Human mini-guts: new insights into intestinal physiology and host-pathogen interactions

scientific article

Human mini-guts: new insights into intestinal physiology and host-pathogen interactions is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1038/NRGASTRO.2016.142
P932PMC publication ID5079760
P698PubMed publication ID27677718

P50authorMary K. EstesQ19957733
P2093author name stringMark Donowitz
Olga Kovbasnjuk
Jennifer Foulke-Abel
Nicholas C. Zachos
Julie G. In
P2860cites workWhole population cell kinetics and postnatal development of the mouse intestinal epitheliumQ70102464
Characterization of a cyclic AMP-activated Cl-transport pathway in the apical membrane of a human colonic epithelial cell lineQ70118791
Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colonQ73302303
Comparison of human duodenum and Caco-2 gene expression profiles for 12,000 gene sequences tags and correlation with permeability of 26 drugsQ78498262
Animal models to study acute and chronic intestinal inflammation in mammalsQ26777430
How to make an intestineQ26991687
A novel human gastric primary cell culture system for modelling Helicobacter pylori infection in vitroQ27318404
Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and PathophysiologyQ27321169
Genetically engineering self-organization of human pluripotent stem cells into a liver bud-like tissue using Gata6.Q27336171
The costs of using unauthenticated, over-passaged cell lines: how much more data do we need?Q27910526
Generating human intestinal tissues from pluripotent stem cells to study development and diseaseQ28081264
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
Long-term culture of genome-stable bipotent stem cells from adult human liverQ28254408
A functional CFTR assay using primary cystic fibrosis intestinal organoidsQ28291898
Differentiated Troy+ chief cells act as reserve stem cells to generate all lineages of the stomach epitheliumQ28300176
Vascularized and functional human liver from an iPSC-derived organ bud transplantQ48453997
Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5⁺ stem cell.Q50501047
Real-time analysis of P-glycoprotein-mediated drug transport across primary intestinal epithelium three-dimensionally cultured in vitro.Q51421714
Modeling colorectal cancer using CRISPR-Cas9-mediated engineering of human intestinal organoids.Q52423411
Sequential cancer mutations in cultured human intestinal stem cells.Q52423597
The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells.Q54191317
Toxin production by an emerging strain of Clostridium difficile associated with outbreaks of severe disease in North America and EuropeQ58924160
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's EpitheliumQ63406947
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patientsQ28303521
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaQ28594441
Paneth cells constitute the niche for Lgr5 stem cells in intestinal cryptsQ29616197
Lgr5(+ve) stem cells drive self-renewal in the stomach and build long-lived gastric units in vitroQ29616198
Origins and evolution of antibiotic resistanceQ29617791
Studies of mucus in mouse stomach, small intestine, and colon. I. Gastrointestinal mucus layers have different properties depending on location as well as over the Peyer's patchesQ30544011
Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and PathophysiologyQ30717134
Escherichia coli O104:H4 Pathogenesis: an Enteroaggregative E. coli/Shiga Toxin-Producing E. coli Explosive Cocktail of High VirulenceQ33423841
Perturbation of the small intestine microbial ecology by streptomycin alters pathology in a Salmonella enterica serovar typhimurium murine model of infectionQ33443646
Pathogens associated with persistent diarrhoea in children in low and middle income countries: systematic reviewQ33465269
History of Helicobacter pylori, duodenal ulcer, gastric ulcer and gastric cancerQ33594828
Human enteroids: preclinical models of non-inflammatory diarrheaQ33645327
Caco-2 monolayers in experimental and theoretical predictions of drug transportQ33939098
Prevalence of gastrointestinal pathogens in developed and developing countries: systematic review and meta-analysisQ34074098
The gastrointestinal mucus system in health and diseaseQ34332180
De novo formation of insulin-producing "neo-β cell islets" from intestinal cryptsQ34409239
Electrolyte transport in the mammalian colon: mechanisms and implications for diseaseQ34482550
Effect of cholera enterotoxin on ion transport across isolated ileal mucosaQ34495789
Mechanism of chloride secretion induced by carbachol in a colonic epithelial cell lineQ34520348
Vasoactive intestinal polypeptide-induced chloride secretion by a colonic epithelial cell line. Direct participation of a basolaterally localized Na+,K+,Cl- cotransport systemQ34530420
In vitro expansion of human gastric epithelial stem cells and their responses to bacterial infectionQ34758575
Persistence and toxin production by Clostridium difficile within human intestinal organoids result in disruption of epithelial paracellular barrier functionQ34889659
Epithelial transport of drugs in cell culture. I: A model for studying the passive diffusion of drugs over intestinal absorptive (Caco-2) cellsQ35003095
Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays.Q35009140
Application of Caco-2 cell line in herb-drug interaction studies: current approaches and challengesQ35164876
