Components and regulation of nuclear transport processes

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Components and regulation of nuclear transport processes is …
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review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1111/FEBS.13163
P8608Fatcat IDrelease_qfujh3bsevhvhki4ypkxp6ydti
P3181OpenCitations bibliographic resource ID3097437
P932PMC publication ID7163960
P698PubMed publication ID25429850

P50authorBastien CautainQ85525907
Richard HillQ39965266
Wolfgang LinkQ57975560
P2093author name stringNuria de Pedro
P2860cites workCalreticulin Is a receptor for nuclear exportQ24290720
Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factorQ24293261
Exportin-5 mediates the nuclear export of pre-microRNAs and short hairpin RNAsQ24302072
The mechanism of nuclear export of Smad3 involves exportin 4 and RanQ24302636
Proteomic analysis of the mammalian nuclear pore complexQ24305242
Herpes simplex virus ICP27 protein directly interacts with the nuclear pore complex through Nup62, inhibiting host nucleocytoplasmic transport pathwaysQ24305296
Protein Tpr is required for establishing nuclear pore-associated zones of heterochromatin exclusionQ24307496
Nuclear export and cytoplasmic processing of precursors to the 40S ribosomal subunits in mammalian cells.Q24309380
Identification of a tRNA-specific nuclear export receptorQ24314506
A novel class of RanGTP binding proteinsQ24316050
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factorQ24316152
FG-Rich Repeats of Nuclear Pore Proteins Form a Three-Dimensional Meshwork with Hydrogel-Like PropertiesQ58076963
Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev functionQ58611466
Kap104p-mediated nuclear import. Nuclear localization signals in mRNA-binding proteins and the role of Ran and RnaQ73041162
Nuclear export of yeast signal recognition particle lacking srp54p by the Xpo1p/Crm1p NES-dependent pathwayQ73292066
A comparison of the activity, sequence specificity, and CRM1-dependence of different nuclear export signalsQ73598439
Ran and nuclear transportQ77171854
Cse1p functions as the nuclear export receptor for importin alpha in yeastQ77323192
Antagonistic effects of NES and NLS motifs determine S. cerevisiae Rna1p subcellular distributionQ77784876
A polypeptide domain that specifies migration of nucleoplasmin into the nucleusQ34056435
The nuclear pore complex: bridging nuclear transport and gene regulationQ34122297
Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.Q34132236
The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import.Q34222991
Nucleocytoplasmic transport enters the atomic age.Q34245364
The human nuclear pore complex as revealed by cryo-electron tomography.Q34282959
Inhibition of nuclear import and alteration of nuclear pore complex composition by rhinovirusQ34344113
Nuclear export of RNA.Q34364012
Recognition of nuclear targeting signals by Karyopherin-β proteinsQ34367559
Comparative mutagenesis of nuclear localization signals reveals the importance of neutral and acidic amino acidsQ34396948
Targeting nucleocytoplasmic transport in cancer therapyQ34398166
SRprises along a messenger's journeyQ34400219
Pom121 links two essential subcomplexes of the nuclear pore complex core to the membraneQ34412386
Nucleocytoplasmic traffic disorder induced by cardioviruses.Q34434945
Effects of poliovirus infection on nucleo-cytoplasmic trafficking and nuclear pore complex composition.Q34450018
Simple fold composition and modular architecture of the nuclear pore complexQ34478878
Analysis of a RanGTP-regulated gradient in mitotic somatic cellsQ34506840
Classical nuclear localization signals: definition, function, and interaction with importin alphaQ34591163
Role of the nuclear envelope in genome organization and gene expressionQ34632599
The nucleoporin Nup98 associates with the intranuclear filamentous protein network of TPR.Q34712774
The nuclear export receptor Xpo1p forms distinct complexes with NES transport substrates and the yeast Ran binding protein 1 (Yrb1p).Q34986205
Nucleocytoplasmic transport: navigating the channelQ35092062
Biology and biophysics of the nuclear pore complex and its componentsQ35195849
Prediction of leucine-rich nuclear export signal containing proteins with NESsentialQ35198286
NESmapper: accurate prediction of leucine-rich nuclear export signals using activity-based profilesQ35261339
Nucleocytoplasmic transport: taking an inventoryQ35541034
Virtual gating and nuclear transport: the hole pictureQ35587487
Regulation of JAK-STAT signalling in the immune systemQ35605437
Nuclear export of mRNA: from the site of transcription to the cytoplasmQ35761786
Importin α: a multipurpose nuclear-transport receptorQ35879618
Importin beta: conducting a much larger cellular symphonyQ35938681
