Interactions between Trypanosoma cruzi Secreted Proteins and Host Cell Signaling Pathways

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Interactions between Trypanosoma cruzi Secreted Proteins and Host Cell Signaling Pathways is …
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scholarly articleQ13442814

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P356DOI10.3389/FMICB.2016.00388
P3181OpenCitations bibliographic resource ID4546500
P932PMC publication ID4814445
P698PubMed publication ID27065960
P5875ResearchGate publication ID299518804

P50authorJosé Franco da SilveiraQ111118044
P2093author name stringDiana Bahia
Renata Watanabe Costa
P2860cites workSignal transduction in human macrophages by gp83 ligand of Trypanosoma cruzi: trypomastigote gp83 ligand up-regulates trypanosome entry through protein kinase C activationQ73098076
Lipids shed into the culture medium by trypomastigotes of Trypanosoma cruziQ73404734
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A novel cell surface trans-sialidase of trypanosoma cruzi generates a stage-specific epitope required for invasion of mammalian cellsQ28323919
The Trypanosoma cruzi protease cruzain mediates immune evasionQ28476751
CD8+ T-Cell responses to Trypanosoma cruzi are highly focused on strain-variant trans-sialidase epitopesQ33252349
Genomic organization and expression profile of the mucin-associated surface protein (masp) family of the human pathogen Trypanosoma cruziQ33425111
A Cdc42 activation cycle coordinated by PI 3-kinase during Fc receptor-mediated phagocytosisQ33623817
A synthetic peptide from Trypanosoma cruzi mucin-like associated surface protein as candidate for a vaccine against Chagas diseaseQ33760119
Stage-specific phospholipase C-mediated release of Trypanosoma cruzi neuraminidaseQ67903391
Turnover and shedding of the Tc-85 surface glycoprotein of Trypanosoma cruzi trypomastigotesQ71336469
Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruziQ33889376
A B-cell mitogen from a pathogenic trypanosome is a eukaryotic proline racemaseQ33912838
Secretory pathway of trypanosomatid parasitesQ33969495
A soluble factor from Trypanosoma cruzi inhibits transforming growth factor-ß-induced MAP kinase activation and gene expression in dermal fibroblasts.Q34023102
A cysteine protease inhibitor protects dogs from cardiac damage during infection by Trypanosoma cruzi.Q34228426
Parasite polyclonal activators: new targets for vaccination approaches?Q34240147
The MASP family of Trypanosoma cruzi: changes in gene expression and antigenic profile during the acute phase of experimental infectionQ34385087
A recombinant protein based on Trypanosoma cruzi P21 enhances phagocytosisQ34516532
Extracellular vesicles in parasitic diseasesQ34767634
Unconventional mechanisms of protein transport to the cell surface of eukaryotic cellsQ34790521
AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancerQ34990362
Cell signalling and Trypanosoma cruzi invasionQ34994362
Evidence of reversible bradycardia and arrhythmias caused by immunogenic proteins secreted by T. cruzi in isolated rat heartsQ35043895
Anatomical route of invasion and protective mucosal immunity in Trypanosoma cruzi conjunctival infection.Q35073839
Molecular characterization of Trypanosoma cruzi SAP proteins with host-cell lysosome exocytosis-inducing activity required for parasite invasionQ35082650
Uptake of host cell transforming growth factor-beta by Trypanosoma cruzi amastigotes in cardiomyocytes: potential role in parasite cycle completion.Q35085273
Differential expression and characterization of a member of the mucin-associated surface protein family secreted by Trypanosoma cruzi.Q35273171
Cruzipain Activates Latent TGF-β from Host Cells during T. cruzi Invasion.Q35621418
Biochemical analysis of the membrane and soluble forms of the complement regulatory protein of Trypanosoma cruziQ35771684
Introduction to Thematic Review Series: Phospholipases: Central Role in Lipid Signaling and DiseaseQ35776610
Molecular Characterization of a Novel Family of Trypanosoma cruzi Surface Membrane Proteins (TcSMP) Involved in Mammalian Host Cell Invasion.Q35840717
