Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.

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Mutational definition of the human immunodeficiency virus type 1 Rev activation domain. is …
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scholarly articleQ13442814

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P356DOI10.1128/JVI.65.8.4248-4254.1991
P932PMC publication ID248862
P698PubMed publication ID2072452

P2093author name stringB R Cullen
D F McCarn
M H Malim
L S Tiley
P2860cites workPeriodicity of leucine and tandem repetition of a 24-amino acid segment in the primary structure of leucine-rich alpha 2-glycoprotein of human serumQ24300009
Visna virus encodes a post-transcriptional regulator of viral structural gene expressionQ24557218
Subcellular localization of the human immunodeficiency virus trans-acting art gene productQ24651489
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye bindingQ25938984
The leucine zipper: a hypothetical structure common to a new class of DNA binding proteinsQ27860587
Recombinant genomes which express chloramphenicol acetyltransferase in mammalian cellsQ27860607
DNA sequence and characterization of the S. cerevisiae gene encoding adenylate cyclaseQ27934829
Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clonesQ28237952
HIV-1 regulator of virion expression (Rev) protein binds to an RNA stem-loop structure located within the Rev response element regionQ28256243
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNAQ28279502
rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNAQ28279513
Nucleotide sequence of the visna lentivirus: relationship to the AIDS virusQ28299945
HIV-1 structural gene expression requires the binding of multiple Rev monomers to the viral RRE: implications for HIV-1 latencyQ28646762
HIV-1 structural gene expression requires binding of the Rev trans-activator to its RNA target sequenceQ28646785
Use of eukaryotic expression technology in the functional analysis of cloned genesQ29620166
Intragenic cis-acting art gene-responsive sequences of the human immunodeficiency virusQ33562331
Steroid-receptor fusion of the human immunodeficiency virus type 1 Rev transactivator: mapping cryptic functions of the arginine-rich motifQ33831166
The human immunodeficiency virus: infectivity and mechanisms of pathogenesisQ34049376
A second post-transcriptional trans-activator gene required for HTLV-III replicationQ34162178
HTLV-III expression and production involve complex regulation at the levels of splicing and translation of viral RNA.Q34186306
Functional comparison of the Rev trans-activators encoded by different primate immunodeficiency virus species.Q34314770
The human immunodeficiency virus rev protein is a nuclear phosphoproteinQ34534125
Identification of trans-dominant HIV-1 rev protein mutants by direct transfer of bacterially produced proteins into human cellsQ35837431
Rev activates expression of the human immunodeficiency virus type 1 vif and vpr gene productsQ36683132
Rev-dependent expression of human immunodeficiency virus type 1 gp160 in Drosophila melanogaster cellsQ36773779
The trypanosome leucine repeat gene in the variant surface glycoprotein expression site encodes a putative metal-binding domain and a region resembling protein-binding domains of yeast, Drosophila, and mammalian proteinsQ36774611
Mutational analysis of the human immunodeficiency virus type 1 Rev transactivator: essential residues near the amino terminusQ36793300
Env and Vpu proteins of human immunodeficiency virus type 1 are produced from multiple bicistronic mRNAsQ36793376
Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expressionQ36830303
Leucine periodicity of U2 small nuclear ribonucleoprotein particle (snRNP) A' protein is implicated in snRNP assembly via protein-protein interactionsQ36960061
Activators and targetsQ37856107
Pathogenesis of lentivirus infectionsQ38164170
Regulatory pathways governing HIV-1 replicationQ38360638
Conserved functional organization of the human immunodeficiency virus type 1 and visna virus Rev proteinsQ40067291
Phosphorylation of the rev gene product of human immunodeficiency virus type 1.Q40129721
High level transient expression of a chloramphenicol acetyl transferase gene by DEAE-dextran mediated DNA transfection coupled with a dimethyl sulfoxide or glycerol shock treatment.Q40461112
Interaction of the human immunodeficiency virus type 1 Rev protein with a structured region in env mRNA is dependent on multimer formation mediated through a basic stretch of amino acidsQ41208182
A human cell factor is essential for HIV-1 Rev action.Q41235075