Nuclear envelope budding enables large ribonucleoprotein particle export during synaptic Wnt signalingQ36020221
Translocation through the nuclear pore complex: selectivity and speed by reduction-of-dimensionalityQ36090722
Modularity within the architecture of the nuclear pore complex.Q36101124
Snurportin1, an m3G-cap-specific nuclear import receptor with a novel domain structureQ24316296
Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1Q24316332
Exp5 exports eEF1A via tRNA from nuclei and synergizes with other transport pathways to confine translation to the cytoplasmQ24317462
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88Q24322912
A cap-binding protein complex mediating U snRNA exportQ24336104
RanBP3 influences interactions between CRM1 and its nuclear protein export substratesQ24522587
The role of exportin-t in selective nuclear export of mature tRNAsQ24533485
Importin 13: a novel mediator of nuclear import and exportQ24535585
A masked NES in INI1/hSNF5 mediates hCRM1-dependent nuclear export: implications for tumorigenesisQ24536149
Exportin-5-mediated nuclear export of eukaryotic elongation factor 1A and tRNAQ24537714
ICP27 interacts with the RNA export factor Aly/REF to direct herpes simplex virus type 1 intronless mRNAs to the TAP export pathwayQ24538841
Exportin 5 is a RanGTP-dependent dsRNA-binding protein that mediates nuclear export of pre-miRNAsQ24540256
Identification of different roles for RanGDP and RanGTP in nuclear protein importQ24561933
Exportin 7 defines a novel general nuclear export pathwayQ24563375
A proteasome inhibitor prevents activation of NF-kappa B and stabilizes a newly phosphorylated form of I kappa B-alpha that is still bound to NF-kappa BQ24568234
Rules for nuclear localization sequence recognition by karyopherin beta 2Q24600321
Structural basis for leucine-rich nuclear export signal recognition by CRM1Q24604395
The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleusQ24678911
The yeast nuclear pore complex: composition, architecture, and transport mechanismQ24680784
A role for RanBP1 in the release of CRM1 from the nuclear pore complex in a terminal step of nuclear exportQ24682010
CRM1-mediated recycling of snurportin 1 to the cytoplasmQ24682405
Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein exportQ24685628
Nuclear export of proteins and drug resistance in cancerQ27012444
mRNA export and the TREX complexQ27026569
Structural basis for the interaction between FxFG nucleoporin repeats and importin-beta in nuclear traffickingQ27625995
Structure of Nup58/45 suggests flexible nuclear pore diameter by intermolecular slidingQ27644208
A fence-like coat for the nuclear pore membraneQ27653292
Crystal structure of the nuclear export receptor CRM1 in complex with Snurportin1 and RanGTPQ27655147
Nuclear import mechanism of the EJC component Mago-Y14 revealed by structural studies of importin 13Q27659349
Structural and functional analysis of the interaction between the nucleoporin Nup98 and the mRNA export factor Rae1Q27661891
NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1Q27665346
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
Sequence requirements for nuclear location of simian virus 40 large-T antigenQ29620588
Karyopherins: from nuclear-transport mediators to nuclear-function regulatorsQ30434629
STRADalpha regulates LKB1 localization by blocking access to importin-alpha, and by association with Crm1 and exportin-7.Q30441588
Interaction of HTLV-1 Tax protein with calreticulin: implications for Tax nuclear export and secretionQ30442529
Imaging of single-molecule translocation through nuclear pore complexesQ30832298
A protein inventory of human ribosome biogenesis reveals an essential function of exportin 5 in 60S subunit exportQ30991604
Flexible phenylalanine-glycine nucleoporins as entropic barriers to nucleocytoplasmic transportQ33246576
H2A.Z-mediated localization of genes at the nuclear periphery confers epigenetic memory of previous transcriptional stateQ33279444
An electron microscope study of the nuclear membraneQ33311818
Nuclear export signal consensus sequences defined using a localization-based yeast selection systemQ33371970
Depletion of nucleophosmin via transglutaminase 2 cross-linking increases drug resistance in cancer cellsQ33375544
Ebolavirus VP24 binding to karyopherins is required for inhibition of interferon signalingQ33558506
Comparative genomic evidence for a complete nuclear pore complex in the last eukaryotic common ancestor.Q33719317
Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediatesQ33826732
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES maskingQ33890625
Gatekeepers of the nucleusQ33927537
RanGTP-regulated interactions of CRM1 with nucleoporins and a shuttling DEAD-box helicaseQ33959492
Nuclear import by karyopherin-βs: Recognition and inhibitionQ34024485
