A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains

scientific article (publication date: September 2000)

A mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1038/79690
P3181OpenCitations bibliographic resource ID203188
P698PubMed publication ID10973318
P5875ResearchGate publication ID12349452

P50authorSoňa NevšímalováQ12055524
Christelle PeyronQ34639616
P2093author name stringR Kucherlapati
R Li
J Fan
E Mignot
R Maki
S Nishino
W Rogers
Y Charnay
J Faraco
G J Lammers
S Overeem
D Reynolds
M Pedrazzoli
C Bouras
R Albin
M Aldrich
B Ripley
M Hungs
M Kucherlapati
M Padigaru
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Orexins and orexin receptors: a family of hypothalamic neuropeptides and G protein-coupled receptors that regulate feeding behaviorQ24315738
The hypocretins: hypothalamus-specific peptides with neuroexcitatory activityQ24317782
The sleep disorder canine narcolepsy is caused by a mutation in the hypocretin (orexin) receptor 2 geneQ28142783
Structure and function of human prepro-orexin geneQ28611050
Narcolepsy in orexin knockout mice: molecular genetics of sleep regulationQ29615680
Neurons containing hypocretin (orexin) project to multiple neuronal systemsQ29619641
Orexin A activates locus coeruleus cell firing and increases arousal in the rat.Q30504135
The function of tumour necrosis factor and receptors in models of multi-organ inflammation, rheumatoid arthritis, multiple sclerosis and inflammatory bowel diseaseQ33782327
The hypocretin/orexin ligand-receptor system: implications for sleep and sleep disorders.Q33910875
Autoimmune hypothesis in narcolepsyQ34361380
DQB1*0602 and DQA1*0102 (DQ1) are better markers than DR2 for narcolepsy in Caucasian and black Americans.Q34721708
Pharmacological aspects of human and canine narcolepsyQ34740875
Molecular basis of autosomal dominant neurohypophyseal diabetes insipidus. Cellular toxicity caused by the accumulation of mutant vasopressin precursors within the endoplasmic reticulumQ39782823
Genetic and familial aspects of narcolepsyQ41713413
Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.Q45972137
Major histocompatibility class II molecules in the CNS: increased microglial expression at the onset of narcolepsy in canine modelQ46582738
Characterization of orexin-A and orexin-B in the microdissected rat brain nuclei and their contents in two obese rat modelsQ48101411
Distribution and quantification of immunoreactive orexin A in rat tissues.Q48112935
Perspectives in narcolepsy and hypocretin (orexin) researchQ48724319
Clinical and polysomnographic features in DQB1*0602 positive and negative narcolepsy patients: results from the modafinil clinical trialQ48726831
Hypocretin (orexin) deficiency in human narcolepsy.Q55033530
Narcolepsy and immunityQ60399980
NarcolepsyQ68526268
HLA antigens in Japanese patients with narcolepsy. All the patients were DR2 positiveQ70974817
Inefficient membrane targeting, translocation, and proteolytic processing by signal peptidase of a mutant preproparathyroid hormone proteinQ72428569
Mapping of cocaine and amphetamine regulated transcript (CART) mRNA expression in the hypothalamus of elderly humanQ73299653
Narcolepsy in prepubertal childrenQ74122093
Dynamics of microglial activation in the spinal cord after cerebral infarction are revealed by expression of MHC class II antigenQ77147999
Mutations in the vasopressin prohormone involved in diabetes insipidus impair endoplasmic reticulum export but not sortingQ78010486
P433issue9
P407language of work or nameEnglishQ1860
P921main subjectbrainQ1073
narcolepsyQ189561
P304page(s)991-7
P577publication date2000-09-01
P1433published inNature MedicineQ1633234
P1476titleA mutation in a case of early onset narcolepsy and a generalized absence of hypocretin peptides in human narcoleptic brains
P478volume6

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Q42363420Human hypocretin-deficient narcolepsy - aberrant food choice due to impaired taste?
Q88068341Humanity’s Best Friend: A Dog-Centric Approach to Addressing Global Challenges
Q35236645Hypersomnia
Q34628648Hypersomnia and depressive symptoms: methodological and clinical aspects
Q38366488Hypocretin (orexin) biology and the pathophysiology of narcolepsy with cataplexy
Q43996794Hypocretin (orexin) enhances neuron activity and cell synchrony in developing mouse GFP-expressing locus coeruleus
Q48180671Hypocretin (orexin) induces calcium transients in single spines postsynaptic to identified thalamocortical boutons in prefrontal slice
Q48864091Hypocretin (orexin) input to trigeminal and hypoglossal motoneurons in the cat: a double-labeling immunohistochemical study
Q39648815Hypocretin (orexin) regulates glutamate input to fast-spiking interneurons in layer V of the Fr2 region of the murine prefrontal cortex
Q38191600Hypocretin (orexin) regulation of sleep-to-wake transitions
Q34137170Hypocretin and GABA interact in the pontine reticular formation to increase wakefulness
Q36513244Hypocretin and human African trypanosomiasis
Q34155661Hypocretin and its emerging role as a target for treatment of sleep disorders
Q45289637Hypocretin and melanin-concentrating hormone in patients with Huntington disease
Q55442317Hypocretin as a Hub for Arousal and Motivation.
Q41785536Hypocretin deficiency develops during onset of human narcolepsy with cataplexy
Q44115086Hypocretin increases impulse flow in the septohippocampal GABAergic pathway: implications for arousal via a mechanism of hippocampal disinhibition.
Q48606461Hypocretin is an early member of the incretin gene family
Q37738130Hypocretin ligand deficiency in narcolepsy: recent basic and clinical insights
Q36479367Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a
Q36891142Hypocretin receptor expression in canine and murine narcolepsy models and in hypocretin-ligand deficient human narcolepsy
Q46373122Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement
Q40726270Hypocretin stimulates [(35)S]GTP gamma S binding in Hcrtr 2-transfected cell lines and in brain homogenate
Q45300640Hypocretin-1 (orexin A) levels are normal in Huntington's disease
Q36951865Hypocretin-1 CSF levels in anti-Ma2 associated encephalitis
Q37082095Hypocretin-1 and secondary signs in Huntington's disease
Q34277180Hypocretin-1 causes G protein activation and increases ACh release in rat pons.
