A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission

scientific article

A designed point mutant in Fis1 disrupts dimerization and mitochondrial fission is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1016/J.JMB.2012.06.042
P932PMC publication ID3456991
P698PubMed publication ID22789569
P5875ResearchGate publication ID229080638

P2093author name stringJohn M Flanagan
Karen G Fleming
Cara Marie Manlandro
R Blake Hill
Salvador Casares
Lora K Picton
Jonathan P B Lees
Alexandra Z Ebie Tan
P2860cites workBcl-x(L) sequesters its C-terminal membrane anchor in soluble, cytosolic homodimersQ24292693
The dynamin-like GTPase DLP1 is essential for peroxisome division and is recruited to peroxisomes in part by PEX11Q24296804
Spatial and temporal dynamics of budding yeast mitochondria lacking the division component Fis1pQ44392782
Intra- and intermolecular domain interactions of the C-terminal GTPase effector domain of the multimeric dynamin-like GTPase Drp1.Q47316458
Biochemistry. Metamorphic proteinsQ47610431
Insights into the conformational dynamics of the E3 ubiquitin ligase CHIP in complex with chaperones and E2 enzymes.Q51560326
Fis1p and Caf4p, but not Mdv1p, determine the polar localization of Dnm1p clusters on the mitochondrial surface.Q52572070
BCL-XL dimerization by three-dimensional domain swapping.Q53964467
The effect of point mutations on the free energy of transmembrane alpha-helix dimerization.Q54558747
Heat-Induced Dimerization of BCL-xLthrough α-Helix Swapping†Q57266759
Observation of signal transduction in three-dimensional domain swappingQ57838465
When one and one are not twoQ71727027
EQUILIBRIUM ULTRACENTRIFUGATION OF DILUTE SOLUTIONSQ76836714
Mitochondrial dynamics in yeastQ77803412
The crystal structure of the secreted dimeric form of the hemophore HasA reveals a domain swapping with an exchanged heme ligandQ79368918
TPR-Mediated self-association of plant SGT1Q81314283
Fis1, DLP1, and Pex11p coordinately regulate peroxisome morphogenesisQ24301650
Failure of microtubule-mediated peroxisome division and trafficking in disorders with reduced peroxisome abundanceQ24302576
The mitochondrial protein hFis1 regulates mitochondrial fission in mammalian cells through an interaction with the dynamin-like protein DLP1Q24308767
The novel tail-anchored membrane protein Mff controls mitochondrial and peroxisomal fission in mammalian cellsQ24312865
Levels of human Fis1 at the mitochondrial outer membrane regulate mitochondrial morphologyQ24313537
A role for Fis1 in both mitochondrial and peroxisomal fission in mammalian cellsQ24315986
Regulation of mitochondrial fission and apoptosis by the mitochondrial outer membrane protein hFis1Q24317456
The mitochondrial outer membrane protein hFis1 regulates mitochondrial morphology and fission through self-interactionQ24321524
Cytosolic domain of the human mitochondrial fission protein fis1 adopts a TPR foldQ24610829
3D domain swapping: a mechanism for oligomer assemblyQ24675333
A human dynamin-related protein controls the distribution of mitochondriaQ24682958
An unexpected extended conformation for the third TPR motif of the peroxin PEX5 from Trypanosoma bruceiQ27630549
Two structures of cyclophilin 40: folding and fidelity in the TPR domainsQ27632191
The solution structure of human mitochondria fission protein Fis1 reveals a novel TPR-like helix bundleQ27642557
Crystal structure of murine CstF-77: dimeric association and implications for polyadenylation of mRNA precursorsQ27644241
Structural basis for recruitment of mitochondrial fission complexes by Fis1Q27649021
Interconversion between two unrelated protein folds in the lymphotactin native stateQ27650152
Structure and ligand binding of the soluble domain of a Thermotoga maritima membrane protein of unknown function TM1634.Q27650166
Structural insights into the recognition of peroxisomal targeting signal 1 by Trypanosoma brucei peroxin 5Q27651024
Molecular structure of the N-terminal domain of the APC/C subunit Cdc27 reveals a homo-dimeric tetratricopeptide repeat architectureQ27660126
Metamorphic proteins mediate evolutionary transitions of structureQ27660427
Self-association of TPR domains: Lessons learned from a designed, consensus-based TPR oligomerQ27661466
The APC/C subunit Cdc16/Cut9 is a contiguous tetratricopeptide repeat superhelix with a homo-dimer interface similar to Cdc27Q27664919
Molecular architecture of a dynamin adaptor: implications for assembly of mitochondrial fission complexesQ27666346
Molecular design principles underlying β-strand swapping in the adhesive dimerization of cadherinsQ27667852
The 1.75 Å resolution structure of fission protein Fis1 fromSaccharomyces cerevisiaereveals elusive interactions of the autoinhibitory domainQ27675697
Crystal Structure of Mitochondrial Fission Complex Reveals Scaffolding Function for Mitochondrial Division 1 (Mdv1) Coiled CoilQ27677023