Geographic distribution and mortality risk factors during the cholera outbreak in a rural region of Haiti, 2010-2011.Q35219440
Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tractQ35235398
An in vivo model of human small intestine using pluripotent stem cellsQ35533803
Human Clostridium difficile infection: inhibition of NHE3 and microbiota profileQ35536689
CD44 plays a functional role in Helicobacter pylori-induced epithelial cell proliferation.Q35556818
Interrelationships of chloride, bicarbonate, sodium, and hydrogen transport in the human ileumQ35575684
Human Clostridium difficile infection: altered mucus production and compositionQ35576559
Management of infectious diarrhoeaQ35598312
Transcriptome-wide Analysis Reveals Hallmarks of Human Intestine Development and Maturation In Vitro and In VivoQ35754364
Public Health Investigation of Two Outbreaks of Shiga Toxin-Producing Escherichia coli O157 Associated with Consumption of WatercressQ35914069
A nomenclature for intestinal in vitro cultures.Q36041988
Stem cell-derived human intestinal organoids as an infection model for rotavirusesQ36099785
Absorptive and mucus-secreting subclones isolated from a multipotent intestinal cell line (HT-29) provide new models for cell polarity and terminal differentiationQ36218087
Host protein binding and adhesive properties of H6 and H7 flagella of attaching and effacing Escherichia coliQ36314226
Fucose sensing regulates bacterial intestinal colonizationQ36456598
Cellular chloride and bicarbonate retention alters intracellular pH regulation in Cftr KO crypt epitheliumQ36480411
Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoidsQ36542776
Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and PathophysiologyQ36594641
Secretory diarrhoea: mechanisms and emerging therapiesQ36673563
In vitro expansion of single Lgr5+ liver stem cells induced by Wnt-driven regeneration.Q36791239
Bacteria in the intestine, helpful residents or enemies from within?Q36804240
Functional coupling of the downregulated in adenoma Cl-/base exchanger DRA and the apical Na+/H+ exchangers NHE2 and NHE3.Q37100234
Generating human intestinal tissue from pluripotent stem cells in vitroQ37495400
Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestineQ37588573
Infectious diarrhea: Cellular and molecular mechanismsQ37843682
Shifting the balance: antibiotic effects on host-microbiota mutualismQ37848035
Sodium-coupled chloride transport by epithelial tissuesQ37942242
Clostridium difficile outbreaks: prevention and treatment strategiesQ38028945
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applicationsQ38112669
Gastrointestinal HCO3- transport and epithelial protection in the gut: new techniques, transport pathways and regulatory pathwaysQ38166521
Adult intestinal stem cells: critical drivers of epithelial homeostasis and regenerationQ38170259
Mini-gut organoids: reconstitution of the stem cell nicheQ38599208
Efficient genetic engineering of human intestinal organoids using electroporationQ38838399
Drug discovery and regulatory considerations for improving in silico and in vitro predictions that use Caco-2 as a surrogate for human intestinal permeability measurementsQ39205763
Adult stem cells in the small intestine are intrinsically programmed with their location-specific functionQ39256230
A method for short-term culture of human gastric epithelial cells to study the effects of Helicobacter pylori.Q39270718
Human and mouse tissue-engineered small intestine both demonstrate digestive and absorptive functionQ39680101
T84 cells in culture as a model for enteroaggregative Escherichia coli pathogenesisQ39826624
Identification of gastric cancer stem cells using the cell surface marker CD44.Q39856772
Mechanism of bicarbonate absorption and its relationship to sodium transport in the human jejunumQ40474348
Inhibition and redistribution of NHE3, the apical Na+/H+ exchanger, by Clostridium difficile toxin B.Q40567906
Epithelial cell migration in the intestineQ40950314
Modeling rotavirus infection and antiviral therapy using primary intestinal organoidsQ40980815
Interaction of Salmonella enterica Serovar Typhimurium with Intestinal Organoids Derived from Human Induced Pluripotent Stem Cells.Q41239463
Hospital ward antibiotic prescribing and the risks of Clostridium difficile infectionQ41368332
Modelling human development and disease in pluripotent stem-cell-derived gastric organoidsQ41680408
Characteristics of cell lines established from human gastric carcinomaQ41735874
Directed differentiation of human pluripotent stem cells into intestinal tissue in vitroQ41770080
Endogenous expression of type II cGMP-dependent protein kinase mRNA and protein in rat intestine. Implications for cystic fibrosis transmembrane conductance regulatorQ42102291
Outbreaks of non-O157 Shiga toxin-producing Escherichia coli infection: USA.Q42233868
Peyer's patch M cells derived from Lgr5(+) stem cells require SpiB and are induced by RankL in cultured "miniguts".Q42321791
Caco-2 cell monolayers as a model for drug transport across the intestinal mucosaQ43694499
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectphysiologyQ521
P304page(s)633-642
P577publication date2016-11-01
P1433published inNature Reviews Gastroenterology & HepatologyQ2108255
P1476titleHuman mini-guts: new insights into intestinal physiology and host-pathogen interactions
P478volume13

