| scholarly article | Q13442814 |
| P2093 | author name string | J. Drenth | |
| K. H. Kalk | |||
| H. M. Swen | |||
| P433 | issue | 17 | |
| P407 | language of work or name | English | Q1860 |
| P304 | page(s) | 3731-8 | |
| P577 | publication date | 1976-08-24 | |
| P1433 | published in | Biochemistry | Q764876 |
| P1476 | title | Binding of chloromethyl ketone substrate analogues to crystalline papain | |
| P478 | volume | 15 |
| Q35683586 | 6. Cathepsin K inhibitors: their potential as anti-osteoporosis agents |
| Q43002160 | A 13C-NMR study of the inhibition of papain by a dipeptide-glyoxal inhibitor. |
| Q27648990 | A New Autocatalytic Activation Mechanism for Cysteine Proteases Revealed by Prevotella intermedia Interpain A |
| Q28553135 | A Selective Irreversible Inhibitor of Furin Does Not Prevent Pseudomonas Aeruginosa Exotoxin A-Induced Airway Epithelial Cytotoxicity |
| Q42860086 | A model to explain the pH-dependent specificity of cathepsin B-catalysed hydrolyses |
| Q41769916 | A re-appraisal of the structural basis of stereochemical recognition in papain. Insensitivity of binding-site-catalytic-site signalling to P2-chirality in a time-dependent inhibition |
| Q36281841 | A single amino acid substitution affects substrate specificity in cysteine proteinases from Fasciola hepatica |
| Q67553945 | A theoretical study of glucosamine synthase. II. Combined quantum and molecular mechanics simulation of sulfhydryl attack on the carboxyamide group |
| Q52545911 | A theoretical study of glucosamine synthase. Part I. Molecular mechanics calculations on substrate binding. |
| Q24673908 | A theoretical study of the active sites of papain and S195C rat trypsin: implications for the low reactivity of mutant serine proteinases |
| Q24650814 | A viral cleavage site cassette: identification of amino acid sequences required for tobacco etch virus polyprotein processing |
| Q56903167 | Adaptive amino acid replacements accompanied by domain fusion in reverse transcriptase |
| Q40613575 | African swine fever virus protease, a new viral member of the SUMO-1-specific protease family |
| Q73103778 | Amino acid sequence and some properties of phytolacain G, a cysteine protease from growing fruit of pokeweed, Phytolacca americana |
| Q33891442 | Amino-acid sequence and glycan structures of cysteine proteases with proline specificity from ginger rhizome Zingiber officinale |
| Q30159709 | An episulfide cation (thiiranium ring) trapped in the active site of HAV 3C proteinase inactivated by peptide-based ketone inhibitors |
| Q40880494 | An evolutionarily conserved tripartite tryptophan motif stabilizes the prodomains of cathepsin L-like cysteine proteases |
| Q70610454 | Application of affinity labeling for studying structure and function of enzymes |
| Q27681206 | Autoproteolytic Activation of ThnT Results in Structural Reorganization Necessary for Substrate Binding and Catalysis |
| Q58039002 | Binding modes of a new epoxysuccinyl–peptide inhibitor of cysteine proteases. Where and how do cysteine proteases express their selectivity? |
| Q39879482 | Biosynthesis, purification, and characterization of the human coronavirus 229E 3C-like proteinase. |
| Q42244435 | Chemical Mutation of Enzyme Active Sites |
| Q62649871 | Chemistry of enzyme–substrate complexes revealed by resonance Raman spectroscopy |
| Q41851855 | Chondroitin sulfate promotes activation of cathepsin K. |
| Q42166430 | Chymopapain. Chromatographic purification and immunological characterization |
| Q28366500 | Comparative resonance Raman spectroscopic and kinetic studies of acyl-enzymes involving papain, actinidin and papaya peptidase II |
| Q41909371 | Complete amino acid sequence of ananain and a comparison with stem bromelain and other plant cysteine proteases |
| Q52879960 | Contributions of tryptophan side chains to the far-ultraviolet circular dichroism of proteins. |
| Q27733314 | Crystal structure of a caricain D158E mutant in complex with E-64 |
| Q27729820 | Crystal structure of a conserved protease that binds DNA: the bleomycin hydrolase, Gal6 |
| Q24532257 | Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution |
| Q27734780 | Crystal structure of human cathepsin K complexed with a potent inhibitor |
| Q42846520 | Crystal structure of human cathepsin S. |
| Q27639624 | Crystal structure of microbial transglutaminase from Streptoverticillium mobaraense |
| Q27642171 | Crystal structure of papain-E64-c complex. Binding diversity of E64-c to papain S2 and S3 subsites |
