Structural Characterization of Viral Ortholog of Human DNA Glycosylase NEIL1 Bound to Thymine Glycol or 5-Hydroxyuracil-containing DNA

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Structural Characterization of Viral Ortholog of Human DNA Glycosylase NEIL1 Bound to Thymine Glycol or 5-Hydroxyuracil-containing DNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1074/JBC.M111.315309
P932PMC publication ID3281731
P698PubMed publication ID22170059

P50authorSusan S WallaceQ41886664
Sylvie DoubliéQ28323959
P2093author name stringApril Averill
Kayo Imamura
P2860cites workHuman DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNAQ24318591
Identification and characterization of a human DNA glycosylase for repair of modified bases in oxidatively damaged DNAQ24531459
Structural analysis of an Escherichia coli endonuclease VIII covalent reaction intermediateQ24534729
The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activityQ24564283
Crystal structure of a repair enzyme of oxidatively damaged DNA, MutM (Fpg), from an extreme thermophile, Thermus thermophilus HB8Q24630698
Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cellsQ24650179
Guanine and 7,8-dihydro-8-oxo-guanine-specific oxidation in DNA by chromium(V)Q24815691
NEIL1 excises 3' end proximal oxidative DNA lesions resistant to cleavage by NTH1 and OGG1.Q24816871
Processing of X-ray diffraction data collected in oscillation modeQ26778468
Structure of formamidopyrimidine-DNA glycosylase covalently complexed to DNAQ27638483
Structural insights into lesion recognition and repair by the bacterial 8-oxoguanine DNA glycosylase MutMQ27639141
A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycolQ27641081
DNA lesion recognition by the bacterial repair enzyme MutMQ27642268
Synthesis of the diastereomers of thymidine glycol, determination of concentrations and rates of interconversion of their cis-trans epimers at equilibrium and demonstration of differential alkali lability within DNAQ40534316
Catalytic mechanism of Escherichia coli endonuclease VIII: roles of the intercalation loop and the zinc fingerQ41864512
Identification of the cis-thymine glycol moiety in chemically oxidized and gamma-irradiated deoxyribonucleic acid by high-pressure liquid chromatography analysis.Q42270823
Base-pairing properties of the oxidized cytosine derivative, 5-hydroxy uracil.Q43067847
Substrate specificity and excision kinetics of Escherichia coli endonuclease VIII (Nei) for modified bases in DNA damaged by free radicalsQ43753150
Isolation and characterization of endonuclease VIII from Escherichia coli.Q54640652
An endonuclease activity of Escherichia coli that specifically removes 8-hydroxyguanine residues from DNA.Q54702647
NEIL1 Is the Major DNA Glycosylase that Processes 5-Hydroxyuracil in the Proximity of a DNA Single-Strand BreakQ57942447
Enzymatic processing of radiation-induced free radical damage in DNAQ62061101
Enzymatic Processing of Uracil Glycol, a Major Oxidative Product of DNA CytosineQ62061102
Characterization ofEscherichia coliEndonuclease VIIIQ62061105
Purification and characterization of Escherichia coli formamidopyrimidine-DNA glycosylase that excises damaged 7-methylguanine from deoxyribonucleic acidQ70187587
Identification of radioproducts resulting from the breakage of thymine moiety by gamma irradiation of E. coli DNA in an aerated aqueous solutionQ73940933
Bacterial base excision repair enzyme Fpg recognizes bulky N7-substituted-FapydG lesion via unproductive binding modeQ27651223
Structural Characterization of a Viral NEIL1 Ortholog Unliganded and Bound to Abasic Site-containing DNAQ27656645
The cis -(5 R ,6 S )-Thymine Glycol Lesion Occupies the Wobble Position When Mismatched with Deoxyguanosine in DNAQ27657520
Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion siteQ27658074
Encounter and extrusion of an intrahelical lesion by a DNA repair enzymeQ27658654
5-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylasesQ27667498
A Crystallographic Study of the Role of Sequence Context in Thymine Glycol Bypass by a Replicative DNA Polymerase Serendipitously Sheds Light on the Exonuclease ComplexQ27670953
Version 1.2 of the Crystallography and NMR systemQ27860583
A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIIIQ28201222
Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2Q28206447
A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologueQ28219332
Repair of thymine glycol by hNth1 and hNeil1 is modulated by base pairing and cis-trans epimerizationQ28294552
The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivoQ28586574
Base-excision repair of oxidative DNA damageQ29615373
The Phenix software for automated determination of macromolecular structuresQ29620199
Synthesis and thermodynamic studies of oligonucleotides containing the two isomers of thymine glycolQ30761923
Structural dynamics in DNA damage signaling and repairQ34047906
8-oxoguanine (8-hydroxyguanine) DNA glycosylase and its substrate specificityQ34119141
Structural basis of perturbed pKa values of catalytic groups in enzyme active sitesQ34670783
Biological consequences of free radical-damaged DNA bases.Q34710048
Repair mechanisms for oxidative DNA damageQ35109446
The enigma of endonuclease VIII.Q35114231
Structural characterization of the Fpg family of DNA glycosylasesQ35189594
The DNA trackwalkers: principles of lesion search and recognition by DNA glycosylasesQ36153889
Human endonuclease VIII-like (NEIL) proteins in the giant DNA MimivirusQ36174152
Lesion specificity in the base excision repair enzyme hNeil1: modeling and dynamics studiesQ36855635
Endogenous oxidative damage of deoxycytidine in DNA.Q36951566
Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1Q36952958
Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases.Q37315825
Repair of hydantoins, one electron oxidation product of 8-oxoguanine, by DNA glycosylases of Escherichia coliQ38301102
Recognition of the oxidized lesions spiroiminodihydantoin and guanidinohydantoin in DNA by the mammalian base excision repair glycosylases NEIL1 and NEIL2.Q38334473
Structural basis for the recognition of the FapydG lesion (2,6-diamino-4-hydroxy-5-formamidopyrimidine) by formamidopyrimidine-DNA glycosylaseQ38338981
The radiolysis of pyrimidines in aqueous solutions: an updating reviewQ39498314
P433issue6
P407language of work or nameEnglishQ1860
P921main subjectcell biologyQ7141
thymineQ171973
P304page(s)4288-98
P577publication date2012-02-03
P1433published inJournal of Biological ChemistryQ867727
P1476titleStructural Characterization of Viral Ortholog of Human DNA Glycosylase NEIL1 Bound to Thymine Glycol or 5-Hydroxyuracil-containing DNA
P478volume287

