| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1049549036 |
| P356 | DOI | 10.1038/NG0796-347 |
| P3181 | OpenCitations bibliographic resource ID | 3679100 |
| P698 | PubMed publication ID | 8673135 |
| P50 | author | Bert Vogelstein | Q827502 |
| Kenneth W. Kinzler | Q28031580 | ||
| Sam Thiagalingam | Q42609448 | ||
| P2093 | author name string | G J Riggins | |
| S R Hamilton | |||
| J K Willson | |||
| S E Kern | |||
| S D Markowitz | |||
| E Rozenblum | |||
| C L Weinstein | |||
| P2860 | cites work | Basic local alignment search tool | Q25938991 |
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| Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components | Q29036482 | ||
| DPC4, a candidate tumor suppressor gene at human chromosome 18q21.1 | Q29616726 | ||
| A workbench for multiple alignment construction and analysis | Q29618211 | ||
| The TGF-beta superfamily: new members, new receptors, and new genetic tests of function in different organisms | Q34349039 | ||
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| Common deleted region on the long arm of chromosome 5 in esophageal carcinoma | Q53458991 | ||
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| Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers | Q71167724 | ||
| Integration of the 1993-94 Généthon genetic linkage map for chromosome 18 with the physical map using a somatic cell hybrid mapping panel | Q72297615 | ||
| P433 | issue | 3 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 347-9 | |
| P577 | publication date | 1996-07-01 | |
| P1433 | published in | Nature Genetics | Q976454 |
| P1476 | title | Mad-related genes in the human | |
| P478 | volume | 13 |
| Q24318523 | 15-Hydroxyprostaglandin dehydrogenase, a COX-2 oncogene antagonist, is a TGF-beta-induced suppressor of human gastrointestinal cancers |
| Q36449039 | AGR2 is a SMAD4-suppressible gene that modulates MUC1 levels and promotes the initiation and progression of pancreatic intraepithelial neoplasia |
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| Q78141327 | Allelic imbalance in chromosome band 18q21 and SMAD4 mutations in ovarian cancers |
| Q73549440 | Allelic imbalance on chromosome 18 in neuroblastoma |
| Q74606005 | Allelic loss on chromosome 18q as a prognostic marker in stage II colorectal cancer |
| Q73790957 | Allelic losses on 18q21 are associated with progression and metastasis in human prostate cancer |
| Q40951183 | Altered phenotype of HT29 colonic adenocarcinoma cells following expression of the DCC gene |
| Q22008821 | An antisense transcript to SMAD5 expressed in fetal and tumor tissues |
| Q40990772 | Analysis of 5'-flanking region of human Smad4 (DPC4) gene |
| Q36830940 | Analysis of genomic alterations in benign, atypical, and anaplastic meningiomas: toward a genetic model of meningioma progression |
| Q48915619 | Analysis of human meningiomas for aberrations of the MADH2, MADH4, APM-1 and DCC tumor suppressor genes on the long arm of chromosome 18. |
| Q28276431 | BRAM1, a BMP receptor-associated molecule involved in BMP signalling |
| Q34558159 | Biology and genetics of colorectal cancer |
| Q41469668 | Biology of TGF-beta in knockout and transgenic mouse models |
| Q60046390 | Biomarkers in colorectal cancer: Current clinical utility and future perspectives |
| Q47975683 | Bone Morphogenetic Proteins: From Basic Studies to Clinical Approaches |
| Q34025148 | Bone morphogenetic proteins and their antagonists: current and emerging clinical uses |
| Q41332704 | Cancer gets Mad: DPC4 and other TGFbeta pathway genes in human cancer |
| Q48039568 | Characterization of theMADH2/Smad2Gene, a HumanMadHomolog Responsible for the Transforming Growth Factor-β and Activin Signal Transduction Pathway |
| Q77357704 | Chromosomal aberrations in colorectal cancers and liver metastases analyzed by comparative genomic hybridization |
| Q41666671 | Chromosome arm 20q gains and other genomic alterations in colorectal cancer metastatic to liver, as analyzed by comparative genomic hybridization and fluorescence in situ hybridization |
| Q40459372 | Cloning of Smad2, Smad3, Smad4, and Smad7 from the goldfish pituitary and evidence for their involvement in activin regulation of goldfish FSHbeta promoter activity. |
| Q34624184 | Colorectal cancer: chemopreventive role of curcumin and resveratrol |
| Q57274830 | Comparative genomic hybridization reveals frequent gains of 20q, 8q, 11q, 12p, and 17q, and losses of 18q, 9p, and 15q in pancreatic cancer |
| Q39591748 | Counting alleles to predict recurrence of early-stage colorectal cancers |
