| scholarly article | Q13442814 |
| P50 | author | Richard M. Epand | Q43656907 |
| P2093 | author name string | Jianrun Xia | |
| Jillian Taylor | |||
| Ray Truant | |||
| Deborah Pinchev | |||
| Randy Singh Atwal | |||
| P2860 | cites work | Huntingtin contains a highly conserved nuclear export signal | Q24303895 |
| Huntingtin interacting protein 1 modulates the transcriptional activity of nuclear hormone receptors | Q24308715 | ||
| Differential interaction of nuclear receptors with the putative human transcriptional coactivator hTIF1 | Q24315063 | ||
| Huntingtin is a cytoplasmic protein associated with vesicles in human and rat brain neurons | Q24317574 | ||
| SUMO modification of Huntingtin and Huntington's disease pathology | Q24324137 | ||
| Visualization of Rab9-mediated vesicle transport from endosomes to the trans-Golgi in living cells | Q24673272 | ||
| Induction of autophagy causes dramatic changes in the subcellular distribution of GFP-Rab24. | Q44016477 | ||
| Disruption of Axonal Transport by Loss of Huntingtin or Expression of Pathogenic PolyQ Proteins in Drosophila | Q44607268 | ||
| Monoclonal antibodies from three new regions of huntingtin, the Huntington's disease protein | Q45293875 | ||
| Neuropathological classification of Huntington's disease | Q45297167 | ||
| Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin | Q45297223 | ||
| A YAC mouse model for Huntington's disease with full-length mutant huntingtin, cytoplasmic toxicity, and selective striatal neurodegeneration. | Q45298582 | ||
| Huntingtin expression stimulates endosomal-lysosomal activity, endosome tubulation, and autophagy. | Q45301281 | ||
| Dominant phenotypes produced by the HD mutation in STHdh(Q111) striatal cells | Q45301722 | ||
| HEAT repeats in the Huntington's disease protein | Q45307276 | ||
| Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions. | Q48373564 | ||
| Detection of autophagy in tissue by standard immunohistochemistry: possibilities and limitations. | Q50721155 | ||
| Mouse Models of Triplet Repeat Diseases | Q57877560 | ||
| Gain of glutamines, gain of function? | Q71990830 | ||
| Live-cell nucleocytoplasmic protein shuttle assay utilizing laser confocal microscopy and FRAP | Q77540431 | ||
| Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding | Q24674800 | ||
| Huntingtin interacts with REST/NRSF to modulate the transcription of NRSE-controlled neuronal genes | Q28189644 | ||
| Loss of huntingtin-mediated BDNF gene transcription in Huntington's disease | Q28202050 | ||
| Nrf1 is targeted to the endoplasmic reticulum membrane by an N-terminal transmembrane domain. Inhibition of nuclear translocation and transacting function | Q28239381 | ||
| LC3 conjugation system in mammalian autophagy | Q28278334 | ||
| Inclusion body formation reduces levels of mutant huntingtin and the risk of neuronal death | Q28287762 | ||
| Comparative genomics, evolution and origins of the nuclear envelope and nuclear pore complex | Q28299432 | ||
| Long glutamine tracts cause nuclear localization of a novel form of huntingtin in medium spiny striatal neurons in HdhQ92 and HdhQ111 knock-in mice | Q28505664 | ||
| Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro | Q28510315 | ||
| siRNA-mediated inhibition of endogenous Huntington disease gene expression induces an aberrant configuration of the ER network in vitro | Q28510833 | ||
| Dynamics of intracellular granules with CD63-GFP in rat basophilic leukemia cells | Q28576303 | ||
| Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles | Q28589989 | ||
| Huntingtin controls neurotrophic support and survival of neurons by enhancing BDNF vesicular transport along microtubules | Q28590634 | ||
| Exon 1 of the HD gene with an expanded CAG repeat is sufficient to cause a progressive neurological phenotype in transgenic mice | Q29615357 | ||
| Comparison of ARM and HEAT protein repeats | Q29616046 | ||
| Aggregation of huntingtin in neuronal intranuclear inclusions and dystrophic neurites in brain | Q29617982 | ||
| Rab7: a key to lysosome biogenesis | Q29620369 | ||
| An amino-terminal amphipathic alpha-helix mediates membrane association of the hepatitis C virus nonstructural protein 5A | Q29620628 | ||
