| scholarly article | Q13442814 |
| P8978 | DBLP publication ID | journals/ploscb/ZhangDS06 |
| P356 | DOI | 10.1371/JOURNAL.PCBI.0020013 |
| P932 | PMC publication ID | 1364505 |
| P698 | PubMed publication ID | 16485037 |
| P5875 | ResearchGate publication ID | 7292197 |
| P50 | author | Jeffrey Skolnick | Q17516035 |
| P2093 | author name string | Yang Zhang | |
| Mark E Devries | |||
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| Substitutions in a homologous region of extracellular loop 2 of CXCR4 and CCR5 alter coreceptor activities for HIV-1 membrane fusion and virus entry | Q45742209 | ||
| Complete mutagenesis of the extracellular domain of interleukin-8 (IL-8) type A receptor identifies charged residues mediating IL-8 binding and signal transduction | Q46158410 | ||
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| Species selectivity of nonpeptide antagonists of the gonadotropin-releasing hormone receptor is determined by residues in extracellular loops II and III and the amino terminus | Q47448039 | ||
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| Identification and pharmacological characterization of prokineticin 2 beta as a selective ligand for prokineticin receptor 1. | Q48964677 | ||
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| Modeling the G-protein-coupled neuropeptide Y Y1 receptor agonist and antagonist binding sites. | Q52043997 | ||
| How Well is Enzyme Function Conserved as a Function of Pairwise Sequence Identity? | Q52956083 | ||
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| Identification of Putative Sites of Interaction between the Human Formyl Peptide Receptor and G Protein | Q59942394 | ||
| Two basic amino acids in the second inner loop of the interleukin-8 receptor are essential for Galpha16 coupling | Q73735495 | ||
| Role of the first extracellular loop in the functional activation of CCR2. The first extracellular loop contains distinct domains necessary for both agonist binding and transmembrane signaling | Q22010723 | ||
| Finishing the euchromatic sequence of the human genome | Q22122488 | ||
| The protein structure prediction problem could be solved using the current PDB library | Q22248093 | ||
| Identification of the binding site for a novel class of CCR2b chemokine receptor antagonists: binding to a common chemokine receptor motif within the helical bundle | Q22253922 | ||
| The Protein Data Bank | Q24515306 | ||
| TM-align: a protein structure alignment algorithm based on the TM-score | Q24522708 | ||
| CDD: a Conserved Domain Database for protein classification | Q24795306 | ||
| Crystal structure of rhodopsin: A G protein-coupled receptor | Q27625972 | ||
| Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor | Q27627995 | ||
| Protein secondary structure prediction based on position-specific scoring matrices | Q27860483 | ||
| Comparative protein structure modeling of genes and genomes | Q27860712 | ||
| Comparative protein modelling by satisfaction of spatial restraints | Q27860866 | ||
| Mapping the protein universe | Q27861112 | ||
| Drug discovery: a historical perspective | Q28138834 | ||
| Protein structure prediction and structural genomics | Q28190526 | ||
| Identification of G protein-coupled receptor genes from the human genome sequence | Q28202262 | ||
| Mapping of a ligand-binding site for the human thromboxane A2 receptor protein | Q28205029 | ||
| A Method to Identify Protein Sequences That Fold into a Known Three-Dimensional Structure | Q28282741 | ||
| Identification of G-protein binding sites of the human interleukin-8 receptors by functional mapping of the intracellular loops | Q28295751 | ||
| A binding pocket for a small molecule inhibitor of HIV-1 entry within the transmembrane helices of CCR5 | Q28344177 | ||
| GPCRDB: an information system for G protein-coupled receptors | Q28679239 | ||
| The G-protein-coupled receptors in the human genome form five main families. Phylogenetic analysis, paralogon groups, and fingerprints | Q29547321 | ||
| RASMOL: biomolecular graphics for all | Q29547757 | ||
| Scoring function for automated assessment of protein structure template quality | Q29615862 | ||
| Assembly of protein tertiary structures from fragments with similar local sequences using simulated annealing and Bayesian scoring functions | Q29616398 | ||
| Protein structure prediction by global optimization of a potential energy function. | Q30322315 | ||
| Structural genomics and its importance for gene function analysis. | Q30326344 | ||
| Local energy landscape flattening: parallel hyperbolic Monte Carlo sampling of protein folding. | Q30331169 | ||
| TOUCHSTONE II: a new approach to ab initio protein structure prediction | Q30333234 | ||
| Assessment of homology-based predictions in CASP5. | Q30336223 | ||
| Critical assessment of methods of protein structure prediction (CASP)-round V. | Q30336229 | ||
