Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha

scientific article published on 11 September 2003

Expression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1074/JBC.M302287200
P698PubMed publication ID12970362
P5875ResearchGate publication ID10571478

P50authorJan-Åke GustafssonQ5777769
P2093author name stringKnut Tomas Dalen
Hilde I Nebb
Stine Marie Ulven
Krister Bamberg
P2860cites workMolecular recognition of fatty acids by peroxisome proliferator-activated receptorsQ22009367
Role of LXRs in control of lipogenesisQ24290548
Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathwayQ24316367
LXR, a nuclear receptor that defines a distinct retinoid response pathwayQ24317347
LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytesQ24548189
Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoterQ24550969
Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptorsQ24562732
OR-1, a member of the nuclear receptor superfamily that interacts with the 9-cis-retinoic acid receptorQ24563731
Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbetaQ24598068
A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamilyQ24609094
Hepatic cholesterol metabolism and resistance to dietary cholesterol in LXRbeta-deficient miceQ24681140
Human white/murine ABC8 mRNA levels are highly induced in lipid-loaded macrophages. A transcriptional role for specific oxysterolsQ28143718
PPARγ Is Required for the Differentiation of Adipose Tissue In Vivo and In VitroQ28146187
A PPAR gamma-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesisQ28199913
Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liverQ28202134
Characterization of a human preadipocyte cell strain with high capacity for adipose differentiationQ28204416
Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptorsQ28215527
The mechanisms of action of PPARsQ28216953
Cholesterol and bile acid metabolism are impaired in mice lacking the nuclear oxysterol receptor LXR alphaQ28273937
An oxysterol signalling pathway mediated by the nuclear receptor LXR alphaQ28294042
Liver X receptors as insulin-mediating factors in fatty acid and cholesterol biosynthesisQ28568747
15-Deoxy-delta 12, 14-prostaglandin J2 is a ligand for the adipocyte determination factor PPAR gammaQ29615221
An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)Q29615693
mPPAR gamma 2: tissue-specific regulator of an adipocyte enhancerQ29617271
GLUT4--at the cross roads between membrane trafficking and signal transductionQ32029923
PPARgamma, the ultimate thrifty geneQ33711175
Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytesQ33852762
Sterol upregulation of human CETP expression in vitro and in transgenic mice by an LXR elementQ33939047
Autoregulation of the human liver X receptor alpha promoterQ34012691
Microarray analyses during adipogenesis: understanding the effects of Wnt signaling on adipogenesis and the roles of liver X receptor alpha in adipocyte metabolismQ34284209
Tissue distribution and quantification of the expression of mRNAs of peroxisome proliferator-activated receptors and liver X receptor-alpha in humans: no alteration in adipose tissue of obese and NIDDM patientsQ34433361
Pretranslational suppression of a glucose transporter protein causes insulin resistance in adipocytes from patients with non-insulin-dependent diabetes mellitus and obesityQ35820541
Evidence that insulin causes translocation of glucose transport activity to the plasma membrane from an intracellular storage siteQ36387605
PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytesQ37376857
Repeat treatment of obese mice with BRL 49653, a new potent insulin sensitizer, enhances insulin action in white adipocytes. Association with increased insulin binding and cell-surface GLUT4 as measured by photoaffinity labeling.Q38292064
An efficient method for simultaneous isolation of biologically active transcription factors and DNA.Q40912739
Unique requirements for retinoid-dependent transcriptional activation by the orphan receptor LXR.Q41130960
On the role of liver X receptors in lipid accumulation in adipocytesQ42805825
Accumulation of foam cells in liver X receptor-deficient miceQ44114728
Antidiabetic action of a liver x receptor agonist mediated by inhibition of hepatic gluconeogenesis.Q44203895
Thiazolidinediones and their effects on glucose transporters.Q45983641
Cross-talk between fatty acid and cholesterol metabolism mediated by liver X receptor-alpha.Q51556346
Decreased expression of the insulin-responsive glucose transporter in diabetes and fasting.Q51620236
Glucose transport deficiency in diabetic animals is corrected by treatment with the oral antihyperglycemic agent pioglitazone.Q54287151
Pretranslational suppression of an insulin-responsive glucose transporter in rats with diabetes mellitus.Q54348903
P433issue48
P407language of work or nameEnglishQ1860
P921main subjectadipocyteQ357519
preproinsulinQ7240673
P304page(s)48283-48291
P577publication date2003-09-11
P1433published inJournal of Biological ChemistryQ867727
P1476titleExpression of the insulin-responsive glucose transporter GLUT4 in adipocytes is dependent on liver X receptor alpha
P478volume278