| Q64994186 | Cytogenetic analysis of colorectal adenomas: karyotypic comparisons of synchronous tumors. |
| Q53431099 | Cytogenetic analysis of pancreatic carcinomas: intratumor heterogeneity and nonrandom pattern of chromosome aberrations |
| Q73592146 | Cytogenetic findings in metastases from colorectal cancer |
| Q58109999 | DCC and SMAD4 alterations in human colorectal and pancreatic tumor dissemination |
| Q34014701 | DEC1 is a downstream target of TGF-beta with sequence-specific transcriptional repressor activities |
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| Q39567490 | Dietary fiber enhances TGF-β signaling and growth inhibition in the gut |
| Q63977064 | Dietary fiber enhances a tumor suppressor signaling pathway in the gut |
| Q33534117 | Downstream factors in transforming growth factor-beta family signaling |
| Q41090615 | DrosophilaMAD, a Member of the Smad Family, Translocates to the Nucleus upon Stimulation of thedppPathway |
| Q24310852 | Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes |
| Q37696106 | Epstein-Barr virus BARF1-induced NFκB/miR-146a/SMAD4 alterations in stomach cancer cells. |
| Q71167724 | Evaluation of candidate tumour suppressor genes on chromosome 18 in colorectal cancers |
| Q37454450 | Evaluation of the colorectal cancer risk conferred by rare UNC5C alleles. |
| Q38322507 | Expression and mutational analysis of the MADR2/Smad2 gene in human prostate cancer. |
| Q64892050 | Expression of Smad proteins in human colorectal cancer. |
| Q42092796 | Expression of Wnt ligands and Frizzled receptors in colonic mucosa and in colon carcinoma |
| Q54127845 | Extracellular Matrix-Associated Transforming Growth Factor-β: Role in Cancer Cell Growth and Invasion |
| Q55191845 | Frequent allelic imbalance on chromosome 18q21 in early superficial colorectal cancers. |
| Q30700260 | Functional cloning of the proto-oncogene brain factor-1 (BF-1) as a Smad-binding antagonist of transforming growth factor-beta signaling |
| Q28586079 | Gastro-intestinal tumorigenesis in Smad4 mutant mice |
| Q73358117 | Genetic alterations in sinonasal adenocarcinoma in wood workers studies with comparative genomic hybridization |
| Q40901517 | Genetic and biochemical analysis of TGF beta signal transduction |
| Q33824603 | Genetic approaches to TGFbeta signaling pathways |
| Q35355359 | Genetic epidemiology of mutated K-ras proto-oncogene, altered suppressor genes, and microsatellite instability in colorectal adenomas |
| Q47604291 | Genetic imbalances with impact on survival in colorectal cancer patients |
| Q33711610 | Genetic pathways in colorectal and other cancers |
| Q57337198 | Genetic pathways in colorectal and other cancers |
| Q41690568 | Genetics of pancreatic cancer. From genes to families. |
| Q45183732 | Genome-wide search for loss of heterozygosity in Chinese patients with sporadic colorectal cancer |
| Q35525580 | Genomic Analysis of the BMP Family in Glioblastomas |
| Q35787099 | Genomic instability is an early event during the progression pathway of ulcerative-colitis-related neoplasia |
| Q48040403 | Genomic structure of the human Smad3 gene and its infrequent alterations in colorectal cancers |
| Q40647622 | Growth-promoting effect of muscarinic acetylcholine receptors in colon cancer cells |
| Q50335584 | Heterogeneities in the biological and biochemical functions of Smad2 and Smad4 mutants naturally occurring in human lung cancers |
| Q77787482 | Higher frequency of Smad4 gene mutation in human colorectal cancer with distant metastasis |
| Q28276193 | Human Smad3 and Smad4 Are Sequence-Specific Transcription Activators |
| Q42453280 | Identification and characterisation of two distinct Smad proteins from the fox-tapeworm Echinococcus multilocularis |
| Q40832340 | Identification and characterization of a Smad2 homologue from Schistosoma mansoni, a transforming growth factor-beta signal transducer |
| Q38349140 | Identification of Smad2, a human Mad-related protein in the transforming growth factor beta signaling pathway |
| Q73748200 | Identification of allelic losses in benign, borderline, and invasive epithelial ovarian tumors and correlation with clinical outcome |
| Q35751276 | Identifying disease genes and module biomarkers by differential interactions |
| Q35587209 | Immunohistochemical analysis of adenocarcinoma of the small intestine: a tissue microarray study |
| Q28508338 | Intestinal tumorigenesis in compound mutant mice of both Dpc4 (Smad4) and Apc genes |
