A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII

scientific article (publication date: 17 July 2002)

A novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/S1568-7864(02)00036-8
P3181OpenCitations bibliographic resource ID4103913
P698PubMed publication ID12509226

P50authorSusan S WallaceQ41886664
P2093author name stringJeffrey P Bond
Viswanath Bandaru
Sirisha Sunkara
P433issue7
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
DNA damageQ5205747
P304page(s)517-29
P577publication date2002-07-17
P1433published inDNA RepairQ3894086
P1476titleA novel human DNA glycosylase that removes oxidative DNA damage and is homologous to Escherichia coli endonuclease VIII
P478volume1

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cites work (P2860)
Q367010593CAPS - a structural AP-site analogue as a tool to investigate DNA base excision repair
Q276674985-Hydroxy-5-methylhydantoin DNA lesion, a molecular trap for DNA glycosylases
Q27670953A Crystallographic Study of the Role of Sequence Context in Thymine Glycol Bypass by a Replicative DNA Polymerase Serendipitously Sheds Light on the Exonuclease Complex
Q39506181A Novel GT-Mismatch Binding Protein That Recognizes Strict DNA Sequences with High Affinity
Q28219332A back-up glycosylase in Nth1 knock-out mice is a functional Nei (endonuclease VIII) homologue
Q21558626A critical re-assessment of DNA repair gene promoter methylation in non-small cell lung carcinoma
Q27641081A structural rationale for stalling of a replicative DNA polymerase at the most common oxidative thymine lesion, thymine glycol
Q36751371A unified view of base excision repair: lesion-dependent protein complexes regulated by post-translational modification
Q36234156APE2 Zf-GRF facilitates 3'-5' resection of DNA damage following oxidative stress.
Q24563827Acetylation of the human DNA glycosylase NEIL2 and inhibition of its activity
Q35037457Arabidopsis thaliana, a versatile model system for study of eukaryotic genome-maintenance functions
Q57603139Array comparative genomic hybridisation testing in CHD
Q34305503Association of polymorphisms in oxidative stress genes with clinical outcomes for bladder cancer treated with Bacillus Calmette-Guérin
Q35886189Base and Nucleotide Excision Repair of Oxidatively Generated Guanine Lesions in DNA.
Q28288115Base excision repair
Q27025537Base excision repair and cancer
Q42230093Base excision repair and the role of MUTYH
Q36538373Base excision repair in physiology and pathology of the central nervous system
Q36853499Base excision repair, aging and health span.
Q34374847Base excision repair.
Q29615373Base-excision repair of oxidative DNA damage
Q27658074Binding of the human nucleotide excision repair proteins XPA and XPC/HR23B to the 5R-thymine glycol lesion and structure of the cis-(5R,6S) thymine glycol epimer in the 5'-GTgG-3' sequence: destabilization of two base pairs at the lesion site
Q41718273Cadmium effects on DNA and protein metabolism in oyster (Crassostrea gigas) revealed by proteomic analyses
Q90546786Cervical carcinoma risk associate with genetic polymorphisms of NEIL2 gene in Chinese population and its significance as predictive biomarker
Q33649473Chemical Biology of N5-Substituted Formamidopyrimidine DNA Adducts.
Q37933191Chemistry and structural biology of DNA damage and biological consequences
Q44454290Comparative analysis of 8-oxoG:C, 8-oxoG:A, A:C and C:C DNA repair in extracts from wild type or 8-oxoG DNA glycosylase deficient mammalian and bacterial cells
Q44486177Compromised incision of oxidized pyrimidines in liver mitochondria of mice deficient in NTH1 and OGG1 glycosylases.
Q92948154Computational and Experimental Druggability Assessment of Human DNA Glycosylases
Q89977186Contributions of DNA Damage to Alzheimer's Disease
Q37719258DNA glycosylases search for and remove oxidized DNA bases
Q27642268DNA lesion recognition by the bacterial repair enzyme MutM
Q43045076DNA repair and the origins of urinary oxidized 2'-deoxyribonucleosides.
Q40586328DNA repair investigations using siRNA.
Q44454284Decline of nuclear and mitochondrial oxidative base excision repair activity in late passage human diploid fibroblasts
Q54457471Deoxyribophosphate lyase activity of mammalian endonuclease VIII-like proteins.