| Huntingtin bodies sequester vesicle-associated proteins by a polyproline-dependent interaction. | Q30164317 | ||
| Computer-assisted image analysis protocol that quantitatively measures subnuclear protein organization in cell populations | Q30312129 | ||
| Huntingtin-HAP40 complex is a novel Rab5 effector that regulates early endosome motility and is up-regulated in Huntington's disease | Q30480364 | ||
| Interaction of huntingtin fragments with brain membranes--clues to early dysfunction in Huntington's disease | Q33231356 | ||
| Recent insights into the molecular pathogenesis of Huntington disease | Q33862546 | ||
| Identification of the endoplasmic reticulum targeting signal in vesicle-associated membrane proteins. | Q33883841 | ||
| Wild-type huntingtin reduces the cellular toxicity of mutant huntingtin in vivo | Q34044164 | ||
| Intracellular signaling from the endoplasmic reticulum to the nucleus: the unfolded protein response in yeast and mammals | Q34245400 | ||
| Flanking sequences profoundly alter polyglutamine toxicity in yeast | Q34984292 | ||
| Wild-type huntingtin plays a role in brain development and neuronal survival | Q35622306 | ||
| Autosomal dominant cerebellar ataxias: clinical features, genetics, and pathogenesis | Q35751839 | ||
| Beyond lectins: the calnexin/calreticulin chaperone system of the endoplasmic reticulum | Q36391681 | ||
| Endoplasmic reticulum stress in health and disease | Q36510035 | ||
| Subcellular localization of the Huntington's disease gene product in cell lines by immunofluorescence and biochemical subcellular fractionation | Q36823776 | ||
| Cytoplasmic aggregates trap polyglutamine-containing proteins and block axonal transport in a Drosophila model of Huntington's disease. | Q36854847 | ||
| Autophagosome-like vacuole formation in Huntington's disease lymphoblasts | Q42462336 | ||
| Ataxin-7 can export from the nucleus via a conserved exportin-dependent signal. | Q42807632 | ||
| P433 | issue | 21 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | Huntingtin | Q2620886 |
| P304 | page(s) | 2600-2615 | |
| P577 | publication date | 2007-08-18 | |
| P1433 | published in | Human Molecular Genetics | Q2720965 |
| P1476 | title | Huntingtin has a membrane association signal that can modulate huntingtin aggregation, nuclear entry and toxicity | |
| P478 | volume | 16 |
| Q42395501 | A Plasma Membrane Association Module in Yeast Amino Acid Transporters |
| Q47787775 | A comprehensive in silico analysis of huntingtin and its interactome |
| Q37157263 | A flexible polyglutamine hinge opens new doors for understanding huntingtin function |
| Q27301289 | A huntingtin-mediated fast stress response halting endosomal trafficking is defective in Huntington's disease. |
| Q39358037 | A multifunctional, multi-pathway intracellular localization signal in Huntingtin. |
| Q64882921 | A patient-derived cellular model for Huntington's disease reveals phenotypes at clinically relevant CAG lengths. |
| Q45290293 | A study of molecular changes relating to energy metabolism and cellular stress in people with Huntington's disease: looking for biomarkers |
| Q34627072 | Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage |
| Q48822102 | Accumulation of the sigma-1 receptor is common to neuronal nuclear inclusions in various neurodegenerative diseases |
| Q37142133 | Acetylation within the First 17 Residues of Huntingtin Exon 1 Alters Aggregation and Lipid Binding. |
| Q41851500 | Altered Co-Translational Processing Plays a Role in Huntington's Pathogenesis-A Hypothesis |
| Q64931945 | Altered lactate metabolism in Huntington's disease is dependent on GLUT3 expression. |
| Q35912172 | Altered lysosomal positioning affects lysosomal functions in a cellular model of Huntington's disease |
| Q30385936 | An Intein-based Strategy for the Production of Tag-free Huntingtin Exon 1 Proteins Enables New Insights into the Polyglutamine Dependence of Httex1 Aggregation and Fibril Formation |
| Q36647206 | An N-terminal nuclear export signal regulates trafficking and aggregation of Huntingtin (Htt) protein exon 1. |
| Q37810562 | Antibody Therapy in Neurodegenerative Disease |
| Q44962020 | Assessing mutant huntingtin fragment and polyglutamine aggregation by atomic force microscopy |
