Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels

scientific article published on 08 July 2020

Animal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels is …
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scholarly articleQ13442814

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P356DOI10.3389/FPHAR.2020.00991
P932PMC publication ID7360831
P698PubMed publication ID32733241

P2093author name stringDmitry I Osmakov
Sergey A Kozlov
Yaroslav A Andreev
Ekaterina N Lyukmanova
Timur A Khasanov
P2860cites workEffect of chlorogenic acid on hydroxyl radicalQ23917185
The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memoryQ24296641
A proton-gated cation channel involved in acid-sensingQ24329227
Structure of the acid-sensing ion channel 1 in complex with the gating modifier Psalmotoxin 1Q24339479
Functional implications of the localization and activity of acid-sensitive channels in rat peripheral nervous systemQ24530236
Endogenous formation of morphine in human cellsQ24564112
Overexpression of acid-sensing ion channel 1a in transgenic mice increases acquired fear-related behaviorQ24633434
The tarantula toxin psalmotoxin 1 inhibits acid-sensing ion channel (ASIC) 1a by increasing its apparent H+ affinityQ24655228
Interaction of acid-sensing ion channel (ASIC) 1 with the tarantula toxin psalmotoxin 1 is state dependentQ24684643
ASIC3, an acid-sensing ion channel, is expressed in metaboreceptive sensory neuronsQ24815639
Potential Roles of Amiloride-Sensitive Sodium Channels in Cancer DevelopmentQ26741089
Salicylic acid as a peeling agent: a comprehensive reviewQ26782958
Non-proton ligand-sensing domain of acid-sensing ion channel 3 is required for itch sensationQ41914107
Chloroquine impairs visual transduction via modulation of acid sensing ion channel 1a.Q41921454
Potent neuroprotection after stroke afforded by a double-knot spider-venom peptide that inhibits acid-sensing ion channel 1a.Q41929851
Conformational dynamics and role of the acidic pocket in ASIC pH-dependent gatingQ42257199
Functional and pharmacological characterization of two different ASIC1a/2a heteromers reveals their sensitivity to the spider toxin PcTx1.Q42269220
Neuroprotective effects of chlorogenic acid against apoptosis of PC12 cells induced by methylmercuryQ42729470
Structural elements for the generation of sustained currents by the acid pain sensor ASIC3.Q42948766
Behavioral differentiation between itch and pain in mouseQ43075533
Identification of a cono-RFamide from the venom of Conus textile that targets ASIC3 and enhances muscle pain.Q43100941
Daurisoline suppressed early afterdepolarizations and inhibited L-type calcium currentQ43175858
Ligustrazine is a vasodilator of human pulmonary and bronchial arteriesQ43411656
The phenylpropanoid micronutrient chlorogenic acid improves clinical rating scores in rabbits following multiple infarct ischemic strokes: synergism with tissue plasminogen activatorQ43682726
A novel sea anemone peptide that inhibits acid-sensing ion channelsQ43687065
Effect of tetramethyl pyrazine on L-type calcium channel in rat ventricular myocytesQ43691287
Lactate enhances the acid-sensing Na+ channel on ischemia-sensing neuronsQ43723705
Alternative splicing and interaction with di- and polyvalent cations control the dynamic range of acid-sensing ion channel 1 (ASIC1).Q44116135
Modulation of ASIC channels in rat cerebellar Purkinje neurons by ischaemia-related signalsQ44121192
Effects of EGCG on voltage-gated sodium channels in primary cultures of rat hippocampal CA1 neuronsQ44631128
Black mamba venom peptides target acid-sensing ion channels to abolish painQ44940323
Acid-sensing ion channels in postoperative painQ45022640
The protective effects of ligustrazine on ischemia-reperfusion and DPPH free radical-induced myocardial injury in isolated rat heartsQ45073363
Antidepressant-like effects of paeoniflorin on the behavioural, biochemical, and neurochemical patterns of rats exposed to chronic unpredictable stressQ45086577
Block of native and cloned vanilloid receptor 1 (TRPV1) by aminoglycoside antibioticsQ45203659