| Q27748903 | Crystal structure of porcine cathepsin H determined at 2.1 A resolution: location of the mini-chain C-terminal carboxyl group defines cathepsin H aminopeptidase function |
| Q27732676 | Crystal structure of the human adenovirus proteinase with its 11 amino acid cofactor |
| Q27730414 | Crystal structures of recombinant rat cathepsin B and a cathepsin B-inhibitor complex. Implications for structure-based inhibitor design |
| Q40250485 | Current problems in mechanistic studies of serine and cysteine proteinases |
| Q73354891 | Cysteine proteases such as papain are not inhibited by substrate analogue peptidyl boronic acids |
| Q38076304 | Cysteine proteases: mode of action and role in epidermal differentiation |
| Q68412254 | Cysteine proteases: the S2P2 hydrogen bond is more important for catalysis than is the analogous S1P1 bond |
| Q42982609 | Demonstration that 1-trans-epoxysuccinyl-L-leucylamido-(4-guanidino) butane (E-64) is one of the most effective low Mr inhibitors of trypsin-catalysed hydrolysis. Characterization by kinetic analysis and by energy minimization and molecular dynamics |
| Q42031211 | Dependence of the P2-S2 stereochemical selectivity of papain on the nature of the catalytic-site chemistry. Quantification of selectivity in the catalysed hydrolysis of the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides |
| Q28317097 | Dependence of the catalytic activity of papain on the ionization of two acidic groups |
| Q77749521 | Design and synthesis of dipeptidyl alpha',beta'-epoxy ketones, potent irreversible inhibitors of the cysteine protease cruzain |
| Q37326078 | Detection and accumulation of tetrahedral intermediates in elastase catalysis |
| Q28246892 | Deuterium Isotope Effects on Papain Acylation. Evidence for Lack of General Base Catalysis and for Enzyme-Leaving-Group Interaction |
| Q27651072 | Development of Broad-Spectrum Halomethyl Ketone Inhibitors Against Coronavirus Main Protease 3CLpro |
| Q42034522 | Differences between the electric fields of the catalytic sites of papain and actinidin detected by using the thiol-located nitrobenzofurazan label as a spectroscopic reporter group. |
| Q41784990 | Differences in the interaction of the catalytic groups of the active centres of actinidin and papain. Rapid purification of fully active actinidin by covalent chromatography and characterization of its active centre by use of two-protonic-state reac |
| Q41723745 | Distinct Roles of Catalytic Cysteine and Histidine in the Protease and Ligase Mechanisms of Human Legumain As Revealed by DFT-Based QM/MM Simulations |
| Q73837899 | E-64 analogues as inhibitors of cathepsin B. On the role of the absolute configuration of the epoxysuccinyl group |
| Q42084932 | E64 [trans-epoxysuccinyl-L-leucylamido-(4-guanidino)butane] analogues as inhibitors of cysteine proteinases: investigation of S2 subsite interactions |
| Q41844251 | Effects of conformational selectivity and of overlapping kinetically influential ionizations on the characteristics of pH-dependent enzyme kinetics. Implications of free-enzyme pKa variability in reactions of papain for its catalytic mechanism. |
| Q42226668 | Evaluation of hydrogen-bonding and enantiomeric P2-S2 hydrophobic contacts in dynamic aspects of molecular recognition by papain |
| Q42000549 | Evidence for a two-state transition in papain that may have no close analogue in ficin. Differences in the disposition of cationic sites and hydrophobic binding areas in the active centres of papain and ficin |
| Q103828519 | Exploring the Catalytic Reaction of Cysteine Proteases |
| Q54480722 | Exploring the interaction of some N-benzyloxycarbonyl-L-phenyl alanyl-L-alanine ketones and bovine spleen cathepsin B by molecular modeling and binding free energy calculation. |
| Q41859518 | Ferrocenopapain, An Organometallic Protein Formed by Site-Specific Inactivation of Papain Using Chloroacetylferrocene |
| Q36356153 | Fluorescence energy transfer studies on the active site of papain |
| Q40259287 | Fluorescence studies on the active sites of proteinases |
| Q35136147 | Fractionation and purification of the enzymes stored in the latex of Carica papaya |
| Q42684321 | Haloacetamidine-based inactivators of protein arginine deiminase 4 (PAD4): evidence that general acid catalysis promotes efficient inactivation |
| Q43044261 | High-resolution complex of papain with remnants of a cysteine protease inhibitor derived from Trypanosoma brucei. |
| Q68445166 | Hormonal regulation, processing, and secretion of cysteine proteinases in barley aleurone layers |
| Q39204392 | Identification of the Functional Ionic Groups of Papain by pH/Rate Profile Analysis |
