Putative reaction intermediates in Crm1-mediated nuclear protein export

scientific article published in June 1999

Putative reaction intermediates in Crm1-mediated nuclear protein export is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.274.23.16279
P8608Fatcat IDrelease_2eqjxqv57bbfthnzgxqgsgndry
P698PubMed publication ID10347184
P5875ResearchGate publication ID12952057

P50authorGünter BlobelQ60108
P2093author name stringFloer M
P2860cites workIdentification of a tRNA-specific nuclear export receptorQ24314506
Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptideQ24316110
The peptide repeat domain of nucleoporin Nup98 functions as a docking site in transport across the nuclear pore complexQ24316128
Export of importin alpha from the nucleus is mediated by a specific nuclear transport factorQ24316152
Co-activation of RanGTPase and inhibition of GTP dissociation by Ran-GTP binding protein RanBP1Q24316332
Identification of NTF2, a cytosolic factor for nuclear import that interacts with nuclear pore complex protein p62Q24317417
The structural basis of the activation of Ras by SosQ24320225
Identification of a novel cellular cofactor for the Rev/Rex class of retroviral regulatory proteinsQ24321880
The human homologue of yeast CRM1 is in a dynamic subcomplex with CAN/Nup214 and a novel nuclear pore component Nup88Q24322912
The RCC1 protein, a regulator for the onset of chromosome condensation locates in the nucleus and binds to DNAQ24339283
A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a gene implicated in onset of chromosome condensationQ24556596
A role for nucleoporin FG repeat domains in export of human immunodeficiency virus type 1 Rev protein and RNA from the nucleusQ24647511
RanGTP targets p97 to RanBP2, a filamentous protein localized at the cytoplasmic periphery of the nuclear pore complexQ24649249
Molecular and functional characterization of the p62 complex, an assembly of nuclear pore complex glycoproteinsQ24671748
The yeast RNA1 gene product necessary for RNA processing is located in the cytosol and apparently excluded from the nucleusQ24678911
Structural basis for molecular recognition between nuclear transport factor 2 (NTF2) and the GDP-bound form of the Ras-family GTPase RanQ27749032
CRM1 is an export receptor for leucine-rich nuclear export signalsQ27860453
The specificity of the CRM1-Rev nuclear export signal interaction is mediated by RanGTP.Q27867724
Yrb2p is a nuclear protein that interacts with Prp20p, a yeast Rcc1 homologueQ27929950
Identification of a novel nuclear pore-associated protein as a functional target of the HIV-1 Rev protein in yeastQ27933981
Yrb2p, a Nup2p-related yeast protein, has a functional overlap with Rna1p, a yeast Ran-GTPase-activating proteinQ27933997
A member of the Ran-binding protein family, Yrb2p, is involved in nuclear protein exportQ27934656
Nucleus-associated pools of Rna1p, the Saccharomyces cerevisiae Ran/TC4 GTPse activating protein involved in nucleus/cytosol transitQ27934686
The NTF2 gene encodes an essential, highly conserved protein that functions in nuclear transport in vivoQ27935356
Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNAQ27937371
tRNA nuclear export in saccharomyces cerevisiae: in situ hybridization analysisQ27937477
The essential yeast nucleoporin NUP159 is located on the cytoplasmic side of the nuclear pore complex and serves in karyopherin-mediated binding of transport substrateQ27937661
A family of Ran binding proteins that includes nucleoporinsQ27939099
Exportin 1 (Crm1p) is an essential nuclear export factorQ27939696
The HIV-1 Rev activation domain is a nuclear export signal that accesses an export pathway used by specific cellular RNAsQ28131708
Protein import into nuclei: association and dissociation reactions involving transport substrate, transport factors, and nucleoporinsQ28131733
From nucleoporins to nuclear pore complexesQ28238651
The importin-beta family member Crm1p bridges the interaction between Rev and the nuclear pore complex during nuclear exportQ28254641
Characterization of proteins that interact with the cell-cycle regulatory protein Ran/TC4Q28257159
The HIV-1 rev trans-activator acts through a structured target sequence to activate nuclear export of unspliced viral mRNAQ28279502