Acid-sensing ion channels detect moderate acidifications to induce ocular painQ46158061
Animal toxins for channelopathy treatment.Q46272661
Electrophysiological and in vivo characterization of A-317567, a novel blocker of acid sensing ion channelsQ46629850
Discovery and molecular interaction studies of a highly stable, tarantula peptide modulator of acid-sensing ion channel 1.Q46759692
Convenient nomenclature of cysteine-rich polypeptide toxins from sea anemonesQ46794384
pH Dependency and desensitization kinetics of heterologously expressed combinations of acid-sensing ion channel subunitsQ47289083
Paeoniflorin, the Main Active Ingredient of Shuyu Capsule, Inhibits Cav1.2 and Regulates Calmodulin/Calmodulin-Dependent Protein Kinase II Signalling.Q47648489
Proton-independent activation of acid-sensing ion channel ASIC3 by alkaloid lindoldhamine from Laurus nobilis.Q47763899
Acid-sensing ion channel 1 is localized in brain regions with high synaptic density and contributes to fear conditioning.Q48262735
Inhibition of acid-sensing ion channels by diminazene and APETx2 evoke partial and highly variable antihyperalgesia in a rat model of inflammatory pain.Q48310094
A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitroQ48377130
Histamine selectively potentiates acid-sensing ion channel 1a.Q48542820
Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action.Q48545305
A natural point mutation changes both target selectivity and mechanism of action of sea anemone toxinsQ48639787
Effects of neomycin on high-threshold Ca(2+) currents and tetrodotoxin-resistant Na(+) currents in rat dorsal root ganglion neuronQ49063947
Regulation of breast tumorigenesis through acid sensors.Q38810445
Aminoglycosides: An OverviewQ38851189
The function and regulation of acid-sensing ion channels (ASICs) and the epithelial Na(+) channel (ENaC): IUPHAR Review 19.Q38859500
Conversed mutagenesis of an inactive peptide to ASIC3 inhibitor for active sites determinationQ38930014
Cellular acidification as a new approach to cancer treatment and to the understanding and therapeutics of neurodegenerative diseases.Q38963473
Involvement of the prostaglandin E receptor EP2 in paeoniflorin-induced human hepatoma cell apoptosisQ39258719
Reversal of acid-induced and inflammatory pain by the selective ASIC3 inhibitor, APETx2Q39951855
Inhibition of cardiac voltage-gated sodium channels by grape polyphenols.Q40224613
Inhibitory action of L-type Ca2+ current by paeoniflorin, a major constituent of peony root, in NG108-15 neuronal cells.Q40359049
Bioavailability and antioxidant effect of epigallocatechin gallate administered in purified form versus as green tea extract in healthy individuals.Q40399657
Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain.Q40402724
Evaluation of the anti-inflammatory, analgesic and antipyretic activities of the natural polyphenol chlorogenic acid.Q40465837
α-Dendrotoxin inhibits the ASIC current in dorsal root ganglion neurons from rat.Q40599727
Site-specific fluorescence spectrum detection and characterization of hASIC1a channels upon toxin mambalgin-1 binding in live mammalian cellsQ41073759
The Effects of Puerarin on Rat Ventricular Myocytes and the Potential Mechanism.Q41513961
Basic opioid pharmacology: an updateQ41527971
Endogenous Isoquinoline Alkaloids Agonists of Acid-Sensing Ion Channel Type 3.Q41684287
Acid-sensing ion channels in pain and disease.Q26829975
Evidence for the involvement of ASIC3 in sensory mechanotransduction in proprioceptorsQ27318258
Structure of acid-sensing ion channel 1 at 1.9 A resolution and low pHQ27648371
Pore architecture and ion sites in acid-sensing ion channels and P2X receptorsQ27656772
Structural plasticity and dynamic selectivity of acid-sensing ion channel–spider toxin complexesQ27670938
Sea Anemone Peptide with Uncommon  -Hairpin Structure Inhibits Acid-sensing Ion Channel 3 (ASIC3) and Reveals Analgesic ActivityQ27678798
X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective ChannelQ27681632
