CD40-CD40 Ligand Interactions Promote Trafficking of CD8+ T Cells into the Brain and Protection against West Nile Virus Encephalitis

scientific article

CD40-CD40 Ligand Interactions Promote Trafficking of CD8+ T Cells into the Brain and Protection against West Nile Virus Encephalitis is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/JVI.00941-07
P932PMC publication ID2045405
P698PubMed publication ID17626103

P50authorMichael S. DiamondQ28051146
P2093author name stringErin E McCandless
Robyn S Klein
Elizabeth Sitati
P2860cites workRapid detection of west nile virus from human clinical specimens, field-collected mosquitoes, and avian samples by a TaqMan reverse transcriptase-PCR assayQ24575556
Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activationQ24677534
CCR5 deficiency increases risk of symptomatic West Nile virus infectionQ24677652
Complement activation is required for induction of a protective antibody response against West Nile virus infectionQ27469834
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Neuronal CXCL10 directs CD8+ T-cell recruitment and control of West Nile virus encephalitisQ27470828
Alpha/beta interferon protects against lethal West Nile virus infection by restricting cellular tropism and enhancing neuronal survivalQ27472671
CD8+ T Cells Require Perforin To Clear West Nile Virus from Infected NeuronsQ27472780
B cells and antibody play critical roles in the immediate defense of disseminated infection by West Nile encephalitis virus.Q27473103
Development of a humanized monoclonal antibody with therapeutic potential against West Nile virusQ27473186
Gamma Interferon Plays a Crucial Early Antiviral Role in Protection against West Nile Virus InfectionQ27473224
Pathogenesis of West Nile Virus Infection: a Balance between Virulence, Innate and Adaptive Immunity, and Viral EvasionQ27477543
CD4+ T-Cell Responses Are Required for Clearance of West Nile Virus from the Central Nervous SystemQ27477717
Protective immune responses against West Nile virus are primed by distinct complement activation pathwaysQ27482651
A Critical Role for Induced IgM in the Protection against West Nile Virus InfectionQ27485124
Activation of Virus-specific Memory B Cells in the Absence of T Cell HelpQ27485181
Partial Genetic Characterization of West Nile Virus Strains, New York State, 2000Q27487791
CD40-CD40 ligandQ28143324
The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formationQ28586300
Role of CD8+ T cells in control of West Nile virus infectionQ29619668
CD40 ligand-mediated interactions are involved in the generation of memory CD8(+) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infectionQ33783902
Establishment and maintenance of long-term murine gammaherpesvirus 68 latency in B cells in the absence of CD40.Q33834753
Mechanisms of immunotherapeutic intervention by anti-CD40L (CD154) antibody in an animal model of multiple sclerosisQ33835268
Defects of T-cell effector function and post-thymic maturation in X-linked hyper-IgM syndromeQ33849472
CD40 is expressed and functional on neuronal cellsQ34085854
CD8+ T cells mediate recovery and immunopathology in West Nile virus encephalitisQ34226788
CD4+ T cells are required for the maintenance, not programming, of memory CD8+ T cells after acute infection.Q34339494
Impairment of antigen-specific T-cell priming in mice lacking CD40 ligandQ34367466
Regulation and function of class II major histocompatibility complex, CD40, and B7 expression in macrophages and microglia: Implications in neurological diseasesQ35022580
Interferon gamma-producing gammadelta T cell-dependent antibody isotype switching in the absence of germinal center formation during virus infection.Q35797635
CD40: a growing cytoplasmic taleQ35806202
CD40 ligand: a novel target in the fight against cardiovascular diseaseQ35848866
CD40 ligand-deficient mice generate a normal primary cytotoxic T-lymphocyte response but a defective humoral response to a viral infectionQ35873254
West Nile virus: where are we now?Q35874060
The ins and outs of T-lymphocyte trafficking to the CNS: anatomical sites and molecular mechanismsQ36205278
The expression and function of chemokines involved in CNS inflammationQ36323788
Functional interactions of T cells with endothelial cells: the role of CD40L-CD40-mediated signalsQ36365548
CD40-CD40 ligand interactions are critical in T-B cooperation but not for other anti-viral CD4+ T cell functionsQ36366592
The clinical course of experimental autoimmune encephalomyelitis and inflammation is controlled by the expression of CD40 within the central nervous system.Q36369234
