| scholarly article | Q13442814 |
| P6179 | Dimensions Publication ID | 1022441612 |
| P356 | DOI | 10.1038/CDD.2014.239 |
| P932 | PMC publication ID | 4356348 |
| P698 | PubMed publication ID | 25613373 |
| P5875 | ResearchGate publication ID | 271537596 |
| P2093 | author name string | E Gallagher | |
| T Suddason | |||
| P2860 | cites work | Dysregulation of T lymphocyte function in itchy mice: a role for Itch in TH2 differentiation | Q52545197 |
| MEKK1 binds HECT E3 ligase Itch by its amino-terminal RING motif to regulate Th2 cytokine gene expression. | Q54724272 | ||
| Breast cancer susceptibility variants alter risks in familial disease. | Q54731829 | ||
| Identification of 2 serine residues of MEK-1 that are differentially phosphorylated during activation by raf and MEK kinase | Q72068689 | ||
| The JNK signal transduction pathway | Q79781771 | ||
| Ubiquitin ligases and beyond | Q21245382 | ||
| JNKK1 organizes a MAP kinase module through specific and sequential interactions with upstream and downstream components mediated by its amino-terminal extension | Q22007973 | ||
| The WD40-repeat protein Han11 functions as a scaffold protein to control HIPK2 and MEKK1 kinase functions | Q24302518 | ||
| The MEKK1 PHD ubiquitinates TAB1 to activate MAPKs in response to cytokines | Q24304462 | ||
| TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction | Q24312956 | ||
| Identification of a dual specificity kinase that activates the Jun kinases and p38-Mpk2 | Q24313872 | ||
| MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival | Q24338226 | ||
| NIK is a new Ste20-related kinase that binds NCK and MEKK1 and activates the SAPK/JNK cascade via a conserved regulatory domain | Q24532124 | ||
| MEK kinases are regulated by EGF and selectively interact with Rac/Cdc42 | Q24532640 | ||
| Regulation of IL-4 expression by the transcription factor JunB during T helper cell differentiation | Q24533533 | ||
| Signaling by proinflammatory cytokines: oligomerization of TRAF2 and TRAF6 is sufficient for JNK and IKK activation and target gene induction via an amino-terminal effector domain | Q24604330 | ||
| Comprehensive molecular portraits of human breast tumours | Q24630844 | ||
| Genome-wide association study identifies novel breast cancer susceptibility loci | Q24645441 | ||
| Immune-induced epithelial to mesenchymal transition in vivo generates breast cancer stem cells | Q24647546 | ||
| MEKK1 suppresses oxidative stress-induced apoptosis of embryonic stem cell-derived cardiac myocytes | Q24655976 | ||
| Activation of stress-activated protein kinase by MEKK1 phosphorylation of its activator SEK1 | Q28114883 | ||
| MEKK1 binds raf-1 and the ERK2 cascade components | Q28145204 | ||
| MEKK1 Binds Directly to the c-Jun N-terminal Kinases/Stress-activated Protein Kinases | Q28257056 | ||
| 14-3-3 proteins interact with specific MEK kinases | Q28260788 | ||
| A divergence in the MAP kinase regulatory network defined by MEK kinase and Raf | Q28263195 | ||
| Whole-genome analysis informs breast cancer response to aromatase inhibition | Q28269291 | ||
| TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains | Q28278500 | ||
| Grb2 Interaction with MEK-Kinase 1 Is Involved in Regulation of Jun-Kinase Activities in Response to Epidermal Growth Factor | Q28281964 | ||
| Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption | Q28290282 | ||
| Differential regulation and properties of MAPKs | Q28301932 | ||
| Activation of the IkappaB alpha kinase complex by MEKK1, a kinase of the JNK pathway | Q28302102 | ||
| Apoptosis Induced by Cytoskeletal Disruption Requires Distinct Domains of MEKK1 | Q28477283 | ||
| JNK is required for effector T-cell function but not for T-cell activation | Q28507174 | ||
| MEKK1 mediates the ubiquitination and degradation of c-Jun in response to osmotic stress | Q28566574 | ||
| p38 mitogen activated protein kinase controls two successive-steps during the early mesodermal commitment of embryonic stem cells. | Q50662590 | ||
| MEK kinase 1 activity is required for definitive erythropoiesis in the mouse fetal liver. | Q50759032 | ||
| MEK kinase 1 (MEKK1) transduces c-Jun NH2-terminal kinase activation in response to changes in the microtubule cytoskeleton | Q51090624 | ||
| TNFR signaling: ubiquitin-conjugated TRAFfic signals control stop-and-go for MAPK signaling complexes | Q37416269 | ||
