Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver

scientific article (publication date: 8 February 2001)

Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver is …
instance of (P31):
scholarly articleQ13442814

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P6179Dimensions Publication ID1018096384
P356DOI10.1038/35055575
P3181OpenCitations bibliographic resource ID1630725
P698PubMed publication ID11217863

P50authorBarbara KahnQ60572402
Gerald I. ShulmanQ52509909
E. Dale AbelQ59100279
P2093author name stringY B Kim
J K Kim
O Boss
E Hadro
T Minnemann
O Peroni
P2860cites workMechanism of insulin resistance in A-ZIP/F-1 fatless miceQ73561042
Free fatty acid-induced insulin resistance is associated with activation of protein kinase C theta and alterations in the insulin signaling cascadeQ77795070
Cardiac hypertrophy with preserved contractile function after selective deletion of GLUT4 from the heartQ24562618
Generalized lacZ expression with the ROSA26 Cre reporter strainQ27860837
Impaired glucose transport as a cause of decreased insulin-stimulated muscle glycogen synthesis in type 2 diabetesQ28369463
Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4Q28507095
Applications of NMR spectroscopy to study muscle glycogen metabolism in man.Q33540275
Glucose transporters and insulin action--implications for insulin resistance and diabetes mellitusQ33691309
Effects of free fatty acids on glucose transport and IRS-1-associated phosphatidylinositol 3-kinase activityQ33834971
A fat-specific enhancer is the primary determinant of gene expression for adipocyte P2 in vivoQ33923356
Influence of dietary fat composition on development of insulin resistance in rats. Relationship to muscle triglyceride and omega-3 fatty acids in muscle phospholipidQ35013075
Disruption of overlapping transcripts in the ROSA beta geo 26 gene trap strain leads to widespread expression of beta-galactosidase in mouse embryos and hematopoietic cellsQ36105573
Fiber type- and position-dependent expression of a myosin light chain-CAT transgene detected with a novel histochemical stain for CATQ36530391
Acute intravenous leptin infusion increases glucose turnover but not skeletal muscle glucose uptake in ob/ob miceQ38324346
Tumor necrosis factor alpha: a key component of the obesity-diabetes linkQ40632844
Role of fatty acids in the pathogenesis of insulin resistance and NIDDM.Q41275648
Targeted disruption of the glucose transporter 4 selectively in muscle causes insulin resistance and glucose intolerance.Q52540333
Glucosamine infusion in rats rapidly impairs insulin stimulation of phosphoinositide 3-kinase but does not alter activation of Akt/protein kinase B in skeletal muscle.Q54095661
Leptin Directly Alters Lipid Partitioning in Skeletal MuscleQ59515980
P433issue6821
P407language of work or nameEnglishQ1860
P921main subjectpreproinsulinQ7240673
P304page(s)729-733
P577publication date2001-02-01
P1433published inNatureQ180445
P1476titleAdipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver
P478volume409

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Q36248058Mechanistic connections between glucose/lipid disturbances and weight gain induced by antipsychotic drugs
Q47242519Melatonin improves insulin sensitivity independently of weight loss in old obese rats.
Q44936599Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice.
Q38970822Metabolic adaptations in the adipose tissue that underlie the body fat mass gain in middle-aged rats
Q92701392Metabolic and Epigenetic Action Mechanisms of Antidiabetic Medicinal Plants
Q35743894Metabolic consequences of ENPP1 overexpression in adipose tissue.
Q36299339Metabolic diseases and pro- and prebiotics: Mechanistic insights
Q47554905Metabolic effects of resistance or high-intensity interval training among glycemic control-nonresponsive children with insulin resistance
Q40427802Metabolic fuel selection: the importance of being flexible
Q34031701Metabolic syndrome and insulin resistance: underlying causes and modification by exercise training
Q38066238Metabolic syndrome in youth: current insights and novel serum biomarkers
Q46611086Metabolism: A is for adipokine
Q57734357Metabolism: Targeting a fat-accumulation gene
Q38769689Metabolomics and Metabolic Diseases: Where Do We Stand?
