| scholarly article | Q13442814 |
| P819 | ADS bibcode | 2012NatCo...3..791M |
| P6179 | Dimensions Publication ID | 1042974755 |
| P356 | DOI | 10.1038/NCOMMS1795 |
| P3181 | OpenCitations bibliographic resource ID | 2456350 |
| P932 | PMC publication ID | 3337979 |
| P698 | PubMed publication ID | 22531176 |
| P5875 | ResearchGate publication ID | 224834908 |
| P50 | author | Anna K Clark | Q56860619 |
| Marzia Malcangio | Q39184027 | ||
| P2093 | author name string | John N Wood | |
| Fan Wang | |||
| Mohammed A Nassar | |||
| Anthony H Dickenson | |||
| Michael S Minett | |||
| Gayle Passmore | |||
| P2860 | cites work | A single sodium channel mutation produces hyper- or hypoexcitability in different types of neurons | Q24546007 |
| Nociceptor-specific gene deletion reveals a major role for Nav1.7 (PN1) in acute and inflammatory pain | Q24562888 | ||
| Mutations in SCN9A, encoding a sodium channel alpha subunit, in patients with primary erythermalgia | Q24675844 | ||
| Basal and activity-induced release of substance P from primary afferent fibres in NK1 receptor knockout mice: evidence for negative feedback | Q44654039 | ||
| Roles of substance P and somatostatin on transmission of nociceptive information induced by formalin in spinal cord | Q44727391 | ||
| Pituitary adenylate cyclase-activating polypeptide is required for the development of spinal sensitization and induction of neuropathic pain. | Q45022915 | ||
| Comparison of antinociceptive action of morphine in the periaqueductal gray, medial and paramedial medulla in rat. | Q45105261 | ||
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| GTP up-regulated persistent Na+ current and enhanced nociceptor excitability require NaV1.9. | Q46838525 | ||
| Selective silencing of Na(V)1.7 decreases excitability and conduction in vagal sensory neurons | Q48221607 | ||
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| Involvement of the midbrain reticular formation in self-injurious behavior, stereotyped behavior, and analgesia induced by intranigral microinjection of muscimol | Q48365253 | ||
| Nociceptor-specific gene deletion using heterozygous NaV1.8-Cre recombinase mice | Q48811426 | ||
| The Cell and Molecular Basis of Mechanical, Cold, and Inflammatory Pain | Q57771834 | ||
| Sympathectomy alleviates mechanical allodynia in an experimental animal model for neuropathy in the rat | Q67888248 | ||
| Generalized lacZ expression with the ROSA26 Cre reporter strain | Q27860837 | ||
| SCN9A mutations in paroxysmal extreme pain disorder: allelic variants underlie distinct channel defects and phenotypes | Q28118877 | ||
| An SCN9A channelopathy causes congenital inability to experience pain | Q28278844 | ||
| Runx1 determines nociceptive sensory neuron phenotype and is required for thermal and neuropathic pain | Q28294561 | ||
| Identification of PN1, a predominant voltage-dependent sodium channel expressed principally in peripheral neurons | Q28569751 | ||
| A peripheral nervous system actin-binding protein regulates neurite outgrowth | Q28579083 | ||
| Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene | Q28587221 | ||
| Modification of gene activity in mouse embryos in utero by a tamoxifen-inducible form of Cre recombinase | Q29615040 | ||
| Quantitative assessment of tactile allodynia in the rat paw | Q29617366 | ||
| VGLUT2-dependent sensory neurons in the TRPV1 population regulate pain and itch. | Q30498423 | ||
| Loss-of-function mutations in sodium channel Nav1.7 cause anosmia. | Q30540365 | ||
| Wind-up of spinal cord neurones and pain sensation: much ado about something? | Q33855413 | ||
| The tetrodotoxin-resistant sodium channel SNS has a specialized function in pain pathways | Q33871067 | ||
| Sympathetic block for treating primary erythromelalgia | Q33908194 | ||
| Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway | Q33927079 | ||
| Sympathetic nervous system: contribution to chronic pain. | Q34094127 | ||
| Animal models of nociception. | Q34104197 | ||
| Attenuation of neuropathic pain by the nociceptin/orphanin FQ antagonist JTC-801 is mediated by inhibition of nitric oxide production. | Q34192704 | ||
| An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat | Q34239178 | ||
| Gain-of-function mutation in Nav1.7 in familial erythromelalgia induces bursting of sensory neurons | Q34426737 | ||
| Sensory neuron sodium channel Nav1.8 is essential for pain at low temperatures | Q34637485 | ||