Q28345076Hypocretin-2 (orexin-B) modulation of superficial dorsal horn activity in rat
Q33485239Hypocretin-2 saporin lesions of the ventrolateral periaquaductal gray (vlPAG) increase REM sleep in hypocretin knockout mice
Q40781477Hypocretin-2-saporin lesions of the lateral hypothalamus produce narcoleptic-like sleep behavior in the rat.
Q37290211Hypocretin/Orexin Peptides Alter Spike Encoding by Serotonergic Dorsal Raphe Neurons through Two Distinct Mechanisms That Increase the Late Afterhyperpolarization
Q37618039Hypocretin/Orexin Peptides Excite Rat Neuroendocrine Dopamine Neurons through Orexin 2 Receptor-Mediated Activation of a Mixed Cation Current
Q39183160Hypocretin/Orexin and Plastic Adaptations Associated with Drug Abuse
Q44258622Hypocretin/Orexin excites hypocretin neurons via a local glutamate neuron-A potential mechanism for orchestrating the hypothalamic arousal system
Q37299612Hypocretin/Orexin neuropeptides: participation in the control of sleep-wakefulness cycle and energy homeostasis
Q33814590Hypocretin/orexin and narcolepsy: new basic and clinical insights
Q30482268Hypocretin/orexin and nociceptin/orphanin FQ coordinately regulate analgesia in a mouse model of stress-induced analgesia.
Q37596060Hypocretin/orexin in arousal and stress
Q44835118Hypocretin/orexin innervation and excitation of identified septohippocampal cholinergic neurons.
Q38013859Hypocretin/orexin involvement in reward and reinforcement
Q34593415Hypocretin/orexin overexpression induces an insomnia-like phenotype in zebrafish.
Q44785480Hypocretin/orexin peptide signaling in the ascending arousal system: elevation of intracellular calcium in the mouse dorsal raphe and laterodorsal tegmentum
Q35948120Hypocretin/orexin prevents recovery from sickness
Q42510167Hypocretin/orexin suppresses corticotroph responsiveness in vitro
Q28187653Hypocretin/orexin, sleep and narcolepsy
Q33817194Hypocretin1/OrexinA-containing axons innervate locus coeruleus neurons that project to the Rat medial prefrontal cortex. Implication in the sleep-wakefulness cycle and cortical activation
Q34203591Hypocretin1/orexinA-immunoreactive axons form few synaptic contacts on rat ventral tegmental area neurons that project to the medial prefrontal cortex
Q36487999Hypocretinergic and non-hypocretinergic projections from the hypothalamus to the REM sleep executive area of the pons
Q44451302Hypocretinergic facilitation of synaptic activity of neurons in the nucleus pontis oralis of the cat.
Q103028780Hypocretinergic interactions with the serotonergic system regulate REM sleep and cataplexy
Q36260008Hypocretins (orexins) and sleep-wake disorders
Q42527611Hypocretins (orexins) regulate serotonin neurons in the dorsal raphe nucleus by excitatory direct and inhibitory indirect actions.
Q38027689Hypocretins and the neurobiology of sleep-wake mechanisms
Q37738128Hypocretins in the control of sleep and wakefulness.
Q34492938Hypothalamic and vagal neuropeptide circuitries regulating food intake
Q48455813Hypothalamic gray matter changes in narcoleptic patients
Q46564697Hypothalamic hypocretinergic/orexinergic neurons projecting to the oral pontine rapid eye movement sleep inducing site in the cat.
Q34741986Hypothalamic obesity in humans: what do we know and what can be done?
Q30311232Hypothalamic orexin (hypocretin) neurons express vesicular glutamate transporters VGLUT1 or VGLUT2.
Q38353773Hypothalamic orexin neurons regulate arousal according to energy balance in mice
Q37284057Hypothalamic orexins/hypocretins as regulators of breathing
Q29619151Hypothalamic regulation of sleep and circadian rhythms
Q33401580IGFBP3 colocalizes with and regulates hypocretin (orexin)
Q37500060Identifying essential cell types and circuits in autism spectrum disorders.
Q48624631Immunogenetics and sleep disorders
Q30984327Immunohistochemical evidence for synaptic release of glutamate from orexin terminals in the locus coeruleus
Q38156224Immunology of stiff person syndrome and other GAD-associated neurological disorders
Q45987709Impact of obesity in children with narcolepsy.
Q91361810In vivo clonal expansion and phenotypes of hypocretin-specific CD4+ T cells in narcolepsy patients and controls
Q36992168Inactivation of median preoptic nucleus causes c-Fos expression in hypocretin- and serotonin-containing neurons in anesthetized rat
Q48156966Increase of histaminergic tuberomammillary neurons in narcolepsy
Q48614095Increased body mass index (BMI) in male narcoleptic patients, but not in HLA-DR2-positive healthy male volunteers
Q34475721Increased daytime sleepiness in patients with childhood craniopharyngioma and hypothalamic tumor involvement: review of the literature and perspectives.
Q44558376Increased frequency of migraine in narcoleptic patients: a confirmatory study
Q33725437Increased immune complexes of hypocretin autoantibodies in narcolepsy
Q30371742Increased β-haemolytic group A streptococcal M6 serotype and streptodornase B-specific cellular immune responses in Swedish narcolepsy cases.
Q48460311Increasing length of wakefulness and modulation of hypocretin-1 in the wake-consolidated squirrel monkey
Q93022778Independent Component Analysis and Graph Theoretical Analysis in Patients with Narcolepsy
Q45949041Induction of active (REM) sleep and motor inhibition by hypocretin in the nucleus pontis oralis of the cat.