Q28589946Mice deficient in the insulin-regulated membrane aminopeptidase show substantial decreases in glucose transporter GLUT4 levels but maintain normal glucose homeostasis
Q35932403MicroRNA-223 Expression is Upregulated in Insulin Resistant Human Adipose Tissue
Q60950122MicroRNAs as Regulators of Insulin Signaling: Research Updates and Potential Therapeutic Perspectives in Type 2 Diabetes
Q38315463Mitochondria are impaired in the adipocytes of type 2 diabetic mice
Q38171425Mitochondria in metabolic disease: getting clues from proteomic studies.
Q48103576Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.
Q39698741Mitochondrial biogenesis and remodeling during adipogenesis and in response to the insulin sensitizer rosiglitazone
Q42827734Mitochondrial dysfunction leads to impairment of insulin sensitivity and adiponectin secretion in adipocytes
Q34214978Mitogen-activated protein kinase-activated protein kinase 2 deficiency reduces insulin sensitivity in high-fat diet-fed mice
Q37015037Moderate GLUT4 overexpression improves insulin sensitivity and fasting triglyceridemia in high-fat diet-fed transgenic mice
Q28081094Modulation of glucose transporter protein by dietary flavonoids in type 2 diabetes mellitus
Q28551738Modulation of microRNA Expression in Subjects with Metabolic Syndrome and Decrease of Cholesterol Efflux from Macrophages via microRNA-33-Mediated Attenuation of ATP-Binding Cassette Transporter A1 Expression by Statins
Q47343834Molecular adaptations of adipose tissue to 6 weeks of morning fasting vs. daily breakfast consumption in lean and obese adults
Q34655565Molecular insights into insulin action and secretion
Q38261084Molecular mechanisms for the regulation of insulin-stimulated glucose uptake by small guanosine triphosphatases in skeletal muscle and adipocytes
Q37578545Molecular mechanisms involved in obesity-associated insulin resistance: therapeutical approach.
Q26823125Molecular mechanisms of GLUT4 regulation in adipocytes
Q34420707Molecular mechanisms of insulin resistance
Q35668766Molecular motor proteins of the kinesin superfamily proteins (KIFs): structure, cargo and disease
Q38661391Molecular physiopathology of obesity-related diseases: multi-organ integration by GRK2.
Q34393612Morbidity of severe obesity
Q35762322Mouse models of insulin resistance and type 2 diabetes
Q62729690Muscle and adipose tissue insulin resistance: malady without mechanism?
Q36040443Muscle-specific 4E-BP1 signaling activation improves metabolic parameters during aging and obesity
Q37101078Naringenin inhibits adipogenesis and reduces insulin sensitivity and adiponectin expression in adipocytes
Q40648169Naringenin inhibits phosphoinositide 3-kinase activity and glucose uptake in 3T3-L1 adipocytes
Q35126982Naturally occurring compensated insulin resistance selectively alters glucose transporters in visceral and subcutaneous adipose tissues without change in AS160 activation
Q90264211Neferine Promotes GLUT4 Expression and Fusion With the Plasma Membrane to Induce Glucose Uptake in L6 Cells
Q42627298Neural relay from the liver induces proliferation of pancreatic beta cells: a path to regenerative medicine using the self-renewal capabilities
Q44796631Neurohumoral regulation of body weight gain
Q47329751Neuronal PTP1B regulates body weight, adiposity and leptin action.
Q35711985New insights into the integrated physiology of insulin action
Q33935130Nicotinamide N-methyltransferase knockdown protects against diet-induced obesity.
Q39112796Nitrite augments glucose uptake in adipocytes through the protein kinase A-dependent stimulation of mitochondrial fusion.