CD40-deficient, influenza-specific CD8 memory T cells develop and function normally in a CD40-sufficient environmentQ36371544
CD40-independent pathways of T cell help for priming of CD8(+) cytotoxic T lymphocytesQ36375919
Activating anti-CD40 antibodies induce tumour invasion by cytotoxic T-lymphocytes and inhibition of tumour growth in experimental liver cancerQ40299997
Antibody prophylaxis and therapy against West Nile virus infection in wild-type and immunodeficient miceQ40344535
The Role of CD40 and its Ligand in the Regulation of the Immune ResponseQ40391931
RNAi-mediated silencing of CD40 prevents leukocyte adhesion on CD154-activated endothelial cells.Q40488849
IFN-gamma-producing gamma delta T cells help control murine West Nile virus infectionQ40551940
CD154/CD40-mediated expression of CD154 in endothelial cells: consequences for endothelial cell-monocyte interactionQ40587639
Immunity to rotavirus in T cell deficient mice.Q41076599
CD40L-deficient mice show deficits in antiviral immunity and have an impaired memory CD8+ CTL response.Q41898717
Immunobiology of mosquito-borne encephalitic flavivirusesQ42982030
CCL2/monocyte chemoattractant protein-1 mediates enhanced transmigration of human immunodeficiency virus (HIV)-infected leukocytes across the blood-brain barrier: a potential mechanism of HIV-CNS invasion and NeuroAIDS.Q45420445
Costimulation requirements for antiviral CD8+ T cells differ for acute and persistent phases of polyoma virus infectionQ45420662
Measles virus infection induces chemokine synthesis by neuronsQ45721917
Prevention of experimental autoimmune encephalomyelitis by antibodies against alpha 4 beta 1 integrin.Q46007698
CD40-CD40L interactions promote neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolismQ46483832
CD40L deletion delays neuronal death in a model of neurodegeneration due to mild impairment of oxidative metabolismQ46499277
CD40 signaling in vascular cells: a key role in atherosclerosis?Q47726341
T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactionsQ47982736
Help for cytotoxic-T-cell responses is mediated by CD40 signallingQ47982749
A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cellQ47982760
Cutting edge: long-lived CD8 memory and protective immunity in the absence of CD40 expression on CD8 T cellsQ47992054
Induction of beta-chemokine secretion by human brain microvessel endothelial cells via CD40/CD40L interactions.Q48104241
Activation of microglial cells by the CD40 pathway: relevance to multiple sclerosisQ48160439
CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitisQ48365016
CD40 expressed by human brain endothelial cells regulates CD4+ T cell adhesion to endotheliumQ48415768
Leukocyte infiltration, but not neurodegeneration, in the CNS of transgenic mice with astrocyte production of the CXC chemokine ligand 10.Q48537815
Requirement for CD40 ligand in costimulation induction, T cell activation, and experimental allergic encephalomyelitisQ48913563
CD40-mediated activation of T cells accelerates, but is not required for, encephalitogenic potential of myelin basic protein-recognizing T cells in a model of progressive experimental autoimmune encephalomyelitisQ49025682
The X-linked hyper-IgM syndrome: clinical and immunologic features of 79 patients.Q51639878
Maintenance of memory CTL responses by T helper cells and CD40-CD40 ligand: antibodies provide the key.Q52002766
Stromal cell-derived factor-1-CXC chemokine receptor 4 interactions play a central role in CD4+ T cell accumulation in rheumatoid arthritis synovium.Q52023146
Determination of total and merecaptothanol-resistant antibody in the same serum sample.Q54681669
Functional defects of dendritic cells in patients with CD40 deficiencyQ57394761
West Nile virusQ64127859
CD154 (CD40L) induces human endothelial cell chemokine production and migration of leukocyte subsetsQ73386215
A role for CD40 expression on CD8+ T cells in the generation of CD8+ T cell memoryQ74813297
T-cell-independent antiviral antibody responsesQ77174567
CD4 T cell-independent antibody response promotes resolution of primary influenza infection and helps to prevent reinfectionQ81375555
CD40 expression by microglial cells is required for their completion of a two-step activation process during central nervous system autoimmune inflammationQ82310803
P433issue18
P921main subjectWest Nile virusQ158856
encephalitisQ199615
P304page(s)9801-11
P577publication date2007-09-01
P1433published inJournal of VirologyQ1251128
P1476titleCD40-CD40 Ligand Interactions Promote Trafficking of CD8+ T Cells into the Brain and Protection against West Nile Virus Encephalitis
P478volume81

Reverse relations

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