Specific binding of HIV-1 recombinant Rev protein to the Rev-responsive element in vitroQ41258164
Cells nonproductively infected with HIV-1 exhibit an aberrant pattern of viral RNA expression: a molecular model for latencyQ41730261
Nucleotide sequence analysis of SA-OMVV, a visna-related ovine lentivirus: phylogenetic history of lentivirusesQ41738892
Regulation by HIV Rev depends upon recognition of splice sitesQ41758926
Nucleotide sequence and transcriptional analysis of molecular clones of CAEV which generate infectious virusQ42632335
The rev gene product of the human immunodeficiency virus affects envelope-specific RNA localizationQ44022521
Secondary structure is the major determinant for interaction of HIV rev protein with RNA.Q45129827
Trans-activation of human immunodeficiency virus occurs via a bimodal mechanismQ45830933
Immunodeficiency virus rev trans-activator modulates the expression of the viral regulatory genesQ45831871
Structural and functional characterization of the human immunodeficiency virus rev protein.Q45843914
Sequence-specific RNA binding by the HIV-1 Rev protein.Q50335727
Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev functionQ58611466
Secreted placental alkaline phosphatase: a powerful new quantitative indicator of gene expression in eukaryotic cellsQ68504983
Mutants in a conserved region near the carboxy-terminus of HIV-1 Rev identify functionally important residues and exhibit a dominant negative phenotypeQ68535819
P433issue8
P407language of work or nameEnglishQ1860
P921main subjectvirusQ808
P304page(s)4248-4254
P577publication date1991-08-01
P1433published inJournal of VirologyQ1251128
P1476titleMutational definition of the human immunodeficiency virus type 1 Rev activation domain
P478volume65

Reverse relations

cites work (P2860)
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Q35488480A mutant tat protein inhibits HIV-1 reverse transcription by targeting the reverse transcription complex.
Q22009935A new nucleoporin-like protein interacts with both HIV-1 Rev nuclear export signal and CRM-1
Q34421116A novel, mouse mammary tumor virus encoded protein with Rev-like properties
Q24683176A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein
Q41077534A nuclear role for the Fragile X mental retardation protein
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Q28238195A role for Rev in the association of HIV-1 gag mRNA with cytoskeletal beta-actin and viral protein expression
Q24647511A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleus
Q40219824ADAR1 is a novel multi targeted anti-HIV-1 cellular protein
Q41909154Adaptive mutations in the nuclear export protein of human-derived H5N1 strains facilitate a polymerase activity-enhancing conformation
Q24290419Adenomatous polyposis coli protein contains two nuclear export signals and shuttles between the nucleus and cytoplasm
Q24568152Amphibian transcription factor IIIA proteins contain a sequence element functionally equivalent to the nuclear export signal of human immunodeficiency virus type 1 Rev
Q73762090Anti-idiotype RNAs that mimic the leucine-rich nuclear export signal and specifically bind to CRM1/exportin 1
Q34297734Binding of Human Prothymosin α to the Leucine‐Motif/activation Domains of HTLV‐I Rex and HIV‐1 Rev
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Q40041357Biological, molecular, and structural analysis of a cytopathic variant from a molecularly cloned simian immunodeficiency virus
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Q44328482Characterization of the caprine arthritis encephalitis virus (CAEV) rev N-terminal elements required for efficient interaction with the RRE.
Q36562395Characterization of the nuclear export signal of human T-cell lymphotropic virus type 1 Rex reveals that nuclear export is mediated by position-variable hydrophobic interactions
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Q26851989Components and regulation of nuclear transport processes
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Q40308981Definition of the human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex protein activation domain by functional exchange
Q24682912Determination of the functional domain organization of the importin alpha nuclear import factor
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Q33987860Domain- and nucleotide-specific Rev response element regulation of feline immunodeficiency virus production
Q40044710Dominant negative mutants of human T-cell leukemia virus type I Rex and human immunodeficiency virus type 1 Rev fail to multimerize in vivo.