| A sensory subpopulation depends on vesicular glutamate transporter 2 for mechanical pain, and together with substance P, inflammatory pain | Q34805050 | ||
| Sympathetic sprouting in dorsal root ganglia (DRG): a recent histological finding? | Q35089065 | ||
| Highly localized interactions between sensory neurons and sprouting sympathetic fibers observed in a transgenic tyrosine hydroxylase reporter mouse | Q35154922 | ||
| Potential mechanisms for hypoalgesia induced by anti-nerve growth factor immunoglobulin are identified using autoimmune nerve growth factor deprivation | Q35463321 | ||
| Sodium channels and mammalian sensory mechanotransduction. | Q36043204 | ||
| Behavioural and electrophysiological characterisation of experimentally induced osteoarthritis and neuropathy in C57Bl/6 mice | Q37184173 | ||
| Sensory neuron voltage-gated sodium channels as analgesic drug targets | Q37281888 | ||
| Genetics and molecular pathophysiology of Na(v)1.7-related pain syndromes | Q37382551 | ||
| Effects of a new potent analog of tocainide on hNav1.7 sodium channels and in vivo neuropathic pain models | Q39688026 | ||
| Differential changes of autonomic nervous system function with age in man. | Q41608654 | ||
| Hot plate versus tail flick: evaluation of acute tolerance to continuous morphine infusion in the rat model | Q42274754 | ||
| The influence of chemical sympathectomy on pain responsivity and alpha 2-adrenergic antinociception in neuropathic animals | Q42525795 | ||
| Ectopic trkA expression mediates a NGF survival response in NGF-independent sensory neurons but not in parasympathetic neurons | Q43109877 | ||
| Antinociceptive effect of chronic nicotine and nociceptive effect of its withdrawal measured by hot-plate and tail-flick in rats | Q68102838 | ||
| A rotarod suitable for quantitative measurements of motor incoordination in naive mice | Q68416749 | ||
| Site of autonomic deficit in harlequin syndrome: local autonomic failure affecting the arm and the face | Q72632062 | ||
| Behavioral Measures of Pain Thresholds | Q85363959 | ||
| Differential mechanisms mediating beta-endorphin- and morphine-induced analgesia in mice | Q93527324 | ||
| Peripheral sympathetic denervation alters both the primary and memory cellular immune responses to herpes simplex virus infection | Q95807326 | ||
| P275 | copyright license | Creative Commons Attribution-NonCommercial-NoDerivs 3.0 Unported | Q19125045 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 791 | |
| P577 | publication date | 2012-01-01 | |
| P1433 | published in | Nature Communications | Q573880 |
| P1476 | title | Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons | |
| P478 | volume | 3 |
| Q51012308 | A 'toothache tree' alkylamide inhibits Aδ mechanonociceptors to alleviate mechanical pain. |
| Q64267359 | A Cross-Species Analysis Reveals a General Role for Piezo2 in Mechanosensory Specialization of Trigeminal Ganglia from Tactile Specialist Birds |
| Q59333189 | A link between plasma membrane calcium ATPase 2 (PMCA2), estrogen and estrogen receptor α signaling in mechanical pain |
| Q28240662 | A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief |
| Q34576217 | A novel SCN9A mutation responsible for primary erythromelalgia and is resistant to the treatment of sodium channel blockers |
| Q34338475 | A role for Piezo2 in EPAC1-dependent mechanical allodynia. |
| Q48186265 | Advances in understanding nociception and neuropathic pain |
| Q58744570 | Advillin Is Expressed in All Adult Neural Crest-Derived Neurons |
| Q38826512 | Alleviation of pain in painful diabetic neuropathy |
| Q57133342 | Analgesia linked to Nav1.7 loss of function requires µ- and δ-opioid receptors |
| Q39587472 | Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. |
| Q34385062 | Balancing GRK2 and EPAC1 levels prevents and relieves chronic pain. |
| Q47823508 | Brain-derived neurotrophic factor derived from sensory neurons plays a critical role in chronic pain. |
| Q39360773 | Breaking barriers to novel analgesic drug development |
| Q47950985 | CRISPR/Cas9 editing of Nf1 gene identifies CRMP2 as a therapeutic target in neurofibromatosis type 1-related pain that is reversed by (S)-Lacosamide |
| Q90225343 | Challenges and Opportunities for Therapeutics Targeting the Voltage-Gated Sodium Channel Isoform NaV1.7. |
| Q38941483 | Challenges to develop novel anti-inflammatory and analgesic drugs |
| Q41661963 | Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1. |