Q37081709Influence of inhibitory serotonergic inputs to orexin/hypocretin neurons on the diurnal rhythm of sleep and wakefulness
Q89448495Inhibition of ghrelin-induced feeding in rats by pretreatment with a novel dual orexin receptor antagonist
Q42441383Inhibition of rostral basal forebrain neurons promotes wakefulness and induces FOS in orexin neurons
Q36718073Innervation of orexin/hypocretin neurons by GABAergic, glutamatergic or cholinergic basal forebrain terminals evidenced by immunostaining for presynaptic vesicular transporter and postsynaptic scaffolding proteins
Q34442421Integrating modern concepts of insomnia and its contemporary treatment into primary care
Q34109854Integration of human sleep-wake regulation and circadian rhythmicity
Q43878306Interaction of the hypocretins with neurotransmitters in the nucleus accumbens
Q38534913Interactions of the histamine and hypocretin systems in CNS disorders.
Q38284819Interactions of the orexin/hypocretin neurones and the histaminergic system
Q64052682Interleukin-1-related activity and hypocretin-1 in cerebrospinal fluid contribute to fatigue in primary Sjögren’s syndrome
Q37139316Interspecies genetics of eating disorder traits
Q46498301Intrathecal baclofen associated with improvement of consciousness disorders in spasticity patients
Q58560764Intravenous Immunoglobulin Therapy Administered Early after Narcolepsy Type 1 Onset in Three Patients Evaluated by Clinical and Polysomnographic Follow-Up
Q44355556Intravenously administered hypocretin-1 alters brain amino acid release: an in vivo microdialysis study in rats
Q34528172Invited review: genetic dissection of sleep
Q43878309Involvement of the serotonergic system in orexin-induced behavioral alterations in rats
Q40900071Is suvorexant a better choice than alternative hypnotics?
Q36700601K+ channels stimulated by glucose: a new energy-sensing pathway
Q37700398Lack of hypocretin attenuates behavioral changes produced by glutamatergic activation of the perifornical-lateral hypothalamic area
Q35152159Lateral hypothalamic neuropeptides in reward and drug addiction
Q35875205Lateral hypothalamic orexin/hypocretin neurons that project to ventral tegmental area are differentially activated with morphine preference
Q39563714Lateral hypothalamus: early developmental expression and response to hypocretin (orexin).
Q34611455Localized loss of hypocretin (orexin) cells in narcolepsy without cataplexy
Q47949108Locomotor activity and the expression of orexin A and orexin B in aged female rhesus macaques
Q44859255Locomotor-dependent and -independent components to hypocretin-1 (orexin A) regulation in sleep-wake consolidating monkeys
Q37405078Loss of hypocretin (orexin) neurons with traumatic brain injury
Q48683622Low cerebrospinal fluid hypocretin (Orexin) and altered energy homeostasis in human narcolepsy
Q48687870MAO-A and COMT polymorphisms and gene effects in narcolepsy
Q36430136MHC class II proteins and disease: a structural perspective
Q34259192Mapping of the mRNAs for the hypocretin/orexin and melanin-concentrating hormone receptors: networks of overlapping peptide systems.
Q38558199Mapping the Hypocretin/Orexin Neuronal System: An Unexpectedly Productive Journey
Q44283284Measurement of hypocretin/orexin content in the mouse brain using an enzyme immunoassay: the effect of circadian time, age and genetic background
Q30386292Mechanistic insights into influenza vaccine-associated narcolepsy.
Q46576608Medications for the treatment of narcolepsy
Q28365028Melanin concentrating hormone depresses synaptic activity of glutamate and GABA neurons from rat lateral hypothalamus
Q30486271Melanin-concentrating hormone neurons discharge in a reciprocal manner to orexin neurons across the sleep-wake cycle
Q34822618Melanin-concentrating hormone: a new sleep factor?
Q26770483Metabolic signals in sleep regulation: recent insights
Q36346477Metabolic state signalling through central hypocretin/orexin neurons.
Q55664351Microstructural Changes in Patients With Parkinson's Disease Comorbid With REM Sleep Behaviour Disorder and Depressive Symptoms.
Q40203695Mitigation of murine focal cerebral ischemia by the hypocretin/orexin system is associated with reduced inflammation
Q37999096Models for narcolepsy with cataplexy drug discovery
Q48805520Modulation of neurotransmitter release in orexin/hypocretin-2 receptor knockout mice: a microdialysis study
Q48704998Modulation of the promoter region of prepro-hypocretin by alpha-interferon
Q92376769Molecular codes and in vitro generation of hypocretin and melanin concentrating hormone neurons
Q36497536Molecular genetics and treatment of narcolepsy
Q41903543Monitoring the Right Collection: The Central Cholinergic Neurons as an Instructive Example
Q47772626Monozygotic twins concordant for narcolepsy-cataplexy without any detectable abnormality in the hypocretin (orexin) pathway
Q33948588Monozygotic twins incompletely concordant for narcolepsy
Q46017271Month of birth is not a risk factor for narcolepsy with cataplexy in the Netherlands.
Q44426279Morphological study of orexin neurons in the hypothalamus of the Long–Evans rat, with special reference to co-expression of orexin and NADPH-diaphorase or nitric oxide synthase activities
Q26779153Moving from capstones toward cornerstones: successes and challenges in applying systems biology to identify mechanisms of autism spectrum disorders
Q44338120Mu-opioid receptor-mediated depression of the hypothalamic hypocretin/orexin arousal system.
