Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli

scientific article published on 29 June 2020

Mucus layer modeling of human colonoids during infection with enteroaggragative E. coli is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1038/S41598-020-67104-4
P932PMC publication ID7324601
P698PubMed publication ID32601325

P50authorJames P NataroQ61771354
P2093author name stringMark Donowitz
Lixia Liu
Fernando Ruiz-Perez
Rachel Smith
Nicholas C Zachos
Olga Kovbasnjuk
Julie G In
Laura Gonyar
Waleska Saitz-Rojas
P2860cites workBacterial serine proteases secreted by the autotransporter pathway: classification, specificity, and role in virulenceQ26828625
Bacteria penetrate the inner mucus layer before inflammation in the dextran sulfate colitis modelQ27321389
Human mini-guts: new insights into intestinal physiology and host-pathogen interactionsQ28066574
Origins of the E. coli strain causing an outbreak of hemolytic-uremic syndrome in GermanyQ28244221
Aberrant mucin assembly in mice causes endoplasmic reticulum stress and spontaneous inflammation resembling ulcerative colitisQ28472412
The inner of the two Muc2 mucin-dependent mucus layers in colon is devoid of bacteriaQ28594441
The two mucus layers of colon are organized by the MUC2 mucin, whereas the outer layer is a legislator of host-microbial interactionsQ29617847
Muc2-deficient mice spontaneously develop colitis, indicating that MUC2 is critical for colonic protectionQ29618129
Autotransporter genes pic and tsh are associated with Escherichia coli strains that cause acute pyelonephritis and are expressed during urinary tract infectionQ30164331
Enteroaggregative Escherichia coli Adherence Fimbriae Drive Inflammatory Cell Recruitment via Interactions with Epithelial MUC1.Q30252193
An innate antiviral pathway acting before interferons at epithelial surfacesQ30278039
Broad spectrum activity of a lectin-like bacterial serine protease family on human leukocytesQ30410326
Serine protease autotransporters from Shigella flexneri and pathogenic Escherichia coli target a broad range of leukocyte glycoproteinsQ30431075
Enteroaggregative Escherichia coli produce intestinal inflammation and growth impairment and cause interleukin-8 release from intestinal epithelial cells.Q30471492
Human Enteroids as a Model of Upper Small Intestinal Ion Transport Physiology and PathophysiologyQ30717134
Pic, an autotransporter protein secreted by different pathogens in the Enterobacteriaceae family, is a potent mucus secretagogueQ34177330
Prevalence of diarrheagenic Escherichia coli in acute childhood enteritis: a prospective controlled studyQ81257059
Human Intestinal Enteroids as a Model System of Shigella PathogenesisQ91044273
Human Colonoid Monolayers to Study Interactions Between Pathogens, Commensals, and Host Intestinal EpitheliumQ91599319
A review of an emerging enteric pathogen: enteroaggregative Escherichia coliQ34569402
Pathogenic E. coli exploits SslE mucinase activity to translocate through the mucosal barrier and get access to host cellsQ35581267
A nomenclature for intestinal in vitro cultures.Q36041988
Pathogenesis of enteroaggregative Escherichia coli infectionQ36383861
Enterohemorrhagic Escherichia coli reduce mucus and intermicrovillar bridges in human stem cell-derived colonoidsQ36542776
Human Enteroids/Colonoids and Intestinal Organoids Functionally Recapitulate Normal Intestinal Physiology and PathophysiologyQ36594641
The serine protease Pic as a virulence factor of atypical enteropathogenic Escherichia coliQ36869006
Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone badQ37018335
The Pic protease of enteroaggregative Escherichia coli promotes intestinal colonization and growth in the presence of mucinQ37204458
Autotransporters but not pAA are critical for rabbit colonization by Shiga toxin-producing Escherichia coli O104:H4.Q37526502
EatA, an immunogenic protective antigen of enterotoxigenic Escherichia coli, degrades intestinal mucin.Q37546427
Enterotoxigenic Escherichia coli secretes a highly conserved mucin-degrading metalloprotease to effectively engage intestinal epithelial cells.Q37546507