| Q41111799 | In vitro and ex vivo inhibition of hepatitis A virus 3C proteinase by a peptidyl monofluoromethyl ketone. |
| Q41202007 | In vitro translation and processing of cathepsin B of Schistosoma mansoni |
| Q42995790 | Inactivation of cysteine proteases by peptidyl epoxides: characterization of the alkylation sites on the enzyme and the inactivator |
| Q77917014 | Inhibition of cysteine proteases by peptides containing aziridine-2,3-dicarboxylic acid building blocks |
| Q73992356 | Inhibition of papain with 2-benzyl-3,4-epoxybutanoic acid esters. Mechanistic and stereochemical probe for cysteine protease catalysis |
| Q24806221 | Insight to structural subsite recognition in plant thiol protease-inhibitor complexes : understanding the basis of differential inhibition and the role of water |
| Q42864692 | Investigation of the catalytic site of actinidin by using benzofuroxan as a reactivity probe with selectivity for the thiolate-imidazolium ion-pair systems of cysteine proteinases. Evidence that the reaction of the ion-pair of actinidin (pKI 3.0, pK |
| Q67469257 | Irreversible Inhibition of Transglutaminases by Sulfonium Methylketones: Optimization of Specificity and Potency with w-Aminoacyl Spacers |
| Q42703669 | Lantibiotic transporter requires cooperative functioning of the peptidase domain and the ATP binding domain |
| Q33857460 | Lysosomal cysteine proteases: more than scavengers |
| Q42986002 | Mechanism of cysteine protease inactivation by peptidyl epoxides |
| Q41977669 | Mechanism of the reaction of papain with substrate-derived diazomethyl ketones. Implications for the difference in site specificity of halomethyl ketones for serine proteinases and cysteine proteinases and for stereoelectronic requirements in the pa |
| Q69963173 | Mode of binding of E-64-c, a potent thiol protease inhibitor, to papain as determined by X-ray crystal analysis of the complex |
| Q36915183 | Molecular dynamics simulations of the catalytic pathway of a cysteine protease: a combined QM/MM study of human cathepsin K. |
| Q42924458 | Mutagenesis and crystallographic studies of the catalytic residues of the papain family protease bleomycin hydrolase: new insights into active-site structure |
| Q31059775 | Mutational analysis of Cvab, an ABC transporter involved in the secretion of active colicin V. |
| Q44606529 | Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo |
| Q41670274 | On the role of the active site helix in papain, an AB initio molecular orbital study |
| Q43530114 | Peptide methyl ketones as reversible inhibitors of cysteine proteinases |
| Q37973752 | Phytochelatin synthase: of a protease a peptide polymerase made |
| Q34340015 | Picornaviral 3C cysteine proteinases have a fold similar to chymotrypsin-like serine proteinases |
| Q30046956 | Plasmodium falciparum SERA5 plays a non-enzymatic role in the malarial asexual blood-stage lifecycle |
| Q28286937 | Poliovirus-encoded proteinase 3C: a possible evolutionary link between cellular serine and cysteine proteinase families |
| Q30848784 | Probing the specificity of cysteine proteinases at subsites remote from the active site: analysis of P4, P3, P2' and P3' variations in extended substrates. |
| Q80347304 | Purification and characterization of kininogens from sheep plasma |
| Q30320894 | Purification of soluble and membrane-bound proteases with substrate-analogous inhibitors by affinity chromatography |
| Q52214771 | QM/MM study of the active site of free papain and of the NMA-papain complex. |
| Q85583743 | Quantifying tetrahedral adduct formation and stabilization in the cysteine and the serine proteases |
| Q41851224 | Reaction pathway and free energy profile for papain-catalyzed hydrolysis of N-acetyl-Phe-Gly 4-nitroanilide. |
| Q41730414 | Revised definition of substrate binding sites of papain-like cysteine proteases |
| Q74643772 | Revisiting the S2 specificity of papain by structural analogs of Phe |
| Q31152886 | SCA3: neurological features, pathogenesis and animal models |
| Q39677476 | Semisynthetic enzymes: design of flavin-dependent oxidoreductases |
| Q72180591 | Sequence and structure similarities of cathepsin B from the parasite Schistosoma mansoni and human liver |
| Q33448603 | Sequencing and characterization of asclepain f: the first cysteine peptidase cDNA cloned and expressed from Asclepias fruticosa latex |
| Q34111419 | Site-directed mutagenesis study of yeast peptide:N-glycanase. Insight into the reaction mechanism of deglycosylation |
