Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology

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Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology is …
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scholarly articleQ13442814

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P356DOI10.1053/J.GASTRO.2015.11.047
P932PMC publication ID4766025
P698PubMed publication ID26677983

P50authorMary K. EstesQ19957733
P2093author name stringMark Donowitz
Nicholas C Zachos
Olga Kovbasnjuk
Hugo de Jonge
Julie In
Jennifer Foulke-Abel
Jianyi Yin
P2860cites workPermeability of the rat small intestinal epithelium along the villus-crypt axis: effects of glucose transportQ42494774
A microelectrode study of responses to secretagogues by epithelial cells on villus and crypt of rat small intestineQ42499736
Acid-base transport in isolated rabbit duodenal villus and crypt cellsQ42527510
cAMP inhibition of murine intestinal Na/H exchange requires CFTR-mediated cell shrinkage of villus epitheliumQ44601450
The response of small intestinal villous and crypt epithelium to choleratoxin in rat and guinea pig. Evidence against a specific role of the crypt cells in choleragen-induced secretionQ44636536
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein responseQ46116386
An electroneutral sodium/bicarbonate cotransporter NBCn1 and associated sodium channelQ47853906
Reversible and irreversible interactions of DIDS with the human electrogenic Na/HCO3 cotransporter NBCe1-A: role of lysines in the KKMIK motif of TM5.Q50639843
Colonic anion secretory defects and metabolic acidosis in mice lacking the NBC1 Na+/HCO3- cotransporter.Q52575904
The electroneutral Na⁺:HCO₃⁻ cotransporter NBCn1 is a major pHi regulator in murine duodenum.Q52625350
Origin of cAMP-dependent Cl- secretion from both crypts and surface epithelia of rat intestine.Q53022491
The bumetanide-resistant part of forskolin-induced anion secretion in rat colon.Q54118029
Isolation and in vitro expansion of human colonic stem cells.Q54350641
CholeraQ57116811
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's EpitheliumQ63406947
The acidosis of cholera. Contributions of hyperproteinemia, lactic acidemia, and hyperphosphatemia to an increased serum anion gapQ69671046
Changes in cyclic 3'5'-adenosine monophosphate tissue concentration and net fluid transport in the cat's small intestine elicited by cholera toxin, arachidonic acid, vasoactive intestinal polypeptide and 5-hydroxytryptamineQ70172927
Evidence for cholera secretion emanating from the crypts. A study of villus tissue osmolality and fluid and electrolyte transport in the small intestine of the catQ70451715
Inhibition of cholera toxin action in the rabbit by cycloheximideQ72343470
Differential role of cyclic GMP-dependent protein kinase II in ion transport in murine small intestine and colonQ73302303
Tissue-specific regulation of sodium/proton exchanger isoform 3 activity in Na(+)/H(+) exchanger regulatory factor 1 (NHERF1) null mice. cAMP inhibition is differentially dependent on NHERF1 and exchange protein directly activated by cAMP in ileum vQ80502556
AE2 Cl-/HCO3- exchanger is required for normal cAMP-stimulated anion secretion in murine proximal colonQ24597250
Acute regulation of the SLC26A3 congenital chloride diarrhoea anion exchanger (DRA) expressed in Xenopus oocytesQ24657079