Understanding the molecular basis of toxin promiscuity: the analgesic sea anemone peptide APETx2 interacts with acid-sensing ion channel 3 and hERG channels via overlapping pharmacophoresQ27695723
Neuropeptide FF and FMRFamide potentiate acid-evoked currents from sensory neurons and proton-gated DEG/ENaC channelsQ28143657
Nonsteroid anti-inflammatory drugs inhibit both the activity and the inflammation-induced expression of acid-sensing ion channels in nociceptorsQ28189783
ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filtersQ28278216
Acid-sensing ion channel 2 (ASIC2) modulates ASIC1 H+-activated currents in hippocampal neuronsQ28505408
A modulatory subunit of acid sensing ion channels in brain and dorsal root ganglion cellsQ28572405
ASIC2b-dependent regulation of ASIC3, an essential acid-sensing ion channel subunit in sensory neurons via the partner protein PICK-1Q28584265
A novel strategy for the identification of toxinlike structures in spider venom.Q30350110
Restoring Acid-sensing ion channel-1a in the amygdala of knock-out mice rescues fear memory but not unconditioned fear responsesQ30486301
Puerarin inhibits acid-sensing ion channels and protects against neuron death induced by acidosisQ33516064
The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior.Q33597376
Cancer prevention by tea: animal studies, molecular mechanisms and human relevanceQ33693371
Protons are a neurotransmitter that regulates synaptic plasticity in the lateral amygdalaQ33790161
The mining of toxin-like polypeptides from EST database by single residue distribution analysisQ33807733
Isolation of a tarantula toxin specific for a class of proton-gated Na+ channels.Q33903469
Proinflammatory mediators, stimulators of sensory neuron excitability via the expression of acid-sensing ion channels.Q34165309
A high-throughput method for isolation of salicylic acid metabolic mutantsQ34173653
Biophysical properties of acid-sensing ion channels (ASICs).Q34458030
Acid-sensing ion channels and their modulators.Q34466126
Mambalgin-1 Pain-relieving Peptide, Stepwise Solid-phase Synthesis, Crystal Structure, and Functional Domain for Acid-sensing Ion Channel 1a InhibitionQ34505601
Paeoniflorin regulates macrophage activation in dimethylnitrosamine-induced liver fibrosis in rats.Q34511539
Antinociception produced by Thalassia testudinum extract BM-21 is mediated by the inhibition of acid sensing ionic channels by the phenolic compound thalassiolin B.Q34569637
A tarantula peptide against pain via ASIC1a channels and opioid mechanismsQ34651215
Regulation of ASIC activity by ASIC4--new insights into ASIC channel function revealed by a yeast two-hybrid assayQ34801941
Acid sensing ion channel (ASIC) inhibitors exhibit anxiolytic-like activity in preclinical pharmacological modelsQ34864899
Extracellular spermine exacerbates ischemic neuronal injury through sensitization of ASIC1a channels to extracellular acidosisQ35006657
Quercetin as a novel activator of L-type Ca(2+) channels in rat tail artery smooth muscle cellsQ35044277
Heteromeric acid-sensing ion channels (ASICs) composed of ASIC2b and ASIC1a display novel channel properties and contribute to acidosis-induced neuronal deathQ35178328
Quercetin inhibits acid-sensing ion channels through a putative binding site in the central vestibular region.Q51122382
NS383 Selectively Inhibits Acid-Sensing Ion Channels Containing 1a and 3 Subunits to Reverse Inflammatory and Neuropathic Hyperalgesia in Rats.Q51739932
Upregulation of acid-sensing ion channel ASIC1a in spinal dorsal horn neurons contributes to inflammatory pain hypersensitivity.Q51794095
PcTx1 affords neuroprotection in a conscious model of stroke in hypertensive rats via selective inhibition of ASIC1a.Q52150259
New APETx-like peptides from sea anemone Heteractis crispa modulate ASIC1a channels.Q52569645
Current and Future Use of Chloroquine and Hydroxychloroquine in Infectious, Immune, Neoplastic, and Neurological Diseases: A Mini-Review.Q54218397
Cryo-EM structure of the ASIC1a-mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect.Q55004104
Identification of a unique Ca2+-binding site in rat acid-sensing ion channel 3.Q55241951
