Methods for Improving Aptamer Binding Affinity

scientific article

Methods for Improving Aptamer Binding Affinity is …
instance of (P31):
scholarly articleQ13442814
review articleQ7318358

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P356DOI10.3390/MOLECULES21040421
P3181OpenCitations bibliographic resource ID4319893
P932PMC publication ID6273865
P698PubMed publication ID27043498
P5875ResearchGate publication ID299499376

P50authorNasa SavoryQ84692584
Kazunori IkebukuroQ44189176
P2093author name stringKoichi Abe
Hijiri Hasegawa
P2860cites workBias and artifacts in multitemplate polymerase chain reactions (PCR).Q54635486
LNA (Locked Nucleic Acids): Synthesis of the adenine, cytosine, guanine, 5-methylcytosine, thymine and uracil bicyclonucleoside monomers, oligomerisation, and unprecedented nucleic acid recognitionQ56289031
In Vitro Selection of DNA Aptamers on Chips Using a Method for Generating Point MutationsQ58255622
Spanning binding sites on allosteric proteins with polymer-linked ligand dimersQ59070068
RNA aptamers that bind flavin and nicotinamide redox cofactorsQ74467988
Quadruplex DNA: sequence, topology and structureQ22065978
Generation of high-affinity DNA aptamers using an expanded genetic alphabetQ22122129
Mfold web server for nucleic acid folding and hybridization predictionQ24498105
The effect of chemical modifications on the thermal stability of different G-quadruplex-forming oligonucleotidesQ24793800
A novel method of screening thrombin-inhibiting DNA aptamers using an evolution-mimicking algorithmQ24816305
Unique motifs and hydrophobic interactions shape the binding of modified DNA ligands to protein targetsQ27675037
Structural basis of the non-coding RNA RsmZ acting as a protein spongeQ27690232
Structural basis of RNA folding and recognition in an AMP-RNA aptamer complexQ27733164
Solution structure of an ATP-binding RNA aptamer reveals a novel fold.Q27733295
Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymeraseQ27860794
In vitro selection of RNA molecules that bind specific ligandsQ27861109
Aptamer-based multiplexed proteomic technology for biomarker discoveryQ28744329
Isolation of high-affinity GTP aptamers from partially structured RNA librariesQ30843685
The joys of in vitro selection: chemically dressing oligonucleotides to satiate protein targetsQ32053056
Aptamer selection based on inhibitory activity using an evolution-mimicking algorithmQ33248581
Exploring the sequence space of a DNA aptamer using microarraysQ33304953
Selection of DNA aptamers against VEGF165 using a protein competitor and the aptamer blotting methodQ33313271
Expanding the chemistry of DNA for in vitro selectionQ33536734
Nucleic acid evolution and minimization by nonhomologous random recombinationQ33641842
Selection of DNA aptamer against prostate specific antigen using a genetic algorithm and application to sensing.Q33652031
Bioimaging of nucleolin aptamer-containing 5-(N-benzylcarboxyamide)-2'-deoxyuridine more capable of specific binding to targets in cancer cellsQ33693099
Aptamer evolution for array-based diagnosticsQ38354972
Bivalent ligands with long nanometer-scale flexible linkersQ38357837
Array-based evolution of DNA aptamers allows modelling of an explicit sequence-fitness landscapeQ38358691
Dual-aptamer-based delivery vehicle of doxorubicin to both PSMA (+) and PSMA (-) prostate cancersQ39621579
Improvement of Aptamer Affinity by Dimerization.Q41962152
Convergent evolution to an aptamer observed in small populations on DNA microarraysQ42920087
DNA persistence length revisitedQ44062233
Mutant ATP-binding RNA aptamers reveal the structural basis for ligand bindingQ46555614
Analysis of the evolution of the thrombin-inhibiting DNA aptamers using a genetic algorithm.Q51932207
Towards a rational spacer design for bivalent inhibition of estrogen receptor.Q52897990
A streamlined protocol for emulsion polymerase chain reaction and subsequent purificationQ33757064
Emulsion PCR: a high efficient way of PCR amplification of random DNA libraries in aptamer selectionQ34031592
Probing high affinity sequences of DNA aptamer against VEGF165Q34168165
Pegaptanib, a targeted anti-VEGF aptamer for ocular vascular diseaseQ34499843