Human Intestinal Enteroids: a New Model To Study Human Rotavirus Infection, Host Restriction, and PathophysiologyQ27321169
Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal nicheQ28239639
A functional CFTR assay using primary cystic fibrosis intestinal organoidsQ28291898
IRBIT coordinates epithelial fluid and HCO3- secretion by stimulating the transporters pNBC1 and CFTR in the murine pancreatic ductQ28504720
Cloning, tissue distribution, and functional analysis of the human Na+/N+ exchanger isoform, NHE3Q28609283
Duodenal acidity "sensing" but not epithelial HCO3- supply is critically dependent on carbonic anhydrase II expressionQ30489328
Sustained in vitro intestinal epithelial culture within a Wnt-dependent stem cell nicheQ30495954
Functional Cftr in crypt epithelium of organotypic enteroid cultures from murine small intestineQ30514240
Molecular and functional evidence for electrogenic and electroneutral Na(+)-HCO(3)(-) cotransporters in murine duodenum.Q31919801
Development of a primary mouse intestinal epithelial cell monolayer culture system to evaluate factors that modulate IgA transcytosisQ33605404
Human enteroids: preclinical models of non-inflammatory diarrheaQ33645327
Physiological relevance of cell-specific distribution patterns of CFTR, NKCC1, NBCe1, and NHE3 along the crypt-villus axis in the intestineQ34513510
Development of an enhanced human gastrointestinal epithelial culture system to facilitate patient-based assays.Q35009140
NHERF2 is necessary for basal activity, second messenger inhibition, and LPA stimulation of NHE3 in mouse distal ileumQ35086764
Human enteroids as an ex-vivo model of host-pathogen interactions in the gastrointestinal tractQ35235398
Fluid absorption in isolated perfused colonic cryptsQ35766436
Human intestinal epithelial cell line SK-CO15 is a new model system to study Na(+)/H(+) exchanger 3Q36114911
Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoidsQ36542776
S3226, a novel inhibitor of Na+/H+ exchanger subtype 3 in various cell typesQ36898184
Heat-stable enterotoxin of Escherichia coli: in vitro effects on guanylate cyclase activity, cyclic GMP concentration, and ion transport in small intestineQ37588573
Growing self-organizing mini-guts from a single intestinal stem cell: mechanism and applicationsQ38112669
Adult stem cells in the small intestine are intrinsically programmed with their location-specific functionQ39256230
Canonical Wnt signals are essential for homeostasis of the intestinal epitheliumQ39895829
Role of cyclic GMP in the action of heat-stable enterotoxin of Escherichia coliQ40130998
Development of an endogenous epithelial Na(+)/H(+) exchanger (NHE3) in three clones of caco-2 cells.Q40936001
Pharmacological characterization of stably transfected Na+/H+ antiporter isoforms using amiloride analogs and a new inhibitor exhibiting anti-ischemic properties.Q41516472
S0859, an N-cyanosulphonamide inhibitor of sodium-bicarbonate cotransport in the heart.Q42068897
Electroneutral sodium absorption and electrogenic anion secretion across murine small intestine are regulated in parallelQ42465531
P433issue3
P407language of work or nameEnglishQ1860
P921main subjectpathophysiologyQ1135939
P304page(s)638-649.e8
P577publication date2015-12-08
P1433published inGastroenterologyQ4039279
P1476titleHuman Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and Pathophysiology
P478volume150