Q46424846Muscarinic-2 and orexin-2 receptors on GABAergic and other neurons in the rat mesopontine tegmentum and their potential role in sleep-wake state control
Q46399561Muscle Activity During Sleep in Human Subjects, Rats, and Mice: Towards Translational Models of REM Sleep Without Atonia
Q48622072Muscle tone facilitation and inhibition after orexin-a (hypocretin-1) microinjections into the medial medulla
Q36301666Mutations in DNMT1 cause autosomal dominant cerebellar ataxia, deafness and narcolepsy
Q33194998NMR Conformational Studies of Micelle-Bound Orexin-B: A Neuropeptide Involved in the Sleep/Awake Cycle and Feeding Regulation
Q56627695Narcolepsy
Q92035817Narcolepsy - clinical spectrum, aetiopathophysiology, diagnosis and treatment
Q57094544Narcolepsy Associated with Pandemrix Vaccine
Q36255408Narcolepsy Type 1 Is Associated with a Systemic Increase and Activation of Regulatory T Cells and with a Systemic Activation of Global T Cells.
Q41995022Narcolepsy Type 1 as an Autoimmune Disorder: Evidence, and Implications for Pharmacological Treatment.
Q37807703Narcolepsy and cataplexy
Q60932913Narcolepsy and emotional experience: a review of the literature
Q33981657Narcolepsy and excessive daytime sleepiness
Q42370355Narcolepsy and influenza vaccination-the inappropriate awakening of immunity
Q33351116Narcolepsy and orexins: an example of progress in sleep research
Q33587566Narcolepsy and predictors of positive MSLTs in the Wisconsin Sleep Cohort
Q34296069Narcolepsy and the HLA region
Q47720695Narcolepsy and the T-cell receptor
Q36600966Narcolepsy and the hypocretin system--where motion meets emotion
Q30582000Narcolepsy as an adverse event following immunization: case definition and guidelines for data collection, analysis and presentation
Q30362783Narcolepsy as an autoimmune disease: the role of H1N1 infection and vaccination.
Q30359247Narcolepsy as an immune-mediated disease
Q36744152Narcolepsy in African Americans
Q35107716Narcolepsy in the older adult: epidemiology, diagnosis and management
Q48113682Narcolepsy is a common phenotype in HSAN IE and ADCA-DN.
Q24649513Narcolepsy is strongly associated with the T-cell receptor alpha locus
Q34144175Narcolepsy patients have antibodies that stain distinct cell populations in rat brain and influence sleep patterns
Q47094264Narcolepsy susceptibility gene CCR3 modulates sleep-wake patterns in mice.
Q36733271Narcolepsy with cataplexy
Q48500623Narcolepsy with cataplexy in early childhood
Q38195524Narcolepsy with cataplexy: diagnostic challenge in children
Q45246927Narcolepsy, from Westphal to hypocretin
Q48232721Narcolepsy, idiopathic hypersomnolence and related conditions
Q36606370Narcolepsy-Associated HLA Class I Alleles Implicate Cell-Mediated Cytotoxicity
Q47869008Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT.
Q38211898Narcolepsy: a clinical review
Q34072315Narcolepsy: a neurodegenerative disease of the hypocretin system?
Q35212990Narcolepsy: a review
Q36364195Narcolepsy: a review of evidence for autoimmune diathesis
Q34843237Narcolepsy: current treatment options and future approaches
Q35075673Narcolepsy: differential diagnosis or etiology in some cases of bipolar disorder and schizophrenia?
Q37091394Narcolepsy: immunological aspects
Q34691643Narcolepsy: let the patient's voice awaken us!
Q27004322Narcolepsy: neural mechanisms of sleepiness and cataplexy
Q32049276Narcolepsy: new understanding of irresistible sleep
Q42419076Narcoleptic orexin receptor knockout mice express enhanced cholinergic properties in laterodorsal tegmental neurons
Q51740583Neural Damage in Experimental Trypanosoma brucei gambiense Infection: Hypothalamic Peptidergic Sleep and Wake-Regulatory Neurons.
Q46750593Neural correlates of arousal-induced circadian clock resetting: hypocretin/orexin and the intergeniculate leaflet
Q59755770Neural network analysis of sleep stages enables efficient diagnosis of narcolepsy
Q29615343Neural substrates of awakening probed with optogenetic control of hypocretin neurons
Q37807663Neurobiology of waking and sleeping
Q35791191Neurodegenerative disorders associated with diabetes mellitus
Q38049844Neuromodulation of brain states
Q46865807Neuronal Mechanisms for Sleep/Wake Regulation and Modulatory Drive
Q34571598Neuronal activity of histaminergic tuberomammillary neurons during wake-sleep states in the mouse.
Q38477044Neuronal nicotinic receptors in sleep-related epilepsy: studies in integrative biology
Q39207789Neuronal substrates for initiation, maintenance, and structural organization of sleep/wake states
Q28085477Neurons containing orexin or melanin concentrating hormone reciprocally regulate wake and sleep
Q34356717Neuropeptide Y inhibits hypocretin/orexin neurons by multiple presynaptic and postsynaptic mechanisms: tonic depression of the hypothalamic arousal system.
Q35600016Neuropeptide gene polymorphisms and human behavioural disorders
Q36675494Neuropeptides as possible targets in sleep disorders
Q35952741Neuropeptides in hypothalamic neuronal disorders
Q35183957Neuropeptides: opportunities for drug discovery
Q34518670Neuropharmacology of Sleep and Wakefulness
Q36393701Neuropharmacology of Sleep and Wakefulness: 2012 Update
Q24658243Neurophysiology of sleep and wakefulness: basic science and clinical implications
Q48140316Neuropsychological findings in childhood narcolepsy
Q48711734Neuroscience. The sandman's secrets
Q47751740New Neuroscience Tools That Are Identifying the Sleep-Wake Circuit
Q27686789New approaches for the study of orexin function
Q37709565New approaches for the treatment of sleep disorders
Q34878785New developments in sleep research: molecular genetics, gene expression, and systems neurobiology
Q26851338New technologies for integrating genomic, environmental and trait data
Q36000839No Evidence for Disease History as a Risk Factor for Narcolepsy after A(H1N1)pdm09 Vaccination
Q28480931Non-dipping blood pressure profile in narcolepsy with cataplexy
Q44871025Nonpeptide orexin type-2 receptor agonist ameliorates narcolepsy-cataplexy symptoms in mouse models
Q42124350Normal Morning Melanin-Concentrating Hormone Levels and No Association with Rapid Eye Movement or Non-Rapid Eye Movement Sleep Parameters in Narcolepsy Type 1 and Type 2.