| Q45297035 | Atomistic mechanisms of huntingtin N-terminal fragment insertion on a phospholipid bilayer revealed by molecular dynamics simulations |
| Q28084804 | Autophagosome dynamics in neurodegeneration at a glance |
| Q38528206 | Autophagy and Lipid Droplets in the Liver |
| Q37935233 | Autophagy and polyglutamine diseases |
| Q27011387 | Autophagy in polyglutamine disease: Imposing order on disorder or contributing to the chaos? |
| Q27676093 | Beta conformation of polyglutamine track revealed by a crystal structure of Huntingtin N-terminal region with insertion of three histidine residues |
| Q34117333 | Bifunctional anti-huntingtin proteasome-directed intrabodies mediate efficient degradation of mutant huntingtin exon 1 protein fragments |
| Q30427825 | Biophysical insights into how surfaces, including lipid membranes, modulate protein aggregation related to neurodegeneration. |
| Q35703870 | CAG repeat lengths > or =335 attenuate the phenotype in the R6/2 Huntington's disease transgenic mouse |
| Q42353203 | CCT complex restricts neuropathogenic protein aggregation via autophagy |
| Q33814719 | Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease |
| Q57246845 | Chaperone-Mediated Autophagy and Parkinson's Disease |
| Q30787791 | Cholesterol Modifies Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes |
| Q36588291 | Conformation sensors that distinguish monomeric proteins from oligomers in live cells |
| Q92777658 | Conformational studies of pathogenic expanded polyglutamine protein deposits from Huntington's disease |
| Q33459255 | Conformational targeting of fibrillar polyglutamine proteins in live cells escalates aggregation and cytotoxicity |
| Q61135436 | Contact inhibition controls cell survival and proliferation via YAP/TAZ-autophagy axis |
| Q58994518 | Crosstalk between Endoplasmic Reticulum Stress and Protein Misfolding in Neurodegenerative Diseases |
| Q37760791 | Current understanding on the pathogenesis of polyglutamine diseases |
| Q34752467 | Cysteine proteases bleomycin hydrolase and cathepsin Z mediate N-terminal proteolysis and toxicity of mutant huntingtin |
| Q30437121 | Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. |
| Q30425063 | Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice |
| Q37571975 | Developing intrabodies for the therapeutic suppression of neurodegenerative pathology |
| Q35052612 | Development of an ELISA assay for the quantification of soluble huntingtin in human blood cells |
| Q34313192 | Differential nuclear localization of complexes may underlie in vivo intrabody efficacy in Huntington's disease |
| Q35641611 | Discovery of novel isoforms of huntingtin reveals a new hominid-specific exon |
| Q34618914 | Does Huntingtin play a role in selective macroautophagy? |
| Q41822886 | Early and late events induced by polyQ-expanded proteins: identification of a common pathogenic property of polYQ-expanded proteins |
| Q34112214 | Early autophagic response in a novel knock-in model of Huntington disease |
| Q37961564 | Engineered antibody therapies to counteract mutant huntingtin and related toxic intracellular proteins |
| Q37962584 | Epigenetic treatment of neurological disease |
| Q44933645 | Essential sequence of the N-terminal cytoplasmic localization-related domain of huntingtin and its effect on huntingtin aggregates |
| Q47558279 | Evaluation of Cognition and Cortical Excitability in Huntington's Disease |
| Q33530121 | F-actin binding regions on the androgen receptor and huntingtin increase aggregation and alter aggregate characteristics |
| Q33761247 | Fibril polymorphism affects immobilized non-amyloid flanking domains of huntingtin exon1 rather than its polyglutamine core |
| Q31055925 | Free-Energy Landscape of the Amino-Terminal Fragment of Huntingtin in Aqueous Solution |
| Q38259591 | From pathways to targets: understanding the mechanisms behind polyglutamine disease. |
| Q39877377 | GFP-LC3 labels organised smooth endoplasmic reticulum membranes independently of autophagy |
| Q30506469 | Ganglioside GM1 induces phosphorylation of mutant huntingtin and restores normal motor behavior in Huntington disease mice |
| Q30353131 | Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion. |
| Q64896030 | Generation of Native, Untagged Huntingtin Exon1 Monomer and Fibrils Using a SUMO Fusion Strategy. |