Q40066482Dominant-negative mutants are clustered in a domain of the human T-cell leukemia virus type I Rex protein: implications for trans dominance
Q40113221Effector domains of human immunodeficiency virus type 1 Rev and human T-cell leukemia virus type I Rex are functionally interchangeable and share an essential peptide motif
Q38296024Effects of translation initiation factor eIF-5A on the functioning of human T-cell leukemia virus type I Rex and human immunodeficiency virus Rev inhibited trans dominantly by a Rex mutant deficient in RNA binding
Q37145307Elevated hypermutation levels in HIV-1 natural viral suppressors
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Q33806883Epstein-Barr virus EB2 protein exports unspliced RNA via a Crm-1-independent pathway
Q36633475Equine infectious anemia virus trans-regulatory protein Rev controls viral mRNA stability, accumulation, and alternative splicing
Q24657633Eukaryotic initiation factor 5A is a cellular target of the human immunodeficiency virus type 1 Rev activation domain mediating trans-activation
Q28646843Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNA
Q28742565Evolution of a species-specific determinant within human CRM1 that regulates the post-transcriptional phases of HIV-1 replication
Q92340071Evolution of the HIV-1 Rev Response Element during Natural Infection Reveals Nucleotide Changes That Correlate with Altered Structure and Increased Activity over Time
Q33866139Exchange of the basic domain of human immunodeficiency virus type 1 Rev for a polyarginine stretch expands the RNA binding specificity, and a minimal arginine cluster is required for optimal RRE RNA binding affinity, nuclear accumulation, and trans-
Q34529776Export of adenoviral late mRNA from the nucleus requires the Nxf1/Tap export receptor
Q37679611Expression of a protective gene-prolongs survival of T cells in human immunodeficiency virus-infected patients
Q34295820Formation of trans-activation competent HIV-1 Rev:RRE complexes requires the recruitment of multiple protein activation domains
Q46301219Functional T-cell responses generated by dendritic cells expressing the early HIV-1 proteins Tat, Rev and Nef.
Q39579073Functional analysis of the human immunodeficiency virus type 1 Rev protein oligomerization interface.
Q28209036Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors
Q73806944Functional role of the HIV-1 Rev exon 1 encoded region in complex formation and trans-dominant inhibition
Q40475569Functionally-inactive and immunogenic Tat, Rev and Nef DNA vaccines derived from sub-Saharan subtype C human immunodeficiency virus type 1 consensus sequences.
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Q28289718HIV Rev uses a conserved cellular protein export pathway for the nucleocytoplasmic transport of viral RNAs
Q24671943HIV Rev-dependent binding of SF2/ASF to the Rev response element: possible role in Rev-mediated inhibition of HIV RNA splicing
Q64121615Highly Mutable Linker Regions Regulate HIV-1 Rev Function and Stability
Q36687462Human immunodeficiency virus type 1 Rev activation can be achieved without Rev-responsive element RNA if Rev is directed to the target as a Rev/MS2 fusion protein which tethers the MS2 operator RNA
Q24645943Human immunodeficiency virus type 1 Rev is required in vivo for binding of poly(A)-binding protein to Rev-dependent RNAs
Q33350161Human immunodeficiency virus type 1 long-term non-progressors: the viral, genetic and immunological basis for disease non-progression
Q42800068Human p32 protein relieves a post-transcriptional block to HIV replication in murine cells
Q38953321IFITM proteins inhibit entry driven by the MERS-coronavirus spike protein: evidence for cholesterol-independent mechanisms
Q24678215Identification of a Rev-related protein by analysis of spliced transcripts of the human endogenous retroviruses HTDV/HERV-K
Q24321880Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteins
Q27933981Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeast
Q29547742Identification of a signal for rapid export of proteins from the nucleus
Q33966215Identification of novel Saccharomyces cerevisiae proteins with nuclear export activity: cell cycle-regulated transcription factor ace2p shows cell cycle-independent nucleocytoplasmic shuttling
Q33959518Identification of novel import and export signals of human TAP, the protein that binds to the constitutive transport element of the type D retrovirus mRNAs
Q36655230Identification of the activation domain of equine infectious anemia virus rev
Q40309262In vivo binding of wild-type and mutant human immunodeficiency virus type 1 Rev proteins: implications for function
Q30439541Inability of human immunodeficiency virus type 1 produced in murine cells to selectively incorporate primer formula
Q48026294Influence of host species on the evolution of the nonstructural (NS) gene of influenza A viruses
Q24529536Influenza B and C virus NEP (NS2) proteins possess nuclear export activities
Q24523655Inhibition of human immunodeficiency virus Rev and human T-cell leukemia virus Rex function, but not Mason-Pfizer monkey virus constitutive transport element activity, by a mutant human nucleoporin targeted to Crm1
Q37256308Inhibition of human immunodeficiency virus type 1 replication in human T cells by retroviral-mediated gene transfer of a dominant-negative Rev trans-activator
Q35865426Inhibition of human immunodeficiency virus type 1 replication is enhanced by a combination of transdominant Tat and Rev proteins
Q36816824Inhibition of mRNA export in vertebrate cells by nuclear export signal conjugates
Q24310012Interaction of the HIV-1 rev cofactor eukaryotic initiation factor 5A with ribosomal protein L5
Q39579580Involvement of human CRM1 (exportin 1) in the export and multimerization of the Rex protein of human T-cell leukemia virus type 1.