| Q41238186 | Intracellular signalling: the mad way to do it. |
| Q77759638 | Involvement of mutations in the DPC4 promoter in endometrial carcinoma development |
| Q40933612 | Lack of responsiveness to TGF-beta1 in a thyroid carcinoma cell line with functional type I and type II TGF-beta receptors and Smad proteins, suggests a novel mechanism for TGF-beta insensitivity in carcinoma cells |
| Q41046075 | Lack of transforming growth factor-β type II receptor expression in human retinoblastoma cells |
| Q58408875 | Le cancer du côlon: du diagnostic moléculaire à la conduite diagnostique et thérapeutique |
| Q28131788 | Lessons from hereditary colorectal cancer |
| Q28201487 | Limiting the location of putative human prostate cancer tumor suppressor genes on chromosome 18q |
| Q29619810 | Linking colorectal cancer to Wnt signaling |
| Q34493845 | Loss of heterozygosity as a predictor to map tumor suppressor genes in cancer: molecular basis of its occurrence |
| Q57786534 | Loss of heterozygosity at 18q21 region in gastric cancer involves a number of cancer-related genes and correlates with stage and histology, but lacks independent prognostic value |
| Q55410356 | MAD-related genes on 18q21.1, Smad2 and Smad4, are altered infrequently in esophageal squamous cell carcinoma. |
| Q52198314 | MAD-related proteins in TGF-β signalling |
| Q24315119 | MADR2 maps to 18q21 and encodes a TGFbeta-regulated MAD-related protein that is functionally mutated in colorectal carcinoma |
| Q28268871 | Mads and Smads in TGFβ signalling |
| Q30303987 | Mapping of genetic deletions on the long arm of chromosome 4 in human esophageal adenocarcinomas |
| Q41662768 | Mechanism and Function of Signaling by the TGFβ Superfamily |
| Q34485665 | Mechanisms underlying losses of heterozygosity in human colorectal cancers |
| Q37233285 | MicroRNA-23a regulates epithelial-to-mesenchymal transition in endometrial endometrioid adenocarcinoma by targeting SMAD3 |
| Q64967937 | MicroRNA‑486‑5p inhibits the growth of human hypertrophic scar fibroblasts by regulating Smad2 expression. |
| Q78087666 | Microsatellite instability and 8p allelic imbalance in stage B2 and C colorectal cancers |
| Q47975216 | Molecular Mechanisms of Transforming Growth Factor-β Signaling |
| Q42819903 | Molecular analyses of the 15q and 18q SMAD genes in pancreatic cancer |
| Q41686589 | Molecular biology of colorectal cancer |
| Q36243996 | Molecular delineation of the smallest commonly deleted region of chromosome 5 in malignant myeloid diseases to 1-1.5 Mb and preparation of a PAC-based physical map. |
| Q24617331 | Molecular origins of cancer: Molecular basis of colorectal cancer |
| Q37090445 | Mouse models for the study of colon carcinogenesis |
| Q34997348 | Mutation and expression of the DCC gene in human lung cancer |
| Q35695989 | Mutations in the tumor suppressors Smad2 and Smad4 inactivate transforming growth factor beta signaling by targeting Smads to the ubiquitin-proteasome pathway |
| Q45345228 | Mutations increasing autoinhibition inactivate tumour suppressors Smad2 and Smad4 |
| Q73180060 | Mutations of the Smad2 and Smad4 genes in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats |
| Q28295909 | Netrin-1 and its receptors in tumorigenesis |
| Q74670128 | Overexpression of c-erbB-2 protein correlates with chromosomal gain at the c-erbB-2 locus and patient survival in advanced colorectal carcinomas |
| Q28631440 | Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling |
| Q36547210 | Postgastrulation Smad2-deficient embryos show defects in embryo turning and anterior morphogenesis |
| Q34016415 | Prevalence of somatic alterations in the colorectal cancer cell genome |
| Q45991311 | Prognostic significance of allelic loss at chromosome 18q21 for stage II colorectal cancer |
| Q37746284 | Prognostic value of loss of heterozygosity and sub-cellular localization of SMAD4 varies with tumor stage in colorectal cancer |
| Q40383884 | Proliferation and Cdk4 expression in microsatellite unstable colon cancers with TGFBR2 mutations |
| Q24291512 | Promoting bone morphogenetic protein signaling through negative regulation of inhibitory Smads |
| Q24318330 | Receptor-associated Mad homologues synergize as effectors of the TGF-beta response |
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| Q33610904 | SMAD4--molecular gladiator of the TGF-beta signaling is trampled upon by mutational insufficiency in colorectal carcinoma of Kashmiri population: an analysis with relation to KRAS proto-oncogene. |
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