| Q37165188 | Genetic manipulations of mutant huntingtin in mice: new insights into Huntington's disease pathogenesis |
| Q27023050 | Genetics and neuropathology of Huntington's disease |
| Q35014895 | Grb2 is regulated by foxd3 and has roles in preventing accumulation and aggregation of mutant huntingtin |
| Q90411062 | High-mobility group box 1 links sensing of reactive oxygen species by huntingtin to its nuclear entry |
| Q41731654 | Huntingtin N17 domain is a reactive oxygen species sensor regulating huntingtin phosphorylation and localization |
| Q35867566 | Huntingtin Subcellular Localisation Is Regulated by Kinase Signalling Activity in the StHdhQ111 Model of HD. |
| Q41881745 | Huntingtin cleavage product A forms in neurons and is reduced by gamma-secretase inhibitors |
| Q30498164 | Huntingtin coordinates the dynein-mediated dynamic positioning of endosomes and lysosomes |
| Q33529116 | Huntingtin interacts with the cue domain of gp78 and inhibits gp78 binding to ubiquitin and p97/VCP. |
| Q45299796 | Huntingtin is a scaffolding protein in the ATM oxidative DNA damage response complex. |
| Q36098669 | Huntingtin proteolysis releases non-polyQ fragments that cause toxicity through dynamin 1 dysregulation. |
| Q56083219 | Huntington disease |
| Q42472433 | Huntington's disease and mitochondrial alterations: emphasis on experimental models |
| Q45303341 | Huntington's disease: flipping a switch on huntingtin |
| Q34797845 | Huntington's disease: revisiting the aggregation hypothesis in polyglutamine neurodegenerative diseases |
| Q30435758 | IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. |
| Q30447129 | Identification of a karyopherin β1/β2 proline-tyrosine nuclear localization signal in huntingtin protein |
| Q30578636 | Identification of a post-translationally myristoylated autophagy-inducing domain released by caspase cleavage of huntingtin. |
| Q89135698 | Identification of distinct conformations associated with monomers and fibril assemblies of mutant huntingtin |
| Q99614732 | Implications of the Orb2 Amyloid Structure in Huntington's Disease |
| Q34313991 | Increased mitochondrial fission and neuronal dysfunction in Huntington's disease: implications for molecular inhibitors of excessive mitochondrial fission |
| Q39426587 | Inhibiting the nucleation of amyloid structure in a huntingtin fragment by targeting α-helix-rich oligomeric intermediates |
| Q39943981 | Intrabodies binding the proline-rich domains of mutant huntingtin increase its turnover and reduce neurotoxicity |
| Q44742505 | Investigation of membrane penetration depth and interactions of the amino-terminal domain of huntingtin: refined analysis by tryptophan fluorescence measurement |
| Q26829932 | Iron dysregulation in Huntington's disease |
| Q30353134 | Is Huntingtin Dispensable in the Adult Brain? |
| Q39533990 | Kinase inhibitors modulate huntingtin cell localization and toxicity. |
| Q36088674 | Kinetically competing huntingtin aggregation pathways control amyloid polymorphism and properties |
| Q35940409 | Latrepirdine, a potential novel treatment for Alzheimer's disease and Huntington's chorea |
| Q90684471 | Lipid Membranes Influence the Ability of Small Molecules To Inhibit Huntingtin Fibrillization |
| Q45008320 | Lysine residues in the N-terminal huntingtin amphipathic α-helix play a key role in peptide aggregation |
| Q45290192 | Mass Spectrometry Analysis of Wild-Type and Knock-in Q140/Q140 Huntington's Disease Mouse Brains Reveals Changes in Glycerophospholipids Including Alterations in Phosphatidic Acid and Lyso-Phosphatidic Acid |
| Q30378040 | Membrane Curvature-sensing and Curvature-inducing Activity of Islet Amyloid Polypeptide and Its Implications for Membrane Disruption. |
| Q38974698 | Mitochondria-Associated Membranes (MAMs): Overview and Its Role in Parkinson's Disease |
| Q41998875 | Mitochondrial division inhibitor 1 protects against mutant huntingtin-induced abnormal mitochondrial dynamics and neuronal damage in Huntington's disease |
| Q37356257 | Mitochondrial structural and functional dynamics in Huntington's disease |
| Q37776087 | Molecular Mechanisms and Potential Therapeutical Targets in Huntington's Disease |