Q47432231Differential effects of silver nanoparticles on DNA damage and DNA repair gene expression in Ogg1-deficient and wild type mice
Q28239818Differential specificity of human and Escherichia coli endonuclease III and VIII homologues for oxidative base lesions
Q24650179Early steps in the DNA base excision/single-strand interruption repair pathway in mammalian cells
Q21558654Effects of base excision repair proteins on mutagenesis by 8-oxo-7,8-dihydroguanine (8-hydroxyguanine) paired with cytosine and adenine
Q36713854Efficient removal of formamidopyrimidines by 8-oxoguanine glycosylases
Q21558627Epigenetic screen of human DNA repair genes identifies aberrant promoter methylation of NEIL1 in head and neck squamous cell carcinoma
Q42686558Evaluation of oxidative stress markers in pathogenesis of primary open-angle glaucoma
Q42674153Evidence for base excision repair of oxidative DNA damage in chloroplasts of Arabidopsis thaliana
Q33635477Evidence for the involvement of DNA repair enzyme NEIL1 in nucleotide excision repair of (5'R)- and (5'S)-8,5'-cyclo-2'-deoxyadenosines
Q36559344Evolution in fast forward: a potential role for mutators in accelerating Staphylococcus aureus pathoadaptation
Q35596477Exploiting base excision repair to improve therapeutic approaches for pancreatic cancer
Q36044239Expression and purification of active mouse and human NEIL3 proteins.
Q39018239Formation and processing of DNA damage substrates for the hNEIL enzymes
Q47446317Formation and repair of DNA-protein crosslink damage.
Q34514783Functional variants of the NEIL1 and NEIL2 genes and risk and progression of squamous cell carcinoma of the oral cavity and oropharynx
Q37780480Functions of disordered regions in mammalian early base excision repair proteins
Q33367810Gene expression variation to predict 10-year survival in lymph-node-negative breast cancer
Q27681153Genome and cancer single nucleotide polymorphisms of the human NEIL1 DNA glycosylase: Activity, structure, and the effect of editing
Q30370866Genome-wide association of polycystic ovary syndrome implicates alterations in gonadotropin secretion in European ancestry populations
Q37002577Genome-wide association study of serum selenium concentrations
Q37247774Going ape as an approach to cancer therapeutics
Q36728705Guanine oxidation product 5-carboxamido-5-formamido-2-iminohydantoin induces mutations when bypassed by DNA polymerases and is a substrate for base excision repair
Q26740627Gut Microbiota Imbalance and Base Excision Repair Dynamics in Colon Cancer
Q39014392Hide and seek: How do DNA glycosylases locate oxidatively damaged DNA bases amidst a sea of undamaged bases?
Q42130654Human DNA Glycosylase NEIL1's Interactions with Downstream Repair Proteins Is Critical for Efficient Repair of Oxidized DNA Base Damage and Enhanced Cell Survival
Q24318591Human DNA glycosylases of the bacterial Fpg/MutM superfamily: an alternative pathway for the repair of 8-oxoguanine and other oxidation products in DNA
Q24322513Human Nei-like protein NEIL3 has AP lyase activity specific for single-stranded DNA and confers oxidative stress resistance in Escherichia coli mutant
Q46335843Human cells contain a factor that facilitates the DNA glycosylase-mediated excision of oxidized bases from occluded sites in nucleosomes
Q36174152Human endonuclease VIII-like (NEIL) proteins in the giant DNA Mimivirus
Q36079274Human thymine DNA glycosylase (TDG) and methyl-CpG-binding protein 4 (MBD4) excise thymine glycol (Tg) from a Tg:G mispair
Q36341399Identification of DNA lesions using a third base pair for amplification and nanopore sequencing
Q36645850Identification of a genetic locus on chromosome 4q34-35 for type 2 diabetes with overweight
Q28279961Identification of a zinc finger domain in the human NEIL2 (Nei-like-2) protein
Q57470790Identification of retinal homeobox (rax) gene-dependent genes by a microarray approach: the DNA endoglycosylase neil3 is a major downstream component of the rax genetic pathway
Q35992170Increased risk of lung cancer associated with a functionally impaired polymorphic variant of the human DNA glycosylase NEIL2.
Q28268678Induction of the human oxidized base-specific DNA glycosylase NEIL1 by reactive oxygen species
Q46684221Influence of Ogg1 repair on the genetic stability of ccc2 mutant of Saccharomyces cerevisiae chemically challenged with 4-nitroquinoline-1-oxide (4-NQO).
Q46886711Interaction of the human DNA glycosylase NEIL1 with proliferating cell nuclear antigen. The potential for replication-associated repair of oxidized bases in mammalian genomes
Q43176326Interconversion of the cis-5R,6S- and trans-5R,6R-thymine glycol lesions in duplex DNA.