| Automated structure prediction of weakly homologous proteins on a genomic scale | Q30341442 | ||
| A model recognition approach to the prediction of all-helical membrane protein structure and topology | Q30420917 | ||
| Automated method for modeling seven-helix transmembrane receptors from experimental data | Q30423649 | ||
| What is the probability of a chance prediction of a protein structure with an rmsd of 6 A? | Q30430314 | ||
| High-throughput modeling of human G-protein coupled receptors: amino acid sequence alignment, three-dimensional model building, and receptor library screening | Q31063961 | ||
| Development and large scale benchmark testing of the PROSPECTOR_3 threading algorithm | Q31086785 | ||
| PREDICT modeling and in-silico screening for G-protein coupled receptors. | Q31107931 | ||
| Tyrosine 220 in the 5th transmembrane domain of the neuromedin B receptor is critical for the high selectivity of the peptoid antagonist PD168368. | Q31442619 | ||
| Identification of a ligand binding site in the human neutrophil formyl peptide receptor using a site-specific fluorescent photoaffinity label and mass spectrometry. | Q32066951 | ||
| The seventh transmembrane domain of cc chemokine receptor 5 is critical for MIP-1beta binding and receptor activation: role of MET 287. | Q32125508 | ||
| The SWISS-PROT protein sequence data bank and its supplement TrEMBL in 1998. | Q32178008 | ||
| Modelling G-protein-coupled receptors for drug design | Q33766736 | ||
| Mutagenesis of CXCR4 identifies important domains for human immunodeficiency virus type 1 X4 isolate envelope-mediated membrane fusion and virus entry and reveals cryptic coreceptor activity for R5 isolates | Q33817249 | ||
| Tertiary structure predictions on a comprehensive benchmark of medium to large size proteins | Q34187374 | ||
| Prediction of structure and function of G protein-coupled receptors | Q34188824 | ||
| Identification of Essential Residues Involved in the Allosteric Modulation of the Human A3Adenosine Receptor | Q34190610 | ||
| Regulation of corticotropin-releasing hormone in vitro | Q34241345 | ||
| SPICKER: a clustering approach to identify near-native protein folds | Q34304367 | ||
| Determining the environment of the ligand binding pocket of the human angiotensin II type I (hAT1) receptor using the methionine proximity assay. | Q34418452 | ||
| Four amino acid residues are critical for high affinity binding of neuromedin B to the neuromedin B receptor | Q34472389 | ||
| The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop | Q34504076 | ||
| Rhodopsin crystal: new template yielding realistic models of G-protein-coupled receptors? | Q35033301 | ||
| Modeling the 3D structure of GPCRs: advances and application to drug discovery | Q35166029 | ||
| Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling. | Q36201452 | ||
| Exploring distal regions of the A3 adenosine receptor binding site: sterically constrained N6-(2-phenylethyl)adenosine derivatives as potent ligands. | Q36342342 | ||
| Optimal bundling of transmembrane helices using sparse distance constraints | Q36526243 | ||
| Site-directed mutagenesis of cysteinyl and serine residues of human thromboxane A2 receptor in insect cells | Q36823316 | ||
| G protein-coupled receptors: in silico drug discovery in 3D. | Q37388375 | ||
| Expression and functional characterization of mutant human CXCR4 in insect cells: role of cysteinyl and negatively charged residues in ligand binding | Q38316857 | ||
| Analysis of the third transmembrane domain of the human type 1 angiotensin II receptor by cysteine scanning mutagenesis | Q38336040 | ||
| Constitutive activation of the angiotensin II type 1 receptor alters the spatial proximity of transmembrane 7 to the ligand-binding pocket | Q38352900 | ||
| Role of the first and third extracellular domains of CXCR-4 in human immunodeficiency virus coreceptor activity | Q38920578 | ||
| Amino-terminal substitutions in the CCR5 coreceptor impair gp120 binding and human immunodeficiency virus type 1 entry | Q38977702 | ||
| Characterization of sequence determinants within the carboxyl-terminal domain of chemokine receptor CCR5 that regulate signaling and receptor internalization | Q39147310 | ||
| Role of the amino-terminal extracellular domain of CXCR-4 in human immunodeficiency virus type 1 entry | Q39355101 | ||
| Regions in beta-chemokine receptors CCR5 and CCR2b that determine HIV-1 cofactor specificity | Q39413074 | ||
| The second extracellular loop of CCR5 is the major determinant of ligand specificity. | Q39427062 | ||
| CXCR4 sequences involved in coreceptor determination of human immunodeficiency virus type-1 tropism. Unmasking of activity with M-tropic Env glycoproteins | Q39577767 | ||
| Alanine substitutions of polar and nonpolar residues in the amino-terminal domain of CCR5 differently impair entry of macrophage- and dualtropic isolates of human immunodeficiency virus type 1. | Q39579651 | ||