| Q35048841 | Molecular interaction between the chaperone Hsc70 and the N-terminal flank of huntingtin exon 1 modulates aggregation |
| Q33788913 | Monomeric, oligomeric and polymeric proteins in huntington disease and other diseases of polyglutamine expansion |
| Q42089641 | Mutant A53T alpha-synuclein induces neuronal death by increasing mitochondrial autophagy |
| Q37308357 | Mutant huntingtin and mitochondrial dysfunction |
| Q34829422 | Mutant huntingtin causes defective actin remodeling during stress: defining a new role for transglutaminase 2 in neurodegenerative disease |
| Q92185503 | Mutant huntingtin disrupts mitochondrial proteostasis by interacting with TIM23 |
| Q55711820 | Mutant huntingtin induces iron overload via up-regulating IRP1 in Huntington's disease. |
| Q35747131 | Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease |
| Q35645271 | Mutant huntingtin, abnormal mitochondrial dynamics, defective axonal transport of mitochondria, and selective synaptic degeneration in Huntington's disease |
| Q64944850 | N-terminal Huntingtin (Htt) phosphorylation is a molecular switch regulating Htt aggregation, helical conformation, internalization, and nuclear targeting. |
| Q27306025 | N17 Modifies mutant Huntingtin nuclear pathogenesis and severity of disease in HD BAC transgenic mice |
| Q89480421 | N6-Furfuryladenine is protective in Huntington's disease models by signaling huntingtin phosphorylation |
| Q35572092 | Neurodegenerative processes in Huntington's disease |
| Q38074521 | Neuronal Ca(2+) dyshomeostasis in Huntington disease. |
| Q45341843 | One-pot semisynthesis of exon 1 of the Huntingtin protein: new tools for elucidating the role of posttranslational modifications in the pathogenesis of Huntington's disease |
| Q33815642 | Perturbation with intrabodies reveals that calpain cleavage is required for degradation of huntingtin exon 1 |
| Q45305618 | Phosphorylation of huntingtin at residue T3 is decreased in Huntington's disease and modulates mutant huntingtin protein conformation |
| Q37447680 | Phosphorylation of threonine 3: implications for Huntingtin aggregation and neurotoxicity |
| Q37981477 | Physical chemistry of polyglutamine: intriguing tales of a monotonous sequence |
| Q34414446 | Polyglutamine amyloid core boundaries and flanking domain dynamics in huntingtin fragment fibrils determined by solid-state nuclear magnetic resonance. |
| Q42904942 | Polyglutamine dances the conformational cha-cha-cha |
| Q43100835 | Polyglutamine disruption of the huntingtin exon 1 N terminus triggers a complex aggregation mechanism |
| Q37157299 | Polyglutamine domain flexibility mediates the proximity between flanking sequences in huntingtin |
| Q33818809 | Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences |
| Q35479250 | Polyglutamine- and temperature-dependent conformational rigidity in mutant huntingtin revealed by immunoassays and circular dichroism spectroscopy |
| Q38374920 | Post-Translational Modifications (PTMs), Identified on Endogenous Huntingtin, Cluster within Proteolytic Domains between HEAT Repeats |
| Q57789346 | PreSMo Target-Binding Signatures in Intrinsically Disordered Proteins |
| Q35096897 | Prevalent polymorphism in thyroid hormone-activating enzyme leaves a genetic fingerprint that underlies associated clinical syndromes |
| Q51238345 | Preventing mutant huntingtin proteolysis and intermittent fasting promote autophagy in models of Huntington disease. |
| Q35221894 | Probing the Huntingtin 1-17 membrane anchor on a phospholipid bilayer by using all-atom simulations |
| Q47767382 | Protein phosphatase 1 regulates huntingtin exon 1 aggregation and toxicity. |
| Q39124557 | Proteins Containing Expanded Polyglutamine Tracts and Neurodegenerative Disease |
| Q30418699 | Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis |
| Q28506165 | Proteotoxic stress increases nuclear localization of ataxin-3 |
| Q40355188 | Prothymosin-α interacts with mutant huntingtin and suppresses its cytotoxicity in cell culture. |
| Q35005658 | RNAi screening in Drosophila cells identifies new modifiers of mutant huntingtin aggregation |
| Q88316783 | Redox Mechanisms in Neurodegeneration: From Disease Outcomes to Therapeutic Opportunities |