| Q89664859 | Complementary roles of murine NaV1.7, NaV1.8 and NaV1.9 in acute itch signalling |
| Q64058142 | Defining the Functional Role of Na1.7 in Human Nociception |
| Q90019912 | Dehydrocrenatidine Inhibits Voltage-Gated Sodium Channels and Ameliorates Mechanic Allodia in a Rat Model of Neuropathic Pain |
| Q88342658 | Deletion of the insulin receptor in sensory neurons increases pancreatic insulin levels |
| Q36633107 | Development of a Rapid Throughput Assay for Identification of hNav1.7 Antagonist Using Unique Efficacious Sodium Channel Agonist, Antillatoxin |
| Q38966383 | Discovery of Aryl Sulfonamides as Isoform-Selective Inhibitors of NaV1.7 with Efficacy in Rodent Pain Models. |
| Q24605644 | Discovery of a selective NaV1.7 inhibitor from centipede venom with analgesic efficacy exceeding morphine in rodent pain models |
| Q99248373 | Discovery of a selective, state-independent inhibitor of NaV1.7 by modification of guanidinium toxins |
| Q91969140 | Discovery of aryl sulfonamide-selective Nav1.7 inhibitors with a highly hydrophobic ethanoanthracene core |
| Q28270611 | Endogenous opioids contribute to insensitivity to pain in humans and mice lacking sodium channel Nav1.7 |
| Q47633059 | Enhanced Nociception in Angelman Syndrome Model Mice |
| Q34586363 | Enhanced behavioral responses to cold stimuli following CGRPα sensory neuron ablation are dependent on TRPM8. |
| Q41901986 | Expression of Nav1.7 in DRG neurons extends from peripheral terminals in the skin to central preterminal branches and terminals in the dorsal horn |
| Q92131169 | Extreme Ends of Pain Sensitivity in SCN9A Mutation Variants: Case Report and Literature Review |
| Q47566382 | From Mechanism to Cure: Renewing the Goal to Eliminate the Disease of Pain |
| Q48191615 | Fusion of Ssm6a with a protein scaffold retains selectivity on NaV 1.7 and improves its therapeutic potential against chronic pain. |
| Q38026870 | Genetic aspects of sodium channelopathy in small fiber neuropathy |
| Q28542818 | Global Nav1.7 knockout mice recapitulate the phenotype of human congenital indifference to pain |
| Q38030606 | Human Mendelian pain disorders: a key to discovery and validation of novel analgesics. |
| Q47788067 | Human vs. Mouse Nociceptors - Similarities and Differences |
| Q47988374 | Impaired sensitivity to pain stimuli in plasma membrane calcium ATPase 2 (PMCA2) heterozygous mice: a possible modality- and sex-specific role for PMCA2 in nociception |
| Q27308729 | Implication of Genetic Deletion of Wdr13 in Mice: Mild Anxiety, Better Performance in Spatial Memory Task, with Upregulation of Multiple Synaptic Proteins. |
| Q33390819 | Insensitivity to pain induced by a potent selective closed-state Nav1.7 inhibitor |
| Q57290396 | Insensitivity to pain upon adult-onset deletion of Na1.7 or its blockade with selective inhibitors |
| Q34850116 | Linkage between increased nociception and olfaction via a SCN9A haplotype |
| Q48240918 | Mapping protein interactions of sodium channel NaV1.7 using epitope-tagged gene-targeted mice. |
| Q45905935 | Membrane protein Nav1.7 contributes to the persistent post-surgical pain regulated by p-p65 in dorsal root ganglion (DRG) of SMIR rats model. |
| Q37368204 | MicroRNA-30b regulates expression of the sodium channel Nav1.7 in nerve injury-induced neuropathic pain in the rat |
| Q40601290 | Molecular architecture of a sodium channel S6 helix: radial tuning of the voltage-gated sodium channel 1.7 activation gate |
| Q89850313 | Molecular mechanisms of cold pain |
| Q60924107 | Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes |
| Q28548026 | Mouse DRG Cell Line with Properties of Nociceptors |
| Q43458633 | Multiple postnatal craniofacial anomalies are characterized by conditional loss of polycystic kidney disease 2 (Pkd2). |
| Q41978464 | NaV1.7: stress-induced changes in immunoreactivity within magnocellular neurosecretory neurons of the supraoptic nucleus |
| Q28273870 | Nav1.7 and other voltage-gated sodium channels as drug targets for pain relief |
| Q38042001 | Neurological perspectives on voltage-gated sodium channels. |
| Q57255327 | Neuropathy following spinal nerve injury shares features with the irritable nociceptor phenotype: A back-translational study of oxcarbazepine |
| Q45170224 | No pain, more gain |
| Q38203871 | Nociception and pain: lessons from optogenetics |
| Q35843983 | Novel sodium channel antagonists in the treatment of neuropathic pain. |