| Degradation of activated protein kinases by ubiquitination | Q37419861 | ||
| MEKK1/JNK signaling stabilizes and activates p53. | Q37474256 | ||
| Protein microarrays for genome-wide posttranslational modification analysis. | Q37791995 | ||
| Breast cancer genome-wide association studies: there is strength in numbers | Q37945448 | ||
| Mitogen-activated protein kinase kinase kinase 1 activates androgen receptor-dependent transcription and apoptosis in prostate cancer | Q39446502 | ||
| Urokinase-type plasminogen activator: proenzyme, receptor, and inhibitors | Q39508019 | ||
| MEKK1 regulates calpain-dependent proteolysis of focal adhesion proteins for rear-end detachment of migrating fibroblasts. | Q39790978 | ||
| E6201 [(3S,4R,5Z,8S,9S,11E)-14-(ethylamino)-8, 9,16-trihydroxy-3,4-dimethyl-3,4,9,19-tetrahydro-1H-2-benzoxacyclotetradecine-1,7(8H)-dione], a novel kinase inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase (M | Q39812078 | ||
| MEK kinase 1 is a negative regulator of virus-specific CD8(+) T cells | Q40270124 | ||
| MEK kinase 1 interacts with focal adhesion kinase and regulates insulin receptor substrate-1 expression | Q40686612 | ||
| Binding of JNK/SAPK to MEKK1 is regulated by phosphorylation | Q40704480 | ||
| Dominant negative MEKK1 inhibits survival of pancreatic cancer cells | Q40709901 | ||
| Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling | Q40915793 | ||
| MEKK1 interacts with alpha-actinin and localizes to stress fibers and focal adhesions | Q40942643 | ||
| Differential involvement of MEK kinase 1 (MEKK1) in the induction of apoptosis in response to microtubule-targeted drugs versus DNA damaging agents | Q40962091 | ||
| Potentiation of apoptosis by low dose stress stimuli in cells expressing activated MEK kinase 1. | Q41077321 | ||
| Signal transduction pathways regulated by mitogen-activated/extracellular response kinase kinase kinase induce cell death | Q41228964 | ||
| Selective activation of c-Jun kinase mitogen-activated protein kinase by CD40 on human B cells | Q41257915 | ||
| Direct interaction between Ras and the kinase domain of mitogen-activated protein kinase kinase kinase (MEKK1). | Q41344713 | ||
| Essential cytoplasmic translocation of a cytokine receptor-assembled signaling complex | Q42006832 | ||
| MEK kinase is involved in tumor necrosis factor alpha-induced NF-kappaB activation and degradation of IkappaB-alpha. | Q42812855 | ||
| Distribution of FGFR2, TNRC9, MAP3K1, LSP1, and 8q24 alleles in genetically enriched breast cancer patients versus elderly tumor-free women. | Q43086310 | ||
| RhoA binds to the amino terminus of MEKK1 and regulates its kinase activity | Q44634028 | ||
| The regulation of anoikis: MEKK-1 activation requires cleavage by caspases | Q46102806 | ||
| Jun turnover is controlled through JNK-dependent phosphorylation of the E3 ligase Itch | Q46802020 | ||
| Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production | Q46892881 | ||
| HTLV-I Tax protein binds to MEKK1 to stimulate IkappaB kinase activity and NF-kappaB activation | Q47964174 | ||
| Cloning of rat MEK kinase 1 cDNA reveals an endogenous membrane-associated 195-kDa protein with a large regulatory domain | Q28573164 | ||
| The PHD domain of MEKK1 acts as an E3 ubiquitin ligase and mediates ubiquitination and degradation of ERK1/2 | Q28576814 | ||
| The E3 ubiquitin ligase itch couples JNK activation to TNFalpha-induced cell death by inducing c-FLIP(L) turnover | Q28588830 | ||
| A role for MEK kinase 1 in TGF-beta/activin-induced epithelium movement and embryonic eyelid closure | Q28588921 | ||
| Differential activation of ERK and JNK mitogen-activated protein kinases by Raf-1 and MEKK | Q29620274 | ||
| p115 Rho GTPase activating protein interacts with MEKK1. | Q30165313 | ||
| c-Jun NH2-terminal kinase is required for lineage-specific differentiation but not stem cell self-renewal | Q30493483 | ||
| Deltex regulates T-cell activation by targeted degradation of active MEKK1. | Q33823429 | ||
| MEK Kinase 1, a Substrate for DEVD-Directed Caspases, Is Involved in Genotoxin-Induced Apoptosis | Q33996873 | ||
| MEKK1 is essential for cardiac hypertrophy and dysfunction induced by Gq. | Q34020904 | ||
| Timed inhibition of p38MAPK directs accelerated differentiation of human embryonic stem cells into cardiomyocytes | Q34158807 | ||