Q34989590Interplay between DNA repair and inflammation, and the link to cancer
Q91657262Isoforms of Base Excision Repair Enzymes Produced by Alternative Splicing
Q36855635Lesion specificity in the base excision repair enzyme hNeil1: modeling and dynamics studies
Q34771368Limited repair of 8-hydroxy-7,8-dihydroguanine residues in human testicular cells
Q35576447Mammalian DNA base excision repair proteins: their interactions and role in repair of oxidative DNA damage
Q36223869Mitochondrial DNA, base excision repair and neurodegeneration
Q38573535Mutagenic potential of DNA-peptide crosslinks mediated by acrolein-derived DNA adducts
Q33858180Mutation versus repair: NEIL1 removal of hydantoin lesions in single-stranded, bulge, bubble, and duplex DNA contexts
Q39979884Mutator phenotype of mammalian cells due to deficiency of NEIL1 DNA glycosylase, an oxidized base-specific repair enzyme
Q83228165NEIL1 and NEIL2 DNA glycosylases protect neural crest development against mitochondrial oxidative stress
Q36266557NEIL1 binding to DNA containing 2'-fluorothymidine glycol stereoisomers and the effect of editing
Q24647462NEIL2-initiated, APE-independent repair of oxidized bases in DNA: Evidence for a repair complex in human cells
Q41484741Nei-like 1 (NEIL1) excises 5-carboxylcytosine directly and stimulates TDG-mediated 5-formyl and 5-carboxylcytosine excision
Q38804981Neil DNA glycosylases promote substrate turnover by Tdg during DNA demethylation.
Q36139765Neil2-null Mice Accumulate Oxidized DNA Bases in the Transcriptionally Active Sequences of the Genome and Are Susceptible to Innate Inflammation
Q34362594Neil3 and NEIL1 DNA glycosylases remove oxidative damages from quadruplex DNA and exhibit preferences for lesions in the telomeric sequence context
Q37439348Neil3 induced neurogenesis protects against prion disease during the clinical phase
Q36853206Neil3, the final frontier for the DNA glycosylases that recognize oxidative damage.
Q26996127New perspectives on oxidized genome damage and repair inhibition by pro-oxidant metals in neurological diseases
Q47143560Non-bulky Lesions in Human DNA: the Ways of Formation, Repair, and Replication
Q33518545Nucleotide, cytogenetic and expression impact of the human chromosome 8p23.1 inversion polymorphism
Q34805446Obesity and hepatosteatosis in mice with enhanced oxidative DNA damage processing in mitochondria
Q41957575Oxanine DNA glycosylase activities in mammalian systems.
Q62061093Oxidative DNA Glycosylases: Recipes from Cloning to Characterization
Q36658399Oxidative DNA damage repair in mammalian cells: a new perspective
Q37858347Oxidative genome damage and its repair in neurodegenerative diseases: function of transition metals as a double-edged sword
Q35957287Oxidative genome damage and its repair: implications in aging and neurodegenerative diseases.
Q36102804Phosphorylation Sites Identified in the NEIL1 DNA Glycosylase Are Potential Targets for the JNK1 Kinase.
Q36914462Physical and functional interaction between human oxidized base-specific DNA glycosylase NEIL1 and flap endonuclease 1
Q37315825Plant and fungal Fpg homologs are formamidopyrimidine DNA glycosylases but not 8-oxoguanine DNA glycosylases.
Q34685037Polymorphism of the DNA base excision repair genes in keratoconus
Q41225003Pre-Replicative Repair of Oxidized Bases Maintains Fidelity in Mammalian Genomes: The Cowcatcher Role of NEIL1 DNA Glycosylase
Q34675663Preferential repair of oxidized base damage in the transcribed genes of mammalian cells
Q64388814Processing of N-substituted formamidopyrimidine DNA adducts by DNA glycosylases NEIL1 and NEIL3
Q36955832Production, Purification, and Characterization of ¹⁵N-Labeled DNA Repair Proteins as Internal Standards for Mass Spectrometric Measurements.
Q35165256Profiling base excision repair glycosylases with synthesized transition state analogs
Q36145393Psoralen-induced DNA adducts are substrates for the base excision repair pathway in human cells
Q34376081RNA editing changes the lesion specificity for the DNA repair enzyme NEIL1
Q33546272RPA physically interacts with the human DNA glycosylase NEIL1 to regulate excision of oxidative DNA base damage in primer-template structures
Q35781828Rapid determination of the active fraction of DNA repair glycosylases: a novel fluorescence assay for trapped intermediates.
Q34306735Recent advances in the structural mechanisms of DNA glycosylases
Q33672967Regulatory regions responsive to oxidative stress in the promoter of the human DNA glycosylase gene NEIL2.
Q39000410Removal of oxidatively generated DNA damage by overlapping repair pathways
Q28206447Repair of Oxidized Bases in DNA Bubble Structures by Human DNA Glycosylases NEIL1 and NEIL2
Q44195377Repair of dihydrouracil supported by base excision repair in mNTH1 knock-out cell extracts.