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
The GTPase superfamily: conserved structure and molecular mechanismQ27860524
Nuclear export of microRNA precursorsQ27860686
Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathwayQ27936568
Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNAQ27937371
Nuclear export of 60s ribosomal subunits depends on Xpo1p and requires a nuclear export sequence-containing factor, Nmd3p, that associates with the large subunit protein Rpl10pQ27937695
Regulated nucleo/cytoplasmic exchange of HOG1 MAPK requires the importin beta homologs NMD5 and XPO1.Q27937992
Homeodomain of yeast repressor alpha 2 contains a nuclear localization signalQ27938014
Roles of phosphorylation sites in regulating activity of the transcription factor Pho4.Q27938391
Nmd3p is a Crm1p-dependent adapter protein for nuclear export of the large ribosomal subunitQ27939125
Kap104p imports the PY-NLS-containing transcription factor Tfg2p into the nucleusQ27939454
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
Telomere tethering at the nuclear periphery is essential for efficient DNA double strand break repair in subtelomeric regionQ27940251
Integrated structural analysis of the human nuclear pore complex scaffoldQ28115760
Biogenesis and nuclear export of ribosomal subunits in higher eukaryotes depend on the CRM1 export pathwayQ28116115
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporinsQ28131733
Vesicular stomatitis virus matrix protein inhibits host cell gene expression by targeting the nucleoporin Nup98Q28139522
Molecular dissection of the importin beta1-recognized nuclear targeting signal of parathyroid hormone-related proteinQ28201295
Exporting RNA from the nucleus to the cytoplasmQ28245155
Identification of a nuclear export receptor for tRNAQ28265348
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNAQ28279502
Molecular basis for specificity of nuclear import and prediction of nuclear localizationQ28296734
Nucleo-cytoplasmic distribution of human hnRNP proteins: a search for the targeting domains in hnRNP A1Q28302458
PHAX, a mediator of U snRNA nuclear export whose activity is regulated by phosphorylationQ28511197
Nuclear localization of NF-ATc by a calcineurin-dependent, cyclosporin-sensitive intramolecular interactionQ28616185
HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequenceQ28646785
Identification of a signal for rapid export of proteins from the nucleusQ29547742
A short amino acid sequence able to specify nuclear locationQ29547781
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
Structural biology of nucleocytoplasmic transportQ29615350
Transport into and out of the nucleusQ29615611
Analysis and prediction of leucine-rich nuclear export signalsQ29619228
The SR protein family of splicing factors: master regulators of gene expressionQ29619935
The GTP-binding protein Ran/TC4 is required for protein import into the nucleusQ29620192
Inhibition of nuclear protein import by nonhydrolyzable analogues of GTP and identification of the small GTPase Ran/TC4 as an essential transport factorQ29620193
Structural basis for assembly and disassembly of the CRM1 nuclear export complexQ36220837
NESdb: a database of NES-containing CRM1 cargoesQ36234505
A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.Q36237387
The cytoplasmic filaments of the nuclear pore complex are dispensable for selective nuclear protein importQ36323649
Karyopherin flexibility in nucleocytoplasmic transportQ36432992
ValidNESs: a database of validated leucine-rich nuclear export signalsQ36491242
Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assayQ36561338
The role of nuclear envelope calcium in modifying nuclear pore complex structureQ36562700
Nup358/RanBP2 attaches to the nuclear pore complex via association with Nup88 and Nup214/CAN and plays a supporting role in CRM1-mediated nuclear protein exportQ36572321
Severe acute respiratory syndrome coronavirus protein 6 accelerates murine hepatitis virus infections by more than one mechanism.Q36747726
Nuclear pore complexes: guardians of the nuclear genomeQ36829705
Dynamic trafficking of STAT5 depends on an unconventional nuclear localization signalQ37061528
Nucleocytoplasmic transport of proteinsQ37087415
Leader-induced phosphorylation of nucleoporins correlates with nuclear trafficking inhibition by cardiovirusesQ37099800
Mengovirus-induced rearrangement of the nuclear pore complex: hijacking cellular phosphorylation machineryQ37127856
Rhinovirus 3C protease can localize in the nucleus and alter active and passive nucleocytoplasmic transportQ37247979
CRM1-mediated nuclear export of proteins and drug resistance in cancerQ37320237
First and last ancestors: reconstructing evolution of the endomembrane system with ESCRTs, vesicle coat proteins, and nuclear pore complexesQ37388173