Q48434049Normal levels of cerebrospinal fluid hypocretin-1 and daytime sleepiness during attacks of relapsing-remitting multiple sclerosis and monosymptomatic optic neuritis
Q47259221Not asleep, not quite awake
Q35011921Novel therapies for narcolepsy
Q26865384OX1 and OX2 orexin/hypocretin receptor pharmacogenetics
Q46417496Olfactory dysfunction in patients with narcolepsy with cataplexy is restored by intranasal Orexin A (Hypocretin-1).
Q90636795Optical probing of orexin/hypocretin receptor antagonists
Q38642277Optogenetic Investigation of Arousal Circuits
Q33623396Optogenetic deconstruction of sleep-wake circuitry in the brain
Q30485386Orexin (hypocretin) gene transfer diminishes narcoleptic sleep behavior in mice
Q38077489Orexin (hypocretin) receptor agonists and antagonists for treatment of sleep disorders. Rationale for development and current status
Q41957445Orexin 2 receptor as a potential target for immunotoxin and antibody-drug conjugate cancer therapy
Q54963732Orexin A Differentially Influences the Extinction Retention of Recent and Remote Fear Memory.
Q34559586Orexin A activates hypoglossal motoneurons and enhances genioglossus muscle activity in rats.
Q37576044Orexin A and orexin receptor 1 axonal traffic in dorsal roots at the CNS/PNS interface
Q45233267Orexin A promotes histamine, but not norepinephrine or serotonin, release in frontal cortex of mice.
Q30377394Orexin Neurons Respond Differentially to Auditory Cues Associated with Appetitive versus Aversive Outcomes.
Q39026714Orexin OX2 Receptor Antagonists as Sleep Aids
Q59201264Orexin Receptor Antagonists
Q44349574Orexin Receptor Multimerization versus Functional Interactions: Neuropharmacological Implications for Opioid and Cannabinoid Signalling and Pharmacogenetics.
Q33742356Orexin System: The Key for a Healthy Life
Q48465332Orexin excites rat inferior vestibular nuclear neurons via co-activation of OX1 and OX 2 receptors
Q36980393Orexin gene therapy restores the timing and maintenance of wakefulness in narcoleptic mice.
Q36665322Orexin gene transfer into the amygdala suppresses both spontaneous and emotion-induced cataplexy in orexin-knockout mice
Q36790716Orexin gene transfer into zona incerta neurons suppresses muscle paralysis in narcoleptic mice
Q90260823Orexin in Respiratory and Autonomic Regulation, Health and Diseases
Q34050036Orexin mediates initiation of sexual behavior in sexually naive male rats, but is not critical for sexual performance.
Q24654773Orexin mediates the expression of precipitated morphine withdrawal and concurrent activation of the nucleus accumbens shell
Q34696872Orexin neuronal circuitry: role in the regulation of sleep and wakefulness
Q34513315Orexin neurons are directly and indirectly regulated by catecholamines in a complex manner
Q37332460Orexin neurons are necessary for the circadian control of REM sleep.
Q30558348Orexin peptides prevent cataplexy and improve wakefulness in an orexin neuron-ablated model of narcolepsy in mice
Q36018973Orexin receptor antagonism, a new sleep-enabling paradigm: a proof-of-concept clinical trial.
Q39603334Orexin receptor antagonism: an ascending multiple-dose study with almorexant.
Q38269308Orexin receptor antagonists--a patent review (2010 to August 2014).
Q37764786Orexin receptor antagonists: a new concept in CNS disorders?
Q37697791Orexin receptor antagonists: a review of promising compounds patented since 2006.
Q43889435Orexin receptor-1 (OX-R1) immunoreactivity in chemically identified neurons of the hypothalamus: focus on orexin targets involved in control of food and water intake
Q47982827Orexin receptor-1 in the locus coeruleus plays an important role in cue-dependent fear memory consolidation.
Q24597418Orexin receptors: pharmacology and therapeutic opportunities
Q33717450Orexin regulates bone remodeling via a dominant positive central action and a subordinate negative peripheral action
Q47718610Orexin research: patent news from 2016.
Q33770861Orexin signaling via the orexin 1 receptor mediates operant responding for food reinforcement.
Q36880278Orexin, stress, and anxiety/panic states
Q48239014Orexin-A expression in human peripheral tissues
Q37387709Orexin-A inputs onto visuomotor cell groups in the monkey brainstem
Q78482568Orexin-mediated feeding behavior involves both leptin-sensitive and -insensitive pathways
Q47699370Orexin/Hypocretin and Organizing Principles for a Diversity of Wake-Promoting Neurons in the Brain
Q43805360Orexin/hypocretin excites the histaminergic neurons of the tuberomammillary nucleus.
Q33643534Orexin/hypocretin modulation of the basal forebrain cholinergic system: Role in attention
Q39416935Orexins and the cardiovascular events of awakening
Q92537514Orexins/Hypocretins: Key Regulators of Energy Homeostasis
Q42513781Orexins/hypocretins excite basal forebrain cholinergic neurones
Q42696475Orexins: looking forward to sleep, back at addiction
Q47994268Organization of the histaminergic system in adult zebrafish (Danio rerio) brain: neuron number, location, and cotransmitters
Q37028758Orphan GPCR research
Q84979056Pathophysiology of cluster headache and other trigeminal autonomic cephalalgias
Q47927503Peptides that regulate food intake: regional, metabolic, and circadian specificity of lateral hypothalamic orexin A feeding stimulation
Q48459072Periodic leg movements during sleep and wakefulness in narcolepsy
Q95840633Perspective on the Multiple Pathways to Changing Brain States
Q36730631Pharmacogenetics of antiparkinsonian drug treatment: a systematic review.