| Q92847004 | Nuclear Factor-kappaB Gates Nav1.7 Channels in DRG Neurons via Protein-Protein Interaction |
| Q42078485 | Null mutation in SCN9A in which noxious stimuli can be detected in the absence of pain. |
| Q40079298 | Osteoarthritis-dependent changes in antinociceptive action of Nav1.7 and Nav1.8 sodium channel blockers: An in vivo electrophysiological study in the rat. |
| Q34387316 | Pain related channels are differentially expressed in neuronal and non-neuronal cells of glabrous skin of fabry knockout male mice |
| Q38552593 | Pain without nociceptors? Nav1.7-independent pain mechanisms. |
| Q46338170 | Pain-like behaviour and spinal changes in the monosodium iodoacetate model of osteoarthritis in C57Bl/6 mice |
| Q38210568 | Painful and painless channelopathies. |
| Q36772210 | Peptidergic CGRPα primary sensory neurons encode heat and itch and tonically suppress sensitivity to cold |
| Q28550966 | Peptidomimetic Star Polymers for Targeting Biological Ion Channels |
| Q30835612 | Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a |
| Q55037976 | Pharmacological characterization of potent and selective NaV1.7 inhibitors engineered from Chilobrachys jingzhao tarantula venom peptide JzTx-V. |
| Q36249467 | Post-translational modifications of voltage-gated sodium channels in chronic pain syndromes |
| Q91900172 | RGS4 Maintains Chronic Pain Symptoms in Rodent Models |
| Q90258766 | Rat NaV1.7 loss-of-function genetic model: Deficient nociceptive and neuropathic pain behavior with retained olfactory function and intra-epidermal nerve fibers |
| Q35649709 | Regulation of Nav1.7: A Conserved SCN9A Natural Antisense Transcript Expressed in Dorsal Root Ganglia. |
| Q41998701 | Safety and Efficacy of a Topical Sodium Channel Inhibitor (TV-45070) in Patients With Postherpetic Neuralgia (PHN): A Randomized, Controlled, Proof-of-Concept, Crossover Study, With a Subgroup Analysis of the Nav1.7 R1150W Genotype |
| Q37693949 | Sensory Neuron-Specific Deletion of TRPA1 Results in Mechanical Cutaneous Sensory Deficits |
| Q90016856 | Sensory neuron-derived NaV1.7 contributes to dorsal horn neuron excitability |
| Q34015630 | Significant determinants of mouse pain behaviour. |
| Q48139796 | Sodium channel Na(v)1.7 is essential for lowering heat pain threshold after burn injury |
| Q47959907 | Sodium channels in pain disorders: pathophysiology and prospects for treatment |
| Q94569487 | Spider venom-derived peptide induces hyperalgesia in Nav1.7 knockout mice by activating Nav1.9 channels |
| Q101038915 | Status of peripheral sodium channel blockers for non-addictive pain treatment |
| Q42211742 | Structural modelling and mutant cycle analysis predict pharmacoresponsiveness of a Na(V)1.7 mutant channel. |
| Q28601095 | Subtype-Selective Small Molecule Inhibitors Reveal a Fundamental Role for Nav1.7 in Nociceptor Electrogenesis, Axonal Conduction and Presynaptic Release |
| Q44342560 | Synergistic regulation of serotonin and opioid signaling contributes to pain insensitivity in Nav1.7 knockout mice. |
| Q91839760 | Tetrodotoxin-Sensitive Sodium Channels Mediate Action Potential Firing and Excitability in Menthol-Sensitive Vglut3-Lineage Sensory Neurons |
| Q36258703 | The AMPK Activator A769662 Blocks Voltage-Gated Sodium Channels: Discovery of a Novel Pharmacophore with Potential Utility for Analgesic Development |
| Q35542977 | The Fabry disease-associated lipid Lyso-Gb3 enhances voltage-gated calcium currents in sensory neurons and causes pain |
| Q47612358 | The NAv1.7 blocker protoxin II reduces burn injury-induced spinal nociceptive processing. |
| Q38066723 | The Na(V)1.7 sodium channel: from molecule to man. |
| Q27014891 | The functional and anatomical dissection of somatosensory subpopulations using mouse genetics |
| Q38241746 | The role of sodium channels in painful diabetic and idiopathic neuropathy. |
| Q38239812 | Translational pain research: Lessons from genetics and genomics |
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| Q33824948 | [EXPRESS] Ion channels and neuronal hyperexcitability in chemotherapy-induced peripheral neuropathy; cause and effect? |
| Q53067627 | [Pain and analgesia : Mutations of voltage-gated sodium channels]. |
| Q37231466 | α2δ-1 gene deletion affects somatosensory neuron function and delays mechanical hypersensitivity in response to peripheral nerve damage |
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