Reverse relations

cites work (P2860)
Q97527170A Human 2D Primary Organoid-Derived Epithelial Monolayer Model to Study Host-Pathogen Interaction in the Small Intestine
Q91599170A Novel Human Epithelial Enteroid Model of Necrotizing Enterocolitis
Q44870856A microengineered collagen scaffold for generating a polarized crypt-villus architecture of human small intestinal epithelium
Q37721649A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.
Q47200970A surgical orthotopic organoid transplantation approach in mice to visualize and study colorectal cancer progression
Q38866502A vesicle trafficking protein αSNAP regulates Paneth cell differentiation in vivo.
Q90270567Biopolymer-Based Microcarriers for Three-Dimensional Cell Culture and Engineered Tissue Formation
Q47300906Characterization of the Giardia intestinalis secretome during interaction with human intestinal epithelial cells: The impact on host cells
Q55489493Colon organoid formation and cryptogenesis are stimulated by growth factors secreted from myofibroblasts.
Q92785746Differential gene expression and gene-set enrichment analysis in Caco-2 monolayers during a 30-day timeline with Dexamethasone exposure
Q58773623Enterohemorrhagic (EHEC)-Secreted Serine Protease EspP Stimulates Electrogenic Ion Transport in Human Colonoid Monolayers
Q54201990Enterotoxigenic Escherichia coli blood group A interactions intensify diarrheal severity.
Q45071462Enterotoxigenic Escherichia coli is phagocytosed by macrophages underlying villus-like intestinal epithelial cells: modeling ex vivo innate immune defenses of the human gut.
Q38718766Enteroviruses infect human enteroids and induce antiviral signaling in a cell lineage-specific manner
Q40189708Gastrointestinal microphysiological systems
Q97071709Guidance on safety evaluation of sources of nutrients and bioavailability of nutrient from the sources
Q41623268Gut Microbial Influences on the Mammalian Intestinal Stem Cell Niche.
Q89104008Gut Microbiota-Produced Tryptamine Activates an Epithelial G-Protein-Coupled Receptor to Increase Colonic Secretion
Q33758023Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions
Q91599319Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium
Q89174635Human Intestinal Enteroids for the Study of Bacterial Adherence, Invasion, and Translocation
Q40265858Human Intestinal Enteroids: New Models to Study Gastrointestinal Virus Infections
Q64898155Human Microphysiological Systems and Organoids as in Vitro Models for Toxicological Studies.
Q47109988In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses
Q60585226Intestinal organoid as an in vitro model in studying host-microbial interactions
Q36405482Intestinal organoids model human responses to infection by commensal and Shiga toxin producing Escherichia coli
Q52564466Microfabricated Crypt Scaffolds: A New Foundation for Evaluating Human Colon Stem Cells.
Q47795944Microphysiological Systems (Tissue Chips) and their Utility for Rare Disease Research
Q59133328Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age
Q91923175Morphophenotypic classification of tumor organoids as an indicator of drug exposure and penetration potential
Q96816103Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli
Q90699508Neuroimmunophysiology of the gut: advances and emerging concepts focusing on the epithelium
Q44876695Nonsteroidal Anti-Inflammatory Drug-Induced Leaky Gut Modeled Using Polarized Monolayers of Primary Human Intestinal Epithelial Cells.
Q91615027Organoids - New Models for Host-Helminth Interactions
Q58767983Recent Breakthroughs and Ongoing Limitations in Research
Q63246378Type III interferon signaling restricts enterovirus 71 infection of goblet cells
Q101403284Using multi-organ culture systems to study Parkinson's disease

Search more.