Reverse relations

cites work (P2860)
Q27677636(+)-Rutamarin as a Dual Inducer of Both GLUT4 Translocation and Expression Efficiently Ameliorates Glucose Homeostasis in Insulin-Resistant Mice
Q92862273A Crosstalk Between Brain Cholesterol Oxidation and Glucose Metabolism in Alzheimer's Disease
Q36710181Activating signal cointegrator-2 is an essential adaptor to recruit histone H3 lysine 4 methyltransferases MLL3 and MLL4 to the liver X receptors
Q24302119Activation of LXR increases acyl-CoA synthetase activity through direct regulation of ACSL3 in human placental trophoblast cells
Q42812928Activation of liver X receptors prevents statin-induced death of 3T3-L1 preadipocytes
Q33750684Acute inhibition of fatty acid import inhibits GLUT4 transcription in adipose tissue, but not skeletal or cardiac muscle tissue, partly through liver X receptor (LXR) signaling
Q39593888CIDEA interacts with liver X receptors in white fat cells
Q50772546Can the liver X receptor work its magic in skeletal muscle too?
Q42583421Cardiac LXRα protects against pathological cardiac hypertrophy and dysfunction by enhancing glucose uptake and utilization
Q27313235Cold Exposure Improves the Anti-diabetic Effect of T0901317 in Streptozotocin-Induced Diabetic Mice.
Q33608251Coordinated Actions of FXR and LXR in Metabolism: From Pathogenesis to Pharmacological Targets for Type 2 Diabetes
Q41137063Coronary heart disease: Significance of liver X receptor α genomics
Q91297642Defective fasting-induced PKA activation impairs adipose tissue glycogen degradation in obese Zucker rats
Q36724871Effects of liver X receptor agonist treatment on pulmonary inflammation and host defense.
Q40108190Elk1 and SRF transcription factors convey basal transcription and mediate glucose response via their binding sites in the human LXRB gene promoter
Q36322805Emerging role of liver X receptors in cardiac pathophysiology and heart failure
Q35153983Expression of Caveolin 1 is enhanced by DNA demethylation during adipocyte differentiation. status of insulin signaling
Q61813678Expression of NR1H3 in endometrial carcinoma and its effect on the proliferation of Ishikawa cells in vitro
Q42130623Fatty acids regulate perilipin5 in muscle by activating PPARδ
Q33418960Functional and genetic analysis in type 2 diabetes of liver X receptor alleles--a cohort study
Q34110886Gene expression profiles of a mouse congenic strain carrying an obesity susceptibility QTL under obesigenic diets
Q33774706Genetic and genomic analysis of hyperlipidemia, obesity and diabetes using (C57BL/6J × TALLYHO/JngJ) F2 mice
Q42797573Glucose availability controls adipogenesis in mouse 3T3-L1 adipocytes via upregulation of nicotinamide metabolism
Q39366921Immunometabolic Signaling Pathways Contribute to Macrophage and Dendritic Cell Function.
Q45205488Improved insulin sensitivity and adipose tissue dysregulation after short-term treatment with pioglitazone in non-diabetic, insulin-resistant subjects
Q37200875Interrelationship between liver X receptor alpha, sterol regulatory element-binding protein-1c, peroxisome proliferator-activated receptor gamma, and small heterodimer partner in the transcriptional regulation of glucokinase gene expression in liver
Q42439932LXR is a negative regulator of glucose uptake in human adipocytes
Q34428893LXRβ is required for glucocorticoid-induced hyperglycemia and hepatosteatosis in mice.
Q37597310Liver X Receptor: Crosstalk Node for the Signaling of Lipid Metabolism, Carbohydrate Metabolism, and Innate Immunity
Q34452575Liver X receptor (LXR) regulates human adipocyte lipolysis
Q34579301Liver X receptor agonist treatment attenuates cardiac dysfunction in type 2 diabetic db/db mice