gp63 homologues in Trypanosoma cruzi: surface antigens with metalloprotease activity and a possible role in host cell infection.Q36045498
Structural features affecting trafficking, processing, and secretion of Trypanosoma cruzi mucinsQ36122262
Vesicles from different Trypanosoma cruzi strains trigger differential innate and chronic immune responsesQ36326969
Molecular basis of mammalian cell invasion by Trypanosoma cruziQ36419260
Trypanosoma cruzi infection by oral route: how the interplay between parasite and host components modulates infectivityQ37072124
Development of protease inhibitors for protozoan infectionsQ37315245
Reversible cysteine protease inhibitors show promise for a Chagas disease cureQ37544765
A successful strategy for the recovering of active P21, an insoluble recombinant protein of Trypanosoma cruziQ37614927
Review on Trypanosoma cruzi: Host Cell InteractionQ37784694
Secretion by Trypanosoma cruzi of a peptidyl-prolyl cis-trans isomerase involved in cell infectionQ37887045
Vesicles as carriers of virulence factors in parasitic protozoan diseasesQ38034618
Cell signaling during Trypanosoma cruzi invasionQ38066485
The Gp85 surface glycoproteins from Trypanosoma cruziQ38165062
Mucin-like molecules form a negatively charged coat that protects Trypanosoma cruzi trypomastigotes from killing by human anti-alpha-galactosyl antibodiesQ38314745
Cruzipain: An Update on its Potential as Chemotherapy Target against the Human Pathogen Trypanosoma cruziQ38494579
Secreted trypanosome cyclophilin inactivates lytic insect defense peptides and induces parasite calcineurin activation and infectivityQ39198765
Trypanosoma cruzi uses macropinocytosis as an additional entry pathway into mammalian host cellQ39271863
Phosphorylation/inactivation of PTEN by Akt-independent PI3K signaling in retinal pigment epitheliumQ39464756
Changes in isotype composition and antigen recognition of anti-Trypanosoma cruzi antibodies from acute to chronic Chagas diseaseQ39541839
Akt promotes survival of cardiomyocytes in vitro and protects against ischemia-reperfusion injury in mouse heart.Q39870130
Proteins anchored via glycosylphosphatidylinositol and solubilizing phospholipases in Trypanosoma cruziQ40479776
Molecular, functional and structural properties of the prolyl oligopeptidase of Trypanosoma cruzi (POP Tc80), which is required for parasite entry into mammalian cellsQ40484418
Analysis of cyclosporin A and a set of analogs as inhibitors of a T. cruzi cyclophilin by docking and molecular dynamicsQ40866353
Plasma membrane vesicles isolated from epimastigote forms of trypanosoma cruziQ40975893
Alteration of macrophage function by a Trypanosoma cruzi membrane mucinQ41079691
Fibronectin-degrading activity of Trypanosoma cruzi cysteine proteinase plays a role in host cell invasionQ41721965
A T. cruzi-secreted protein immunologically related to the complement component C9: evidence for membrane pore-forming activity at low pH.Q41730283
Lysosomal phospholipase A1 in Trypanosoma cruzi: an enzyme with a possible role in the pathogenesis of Chagas' diseaseQ41961583
Inhibition of host connective tissue growth factor expression: a novel Trypanosoma cruzi-mediated responseQ42470075
Isolation and characterization of a novel insect defensin from Rhodnius prolixus, a vector of Chagas diseaseQ42595408
Trypanosoma cruzi exoantigen is a member of a 160 kDa gene family.Q42689354
Developmentally regulated, phospholipase C-mediated release of the major surface glycoprotein of amastigotes of Trypanosoma cruziQ42939016
Host cell invasion by Trypanosoma cruzi is potentiated by activation of bradykinin B(2) receptorsQ42944340
A lipid-modified phosphoinositide-specific phospholipase C (TcPI-PLC) is involved in differentiation of trypomastigotes to amastigotes of Trypanosoma cruziQ43218641
Molecular characterization of serine-, alanine-, and proline-rich proteins of Trypanosoma cruzi and their possible role in host cell infectionQ43254872
Trypanosoma cruzi, the causative agent of Chagas disease, modulates interleukin-6-induced STAT3 phosphorylation via gp130 cleavage in different host cells.Q43448689
Inhibitors of the major cysteinyl proteinase (GP57/51) impair host cell invasion and arrest the intracellular development of Trypanosoma cruzi in vitroQ43499829