Q24685870Leptomycin B inactivates CRM1/exportin 1 by covalent modification at a cysteine residue in the central conserved region
Q34987465Matrix mediates the functional link between human immunodeficiency virus type 1 RNA nuclear export elements and the assembly competency of Gag in murine cells.
Q35403061Mechanism of action of regulatory proteins encoded by complex retroviruses
Q41729122Mechanisms involved in natural and experimental neuropathogenicity of influenza viruses: evidence and speculation.
Q37034644Molecular mechanisms of HIV-1 vertical transmission and pathogenesis in infants
Q36687307Molecular profile of human immunodeficiency virus type 1 infection in symptomless patients and in patients with AIDS
Q39581878Multimer formation is not essential for nuclear export of human T-cell leukemia virus type 1 Rex trans-activator protein
Q33603453Multiple blocks to human immunodeficiency virus type 1 replication in rodent cells
Q37596977Murine T cells potently restrict human immunodeficiency virus infection
Q33292384Mutational definition of functional domains within the Rev homolog encoded by human endogenous retrovirus K.
Q27665346NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1
Q35924105Nonviral and viral delivery of a human immunodeficiency virus protective gene into primary human T cells
Q34353375Novel Pol II fusion promoter directs human immunodeficiency virus type 1-inducible coexpression of a short hairpin RNA and protein.
Q24568233Nuclear export of late HIV-1 mRNAs occurs via a cellular protein export pathway
Q40229432Nuclear export of simian immunodeficiency virus Vpx protein.
Q35839437Nuclear export of the human immunodeficiency virus type 1 nucleocytoplasmic shuttle protein Rev is mediated by its activation domain and is blocked by transdominant negative mutants
Q39873549Nuclear preservation and cytoplasmic degradation of human immunodeficiency virus type 1 Rev protein.
Q34381398Nuclear transport of human immunodeficiency virus type 1, visna virus, and equine infectious anemia virus Rev proteins: identification of a family of transferable nuclear export signals.
Q39740420Over-expression of the HIV-1 Rev promotes death of nondividing eukaryotic cells
Q35846005Persistence of attenuated rev genes in a human immunodeficiency virus type 1-infected asymptomatic individual
Q33648134Polyvalent Rev decoys act as artificial Rev-responsive elements
Q36630676Posttranscriptional effector domains in the Rev proteins of feline immunodeficiency virus and equine infectious anemia virus.
Q30879123Potent inhibition of HIV-1 replication by a Tat mutant
Q38180645Practical considerations in gene therapy for HIV cure
Q36561338Protein sequence requirements for function of the human T-cell leukemia virus type 1 Rex nuclear export signal delineated by a novel in vivo randomization-selection assay
Q49485954Putative reaction intermediates in Crm1-mediated nuclear protein export
Q26822052Ran-dependent nuclear export mediators: a structural perspective
Q46400037Rapid targeting of nuclear proteins to the cytoplasm
Q28646696Recruitment of the Crm1 nuclear export factor is sufficient to induce cytoplasmic expression of incompletely spliced human immunodeficiency virus mRNAs
Q40756505Regulation of human immunodeficiency virus infection: implications for pathogenesis
Q34624049Regulation of human retroviral latency by the NF-kappa B/I kappa B family: inhibition of human immunodeficiency virus replication by I kappa B through a Rev-dependent mechanism
Q35837448Restriction of human immunodeficiency virus type 1 production in a human astrocytoma cell line is associated with a cellular block in Rev function.
Q35836276Retroviral mRNA nuclear export elements regulate protein function and virion assembly.