Q42503440Liver X receptor agonists ameliorate TNFalpha-induced insulin resistance in murine brown adipocytes by downregulating protein tyrosine phosphatase-1B gene expression
Q46988057Liver X receptor alpha and beta genes have the potential role on loin lean and fat content in pigs
Q33314702Liver X receptor alpha is a transcriptional repressor of the uncoupling protein 1 gene and the brown fat phenotype.
Q80695266Liver X receptor antagonist reduces lipid formation and increases glucose metabolism in myotubes from lean, obese and type 2 diabetic individuals
Q36460531Liver X receptors and fat cell metabolism
Q36411128Liver X receptors as integrators of metabolic and inflammatory signaling
Q51471193Liver X receptors regulate de novo lipogenesis in a tissue-specific manner in C57BL/6 female mice.
Q46919681Major quantitative trait locus on chromosome 2 for glucose tolerance in diabetic SMXA-5 mouse established from non-diabetic SM/J and A/J strains
Q34572847Mechanisms underlying regulation of the expression and activities of the mammalian pyruvate dehydrogenase kinases
Q33642516Minireview: liver X receptor beta: emerging roles in physiology and diseases
Q40153263Molecular basis for repression of liver X receptor-mediated gene transcription by receptor-interacting protein 140.
Q37578545Molecular mechanisms involved in obesity-associated insulin resistance: therapeutical approach.
Q46556309Musclin inhibits insulin activation of Akt/protein kinase B in rat skeletal muscle
Q42779812Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1.
Q38123210Oxysterol receptors and their therapeutic applications in cancer conditions.
Q45424887Paeoniflorin acts as a liver X receptor agonist
Q38314419Reciprocal regulation of hepatic and adipose lipogenesis by liver X receptors in obesity and insulin resistance
Q28289678Regulation of ADRP expression by long-chain polyunsaturated fatty acids in BeWo cells, a human placental choriocarcinoma cell line
Q33817442Regulation of insulin resistance and adiponectin signaling in adipose tissue by liver X receptor activation highlights a cross-talk with PPARγ.
Q36561080Regulatory circuits controlling white versus brown adipocyte differentiation
Q36059564Repression of GLUT4 expression by the endoplasmic reticulum stress response in 3T3-L1 adipocytes
Q42824457Resistin expression in 3T3-L1 adipocytes is reduced by arachidonic acid.
Q47138540Skeletal muscle IL-6 regulates muscle substrate utilization and adipose tissue metabolism during recovery from an acute bout of exercise
Q41918965Structure and activity of the human growth hormone receptor (hGHR) gene V2 promoter
Q33715779Suggestive evidence of associations between liver X receptor β polymorphisms with type 2 diabetes mellitus and obesity in three cohort studies: HUNT2 (Norway), MONICA (France) and HELENA (Europe).
Q64111534The Antagonist Effect of Arachidonic Acid on Gene Expression by Nuclear Receptor Type II Regulation
Q42506312The liver X receptor agonist T0901317 protects mice from high fat diet-induced obesity and insulin resistance
Q24677585The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor
Q42465725Tissue-specific autoregulation of the LXRalpha gene facilitates induction of apoE in mouse adipose tissue
Q36683297Transcriptional integration of metabolism by the nuclear sterol-activated receptors LXR and FXR.
Q35172969Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA
Q85250133[New pathophysiological mechanisms of metabolic syndrome: implication of orphan nuclear receptors?]
Q53261375[Oxysterols: metabolism, biological role and associated diseases].

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