Q37532110Repair of hydantoin lesions and their amine adducts in DNA by base and nucleotide excision repair
Q39200289Repair of oxidatively induced DNA damage by DNA glycosylases: Mechanisms of action, substrate specificities and excision kinetics
Q28570918Role of polynucleotide kinase/phosphatase in mitochondrial DNA repair
Q28082525Snaps and mends: DNA breaks and chromosomal translocations
Q34121351Specific Inhibition of NEIL-initiated repair of oxidized base damage in human genome by copper and iron: potential etiological linkage to neurodegenerative diseases
Q37068680Stereoselective excision of thymine glycol from oxidatively damaged DNA.
Q24648095Stimulation of NEIL2-mediated oxidized base excision repair via YB-1 interaction during oxidative stress
Q27676196Structural Characterization of Viral Ortholog of Human DNA Glycosylase NEIL1 Bound to Thymine Glycol or 5-Hydroxyuracil-containing DNA
Q27675877Structural Characterization of a Mouse Ortholog of Human NEIL3 with a Marked Preference for Single-Stranded DNA
Q27656645Structural Characterization of a Viral NEIL1 Ortholog Unliganded and Bound to Abasic Site-containing DNA
Q35189594Structural characterization of the Fpg family of DNA glycosylases
Q27680235Structural investigation of a viral ortholog of human NEIL2/3 DNA glycosylases
Q24811220Structure of the uncomplexed DNA repair enzyme endonuclease VIII indicates significant interdomain flexibility
Q34077785Substrate specific stimulation of NEIL1 by WRN but not the other human RecQ helicases
Q36952958Superior removal of hydantoin lesions relative to other oxidized bases by the human DNA glycosylase hNEIL1
Q37102321Tautomerization-dependent recognition and excision of oxidation damage in base-excision DNA repair
Q26851561The Fanconi anemia pathway and DNA interstrand cross-link repair
Q37684917The Fanconi anemia pathway promotes DNA glycosylase-dependent excision of interstrand DNA crosslinks
Q27021912The Fpg/Nei family of DNA glycosylases: substrates, structures, and search for damage
Q47139042The Human DNA glycosylases NEIL1 and NEIL3 Excise Psoralen-Induced DNA-DNA Cross-Links in a Four-Stranded DNA Structure.
Q35562087The NEIL glycosylases remove oxidized guanine lesions from telomeric and promoter quadruplex DNA structures
Q21284159The OXR domain defines a conserved family of eukaryotic oxidation resistance proteins
Q37010194The RECQL4 protein, deficient in Rothmund-Thomson syndrome is active on telomeric D-loops containing DNA metabolism blocking lesions
Q27657520The cis -(5 R ,6 S )-Thymine Glycol Lesion Occupies the Wobble Position When Mismatched with Deoxyguanosine in DNA
Q24564283The crystal structure of human endonuclease VIII-like 1 (NEIL1) reveals a zincless finger motif required for glycosylase activity
Q37187941The disordered C-terminal domain of human DNA glycosylase NEIL1 contributes to its stability via intramolecular interactions
Q24316909The human Werner syndrome protein stimulates repair of oxidative DNA base damage by the DNA glycosylase NEIL1
Q35829284The human checkpoint sensor Rad9-Rad1-Hus1 interacts with and stimulates NEIL1 glycosylase
Q39877610The human oxidative DNA glycosylase NEIL1 excises psoralen-induced interstrand DNA cross-links in a three-stranded DNA structure
Q34478554The metabolic syndrome resulting from a knockout of the NEIL1 DNA glycosylase
Q28586574The mouse ortholog of NEIL3 is a functional DNA glycosylase in vitro and in vivo
Q28487547The oxidative DNA glycosylases of Mycobacterium tuberculosis exhibit different substrate preferences from their Escherichia coli counterparts
Q44463888The role of yeast DNA 3'-phosphatase Tpp1 and rad1/Rad10 endonuclease in processing spontaneous and induced base lesions
Q33689355Thyrotroph embryonic factor regulates light-induced transcription of repair genes in zebrafish embryonic cells
Q35099098Tidying up loose ends: the role of polynucleotide kinase/phosphatase in DNA strand break repair
Q91666345Transcriptome changes in undifferentiated Caco-2 cells exposed to food-grade titanium dioxide (E171): contribution of the nano- and micro- sized particles
Q40395945Untwisting of the DNA helix stimulates the endonuclease activity of Bacillus subtilis Nth at AP sites
Q21558646Variant base excision repair proteins: contributors to genomic instability
Q42683844Visualizing the Search for Radiation-damaged DNA Bases in Real Time
Q39142123Zinc finger oxidation of Fpg/Nei DNA glycosylases by 2-thioxanthine: biochemical and X-ray structural characterization