Q37142231Rev and Rex proteins of human complex retroviruses function with the MMTV Rem-responsive element
Q36823499Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotes
Q34033155Rev protein and its cellular partners
Q38025392Role of Nucleocytoplasmic RNA Transport during the Life Cycle of Retroviruses
Q24650446Role of polyadenylation in nucleocytoplasmic transport of mRNA
Q36039006Role of the RNA recognition motif of the E1B 55 kDa protein in the adenovirus type 5 infectious cycle
Q33990712SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA
Q40042468Scanning mutagenesis of the arginine-rich region of the human immunodeficiency virus type 1 Rev trans activator
Q30304057Selection and characterization of human immunodeficiency virus type 1 mutants that are resistant to inhibition by the transdominant negative RevM10 protein
Q27319151Single-Cell and Single-Cycle Analysis of HIV-1 Replication
Q41981808Stable expression of transdominant Rev protein in human T cells inhibits human immunodeficiency virus replication
Q40910855Structural and functional analysis of the avian leukemia virus constitutive transport element
Q24645046Structural and functional analysis of the visna virus Rev-response element
Q36652433Structural and functional characterization of rev-like transcripts of equine infectious anemia virus
Q36628682Subcellular distribution of human immunodeficiency virus type 1 Rev and colocalization of Rev with RNA splicing factors in a speckled pattern in the nucleoplasm
Q21245027Substitution of the Rev-response element in an HIV-1-based gene delivery system with that of SIVmac239 allows efficient delivery of Rev M10 into T-lymphocytes
Q39871345Suppression of simian immunodeficiency virus replication by human immunodeficiency virus type 1 trans-dominant negative rev mutants
Q34976301Susceptibility of Mink ( Mustera vision )-Derived Cells to Replication by Human Immunodeficiency Virus Type 1
Q39852737Synergistic effect of human CycT1 and CRM1 on HIV-1 propagation in rat T cells and macrophages
Q73342583Temperature inducible beta-sheet structure in the transactivation domains of retroviral regulatory proteins of the Rev family
Q40467685The Human Immunodeficiency Virus Type 1 Rev Protein: A Pivotal Protein in the Viral Life Cycle
Q24538664The NS2 proteins of parvovirus minute virus of mice are required for efficient nuclear egress of progeny virions in mouse cells.
Q40062012The blocks to human immunodeficiency virus type 1 Tat and Rev functions in mouse cell lines are independent
Q39753171The carboxy-terminal region of the human immunodeficiency virus type 1 protein Rev has multiple roles in mediating CRM1-related Rev functions
Q38356070The hepatitis B virus posttranscriptional regulatory element is composed of two subelements
Q35898553The human T-cell leukemia virus type 1 Rex regulatory protein exhibits an impaired functionality in human lymphoblastoid Jurkat T cells.
Q35868902The human T-cell leukemia virus type 1 posttranscriptional trans-activator Rex contains a nuclear export signal
Q28646657The human Tap protein is a nuclear mRNA export factor that contains novel RNA-binding and nucleocytoplasmic transport sequences
Q28254641The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear export
Q33888022The influenza virus NEP (NS2 protein) mediates the nuclear export of viral ribonucleoproteins
Q33605916The matrix protein of vesicular stomatitis virus inhibits nucleocytoplasmic transport when it is in the nucleus and associated with nuclear pore complexes
Q26801493Translational Control of the HIV Unspliced Genomic RNA
Q37247695Treatment with the fusion inhibitor enfuvirtide influences the appearance of mutations in the human immunodeficiency virus type 1 regulatory protein rev.
Q24291654Two closely related human nuclear export factors utilize entirely distinct export pathways
Q36632171Two functional domains of the influenza virus NS1 protein are required for regulation of nuclear export of mRNA.
Q39869106Use of a human immunodeficiency virus type 1 Rev mutant without nucleolar dysfunction as a candidate for potential AIDS therapy.
Q28365327Using viral species specificity to define a critical protein/RNA interaction surface
Q37412098Viral factors in non-progression
Q27938169Yeast heat shock mRNAs are exported through a distinct pathway defined by Rip1p
Q40308472trans-dominant inhibition of human immunodeficiency virus type 1 Rev occurs through formation of inactive protein complexes

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