rev protein of human immunodeficiency virus type 1 affects the stability and transport of the viral mRNAQ28279513
Molecular interactions between the importin alpha/beta heterodimer and proteins involved in vertebrate nuclear protein importQ28307560
Identification of a protein complex that is required for nuclear protein import and mediates docking of import substrate to distinct nucleoporinsQ28573887
Evidence that HIV-1 Rev directly promotes the nuclear export of unspliced RNAQ28646843
Identification of a signal for rapid export of proteins from the nucleusQ29547742
CRM1 is responsible for intracellular transport mediated by the nuclear export signalQ29547861
The asymmetric distribution of the constituents of the Ran system is essential for transport into and out of the nucleusQ29616325
Pores for thought: nuclear pore complex proteinsQ29616785
Leptomycin B is an inhibitor of nuclear export: inhibition of nucleo-cytoplasmic translocation of the human immunodeficiency virus type 1 (HIV-1) Rev protein and Rev-dependent mRNAQ29620175
Evidence for a role of CRM1 in signal-mediated nuclear protein exportQ29620231
Purification of a Ran-interacting protein that is required for protein import into the nucleusQ29620570
Nuclear PRP20 protein is required for mRNA exportQ34041464
Mutational definition of the human immunodeficiency virus type 1 Rev activation domain.Q34132236
The rev (trs/art) protein of human immunodeficiency virus type 1 affects viral mRNA and protein expression via a cis-acting sequence in the env regionQ34544493
The GTP-bound form of the yeast Ran/TC4 homologue blocks nuclear protein import and appearance of poly(A)+ RNA in the cytoplasmQ34838735
Higher order chromosome structure is affected by cold-sensitive mutations in a Schizosaccharomyces pombe gene crm1+ which encodes a 115-kD protein preferentially localized in the nucleus and its peripheryQ36220366
Evidence for a dual role for TC4 protein in regulating nuclear structure and cell cycle progressionQ36234292
A nuclear export signal is essential for the cytosolic localization of the Ran binding protein, RanBP1.Q36237387
RanBP1 stabilizes the interaction of Ran with p97 nuclear protein importQ36237637
Rev and the fate of pre-mRNA in the nucleus: implications for the regulation of RNA processing in eukaryotesQ36823499
Nucleotide-specific interaction of Ran/TC4 with nuclear transport factors NTF2 and p97.Q37432537
The nuclear transport factor karyopherin beta binds stoichiometrically to Ran-GTP and inhibits the Ran GTPase activating proteinQ38360627
Cse1p is involved in export of yeast importin alpha from the nucleusQ39576650
Requirement of guanosine triphosphate-bound ran for signal-mediated nuclear protein exportQ41104206
Diverse effects of the guanine nucleotide exchange factor RCC1 on RNA transportQ41358751
Nucleocytoplasmic transport: the last 200 nanometersQ41708889
Karyopherins and kissing cousinsQ47721363
Transport routes through the nuclear pore complexQ47926615
Role of the nuclear transport factor p10 in nuclear importQ48064951
Disassembly of RanGTP-karyopherin beta complex, an intermediate in nuclear protein importQ49486091
Structural Basis for Activation of ARF GTPaseQ56288670
RanBP1 is crucial for the release of RanGTP from importin β-related nuclear transport factorsQ58077231
Functional dissection of the HIV-1 Rev trans-activator—Derivation of a trans-dominant repressor of Rev functionQ58611466
Ran-binding protein 1 (RanBP1) forms a ternary complex with Ran and karyopherin beta and reduces Ran GTPase-activating protein (RanGAP) inhibition by karyopherin betaQ71973464
Interaction of the nuclear GTP-binding protein Ran with its regulatory proteins RCC1 and RanGAP1Q72403668
Dynamic and equilibrium studies on the interaction of Ran with its effector, RanBP1Q73745043
A Ran-binding motif in nuclear pore proteinsQ75292513
Cse1p functions as the nuclear export receptor for importin alpha in yeastQ77323192
P433issue23
P407language of work or nameEnglishQ1860
P304page(s)16279-16286
P577publication date1999-06-01
P1433published inJournal of Biological ChemistryQ867727
P1476titlePutative reaction intermediates in Crm1-mediated nuclear protein export
P478volume274