Q37149405Nonalcoholic fatty liver disease: an overview of current insights in pathogenesis, diagnosis and treatment
Q79437776Novel findings regarding Glut-4 expression in adipose tissue and muscle in horses--a preliminary report
Q24314731Novel repressor regulates insulin sensitivity through interaction with Foxo1
Q45086880Nutrient sensor links obesity with diabetes risk
Q35806814Obesity Resistance and Enhanced Insulin Sensitivity in Ahnak-/- Mice Fed a High Fat Diet Are Related to Impaired Adipogenesis and Increased Energy Expenditure
Q61217312Obesity and Glucose Metabolism
Q44912996Obesity in insulin receptor substrate-2-deficient mice: disrupted control of arcuate nucleus neuropeptides
Q30415102Obesity, systemic inflammation, and increased risk for cardiovascular disease and diabetes among adolescents: a need for screening tools to target interventions
Q28304481Obesity: the two faces of fat
Q42823980Olf-1/early B cell factor is a regulator of glut4 gene expression in 3T3-L1 adipocytes
Q38345848Opposing effects of dietary sugar and saturated fat on cardiovascular risk factors and glucose metabolism in mitochondrially impaired mice
Q93035004Optimizing adipogenic transdifferentiation of bovine mesenchymal stem cells: a prominent role of ascorbic acid in FABP4 induction
Q35200033PPARgamma and metabolism: insights from the study of human genetic variants
Q46051852Pancreas-specific Pten deficiency causes partial resistance to diabetes and elevated hepatic AKT signaling
Q42205947Parathyroid hormone suppresses insulin signaling in adipocytes.
Q34594888Partial inhibition of adipose tissue lipolysis improves glucose metabolism and insulin sensitivity without alteration of fat mass
Q44536348Peripheral insulin resistance develops in transgenic rats overexpressing phosphoenolpyruvate carboxykinase in the kidney
Q27022953Phosphoinositides: Key modulators of energy metabolism
Q36737524Phosphorylation of CCAAT/enhancer-binding protein alpha regulates GLUT4 expression and glucose transport in adipocytes
Q52629909Phthalate is associated with insulin resistance in adipose tissue of male rat: role of antioxidant vitamins.
Q37736477Physiological insights gained from gene expression analysis in obesity and diabetes
Q38112779Phytochemicals targeting genes relevant for type 2 diabetes
Q44003960Plasma leptin concentrations are independently associated with insulin sensitivity in lean and overweight cats
Q57806914Polysaccharide Improves Insulin Sensitivity via AMPK Activation in 3T3-L1 Adipocytes
Q45979834Possible contribution of the non-proteolytic activation of prorenin to the development of insulin resistance in fructose-fed rats.
Q48065425Potential role for purple acid phosphatase in the dephosphorylation of wall proteins in tobacco cells.
Q28486189Prenatal metformin exposure in mice programs the metabolic phenotype of the offspring during a high fat diet at adulthood
Q44007740Prevalence of obesity in a Canarian community. Association with type 2 diabetes mellitus: the Guía Study.
Q57061865Preventative effects of resveratrol and estradiol on streptozotocin-induced diabetes in ovariectomized mice and the related mechanisms
Q47148579Promoting Glucose Transporter-4 Vesicle Trafficking along Cytoskeletal Tracks: PAK-Ing Them Out.
Q41189607Propionic acid and butyric acid inhibit lipolysis and de novo lipogenesis and increase insulin-stimulated glucose uptake in primary rat adipocytes
Q38656791Prospective Relation of Circulating Adipokines to Incident Metabolic Syndrome: The Framingham Heart Study
Q41443354Protection against High-Fat-Diet-Induced Obesity in MDM2C305F Mice Due to Reduced p53 Activity and Enhanced Energy Expenditure.
Q53745498Pu'erh tea extract-mediated protection against hepatosteatosis and insulin resistance in mice with diet-induced obesity is associated with the induction of de novo lipogenesis in visceral adipose tissue.