Structural basis of calcium-induced E-cadherin rigidification and dimerizationQ27732599
Using NMRView to visualize and analyze the NMR spectra of macromoleculesQ27860567
NMRPipe: a multidimensional spectral processing system based on UNIX pipesQ27860859
NMR View: A computer program for the visualization and analysis of NMR dataQ27860951
Gag3p, an outer membrane protein required for fission of mitochondrial tubulesQ27929986
The dynamin-related GTPase, Dnm1p, controls mitochondrial morphology in yeastQ27931434
Novel structure of the N terminus in yeast Fis1 correlates with a specialized function in mitochondrial fission.Q27931656
Mdv1p is a WD repeat protein that interacts with the dynamin-related GTPase, Dnm1p, to trigger mitochondrial divisionQ27932426
Dnm1p GTPase-mediated mitochondrial fission is a multi-step process requiring the novel integral membrane component Fis1pQ27933279
Fzo1p is a mitochondrial outer membrane protein essential for the biogenesis of functional mitochondria in Saccharomyces cerevisiaeQ27935307
The WD40 protein Caf4p is a component of the mitochondrial fission machinery and recruits Dnm1p to mitochondriaQ27937583
Dnm1p-dependent peroxisome fission requires Caf4p, Mdv1p and Fis1pQ27938612
Role of rapsyn tetratricopeptide repeat and coiled-coil domains in self-association and nicotinic acetylcholine receptor clusteringQ28138315
hFis1, a novel component of the mammalian mitochondrial fission machineryQ28208369
Dynamin-like protein 1 is involved in peroxisomal fissionQ28218956
A mutation in the mitochondrial fission gene Dnm1l leads to cardiomyopathyQ28509163
pH-dependent tetramerization and amantadine binding of the transmembrane helix of M2 from the influenza A virusQ28646233
Analysis of functional domains of rat mitochondrial Fis1, the mitochondrial fission-stimulating proteinQ28854275
Energetics of outer membrane phospholipase A (OMPLA) dimerization.Q30159899
The cytosolic domain of Fis1 binds and reversibly clusters lipid vesiclesQ33954852
A lethal de novo mutation in the middle domain of the dynamin-related GTPase Drp1 impairs higher order assembly and mitochondrial divisionQ34186619
The superhelical TPR-repeat domain of O-linked GlcNAc transferase exhibits structural similarities to importin alphaQ34347600
Direct binding of the dynamin-like GTPase, Dnm1, to mitochondrial dynamics protein Fis1 is negatively regulated by the Fis1 N-terminal armQ34613362
Active monomeric and dimeric forms of Pseudomonas putida glyoxalase I: evidence for 3D domain swapping.Q34749570
Versatile TPR domains accommodate different modes of target protein recognition and functionQ35056237
The unfolding story of three-dimensional domain swapping.Q35080182
The role of Fis1p-Mdv1p interactions in mitochondrial fission complex assemblyQ36320310
The WD repeat protein, Mdv1p, functions as a molecular adaptor by interacting with Dnm1p and Fis1p during mitochondrial fissionQ36325123
Dysregulation of mitochondrial fusion and fission: an emerging concept in neurodegenerationQ36391911
Get the balance right: mitofusins roles in health and diseaseQ36436038
Mitochondrial fusion and function in Charcot-Marie-Tooth type 2A patient fibroblasts with mitofusin 2 mutationsQ36692919
Protein metamorphosis: the two-state behavior of Mad2.Q37101664
Crystal structure of the N-terminal domain of anaphase-promoting complex subunit 7.Q37200884
Organelle dynamics and dysfunction: A closer link between peroxisomes and mitochondriaQ37344772
Evidence for conformational heterogeneity of fission protein Fis1 from Saccharomyces cerevisiaeQ37448802
Sgt1 dimerization is required for yeast kinetochore assemblyQ41761643
A lethal defect of mitochondrial and peroxisomal fissionQ41918612
Mitochondrial dynamics in diseaseQ41918618
Explaining the oligomerization properties of the spindle assembly checkpoint protein Mad2.Q42252113
A thermodynamic scale for the helix-forming tendencies of the commonly occurring amino acidsQ44211659
P4510describes a project that usesImageJQ1659584
P433issue2
P407language of work or nameEnglishQ1860
P921main subjectmitochondrial fissionQ6881852
P304page(s)143-58
P577publication date2012-10-19
P1433published inJournal of Molecular BiologyQ925779
P1476titleA designed point mutant in Fis1 disrupts dimerization and mitochondrial fission
P478volume423

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cites work (P2860)
Q41161606A Targeted Mutation Identified through pKa Measurements Indicates a Postrecruitment Role for Fis1 in Yeast Mitochondrial Fission.
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Q90113365Liraglutide Protects Against Brain Amyloid-β1-42 Accumulation in Female Mice with Early Alzheimer's Disease-Like Pathology by Partially Rescuing Oxidative/Nitrosative Stress and Inflammation
Q37594853Mitochondrial Rab GAPs govern autophagosome biogenesis during mitophagy
Q48126999Removal of a consensus proline is not sufficient to allow tetratricopeptide repeat oligomerization