Q35040879Pharmacogenomics in the treatment of narcolepsy
Q91973279Pharmacological Characteristics of Porcine Orexin 2 Receptor and Mutants
Q35952470Pharmacological and Genetic Modulation of REV-ERB Activity and Expression Affects Orexigenic Gene Expression
Q35548163Pharmacological management of narcolepsy
Q28287690Pharmacotherapy options for cataplexy
Q46265368Physiological functions of glucose-inhibited neurones.
Q43735442Physiological properties of hypothalamic MCH neurons identified with selective expression of reporter gene after recombinant virus infection
Q26822470Physiology of the orexinergic/hypocretinergic system: a revisit in 2012
Q48185192Physiology. The perfect hypnotic?
Q44441275Pitolisant versus placebo or modafinil in patients with narcolepsy: a double-blind, randomised trial
Q48670319Plasma orexin-A is lower in patients with narcolepsy
Q48629354Plasma orexin-A-like immunoreactivity in patients with sleep apnea hypopnea syndrome
Q48635419Polymorphisms of the tumor necrosis factor receptors: no association with narcolepsy in German patients
Q47860962Posterior hypothalamic modulation of ocular-responsive trigeminal subnucleus caudalis neurons is mediated by Orexin-A and Orexin1 receptors
Q43266688Potentiation of a functional autoantibody in narcolepsy by a cholinesterase inhibitor.
Q92690906Preclinical in vivo characterization of lemborexant (E2006), a novel dual orexin receptor antagonist for sleep/wake regulation
Q32065449Prepro-orexin mRNA levels in the rat hypothalamus, and orexin receptors mRNA levels in the rat hypothalamus and adrenal gland are not influenced by the thyroid status.
Q34821484Presentations of primary hypersomnia in Chinese children
Q36836807Prevalence of eating disorders and eating attacks in narcolepsy
Q34628298Promotion of sleep by suvorexant-a novel dual orexin receptor antagonist
Q34607196Promotion of sleep by targeting the orexin system in rats, dogs and humans
Q49961724Prostaglandin D2 Receptor DP1 Antibodies Predict Vaccine-induced and Spontaneous Narcolepsy Type 1: Large-scale Study of Antibody Profiling
Q34068000Psychosis in patients with narcolepsy as an adverse effect of sodium oxybate
Q53139157Psychosocial and intellectual functioning in childhood narcolepsy.
Q44917818Pulsatile LH release is diminished, whereas FSH secretion is normal, in hypocretin-deficient narcoleptic men.
Q36564528QRFP and Its Receptors Regulate Locomotor Activity and Sleep in Zebrafish.
Q45128130Quality of life in children with narcolepsy.
Q35995496REM sleep characteristics in narcolepsy and REM sleep behavior disorder
Q37863871REM sleep: a biological and psychological paradox
Q37200112Rapid changes in glutamate levels in the posterior hypothalamus across sleep-wake states in freely behaving rats
Q48321095Rapid eye movement sleep behaviour disorder in patients with narcolepsy is associated with hypocretin-1 deficiency
Q46304849Recovery from Coma Post-Cardiac Arrest Is Dependent on the Orexin Pathway.
Q64966255Reduced Plasma Orexin-A Concentrations are Associated with Cognitive Deficits in Anorexia Nervosa.
Q33285540Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain
Q43832867Reduction of daytime sleepiness in a depressive patient during adjunct treatment with modafinil
Q35586604Refinement of behavioural traits in animals for the genetic dissection of eating disorders
Q46965172Regulation by orexin of feeding behaviour and locomotor activity in the goldfish
Q46773011Regulation of hypocretin (orexin) expression in embryonic zebrafish
Q44368217Regulation of orexin neurons by the monoaminergic and cholinergic systems.
Q26822482Regulation of zebrafish sleep and arousal states: current and prospective approaches
Q48602913Relationship between CSF hypocretin levels and hypocretin neuronal loss
Q42523162Release of hypocretin (orexin) during waking and sleep states.
Q36553108Repeated injections of orexin-A developed behavioral tolerance to its analgesic effects in rats
Q35509945Respiration and autonomic regulation and orexin
Q48317017Respiratory regulation in narcolepsy
Q80973005Response to intravenous immunoglobulins and placebo in a patient with narcolepsy with cataplexy
Q35110705Response variability in Attention-Deficit/Hyperactivity Disorder: a neuronal and glial energetics hypothesis
Q48149724Restoration: potential for compensatory changes in numbers of neurons in adult human brain
Q36868678Reward-based behaviors and emotional processing in human with narcolepsy-cataplexy.
Q35042283Reward-seeking behavior in human narcolepsy
Q39264695Rewiring brain circuits to block cataplexy in murine models of narcolepsy
Q34245006Role for hypocretin in mediating stress-induced reinstatement of cocaine-seeking behavior
Q94561328Role of Brown Adipose Tissue in Adiposity Associated With Narcolepsy Type 1
Q37440794Role of adenosine A(1) receptor in the perifornical-lateral hypothalamic area in sleep-wake regulation in rats
Q36270726Role of lateral hypothalamus in two aspects of attention in associative learning.
Q36774914Role of orexin in modulating arousal, feeding, and motivation
Q47371999Role of the Orexin/Hypocretin System in Stress-Related Psychiatric Disorders.
Q34989372Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy
Q37023183Role of the medial prefrontal cortex in cataplexy.
Q39026723Roles for Orexin/Hypocretin in the Control of Energy Balance and Metabolism
Q35573219Roles of orexins in the regulation of feeding and arousal
Q40243643Running promotes wakefulness and increases cataplexy in orexin knockout mice
Q42706199Safety and efficacy of suvorexant during 1-year treatment of insomnia with subsequent abrupt treatment discontinuation: a phase 3 randomised, double-blind, placebo-controlled trial
Q40596148Screening for anti-ganglioside antibodies in hypocretin-deficient human narcolepsy
Q48585000Screening for candidate gene regions in narcolepsy using a microsatellite based approach and pooled DNA.