The Trypanosoma cruzi trans-sialidase is a T cell-independent B cell mitogen and an inducer of non-specific Ig secretionQ43898130
Phospholipase C gamma and ERK1/2 mitogen activated kinase pathways are differentially modulated by Trypanosoma cruzi during tissue invasion in human placentaQ44115394
Alternative activation and increase of Trypanosoma cruzi survival in murine macrophages stimulated by cruzipain, a parasite antigen.Q44178074
Different signaling pathways are involved in cardiomyocyte survival induced by a Trypanosoma cruzi glycoprotein.Q44179298
The Trypanosoma cruzi membrane glycoprotein AGC10 inhibits human lymphocyte activation by a mechanism preceding translation of both, interleukin-2 and its high-affinity receptor subunitsQ44239911
Proteomic analysis of Trypanosoma cruzi secretome: characterization of two populations of extracellular vesicles and soluble proteins.Q44316258
Activation of TGF-beta by Leishmania chagasi: importance for parasite survival in macrophagesQ44320782
Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturationQ44522457
Cruzipain, a major Trypanosoma cruzi antigen, promotes arginase-2 expression and survival of neonatal mouse cardiomyocytesQ44588538
The Trypanosoma cruzi membrane mucin AgC10 inhibits T cell activation and IL-2 transcription through L-selectinQ45020481
Chagasin, the endogenous cysteine-protease inhibitor of Trypanosoma cruzi, modulates parasite differentiation and invasion of mammalian cellsQ45267339
Characterization of a 21kDa protein from Trypanosoma cruzi associated with mammalian cell invasion.Q46642120
Chagas disease 101.Q47380364
Phospholipase A1: a novel virulence factor in Trypanosoma cruziQ48041550
Involvement of TSSA (trypomastigote small surface antigen) in Trypanosoma cruzi invasion of mammalian cells.Q48051213
Identification of a Trypanosoma cruzi antigen that is shed during the acute phase of Chagas' diseaseQ48297061
A novel phosphatidylinositol-phospholipase C of Trypanosoma cruzi that is lipid modified and activated during trypomastigote to amastigote differentiation.Q52170643
Characterization of a Trypanosoma cruzi C3 binding protein with functional and genetic similarities to the human complement regulatory protein, decay-accelerating factor.Q52445292
Trypanosoma cruzi: parasite shed vesicles increase heart parasitism and generate an intense inflammatory responseQ57067411
Trypanosoma cruzi:The Tc-85 Surface Glycoprotein Shed by Trypomastigotes Bears a Modified Glycosylphosphatidylinositol AnchorQ57067539
Trypanosoma cruzi: Shedding of surface antigens as membrane vesiclesQ57067573
Correlation of tunicamycin-sensitive surface glycoproteins from Trypanosoma cruzi with parasite interiorization into mammalian cellsQ57067626
Extracellular Microvesicles: The Need for Internationally Recognised Nomenclature and Stringent Purification CriteriaQ57091939
A novel and basic mechanism of immunosuppression in Chagas' disease: Trypanosoma cruzi releases in vitro and in vivo a protein which induces T cell unresponsiveness through specific interaction with cysteine and glutathioneQ58843559
Direct lysis of Trypanosoma cruzi: a novel effector mechanism of protection mediated by human anti-gal antibodiesQ58844845
Immunisation with a major Trypanosoma cruzi antigen promotes pro-inflammatory cytokines, nitric oxide production and increases TLR2 expressionQ58844876
Inhibitory effects of theTrypanosoma cruzi membrane glycoprotein AGC10 on the expression of IL-2 receptor chains and secretion of cytokines by subpopulations of activated human T lymphocytesQ58869431
P407language of work or nameEnglishQ1860
P921main subjectTrypanosoma cruziQ150162
P304page(s)388
P577publication date2016-01-01
P1433published inFrontiers in MicrobiologyQ27723481
P1476titleInteractions between Trypanosoma cruzi Secreted Proteins and Host Cell Signaling Pathways
P478volume7

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cites work (P2860)
Q42369950A New Trick for a Conserved Enzyme: Mevalonate Kinase, a Glycosomal Enzyme, Can Be Secreted by Trypanosoma cruzi and Modulate Cell Invasion and Signaling. Is It Another Moonlighting Enzyme?
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