A primary human macrophage-enteroid co-culture model to investigate mucosal gut physiology and host-pathogen interactions.Q37721649
High Prevalence of Virulence Genes in Specific Genotypes of Atypical Enteropathogenic Escherichia coliQ37736014
The StcE metalloprotease of enterohaemorrhagic Escherichia coli reduces the inner mucus layer and promotes adherence to human colonic epithelium ex vivo.Q38774649
Characteristics of enteroaggregative Escherichia coli isolated from healthy carriers and from patients with diarrhoea.Q39099696
Escherichia coli strains that cause diarrhoea but do not produce heat-labile or heat-stable enterotoxins and are non-invasiveQ39488888
Caco-2 and LS174T cell lines provide different models for studying mucin expression in colon cancerQ39563275
Epidemiology of enteroaggregative Escherichia coli infections and associated outcomes in the MAL-ED birth cohortQ40109314
Diarrheagenic Escherichia coli infection in Baltimore, Maryland, and New Haven, Connecticut.Q40474671
Virulence Gene Profile and Multilocus Variable-Number Tandem-Repeat Analysis (MLVA) of Enteroinvasive Escherichia coli (EIEC) Isolates From Patients With Diarrhea in Kerman, IranQ40578681
The Serine Protease Autotransporter Pic Modulates Citrobacter rodentium Pathogenesis and Its Innate Recognition by the HostQ41304756
Etiology of diarrhea in young children in Denmark: a case-control studyQ41457429
The Serine Protease Pic From Enteroaggregative Escherichia coli Mediates Immune Evasion by the Direct Cleavage of Complement Proteins.Q41547882
Short report: high prevalence of serine protease autotransporter cytotoxins among strains of enteroaggregative Escherichia coli.Q42072861
Extracellular Signals of a Human Epithelial Colorectal Adenocarcinoma (Caco-2) Cell Line Facilitate the Penetration of Pseudomonas aeruginosa PAO1 Strain through the Mucin LayerQ42363803
Enteroaggregative Escherichia coli is a cause of acute diarrheal illness: a meta-analysisQ44176525
PicU, a second serine protease autotransporter of uropathogenic Escherichia coliQ44735528
Pre-epithelial mucus layer in the colon of conventional and germ-free ratsQ44844594
Antibody response against plasmid-encoded toxin (Pet) and the protein involved in intestinal colonization (Pic) in children with diarrhea produced by enteroaggregative Escherichia coliQ45244708
ER stress causes rapid loss of intestinal epithelial stemness through activation of the unfolded protein responseQ46116386
Novel Segment- and Host-Specific Patterns of Enteroaggregative Escherichia coli Adherence to Human Intestinal EnteroidsQ49791048
Diarrheagenic Escherichia Coli and Acute Gastroenteritis in Children in Davidson County, Tennessee, United States: A Case-Control StudyQ50002787
Markers of inflammation in bacterial diarrhea among travelers, with a focus on enteroaggregative Escherichia coli pathogenicityQ50110378
Heterogeneity of enteroaggregative Escherichia coli virulence demonstrated in volunteers.Q54617716
Aggregative adherence fimbriae contribute to the inflammatory response of epithelial cells infected with enteroaggregative Escherichia coli.Q54638065
Characterization of enteroadherent-aggregative Escherichia coli, a putative agent of diarrheal disease.Q54746605
Intestinal barrier dysfunction orchestrates the onset of inflammatory host-microbiome cross-talk in a human gut inflammation-on-a-chipQ57805532
Preservation of Mucus in Histological Sections, Immunostaining of Mucins in Fixed Tissue, and Localization of Bacteria with FISHQ59265005
Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's EpitheliumQ63406947
Evaluating Shigella flexneri Pathogenesis in the Human Enteroid ModelQ64055283
P4510describes a project that usesImageJQ1659584
P433issue1
P921main subjectEscherichia coliQ25419
P304page(s)10533
P577publication date2020-06-29
P1433published inScientific ReportsQ2261792
P1476titleMucus layer modeling of human colonoids during infection with enteroaggragative E. coli
P478volume10

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