein and other biomarker profiles in tibiofemoral and patellofemoral osteoarthritis of the kneeQ46828675
Cartilage elasticity resides in shape module decoran and aggrecan sumps of damping fluid: implications in osteoarthrosis.Q50480312
The economic burden of disabling hip and knee osteoarthritis (OA) from the perspective of individuals living with this condition.Q50767186
Analysis of cartilage biomarkers in the early phases of canine experimental osteoarthritis.Q51051011
Health-related and overall quality of life of patients with chronic hip and knee complaints in general practice.Q51927949
Phenotypic effects of biglycan deficiency are linked to collagen fibril abnormalities, are synergized by decorin deficiency, and mimic Ehlers-Danlos-like changes in bone and other connective tissues.Q52546574
Accelerated osteoarthritis in the temporomandibular joint of biglycan/fibromodulin double-deficient mice.Q52565111
Direct and indirect costs attributable to osteoarthritis in active subjects.Q53241700
The cleavage of biglycan by aggrecanases.Q53614862
P433issue4
P407language of work or nameEnglishQ1860
P304page(s)R79
P577publication date2008-07-14
P1433published inArthritis Research and TherapyQ15757229
P1476titleFragmentation of decorin, biglycan, lumican and keratocan is elevated in degenerate human meniscus, knee and hip articular cartilages compared with age-matched macroscopically normal and control tissues
P478volume10

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cites work (P2860)
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