Q27305401Putative regulatory factors associated with intramuscular fat content
Q45145892Quantitative genetic analysis of glucose transporter 4 mRNA levels in baboon adipose
Q42818276RBP4 functions as a hepatokine in the regulation of glucose metabolism by the circadian clock in mice
Q46883044RBP4, an unexpected adipokine
Q34068389Rab5 activity regulates GLUT4 sorting into insulin-responsive and non-insulin-responsive endosomal compartments: a potential mechanism for development of insulin resistance
Q26801347Redox implications in adipose tissue (dys)function--A new look at old acquaintances
Q35237833Reduced Slc2a4/GLUT4 expression in subcutaneous adipose tissue of monosodium glutamate obese mice is recovered after atorvastatin treatment
Q37583680Reduced Socs3 expression in adipose tissue protects female mice against obesity-induced insulin resistance.
Q28207189Reduced expression of PGC-1 and insulin-signaling molecules in adipose tissue is associated with insulin resistance
Q28511723Reduced expression of mitochondrial frataxin in mice exacerbates diet-induced obesity
Q38874154Regulation of GLUT4 and Insulin-Dependent Glucose Flux
Q41869580Regulation of GLUT4 gene expression by SREBP-1c in adipocytes
Q33602767Regulation of Microvascular Function by Adipose Tissue in Obesity and Type 2 Diabetes: Evidence of an Adipose-Vascular Loop
Q38012259Regulation of glucose transport by insulin: traffic control of GLUT4.
Q36059564Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes
Q44509772Requirement for 3-phosphoinositide-kependent dinase-1 (PDK-1) in insulin-induced glucose uptake in immortalized brown adipocytes
Q34467053Resistin and obesity-associated insulin resistance
Q55340404Response to Comment on: Kumar et al. Fat Cell–Specific Ablation of Rictor in Mice Impairs Insulin-Regulated Fat Cell and Whole-Body Glucose and Lipid Metabolism. Diabetes 2010;59:1397–1406.
Q35944715Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits
Q35126137Retinol binding protein 4 concentrations relate to enhanced atherosclerosis in obese patients with rheumatoid arthritis
Q46867117Retinol binding protein 4, low birth weight-related insulin resistance and hormonal contraception
Q37304116Retinol binding protein: marker for insulin resistance and inflammation postburn?
Q91566797Retinol-binding protein 4, fetal overgrowth and fetal growth factors
Q37206162Retinol-binding protein-4 in experimental and clinical metabolic disease
Q37695777Reversible transdifferentiation of secretory epithelial cells into adipocytes in the mammary gland
Q38194819Rho GTPases in insulin-stimulated glucose uptake
Q37097807Role of mitochondrial dysfunction in insulin resistance
Q36197966Role of monosaccharide transport proteins in carbohydrate assimilation, distribution, metabolism, and homeostasis
Q28587094Role of the fatty acid binding protein mal1 in obesity and insulin resistance
Q37063757SEC16A is a RAB10 effector required for insulin-stimulated GLUT4 trafficking in adipocytes
Q36325236SENP1-mediated NEMO deSUMOylation in adipocytes limits inflammatory responses and type-1 diabetes progression
Q42355569SWELL1 is a regulator of adipocyte size, insulin signalling and glucose homeostasis
Q50961758Screening strategy to generate cell specific recombination: a case report with the RIP-Cre mice.
Q35922882Selective enhancement of insulin sensitivity in the mature adipocyte is sufficient for systemic metabolic improvements
Q50722545Selective expression of an aP2/Fatty Acid Binding Protein 4-Cre transgene in non-adipogenic tissues during embryonic development.
Q35560991Selective insulin resistance in adipocytes
Q39004526Selenium-enriched exopolysaccharides improve skeletal muscle glucose uptake of diabetic KKAy mice via AMPK pathway.