Acid-sensing ion channels: dual function proteins for chemo-sensing and mechano-sensing.Q55268854
Knockdown of ASIC2a subunit aggravates injury of rat C6 glioma cells in acidosisQ55463691
Sinomenine Inhibits the Progression of Rheumatoid Arthritis by Regulating the Secretion of Inflammatory Cytokines and Monocyte/Macrophage SubsetsQ57491401
The Aminoglycosides Modulate the Acid-Sensing Ionic Channel Currents in Dorsal Root Ganglion Neurons from the RatQ57615175
Proton sensitivity of ASIC1 appeared with the rise of fishes by changes of residues in the region that follows TM1 in the ectodomain of the channelQ57635778
Electrophysiological and metabolic effects of CHF5074 in the hippocampus: Protection against in vitro ischemiaQ57744812
Gating mechanisms of acid-sensing ion channelsQ59061135
Efficacy and Safety of PPC-5650 on Experimental Rectal Pain in Patients with Irritable Bowel SyndromeQ60190082
Puerarin Relieves Paclitaxel-Induced Neuropathic Pain: The Role of Na1.8 β1 Subunit of Sensory NeuronsQ60919534
Analgesic Activity of Acid-Sensing Ion Channel 3 (ASIС3) Inhibitors: Sea Anemones Peptides Ugr9-1 and APETx2 versus Low Molecular Weight CompoundsQ60958816
Outlines of the pore in open and closed conformations describe the gating mechanism of ASIC1Q61198251
Kalium 2.0, a comprehensive database of polypeptide ligands of potassium channelsQ64286392
A receptor for protons in the nerve cell membraneQ72085090
Effect of membrane lipid composition on the conformational equilibria of the nicotinic acetylcholine receptorQ73334305
Retinopathy following chloroquine therapyQ78766793
Neuroprotective effects of tetramethylpyrazine on hydrogen peroxide-induced apoptosis in PC12 cellsQ79827993
Effects of extracellular calcium on fASIC1 currentsQ81196186
Repair of UVB-damaged skin by the antioxidant sulphated flavone glycoside thalassiolin B isolated from the marine plant Thalassia testudinum Banks ex KönigQ81597245
Silencing acid-sensing ion channel 1a alters cone-mediated retinal functionQ83839898
ASICs mediate the modulatory effect by paeoniflorin on α-synuclein autophagic degradationQ84000085
Effect of daurisoline on HERG channel electrophysiological function and protein expressionQ84968525
[The Biological Activity of the Sevanol and Its Analogues]Q87068803
Morphine inhibits acid-sensing ion channel currents in rat dorsal root ganglion neuronsQ87222806
The effect of ligustrazine on L-type calcium current, calcium transient and contractility in rabbit ventricular myocytesQ87432285
Gastrodin inhibits the activity of acid-sensing ion channels in rat primary sensory neuronsQ87466776
Inhibition of acid-sensing ion channels by chlorogenic acid in rat dorsal root ganglion neuronsQ87553620
Gating modifier toxins isolated from spider venom: Modulation of voltage-gated sodium channels and the role of lipid membranesQ88497955
Subtype-selective inhibition of acid-sensing ion channel 3 by a natural flavonoidQ88749355
Role of lysophosphatidic acid in ion channel function and diseaseQ89279607
Biophysical Characterization of Epigallocatechin-3-Gallate Effect on the Cardiac Sodium Channel Nav1.5.Q89834430
Alkaloid Lindoldhamine Inhibits Acid-Sensing Ion Channel 1a and Reveals Anti-Inflammatory PropertiesQ90194992
Sa12b Peptide from Solitary Wasp Inhibits ASIC Currents in Rat Dorsal Root Ganglion NeuronsQ90973213
Cholesterol-Dependent Gating Effects on Ion ChannelsQ91073741
Regulating ENaC's gateQ91266998
Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channelsQ91560862
Involvement of Acid-Sensing Ion Channel 1b in the Development of Acid-Induced Chronic Muscle PainQ91866868
Cholesterol as a Key Molecule That Regulates TRPV1 Channel FunctionQ92101305
The modulation of acid-sensing ion channel 1 by PcTx1 is pH-, subtype- and species-dependent: Importance of interactions at the channel subunit interface and potential for engineering selective analoguesQ92229265
Characterization of the Inhibitory Effect of Gastrodigenin and Gastrodin on M-type K+ Currents in Pituitary Cells and Hippocampal NeuronsQ92257330