Reverse relations

cites work (P2860)
Q33908163Base excision repair: a critical player in many games
Q37719258DNA glycosylases search for and remove oxidized DNA bases
Q33558133Destabilization of the PCNA trimer mediated by its interaction with the NEIL1 DNA glycosylase
Q27681153Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing
Q39014392Hide and seek: How do DNA glycosylases locate oxidatively damaged DNA bases amidst a sea of undamaged bases?
Q54768076Hydrolysis of the damaged deoxythymidine glycol nucleoside and comparison to canonical DNA.
Q36266557NEIL1 binding to DNA containing 2'-fluorothymidine glycol stereoisomers and the effect of editing
Q41484741Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision
Q36853206Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage.
Q34306735Recent advances in the structural mechanisms of DNA glycosylases
Q38159127Repair of base damage and genome maintenance in the nucleo-cytoplasmic large DNA viruses
Q37532110Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair
Q39200289Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics
Q27675877Structural Characterization of a Mouse Ortholog of Human NEIL3 with a Marked Preference for Single-Stranded DNA
Q27670719Structural and biochemical studies of a plant formamidopyrimidine-DNA glycosylase reveal why eukaryotic Fpg glycosylases do not excise 8-oxoguanine
Q27680235Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases
Q37102321Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair
Q36977957The DNA glycosylase AlkD uses a non-base-flipping mechanism to excise bulky lesions
Q90462365Thiopurine Derivative-Induced Fpg/Nei DNA Glycosylase Inhibition: Structural, Dynamic and Functional Insights
Q33665271Two glycosylase families diffusively scan DNA using a wedge residue to probe for and identify oxidatively damaged bases
Q64231022Uncovering a unique approach for damaged DNA replication: A computational investigation of a mutagenic tobacco-derived thymine lesion
Q42683844Visualizing the Search for Radiation-damaged DNA Bases in Real Time
Q39142123Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization

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