Bidirectional increase in permeability of nuclear envelope upon poliovirus infection and accompanying alterations of nuclear pores.Q37492721
mRNA nuclear export at a glanceQ37506920
Importins and beyond: non-conventional nuclear transport mechanismsQ37528567
Linking gene regulation to mRNA production and export.Q37827981
The structure of the nuclear pore complexQ37865519
Calcium regulation of nucleocytoplasmic transportQ37870091
mRNA export and cancerQ37907202
Protein localization in disease and therapy.Q37947248
New clues to understand the role of THO and other functionally related factors in mRNP biogenesisQ37972238
Functional architecture of the nuclear pore complexQ38009349
Nuclear trafficking of proteins from RNA viruses: potential target for antivirals?Q38023068
Moving to the core: spatiotemporal analysis of Forkhead box O (FOXO) and nuclear factor-κB (NF-κB) nuclear translocationQ38066579
Nuclear trafficking in health and diseaseQ38188343
I kappa B interacts with the nuclear localization sequences of the subunits of NF-kappa B: a mechanism for cytoplasmic retentionQ38325326
Nup214 is required for CRM1-dependent nuclear protein export in vivoQ38411212
Differential processing of nuclear pore complex proteins by rhinovirus 2A proteases from different species and serotypesQ38631844
High-content screening of natural products reveals novel nuclear export inhibitorsQ39094551
Cse1p is involved in export of yeast importin alpha from the nucleusQ39576650
The arginine-rich domains present in human immunodeficiency virus type 1 Tat and Rev function as direct importin beta-dependent nuclear localization signalsQ39610897
The permeability barrier of nuclear pore complexes appears to operate via hydrophobic exclusionQ39647313
A PY-NLS nuclear targeting signal is required for nuclear localization and function of the Saccharomyces cerevisiae mRNA-binding protein Hrp1.Q39647788
Thyroid hormone receptor alpha1 follows a cooperative CRM1/calreticulin-mediated nuclear export pathway.Q39959148
Severe acute respiratory syndrome coronavirus open reading frame (ORF) 3b, ORF 6, and nucleocapsid proteins function as interferon antagonistsQ40208162
Crm1 is a mitotic effector of Ran-GTP in somatic cellsQ40418909
Expanding the definition of the classical bipartite nuclear localization signalQ41113075
Heat-stable inhibitors of cAMP-dependent protein kinase carry a nuclear export signal.Q41408510
Snapshots of nuclear pore complexes in action captured by cryo-electron tomographyQ41624126
Processing of the precursor of NF-kappa B by the HIV-1 protease during acute infectionQ41687257
Exportin 4 mediates a novel nuclear import pathway for Sox family transcription factorsQ41879312
Severe acute respiratory syndrome coronavirus ORF6 antagonizes STAT1 function by sequestering nuclear import factors on the rough endoplasmic reticulum/Golgi membraneQ42624738
Design of peptide inhibitors for the importin alpha/beta nuclear import pathway by activity-based profilingQ42808317
RNA nuclear export is blocked by poliovirus 2A protease and is concomitant with nucleoporin cleavage.Q43269551
Nucleocytoplasmic shuttling of the thyroid hormone receptor alphaQ43552383
Stimulation of nuclear export and inhibition of nuclear import by a Ran mutant deficient in binding to Ran-binding protein 1.Q43559962
Nuclear export of 5S rRNA-containing ribonucleoprotein complexes requires CRM1 and the RanGTPase cycleQ44220022
Inhibition of nuclear import mediated by the Rev-arginine rich motif by RNA molecules.Q44339479
A SOX9 defect of calmodulin-dependent nuclear import in campomelic dysplasia/autosomal sex reversalQ44480806
Cytoplasmic localization of mitogen-activated protein kinase kinase directed by its NH2-terminal, leucine-rich short amino acid sequence, which acts as a nuclear export signalQ45300833
The protein kinase CK2 site (Ser111/112) enhances recognition of the simian virus 40 large T-antigen nuclear localization sequence by importinQ45762248
Binding dynamics of isolated nucleoporin repeat regions to importin-betaQ46843299
Nanomechanical basis of selective gating by the nuclear pore complexQ46966189
Prediction of nuclear export signals using weighted regular expressions (Wregex).Q47681206
Nanomechanical interactions of phenylalanine-glycine nucleoporins studied by single molecule force-volume spectroscopyQ50165583
CRM1-mediated nuclear export: to the pore and beyond.Q50336102
SnapShot: nuclear transport.Q51974366
A Saturated FG-Repeat Hydrogel Can Reproduce the Permeability Properties of Nuclear Pore ComplexesQ58076940
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectnucleusQ40260
P304page(s)445-462
P577publication date2015-02-01
P1433published inFEBS JournalQ1388041
P1476titleComponents and regulation of nuclear transport processes
P478volume282

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