Q42799047Serum amyloid A attenuates cellular insulin sensitivity by increasing JNK activity in 3T3-L1 adipocytes
Q24309211Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes
Q99710690Sex dimorphism in the associations of gestational diabetes with cord blood adiponectin and retinol-binding protein 4
Q34548524Signals of adiposity
Q34149544Single-cell analysis of insulin-regulated fatty acid uptake in adipocytes
Q33734293Skeletal muscle insulin resistance in endocrine disease
Q44639866Skeletal muscle insulin resistance: is it important for the pathogenesis of type 2 diabetes after all?
Q37463518Skeletal muscle insulin resistance: the interplay of local lipid excess and mitochondrial dysfunction.
Q34500390Sleep duration and circulating adipokine levels.
Q41889248Sortilin and retromer mediate retrograde transport of Glut4 in 3T3-L1 adipocytes
Q37039638Spatio-temporal analysis of type 2 diabetes mellitus based on differential expression networks.
Q49647329Spatiotemporal Control of Acetyl-CoA Metabolism in Chromatin Regulation.
Q33655562Spatiotemporal Regulators for Insulin-Stimulated GLUT4 Vesicle Exocytosis
Q37098751Specialized sorting of GLUT4 and its recruitment to the cell surface are independently regulated by distinct Rabs
Q35179254Statin use and risk of diabetes mellitus
Q28771347Stimulation of glucose transport by semicarbazide-sensitive amine oxidase activity in adipocytes from diabetic rats
Q42175860Stress augments insulin resistance and prothrombotic state: role of visceral adipose-derived monocyte chemoattractant protein-1.
Q24535742Suppression of oxidative metabolism and mitochondrial biogenesis by the transcriptional corepressor RIP140 in mouse adipocytes.
Q35173880Suppression of the C/EBP family of transcription factors in adipose tissue causes lipodystrophy
Q35006572TNF-alpha and adipocyte biology
Q29347249TUSC5 regulates insulin-mediated adipose tissue glucose uptake by modulation of GLUT4 recycling
Q42935430Tamoxifen-inducible Cre-mediated recombination in adipocytes
Q26748559Targeting cAMP/PKA pathway for glycemic control and type 2 diabetes therapy
Q91711371Tautomerase Activity-Lacking of the Macrophage Migration Inhibitory Factor Alleviates the Inflammation and Insulin Tolerance in High Fat Diet-Induced Obese Mice
Q37008240Technology Insight: small, noncoding RNA molecules as tools to study and treat endocrine diseases
Q36604099Terminal Galactosylation and Sialylation Switching on Membrane Glycoproteins upon TNF-Alpha-Induced Insulin Resistance in Adipocytes
Q40300384The Genetic Basis of Type 2 Diabetes.
Q95852906The Glucose Lowering Effect of Zornia gibbosa Span Extracts in Diabetic Rats
Q42945471The Gordon Wilson Lecture. Lessons about the control of glucose homeostasis and the pathogenesis of diabetes from knockout mice.
Q38410928The Hypoxia-Inducible Factor Pathway in Adipocytes: The Role of HIF-2 in Adipose Inflammation and Hypertrophic Cardiomyopathy
Q28585457The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4
Q90720544The Regulation of Lipokines by Environmental Factors
Q90567530The Role of Adipose Tissue Mitochondria: Regulation of Mitochondrial Function for the Treatment of Metabolic Diseases
Q33926133The SLC2 (GLUT) family of membrane transporters
Q28204545The SLC2 family of facilitated hexose and polyol transporters
Q36719299The adipose cell lineage is not intrinsically insulin resistant in polycystic ovary syndrome
Q37857051The allenic carotenoid fucoxanthin, a novel marine nutraceutical from brown seaweeds
Q28084054The cell biology of fat expansion
Q37991199The cellular and signaling networks linking the immune system and metabolism in disease
Q35499600The differential role of Hif1β/Arnt and the hypoxic response in adipose function, fibrosis, and inflammation
Q44659829The metabolic syndrome and type 2 diabetes: role of the adipocyte
Q36430696The pathogenesis of insulin resistance: integrating signaling pathways and substrate flux
Q35727731The physiological role of resistin and its connection with metabolic diseases
Q38323251The polygenetically inherited metabolic syndrome of WOKW rats is associated with insulin resistance and altered gene expression in adipose tissue
Q34572292The role of AEBP1 in sex-specific diet-induced obesity
Q36660574The role of GH in adipose tissue: lessons from adipose-specific GH receptor gene-disrupted mice
Q42818947The role of adipose tissue asymmetric dimethylarginine/dimethylarginine dimethylaminohydrolase pathway in adipose tissue phenotype and metabolic abnormalities in subtotally nephrectomized rats
Q34984896The role of endothelial insulin signaling in the regulation of vascular tone and insulin resistance
Q35154081The role of the Niemann-Pick disease, type C1 protein in adipocyte insulin action.