Q44132550Selective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons.
Q43878301Selective excitation of GABAergic neurons in the substantia nigra of the rat by orexin/hypocretin in vitro.
Q44158613Selective expression of Narp, a secreted neuronal pentraxin, in orexin neurons
Q37132728Selective loss of GABA(B) receptors in orexin-producing neurons results in disrupted sleep/wakefulness architecture.
Q34340556Serotonergic regulation of the orexin/hypocretin neurons through the 5-HT1A receptor.
Q43100830Serotonin neurons in the dorsal raphe mediate the anticataplectic action of orexin neurons by reducing amygdala activity
Q48542310Sexually dimorphic expression of prepro-orexin mRNA in the rat hypothalamus
Q36256296Shared genetic risk factors for obstructive sleep apnea and obesity.
Q37167156Shining light on wakefulness and arousal.
Q39684347Similar changes of hypothalamic feeding-regulating peptides mRNAs and plasma leptin levels in PTHrP-, LIF-secreting tumors-induced cachectic rats and adjuvant arthritic rats.
Q37667235Sleep Disorders: Is the Trigemino-Cardiac Reflex a Missing Link?
Q84538458Sleep and headache
Q91856650Sleep and neurological autoimmune diseases
Q34451399Sleep disorders, obesity, and aging: the role of orexin
Q35236639Sleep disturbances, psychiatric disorders, and psychotropic drugs
Q43107033Sleep dynamics beyond traditional sleep macrostructure
Q64889988Sleep homeostasis and the circadian clock: Do the circadian pacemaker and the sleep homeostat influence each other’s functioning?☆.
Q37897942Sleep neurobiology from a clinical perspective
Q37139539Sleep problems in children with neurological disorders
Q34500449Sleep related changes in blood pressure in hypocretin-deficient narcoleptic mice.
Q37822544Sleep state switching
Q36980414Sleep transitions in hypocretin-deficient narcolepsy
Q57817996Sleep-Wake Cycling and Energy Conservation: Role of Hypocretin and the Lateral Hypothalamus in Dynamic State-Dependent Resource Optimization
Q39193471Sleep-Wake Disturbances After Traumatic Brain Injury: Synthesis of Human and Animal Studies.
Q48673197Sleep-waking discharge patterns of neurons recorded in the rat perifornical lateral hypothalamic area
Q48473912Sleep/wake fragmentation disrupts metabolism in a mouse model of narcolepsy
Q35682954Sleep: a functional enigma
Q37999433Sleepiness that cannot be overcome: narcolepsy and cataplexy
Q48643470Somatotropic axis in hypocretin-deficient narcoleptic humans: altered circadian distribution of GH-secretory events
Q43130890Specificity of direct transition from wake to REM sleep in orexin/ataxin-3 transgenic narcoleptic mice
Q42005677Spontaneous reporting of suspected narcolepsy after vaccination against pandemic influenza A (H1N1) in Germany
Q34443676Suvorexant for the treatment of insomnia
Q31113697Suvorexant in Patients with Insomnia: Pooled Analyses of Three-Month Data from Phase-3 Randomized Controlled Clinical Trials
Q42723113Synaptic interactions between perifornical lateral hypothalamic area, locus coeruleus nucleus and the oral pontine reticular nucleus are implicated in the stage succession during sleep-wakefulness cycle
Q45941348Systemic and intrabasalis administration of the orexin-1 receptor antagonist, SB-334867, disrupts attentional performance in rats.
Q34730569Systemic and nasal delivery of orexin-A (Hypocretin-1) reduces the effects of sleep deprivation on cognitive performance in nonhuman primates.
Q38096025Systems level immune response analysis and personalized medicine
Q59069335T cells in patients with narcolepsy target self-antigens of hypocretin neurons
Q35783354TCRA, P2RY11, and CPT1B/CHKB associations in Chinese narcolepsy
Q48624856TNFA promoter polymorphisms and narcolepsy
Q47747609Temporal Changes in the Cerebrospinal Fluid Level of Hypocretin-1 and Histamine in Narcolepsy.
Q38546959The Brain Correlates of Laugh and Cataplexy in Childhood Narcolepsy.
Q64264112The Effects of Amphetamine and Methamphetamine on the Release of Norepinephrine, Dopamine and Acetylcholine From the Brainstem Reticular Formation
Q36310854The G protein-coupled receptors: pharmacogenetics and disease
Q35006664The Geneva brain collection
Q39052250The Hypocretin/Orexin Neuronal Networks in Zebrafish
Q47819498The Molecular Basis of Insomnia: Implication for Therapeutic Approaches
Q34502802The Neurobiology of Sleep and Wakefulness
Q47772845The Neuropeptide Orexin-A Inhibits the GABAA Receptor by PKC and Ca2+/CaMKII-Dependent Phosphorylation of Its β1 Subunit.
Q55603146The Orexin/Receptor System: Molecular Mechanism and Therapeutic Potential for Neurological Diseases.
Q27325381The anatomical distribution of genetic associations.
Q47869796The anatomical, cellular and synaptic basis of motor atonia during rapid eye movement sleep
Q30431335The autoimmune basis of narcolepsy
Q33157223The borderland of epilepsy: clinical and molecular features of phenomena that mimic epileptic seizures
Q43644936The central effects of orexin-A in the hypothalamic-pituitary-adrenal axis in vivo and in vitro in male rats
Q47731938The cnm locus, a canine homologue of human autosomal forms of centronuclear myopathy, maps to chromosome 2.