| Breast cancer susceptibility: current knowledge and implications for genetic counselling | Q34161642 | ||
| Ubiquitin-conjugating enzyme Ubc13 controls breast cancer metastasis through a TAK1-p38 MAP kinase cascade | Q34281252 | ||
| Mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination | Q34381676 | ||
| MEK-1 phosphorylation by MEK kinase, Raf, and mitogen-activated protein kinase: analysis of phosphopeptides and regulation of activity | Q34440555 | ||
| Structure and Notch receptor binding of the tandem WWE domain of Deltex | Q34465487 | ||
| Convergence of Itch-induced ubiquitination with MEKK1-JNK signaling in Th2 tolerance and airway inflammation | Q34468354 | ||
| Activation of the E3 ubiquitin ligase Itch through a phosphorylation-induced conformational change | Q34478754 | ||
| MEKK1 controls matrix degradation and tumor cell dissemination during metastasis of polyoma middle-T driven mammary cancer | Q34506168 | ||
| Tumor necrosis factor alpha rapidly activates the mitogen-activated protein kinase (MAPK) cascade in a MAPK kinase kinase-dependent, c-Raf-1-independent fashion in mouse macrophages | Q34637334 | ||
| The MEKK1-JNK pathway plays a protective role in pressure overload but does not mediate cardiac hypertrophy. | Q34793636 | ||
| Mammalian mitogen-activated protein kinase kinase kinase (MEKK) can function in a yeast mitogen-activated protein kinase pathway downstream of protein kinase C. | Q35324815 | ||
| The control of cell motility and epithelial morphogenesis by Jun kinases | Q35753182 | ||
| Fas-induced proteolytic activation and intracellular redistribution of the stress-signaling kinase MEKK1 | Q36092884 | ||
| From JNK to pay dirt: jun kinases, their biochemistry, physiology and clinical importance | Q36203693 | ||
| Regulating the regulators: control of protein ubiquitination and ubiquitin-like modifications by extracellular stimuli | Q36246889 | ||
| Epidermal growth factor activates m-calpain (calpain II), at least in part, by extracellular signal-regulated kinase-mediated phosphorylation | Q36571781 | ||
| Humoral immunity, inflammation and cancer | Q36727285 | ||
| The MEKK1 SWIM domain is a novel substrate receptor for c-Jun ubiquitylation | Q36841702 | ||
| MEK kinase 1 is critically required for c-Jun N-terminal kinase activation by proinflammatory stimuli and growth factor-induced cell migration. | Q36967719 | ||
| Differential Regulation of c-Jun Protein Plays an Instrumental Role in Chemoresistance of Cancer Cells | Q37000508 | ||
| TRAF6 mediates Smad-independent activation of JNK and p38 by TGF-beta | Q37052635 | ||
| Large-scale detection of ubiquitination substrates using cell extracts and protein microarrays | Q37078212 | ||
| Low-copy piggyBac transposon mutagenesis in mice identifies genes driving melanoma. | Q37191896 | ||
| P275 | copyright license | Creative Commons Attribution 3.0 Unported | Q14947546 |
| P6216 | copyright status | copyrighted | Q50423863 |
| P433 | issue | 4 | |
| P407 | language of work or name | English | Q1860 |
| P921 | main subject | peptide | Q172847 |
| cell biology | Q7141 | ||
| enzyme | Q8047 | ||
| P304 | page(s) | 540-8 | |
| P577 | publication date | 2015-04-01 | |
| P13046 | publication type of scholarly work | review article | Q7318358 |
| P1433 | published in | Cell Death & Differentiation | Q2943974 |
| P1476 | title | A RING to rule them all? Insights into the Map3k1 PHD motif provide a new mechanistic understanding into the diverse roles of Map3k1 | |
| P478 | volume | 22 |
| Q42511544 | Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion |
| Q55118369 | Functional significance of co-occurring mutations in PIK3CA and MAP3K1 in breast cancer. |
| Q60046646 | Gene expression profiling of the early pathogenesis of wooden breast disease in commercial broiler chickens using RNA-sequencing |
| Q42389175 | Genetic insights into Map3k-dependent proliferative expansion of T cells |
| Q26741279 | JNK Signaling: Regulation and Functions Based on Complex Protein-Protein Partnerships |
| Q49508965 | MicroRNA profiles of BMSCs induced into osteoblasts with osteoinductive medium |
| Q41845121 | T-Cell-Specific Deletion of Map3k1 Reveals the Critical Role for Mekk1 and Jnks in Cdkn1b-Dependent Proliferative Expansion |
| Q89782346 | The Oviductal Extracellular Vesicles' RNA Cargo Regulates the Bovine Embryonic Transcriptome |
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