| Q52698196 | Stieltjes integration and differential geometry: a model for enzyme recognition, discrimination, and catalysis. |
| Q58450800 | Structural and Functional Roles of Asparagine 175 in the Cysteine Protease Papain |
| Q27666614 | Structural basis for the removal of ubiquitin and interferon-stimulated gene 15 by a viral ovarian tumor domain-containing protease |
| Q43986703 | Structural features underlying selective inhibition of GSK3β by dibromocantharelline: implications for rational drug design |
| Q34509866 | Structure and mechanism of cysteine peptidase gingipain K (Kgp), a major virulence factor of Porphyromonas gingivalis in periodontitis. |
| Q73077056 | Structure based development of novel specific inhibitors for cathepsin L and cathepsin S in vitro and in vivo |
| Q27636471 | Structure of human dipeptidyl peptidase I (cathepsin C): exclusion domain added to an endopeptidase framework creates the machine for activation of granular serine proteases |
| Q68290685 | Structure of porcine pancreatic prephospholipase A2 |
| Q27734832 | Structure of recombinant human CPP32 in complex with the tetrapeptide acetyl-Asp-Val-Ala-Asp fluoromethyl ketone |
| Q34182659 | Structure of the autocatalytic cysteine protease domain of potyvirus helper-component proteinase |
| Q37714099 | Structure of the streptococcal endopeptidase IdeS, a cysteine proteinase with strict specificity for IgG. |
| Q34580873 | Structure, function and dynamics in adenovirus maturation. |
| Q39038978 | Structure-function relationship of Chikungunya nsP2 protease: A comparative study with papain |
| Q33281473 | Structure-function relationships in the cysteine proteinases actinidin, papain and papaya proteinase omega. Three-dimensional structure of papaya proteinase omega deduced by knowledge-based modelling and active-centre characteristics determined by t |
| Q101574082 | Structures of the free and inhibitors-bound forms of bromelain and ananain from Ananas comosus stem and in vitro study of their cytotoxicity |
| Q28361928 | Substrate-derived two-protonic-state electrophiles as sensitive kinetic specificity probes for cysteine proteinases. Activation of 2-pyridyl disulphides by hydrogen-bonding |
| Q41633132 | Temporal and spatial control of the adenovirus proteinase by both a peptide and the viral DNA. |
| Q27728538 | The 2.0 A X-ray crystal structure of chicken egg white cystatin and its possible mode of interaction with cysteine proteinases |
| Q44809737 | The 2.0 A crystal structure and substrate specificity of the KDEL-tailed cysteine endopeptidase functioning in programmed cell death of Ricinus communis endosperm |
| Q45281613 | The alpha-helix dipole and the properties of proteins |
| Q33743828 | The amino acid sequence of chymopapain from Carica papaya |
| Q28300203 | The basic difference in catalyses by serine and cysteine proteinases resides in charge stabilization in the transition state |
| Q44577217 | The evolution of enzyme specificity in Fasciola spp. |
| Q39282406 | The modification of the catalytic chain sulfhydryl group of aspartate transcarbamylase with mercurinitrophenols |
| Q30423126 | The picornaviral 3C proteinases: cysteine nucleophiles in serine proteinase folds |
| Q27733966 | The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft |
| Q36862775 | The proteasome: a macromolecular assembly designed to confine proteolysis to a nanocompartment |
| Q27651464 | The refined 2.15 A X-ray crystal structure of human liver cathepsin B: the structural basis for its specificity |
| Q33906613 | The solution structure of the Josephin domain of ataxin-3: structural determinants for molecular recognition |
| Q36689443 | Up-regulation of a cysteine protease accompanies the ethylene-insensitive senescence of daylily (Hemerocallis) flowers. |
| Q28343571 | Variation in aspects of cysteine proteinase catalytic mechanism deduced by spectroscopic observation of dithioester intermediates, kinetic analysis and molecular dynamics simulations |
| Q42792741 | Variation in the P2-S2 stereochemical selectivity towards the enantiomeric N-acetylphenylalanylglycine 4-nitroanilides among the cysteine proteinases papain, ficin and actinidin |
| Q39563420 | Viral proteases: an emerging therapeutic target |
| Q27732072 | X-ray crystallographic structure of a papain-leupeptin complex |
| Q28359830 | Consequences of molecular recognition in the S1-S2 intersubsite region of papain for catalytic-site chemistry. Change in pH-dependence characteristics and generation of an inverse solvent kinetic isotope effect by introduction of a P1-P2 amide bond |
Search more.