Q36094392The development of hypocretin (orexin) deficiency in hypocretin/ataxin-3 transgenic rats
Q64275015The development of hypocretin deficiency in narcolepsy type 1 can be swift and closely linked to symptom onset: clues from a singular case
Q48238574The distinct movement disorder in anti-NMDA receptor encephalitis may be related to Status Dissociatus: a hypothesis
Q33947805The diurnal rhythm of hypocretin in young and old F344 rats
Q36375246The dual orexin receptor antagonist almorexant induces sleep and decreases orexin-induced locomotion by blocking orexin 2 receptors
Q34993019The genetic and molecular regulation of sleep: from fruit flies to humans
Q35172453The genetics of sleep disorders
Q38115678The histaminergic network in the brain: basic organization and role in disease
Q36550599The human hypothalamus in metabolic and episodic disorders.
Q38173326The hypocretin system and psychiatric disorders
Q36985867The hypocretin/orexin receptor: therapeutic prospective in sleep disorders
Q24537243The hypocretin/orexin system
Q35182252The hypocretin/orexin system in health and disease
Q34357064The hypocretin/orexin system mediates the extinction of fear memories.
Q38231949The hypocretin/orexin system: an increasingly important role in neuropsychiatry.
Q36923729The hypocretins and the reward function: what have we learned so far?
Q37338664The hypocretins as sensors for metabolism and arousal.
Q26830704The hypocretins/orexins: integrators of multiple physiological functions
Q34623823The hypocretins: setting the arousal threshold
Q35172398The hypothalamus in episodic brain disorders
Q37405862The impact of gender on timeliness of narcolepsy diagnosis
Q37072638The integrative role of orexin/hypocretin neurons in nociceptive perception and analgesic regulation.
Q47675384The link between narcolepsy and autonomic cardiovascular dysfunction: a translational perspective.
Q55921579The locus coeruleus–noradrenergic system: modulation of behavioral state and state-dependent cognitive processes
Q34522821The mouse: genetics meets behaviour
Q48612846The narcoleptic borderland
Q48612827The narcoleptic borderland: a multimodal diagnostic approach including cerebrospinal fluid levels of hypocretin-1 (orexin A).
Q34575514The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness
Q90463916The neurobiological basis of narcolepsy
Q34770328The neurobiology of sleep: genetics, cellular physiology and subcortical networks
Q37802486The neurochemistry of awakening: findings from sleep disorder narcolepsy
Q46902600The orexin 1 receptor (HCRTR1) gene as a susceptibility gene contributing to polydipsia-hyponatremia in schizophrenia
Q34448938The orexin neuropeptide system: physical activity and hypothalamic function throughout the aging process.
Q35575085The orexin/hypocretin system: a critical regulator of neuroendocrine and autonomic function
Q35027209The other side of the orexins: endocrine and metabolic actions
Q83380687The pathophysiologic basis of secondary narcolepsy and hypersomnia
Q27500366The physiological role of orexin/hypocretin neurons in the regulation of sleep/wakefulness and neuroendocrine functions
Q34792771The physiology and pharmacology of the orexins
Q43471042The prevalence of narcolepsy among Chinese in Hong Kong.
Q27014741The regulation of sleep and wakefulness by the hypothalamic neuropeptide orexin/hypocretin
Q35689733The role of chronobiology in sleep disorders medicine
Q35018717The role of hypocretin in driving arousal and goal-oriented behaviors.
Q26851982The role of orexin in post-stroke inflammation, cognitive decline, and depression
Q90627522The signal peptide as a new target for drug design
Q34446039The sleep switch: hypothalamic control of sleep and wakefulness
Q44357295The wake-promoting hypocretin-orexin neurons are in an intrinsic state of membrane depolarization.
Q46448184The wake-promoting hypocretin/orexin neurons change their response to noradrenaline after sleep deprivation.
Q45240196The wake-promoting peptide orexin-B inhibits glutamatergic transmission to dorsal raphe nucleus serotonin neurons through retrograde endocannabinoid signaling.
Q48017568Time- and state-dependent analysis of autonomic control in narcolepsy: higher heart rate with normal heart rate variability independent of sleep fragmentation
Q34439846Timing and consolidation of human sleep, wakefulness, and performance by a symphony of oscillators
Q34668388To ingest or rest? Specialized roles of lateral hypothalamic area neurons in coordinating energy balance
Q47787222Trace Amine-Associated Receptor 1 Agonists as Narcolepsy Therapeutics
Q24532097Transplantation of hypocretin neurons into the pontine reticular formation: preliminary results
Q38828355Treatment Options for Narcolepsy
Q26771634Treatment paradigms for cataplexy in narcolepsy: past, present, and future
Q38533728Type 1 narcolepsy: a CD8(+) T cell-mediated disease?
Q36021334Understanding hereditary diseases using the dog and human as companion model systems
Q26795524Understanding how discrete populations of hypothalamic neurons orchestrate complicated behavioral states
Q28750452Unearthing the phylogenetic roots of sleep
Q90026112Update on narcolepsy
Q42262683Using magnetic resonance spectroscopy in narcolepsy to study the limbic mechanisms of cataplexy
Q33635419Validation of the ICSD-2 criteria for CSF hypocretin-1 measurements in the diagnosis of narcolepsy in the Danish population.
Q34013921Variant between CPT1B and CHKB associated with susceptibility to narcolepsy
Q36712995Vesicular glutamate (VGlut), GABA (VGAT), and acetylcholine (VACht) transporters in basal forebrain axon terminals innervating the lateral hypothalamus
Q42512060Wake-promoting and sleep-suppressing actions of hypocretin (orexin): basal forebrain sites of action
Q34395431Wakefulness: an eye-opening perspective on orexin neurons
Q30434168Why trypanosomes cause sleeping sickness.
Q92420144Widespread white matter connectivity abnormalities in narcolepsy type 1: A diffusion tensor imaging study
Q77727443[Narcolepsy and epidural obstetrical analgesia ]
Q79334194[Narcoleptic dogs. Significance for human narcolepsy]
Q51973350[Normal and disordered sleep]
Q51976629[The neurology of REM sleep. A synoptic tour de force].
Q79935836[The neurotransmitter, hypocretin. An overview]

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