Reverse relations

cites work (P2860)
Q28138319A human importin-beta family protein, transportin-SR2, interacts with the phosphorylated RS domain of SR proteins
Q42063149A link between the synthesis of nucleoporins and the biogenesis of the nuclear envelope.
Q24683176A nuclear kinesin-like protein interacts with and stimulates the activity of the leucine-rich nuclear export signal of the human immunodeficiency virus type 1 rev protein
Q24338666An integrative approach to gain insights into the cellular function of human ataxin-2
Q38632709Crystal structure of the Xpo1p nuclear export complex bound to the SxFG/PxFG repeats of the nucleoporin Nup42p.
Q28204782Deciphering networks of protein interactions at the nuclear pore complex
Q38761090Deciphering the Structure and Function of Nuclear Pores Using Single-Molecule Fluorescence Approaches.
Q64088188Distinct RanBP1 nuclear export and cargo dissociation mechanisms between fungi and animals
Q28209036Functional analysis of the interaction of the human immunodeficiency virus type 1 Rev nuclear export signal with its cofactors
Q35192704Human immunodeficiency virus rev-binding protein is essential for influenza a virus replication and promotes genome trafficking in late-stage infection
Q27667119Insights into the Function of the CRM1 Cofactor RanBP3 from the Structure of Its Ran-Binding Domain
Q33695055Kinetic and molecular analysis of nuclear export factor CRM1 association with its cargo in vivo
Q51056428Leptomycin B alters the subcellular distribution of CRM1 (Exportin 1).
Q27931250Minimal nuclear pore complexes define FG repeat domains essential for transport
Q26783595Multiple Export Mechanisms for mRNAs
Q39453461Nuclear export of heat shock and non-heat-shock mRNA occurs via similar pathways
Q42060064Nuclear export of the transcription factor NirA is a regulatory checkpoint for nitrate induction in Aspergillus nidulans
Q27935127Nuclear import of the TATA-binding protein: mediation by the karyopherin Kap114p and a possible mechanism for intranuclear targeting
Q27937069Nuclear pore complex function in Saccharomyces cerevisiae is influenced by glycosylation of the transmembrane nucleoporin Pom152p
Q34016584Nucleoporin FG domains facilitate mRNP remodeling at the cytoplasmic face of the nuclear pore complex
Q38411212Nup214 is required for CRM1-dependent nuclear protein export in vivo
Q34384095Protein export from the nucleus
Q27934684Proteomic analysis of nucleoporin interacting proteins
Q24305242Proteomic analysis of the mammalian nuclear pore complex
Q41542861RNA biology of disease-associated microsatellite repeat expansions
Q52539072Rev-dependent association of the intron-containing HIV-1 gag mRNA with the nuclear actin bundles and the inhibition of its nucleocytoplasmic transport by latrunculin-B.
Q36366932Selective disruption of nuclear import by a functional mutant nuclear transport carrier
Q30502699Single molecule studies of nucleocytoplasmic transport
Q42917946The Drosophila nucleoporin DNup88 localizes DNup214 and CRM1 on the nuclear envelope and attenuates NES-mediated nuclear export
Q48794579The docking of kinesins, KIF5B and KIF5C, to Ran-binding protein 2 (RanBP2) is mediated via a novel RanBP2 domain.
Q27933902The karyopherin Kap142p/Msn5p mediates nuclear import and nuclear export of different cargo proteins
Q34156668The molecular mechanism of transport of macromolecules through nuclear pore complexes
Q34205241The nuclear pore complex as a transport machine.
Q33912881The nuclear pore complex: a protein machine bridging the nucleus and cytoplasm
Q28139684The nucleoporin Nup98 is a site for GDP/GTP exchange on ran and termination of karyopherin beta 2-mediated nuclear import
Q24680784The yeast nuclear pore complex: composition, architecture, and transport mechanism
Q40191918Topoisomerase II binds importin alpha isoforms and exportin/CRM1 but does not shuttle between the nucleus and cytoplasm in proliferating cells.
Q29615611Transport into and out of the nucleus
Q27936568Yeast Ran-binding protein 1 (Yrb1) shuttles between the nucleus and cytoplasm and is exported from the nucleus via a CRM1 (XPO1)-dependent pathway

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