Q37270420The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey
Q93147070Therapeutic Mechanisms of Herbal Medicines Against Insulin Resistance: A Review
Q37628285Tissue Non-Specific Genes and Pathways Associated with Diabetes: An Expression Meta-Analysis
Q34076176Tissue-specific insulin signaling in the regulation of metabolism and aging
Q24629603Tissue-specific overexpression of lipoprotein lipase causes tissue-specific insulin resistance
Q35080579Tissue-specific targeting of the insulin receptor gene
Q47423025Topical insulin accelerates cutaneous wound healing in insulin-resistant diabetic rats
Q92765807Transcriptional and Epigenomic Regulation of Adipogenesis
Q34713714Transcriptional control of adipose lipid handling by IRF4
Q92376987Transcriptome Changes of Skeletal Muscle RNA-Seq Speculates the Mechanism of Postprandial Hyperglycemia in Diabetic Goto-Kakizaki Rats During the Early Stage of T2D
Q35835529Transgenic rescue of insulin receptor-deficient mice
Q55401329Triphala, Regulates Adipogenesis through Modulation of Expression of Adipogenic Genes in 3T3-L1 Cell Line.
Q42828385Tumor necrosis factor alpha (TNFalpha) stimulates Map4k4 expression through TNFalpha receptor 1 signaling to c-Jun and activating transcription factor 2.
Q30352122Twenty-five years since the discovery of endothelium-derived relaxing factor (EDRF): does a dysfunctional endothelium contribute to the development of type 2 diabetes?
Q47332713UCP1 deficiency increases adipose tissue monounsaturated fatty acid synthesis and trafficking to the liver
Q36140136Urinary Retinol-Binding Protein: Relationship to Renal Function and Cardiovascular Risk Factors in Chronic Kidney Disease
Q28543943Ursolic acid increases glucose uptake through the PI3K signaling pathway in adipocytes
Q36089381Use of GLUT-4 null mice to study skeletal muscle glucose uptake
Q37826464Use of mouse models in studying type 2 diabetes mellitus
Q46911440Vascularized tissue-engineered chambers promote survival and function of transplanted islets and improve glycemic control
Q43090421Virgin coconut oil maintains redox status and improves glycemic conditions in high fructose fed rats
Q34591540Vitamin A metabolism: an update
Q64890764Weighing In on mTOR Complex 2 Signaling: The Expanding Role in Cell Metabolism.
Q35172969Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA
Q91286750iTRAQ-Based Quantitative Proteomic Comparison of 2D and 3D Adipocyte Cell Models Co-cultured with Macrophages Using Online 2D-nanoLC-ESI-MS/MS
Q36661907miR-155 Deletion in Female Mice Prevents Diet-Induced Obesity
Q37015090miRNA-93 inhibits GLUT4 and is overexpressed in adipose tissue of polycystic ovary syndrome patients and women with insulin resistance
Q37583969n-3 PUFA: bioavailability and modulation of adipose tissue function.

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