| Agonist-induced conformational changes in thyrotropin-releasing hormone receptor type I: disulfide cross-linking and molecular modeling approaches. | Q40458709 | ||
| Specific cross-linking of Lys233 and Cys235 in the mu opioid receptor by a reporter affinity label. | Q40458735 | ||
| Site-directed mutagenesis of CC chemokine receptor 1 reveals the mechanism of action of UCB 35625, a small molecule chemokine receptor antagonist. | Q40467514 | ||
| Comparative agonist/antagonist responses in mutant human C5a receptors define the ligand binding site. | Q40468378 | ||
| Site-directed mutagenesis of CCR2 identified amino acid residues in transmembrane helices 1, 2, and 7 important for MCP-1 binding and biological functions. | Q40475616 | ||
| Molecular modeling of human MT2 melatonin receptor: the role of Val204, Leu272 and Tyr298 in ligand binding. | Q40496239 | ||
| Locating ligand-binding sites in 7TM receptors by protein engineering. | Q40535098 | ||
| Identification of amino acid residues crucial for chemokine receptor dimerization. | Q40600436 | ||
| CCR2: characterization of the antagonist binding site from a combined receptor modeling/mutagenesis approach | Q40638101 | ||
| Alanine scanning mutagenesis of CCR3 reveals that the three intracellular loops are essential for functional receptor expression | Q40741689 | ||
| Structural determinants of CCR5 recognition and HIV-1 blockade in RANTES. | Q40796177 | ||
| Interleukin 8, neutrophil-activating peptide-2 and GRO-alpha bind to and elicit cell activation via specific and different amino acid residues of CXCR2. | Q40850596 | ||
| Mutagenic analysis of platelet thromboxane receptor cysteines. Roles in ligand binding and receptor-effector coupling | Q41216013 | ||
| Partial functional mapping of the human interleukin-8 type A receptor. Identification of a major ligand binding domain | Q41528501 | ||
| Accurate reconstruction of all-atom protein representations from side-chain-based low-resolution models | Q41755871 | ||
| Evidence for a model of agonist-induced activation of 5-hydroxytryptamine 2A serotonin receptors that involves the disruption of a strong ionic interaction between helices 3 and 6. | Q42819583 | ||
| Serine residues 110 and 114 are required for agonist binding but not antagonist binding to the melatonin MT(1) receptor | Q43575330 | ||
| Conformational changes that occur during M3 muscarinic acetylcholine receptor activation probed by the use of an in situ disulfide cross-linking strategy | Q43792236 | ||
| Use of an in situ disulfide cross-linking strategy to map proximities between amino acid residues in transmembrane domains I and VII of the M3 muscarinic acetylcholine receptor | Q44022510 | ||
| Identification of cysteines involved in ligand binding to the human melatonin MT(2) receptor | Q44090372 | ||
| Protein-based virtual screening of chemical databases. II. Are homology models of G-Protein Coupled Receptors suitable targets? | Q44242205 | ||
| The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. | Q44259028 | ||
| Identification of residues important for ligand binding of thromboxane A2 receptor in the second extracellular loop using the NMR experiment-guided mutagenesis approach | Q44292843 | ||
| Opioid receptor random mutagenesis reveals a mechanism for G protein-coupled receptor activation | Q44342096 | ||
| Exploring deltorphin II binding to the third extracellular loop of the delta-opioid receptor | Q44344725 | ||
| P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 2 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | protein structure | Q735188 |
| G protein-coupled receptor | Q38173 | ||
| P304 | page(s) | e13 | |
| P577 | publication date | 2006-02-17 | |
| P1433 | published in | PLOS Computational Biology | Q2635829 |
| P1476 | title | Structure modeling of all identified G protein-coupled receptors in the human genome | |
| P478 | volume | 2 |
| Q42037742 | A generalized born implicit-membrane representation compared to experimental insertion free energies. |
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| Q37700209 | Cholesterol modulates the dimer interface of the β₂-adrenergic receptor via cholesterol occupancy sites |
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| Q26995693 | Computational modeling of membrane proteins |
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| Q30401700 | Discrimination of Native-like States of Membrane Proteins with Implicit Membrane-based Scoring Functions. |
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| Q39121106 | Endothelial progenitor cells: Exploring the pleiotropic effects of statins |
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| Q55564362 | GPCR Conformations: Implications for Rational Drug Design. |
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