Multiple Modulation of Acid-Sensing Ion Channel 1a by the Alkaloid DaurisolineQ92421813
Endogenous Neuropeptide Nocistatin Is a Direct Agonist of Acid-Sensing Ion Channels (ASIC1, ASIC2 and ASIC3)Q92826157
Acid-sensing ion channel 3 blockade inhibits durovascular and nitric oxide-mediated trigeminal painQ92895055
APETx-Like Peptides from the Sea Anemone Heteractis crispa, Diverse in Their Effect on ASIC1a and ASIC3 Ion ChannelsQ93186641
Sinomenine protects against ischaemic brain injury: involvement of co-inhibition of acid-sensing ion channel 1a and L-type calcium channelsQ35564271
A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce painQ35580623
Different contributions of ASIC channels 1a, 2, and 3 in gastrointestinal mechanosensory functionQ35597785
Glioma-specific cation conductance regulates migration and cell cycle progressionQ35763208
Synthesis, structure-activity relationship, and pharmacological profile of analogs of the ASIC-3 inhibitor A-317567Q36012306
Cyclisation increases the stability of the sea anemone peptide APETx2 but decreases its activity at acid-sensing ion channel 3Q36126184
Inhibition of voltage-gated Na(+) currents in sensory neurones by the sea anemone toxin APETx2.Q36147308
Molecular dynamics and functional studies define a hot spot of crystal contacts essential for PcTx1 inhibition of acid-sensing ion channel 1a.Q36211191
Lignan from thyme possesses inhibitory effect on ASIC3 channel currentQ36294779
Inhibition of acid sensing ion channel by ligustrazine on angina model in ratQ36309477
Subtype-specific modulation of acid-sensing ion channel (ASIC) function by 2-guanidine-4-methylquinazolineQ36332816
Single channel properties of rat acid-sensitive ion channel-1alpha, -2a, and -3 expressed in Xenopus oocytesQ36436486
ASIC subunit ratio and differential surface trafficking in the brainQ36446204
The molecular basis of chloroquine block of the inward rectifier Kir2.1 channelQ36446243
Solution structure of APETx2, a specific peptide inhibitor of ASIC3 proton-gated channelsQ36518062
Acid-sensing ion channels (ASICs) in mouse skeletal muscle afferents are heteromers composed of ASIC1a, ASIC2, and ASIC3 subunits.Q36534365
Acid-sensing ion channels: advances, questions and therapeutic opportunities.Q36557438
Non-acidic activation of pain-related Acid-Sensing Ion Channel 3 by lipidsQ36584352
Gastrodin protects apoptotic dopaminergic neurons in a toxin-induced Parkinson's disease model.Q36703085
Two residues in the extracellular domain convert a nonfunctional ASIC1 into a proton-activated channelQ37174464
Acid-sensing ion channel 3 expression in mouse knee joint afferents and effects of carrageenan-induced arthritisQ37175428
Sinomenine versus NSAIDs for the treatment of rheumatoid arthritis: a systematic review and meta-analysisQ37236098
Identification of protein domains that control proton and calcium sensitivity of ASIC1aQ37459865
Expression of acid-sensing ion channels and selection of reference genes in mouse and naked mole rat.Q37498305
A new sea anemone peptide, APETx2, inhibits ASIC3, a major acid-sensitive channel in sensory neuronsQ37544583
Overviews of Biological Importance of Quercetin: A Bioactive FlavonoidQ37558700
Puerarin: a review of pharmacological effectsQ38171456
Structural domains underlying the activation of acid-sensing ion channel 2a.Q38309100
Receptor for protons: First observations on Acid Sensing Ion Channels.Q38315853
Acid-Sensing Ion Channels and nociception in the peripheral and central nervous systems.Q38365887
Acid-Sensing Ion Channel Pharmacology, Past, Present, and Future ….Q38681343
Acid-sensing ion channels contribute to the effect of extracellular acidosis on proliferation and migration of A549 cellsQ38700194
ASIC1a mediates the drug resistance of human hepatocellular carcinoma via the Ca2+/PI3-kinase/AKT signaling pathwayQ38727575
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P304page(s)991
P577publication date2020-07-08
P1433published inFrontiers in PharmacologyQ2681208
P1476titleAnimal, Herb, and Microbial Toxins for Structural and Pharmacological Study of Acid-Sensing Ion Channels
P478volume11