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cites work (P2860)
Q51007478A common NHE3 single-nucleotide polymorphism has normal function and sensitivity to regulatory ligands.
Q37721649A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.
Q89108031AC6 is the major adenylate cyclase forming a diarrheagenic protein complex with cystic fibrosis transmembrane conductance regulator in cholera
Q52588795Advances in Evaluation of Chronic Diarrhea in Infants.
Q51313072Benzopyrimido-pyrrolo-oxazine-dione CFTR inhibitor (R)-BPO-27 for antisecretory therapy of diarrheas caused by bacterial enterotoxins.
Q51010188CFTR-mediated anion secretion across intestinal epithelium-like Caco-2 monolayer under PTH stimulation is dependent on intermediate conductance K+ channels.
Q101468174Co-Culture System of Human Enteroids/Colonoids with Innate Immune Cells
Q91725031DNA Methylation Analysis Validates Organoids as a Viable Model for Studying Human Intestinal Aging
Q48297466DNA methylation defines regional identity of human intestinal epithelial organoids and undergoes dynamic changes during development.
Q52575752Engineered Human Gastrointestinal Cultures to Study the Microbiome and Infectious Diseases.
Q99608353Enteroendocrine cells couple nutrient sensing to nutrient absorption by regulating ion transport
Q64055283Evaluating Shigella flexneri Pathogenesis in the Human Enteroid Model
Q92029982Evaluation of mouse enteroids as a model for Lawsonia intracellularis infection
Q40189708Gastrointestinal microphysiological systems
Q49598448Guanylate cyclase 2C agonism corrects CFTR mutants
Q52644144Guanylate cyclase-C as a therapeutic target in gastrointestinal disorders.
Q37284644Guanylin and uroguanylin are produced by mouse intestinal epithelial cells of columnar and secretory lineage
Q55339383Harnessing single-cell genomics to improve the physiological fidelity of organoid-derived cell types.
Q91599319Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal Epithelium
Q90726210Human intestinal enteroids as a model of Clostridioides difficile-induced enteritis
Q47105459Human intestinal epithelium in a dish: Current models for research into gastrointestinal pathophysiology
Q28066574Human mini-guts: new insights into intestinal physiology and host-pathogen interactions
Q52321220Human organoid cultures: transformative new tools for human virus studies.
Q47109988In vitro enteroid-derived three-dimensional tissue model of human small intestinal epithelium with innate immune responses
Q38962735Individualized medicine using intestinal responses to CFTR potentiators and correctors
Q30815469Intestinal Enteroids Model Guanylate Cyclase C-Dependent Secretion Induced by Heat-Stable Enterotoxins
Q38746119Intestinal Organoids: New Frontiers in the Study of Intestinal Disease and Physiology
Q33891569Microphysiological Systems ("Organs-on-Chips") for Drug Efficacy and Toxicity Testing
Q47795944Microphysiological Systems (Tissue Chips) and their Utility for Rare Disease Research
Q59133328Modeling Host-Pathogen Interactions in the Context of the Microenvironment: Three-Dimensional Cell Culture Comes of Age
Q55489531Molecular Basis and Differentiation-Associated Alterations of Anion Secretion in Human Duodenal Enteroid Monolayers.
Q64083816Molecular transport through primary human small intestinal monolayers by culture on a collagen scaffold with a gradient of chemical cross-linking
Q92603183Mouse pancreatic ductal organoid culture as a relevant model to study exocrine pancreatic ion secretion
Q96816103Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli
Q64082364New Age Strategies To Reconstruct Mucosal Tissue Colonization and Growth in Cell Culture Systems
Q28821807PGE2 is a direct and robust mediator of anion/fluid secretion by human intestinal epithelial cells
Q64107046Paneth cell granule dynamics on secretory responses to bacterial stimuli in enteroids
Q47196503Pathology, proteomics and the pathway to personalised medicine.
Q33752154Phenylquinoxalinone CFTR activator as potential prosecretory therapy for constipation
Q34532168Physiologically relevant human tissue models for infectious diseases
Q92677838Physiology of Electrolyte Transport in the Gut: Implications for Disease
Q52856803Retinoic Acid Improves Incidence and Severity of Necrotizing Enterocolitis by Lymphocyte Balance Restitution and Repopulation of LGR5+ Intestinal Stem Cells.
Q56535583SLC6A14, an amino acid transporter, modifies the primary CF defect in fluid secretion
Q52589288Selective inhibition of intestinal guanosine 3',5'-cyclic monophosphate signaling by small-molecule protein kinase inhibitors.
Q48156740Single cell analysis of Crohn's disease patient-derived small intestinal organoids reveals disease activity-dependent modification of stem cell properties
Q57023146Technology Transfer of the Microphysiological Systems: A Case Study of the Human Proximal Tubule Tissue Chip
Q39133310The Contributions of Human Mini-Intestines to the Study of Intestinal Physiology and Pathophysiology
Q58798789The Guanylate Cyclase C-cGMP Signaling Axis Opposes Intestinal Epithelial Injury and Neoplasia
Q50001217The Isolation, Culture, and Propagation of Murine Intestinal Enteroids for the Study of Dietary Lipid Metabolism
Q38773122The third dimension: new developments in cell culture models for colorectal research.
Q38644609Tissue chips - innovative tools for drug development and disease modeling.
Q47669248Using 3D Organoid Cultures to Model Intestinal Physiology and Colorectal Cancer.
Q51153525Using primary murine intestinal enteroids to study dietary TAG absorption, lipoprotein synthesis, and the role of apoC-III in the intestine.
Q92901649What Is the Impact of Diet on Nutritional Diarrhea Associated with Gut Microbiota in Weaning Piglets: A System Review
Q64284586cAMP Stimulates SLC26A3 Activity in Human Colon by a CFTR-Dependent Mechanism That Does Not Require CFTR Activity

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