Selection of single-stranded DNA molecules that bind and inhibit human thrombinQ34616171
A multivalent DNA aptamer specific for the B-cell receptor on human lymphoma and leukemiaQ34723932
Array-based discovery of aptamer pairsQ34879171
Comprehensive analysis of RNA-protein interactions by high-throughput sequencing-RNA affinity profilingQ35165270
RNA aptamers directed to discrete functional sites on a single protein structural domain.Q35676609
Improvement of the VEGF binding ability of DNA aptamers through in silico maturation and multimerization strategyQ35753953
Selection strategy to generate aptamer pairs that bind to distinct sites on protein targets.Q36055136
Selection is more intelligent than design: improving the affinity of a bivalent ligand through directed evolutionQ36478067
Molecular assembly for high-performance bivalent nucleic acid inhibitorQ36558122
1020Fold aptamer library amplification without gel purificationQ36697437
A systematic study of the features critical for designing a high avidity multivalent aptamerQ36862805
Properties of biomolecules measured from atomic force microscope images: a reviewQ36874544
Oligonucleotide inhibitors of human thrombin that bind distinct epitopesQ36890950
Discovery of widespread GTP-binding motifs in genomic DNA and RNAQ36989530
Application of locked nucleic acids to improve aptamer in vivo stability and targeting functionQ37619467
Multivalency as a chemical organization and action principleQ38041060
Selection of DNA aptamers against insulin and construction of an aptameric enzyme subunit for insulin sensing.Q38289118
Systematic selection of modified aptamer pairs for diagnostic sandwich assaysQ38308343
Simultaneous improvement of specificity and affinity of aptamers against Streptococcus mutans by in silico maturation for biosensor development.Q38312729
An ultra-sensitive detection of a whole virus using dual aptamers developed by immobilization-free screeningQ38312918
All you wanted to know about SELEX.Q38313117
Aptameric enzyme subunit for biosensing based on enzymatic activity measurementQ38313421
In silico maturation of binding-specificity of DNA aptamers against Proteus mirabilisQ38316483
G-quadruplex DNA aptamers for zeatin recognizing.Q38322050
Functional-group specific aptamers indirectly recognizing compounds with alkyl amino group.Q38322791
2'-Fluoropyrimidine RNA-based aptamers to the 165-amino acid form of vascular endothelial growth factor (VEGF165). Inhibition of receptor binding and VEGF-induced vascular permeability through interactions requiring the exon 7-encoded domainQ38335060
Conservative secondary structure motif of streptavidin-binding aptamers generated by different laboratories.Q38346489
Screening and improvement of an anti-VEGF DNA aptamer.Q38346870
Aptamers as a model for functional evaluation of LNA and 2'-amino LNA.Q38349317
Analysis of a complete DNA-protein affinity landscapeQ38352043
P275copyright licenseCreative Commons AttributionQ6905323
P6216copyright statuscopyrightedQ50423863
P433issue4
P407language of work or nameEnglishQ1860
P921main subjectnucleotide aptamersQ49849144
P304page(s)421
P577publication date2016-01-01
2016-03-28
P1433published inMoleculesQ151332
P1476titleMethods for Improving Aptamer Binding Affinity
P478volume21

Reverse relations

cites work (P2860)
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Q47942947Aptamers and Glioblastoma: Their Potential Use for Imaging and Therapeutic Applications.
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Q55287229Simple Methods and Rational Design for Enhancing Aptamer Sensitivity and Specificity.
Q64244207Specific Inhibition of Soluble γc Receptor Attenuates Collagen-Induced Arthritis by Modulating the Inflammatory T Cell Responses
Q51135569Structural regulation by a G-quadruplex ligand increases binding abilities of G-quadruplex-forming aptamers.
Q90074483The Growing Interest in Development of Innovative Optical Aptasensors for the Detection of Antimicrobial Residues in Food Products
Q90396933Tuning the Polymorphism of the Anti-VEGF G-rich V7t1 Aptamer by Covalent Dimeric Constructs

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