| Q37696972 | Repeat expansion disease: progress and puzzles in disease pathogenesis |
| Q38743344 | Role of Sigma-1 Receptor in Cocaine Abuse and Neurodegenerative Disease. |
| Q28544898 | Scalable production in human cells and biochemical characterization of full-length normal and mutant huntingtin |
| Q27657408 | Secondary Structure of Huntingtin Amino-Terminal Region |
| Q41520412 | Serine phosphorylation suppresses huntingtin amyloid accumulation by altering protein aggregation properties. |
| Q33594383 | Serines 13 and 16 are critical determinants of full-length human mutant huntingtin induced disease pathogenesis in HD mice |
| Q36600026 | Slow amyloid nucleation via α-helix-rich oligomeric intermediates in short polyglutamine-containing huntingtin fragments. |
| Q52692554 | Small molecule modulator of protein disulfide isomerase attenuates mutant huntingtin toxicity and inhibits endoplasmic reticulum stress in a mouse model of Huntington's disease. |
| Q49331880 | Sphingomyelin and GM1 Influence Huntingtin Binding to, Disruption of, and Aggregation on Lipid Membranes |
| Q27679485 | Structure and Topology of the Huntingtin 1–17 Membrane Anchor by a Combined Solution and Solid-State NMR Approach |
| Q41518158 | Structure of a single-chain Fv bound to the 17 N-terminal residues of huntingtin provides insights into pathogenic amyloid formation and suppression. |
| Q30610715 | Super-resolution fluorescence of huntingtin reveals growth of globular species into short fibers and coexistence of distinct aggregates |
| Q88299111 | Tadpole-like Conformations of Huntingtin Exon 1 Are Characterized by Conformational Heterogeneity that Persists regardless of Polyglutamine Length |
| Q38019159 | Targeting Huntington's disease through histone deacetylases |
| Q91899926 | Targeting N-Terminal Huntingtin with a Dual-sgRNA Strategy by CRISPR/Cas9 |
| Q37774037 | Targeting histone deacetylases for the treatment of Huntington's disease. |
| Q35909430 | Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy |
| Q47251076 | The 17-residue-long N terminus in huntingtin controls step-wise aggregation in solution and on membranes via different mechanisms |
| Q36694395 | The 2.2-Angstrom resolution crystal structure of the carboxy-terminal region of ataxin-3. |
| Q27301298 | The N17 domain mitigates nuclear toxicity in a novel zebrafish Huntington's disease model |
| Q33838789 | The aggregation-enhancing huntingtin N-terminus is helical in amyloid fibrils |
| Q37969749 | The biological function of the Huntingtin protein and its relevance to Huntington's Disease pathology |
| Q42699018 | The chaperonin TRiC blocks a huntingtin sequence element that promotes the conformational switch to aggregation |
| Q50551501 | The composition of the polyglutamine-containing proteins influences their co-aggregation properties |
| Q36110838 | The emerging role of the first 17 amino acids of huntingtin in Huntington's disease |
| Q41154714 | The huntingtin N17 domain is a multifunctional CRM1 and Ran-dependent nuclear and cilial export signal |
| Q36873629 | The interaction of polyglutamine peptides with lipid membranes is regulated by flanking sequences associated with huntingtin |
| Q26823365 | The many faces of autophagy dysfunction in Huntington's disease: from mechanism to therapy |
| Q28591685 | The regulation of autophagosome dynamics by huntingtin and HAP1 is disrupted by expression of mutant huntingtin, leading to defective cargo degradation |
| Q39235671 | The role of the cofilin-actin rod stress response in neurodegenerative diseases uncovers potential new drug targets |
| Q38544332 | The unfolded protein response and its potential role in Huntington's disease elucidated by a systems biology approach. |
| Q37825926 | The unfolded protein response: how protein folding became a restrictive aspect for innate immunity and B lymphocytes |
| Q64859904 | Therapeutic approaches to Huntington disease: from the bench to the clinic |
| Q44087369 | Toxicity and endocytosis of spinocerebellar ataxia type 6 polyglutamine domains: role of myosin IIb. |
| Q28742836 | Unusual structures are present in DNA fragments containing super-long Huntingtin CAG repeats |
| Q52671146 | Wolfram syndrome: MAMs' connection? |
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