scholarly article | Q13442814 |
P50 | author | João F Matias Rodrigues | Q41050167 |
P2093 | author name string | Andreas Wagner | |
P2860 | cites work | Construction of lycopene-overproducing E. coli strains by combining systematic and combinatorial gene knockout targets | Q51506025 |
Modular epistasis in yeast metabolism | Q51982575 | ||
From sequences to shapes and back: a case study in RNA secondary structures | Q52379672 | ||
Adaptive evolution of bacterial metabolic networks by horizontal gene transfer. | Q54474627 | ||
Emergence of Preferred Structures in a Simple Model of Protein Folding | Q56517454 | ||
Exposing the fitness contribution of duplicated genes | Q81072567 | ||
An expanded genome-scale model of Escherichia coli K-12 (iJR904 GSM/GPR) | Q21194867 | ||
Experimental Determination and System Level Analysis of Essential Genes in Escherichia coli MG1655 | Q22065459 | ||
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection | Q22122301 | ||
Lateral gene transfer and the nature of bacterial innovation | Q22122396 | ||
KEGG: kyoto encyclopedia of genes and genomes | Q24515297 | ||
Protein stability promotes evolvability | Q24546311 | ||
Genome-scale reconstruction of the Saccharomyces cerevisiae metabolic network | Q24561581 | ||
The Escherichia coli MG1655 in silico metabolic genotype: its definition, characteristics, and capabilities | Q24655269 | ||
The activity reaction core and plasticity of metabolic networks | Q24811413 | ||
Large-scale 13C-flux analysis reveals mechanistic principles of metabolic network robustness to null mutations in yeast | Q24812466 | ||
Analysis of optimality in natural and perturbed metabolic networks | Q28213254 | ||
Metabolic network structure determines key aspects of functionality and regulation | Q28214885 | ||
Using the topology of metabolic networks to predict viability of mutant strains | Q28246806 | ||
The 'evolvability' of promiscuous protein functions | Q28295483 | ||
Robustness can evolve gradually in complex regulatory gene networks with varying topology | Q28469133 | ||
Genome-scale models of microbial cells: evaluating the consequences of constraints | Q29616789 | ||
Protein structures sustain evolutionary drift | Q30427746 | ||
Neutral genetic drift can alter promiscuous protein functions, potentially aiding functional evolution | Q30479736 | ||
Metabolic functions of duplicate genes in Saccharomyces cerevisiae | Q33224556 | ||
Detection of elementary flux modes in biochemical networks: a promising tool for pathway analysis and metabolic engineering. | Q33543834 | ||
Abundant indispensable redundancies in cellular metabolic networks | Q33633427 | ||
Metabolic pathway analysis: basic concepts and scientific applications in the post-genomic era. | Q33651317 | ||
Chance and necessity in the evolution of minimal metabolic networks | Q33994506 | ||
Roles of mutation and recombination in the evolution of protein thermodynamics | Q34074439 | ||
Neutral networks in protein space: a computational study based on knowledge-based potentials of mean force | Q34435825 | ||
Predicting synthetic rescues in metabolic networks | Q34750436 | ||
Perspectives on protein evolution from simple exact models. | Q35766518 | ||
Determination of redundancy and systems properties of the metabolic network of Helicobacter pylori using genome-scale extreme pathway analysis. | Q35784412 | ||
Plasticity of genetic interactions in metabolic networks of yeast | Q35844612 | ||
Novel food-grade plasmid vector based on melibiose fermentation for the genetic engineering of Lactococcus lactis. | Q39676871 | ||
Genome-scale in silico models of E. coli have multiple equivalent phenotypic states: assessment of correlated reaction subsets that comprise network states. | Q39968205 | ||
Experimental and computational assessment of conditionally essential genes in Escherichia coli | Q41063583 | ||
An evolutionary tree for invertebrate globin sequences | Q41390433 | ||
Systems properties of the Haemophilus influenzae Rd metabolic genotype | Q41671443 | ||
Assessment of the metabolic capabilities of Haemophilus influenzae Rd through a genome-scale pathway analysis | Q41724916 | ||
Influence of metabolic network structure and function on enzyme evolution | Q42235124 | ||
Latent evolutionary potentials under the neutral mutational drift of an enzyme | Q43177884 | ||
Life without dihydrofolate reductase FolA. | Q44462052 | ||
Metabolic flux analysis of pykF gene knockout Escherichia coli based on 13C-labeling experiments together with measurements of enzyme activities and intracellular metabolite concentrations | Q44475462 | ||
Analysis of Escherichia coli anaplerotic metabolism and its regulation mechanisms from the metabolic responses to altered dilution rates and phosphoenolpyruvate carboxykinase knockout | Q44579709 | ||
Large-scale in vivo flux analysis shows rigidity and suboptimal performance of Bacillus subtilis metabolism | Q46478228 | ||
Robustness analysis of the Escherichia coli metabolic network | Q46731594 | ||
Metabolic network analysis of the causes and evolution of enzyme dispensability in yeast | Q47363112 | ||
LIGAND: chemical database for enzyme reactions | Q48629973 | ||
P275 | copyright license | Creative Commons Attribution 4.0 International | Q20007257 |
P6216 | copyright status | copyrighted | Q50423863 |
P433 | issue | 12 | |
P407 | language of work or name | English | Q1860 |
P304 | page(s) | e1000613 | |
P577 | publication date | 2009-12-01 | |
P1433 | published in | PLOS Computational Biology | Q2635829 |
P1476 | title | Evolutionary plasticity and innovations in complex metabolic reaction networks | |
P478 | volume | 5 |
Q34050854 | A computational exploration of bacterial metabolic diversity identifying metabolic interactions and growth-efficient strain communities |
Q51846145 | A genotype network reveals homoplastic cycles of convergent evolution in influenza A (H3N2) haemagglutinin |
Q44785253 | A latent capacity for evolutionary innovation through exaptation in metabolic systems |
Q37229448 | Adaptive Genetic Robustness of Escherichia coli Metabolic Fluxes |
Q48268076 | Adding levels of complexity enhances robustness and evolvability in a multilevel genotype-phenotype map. |
Q90442733 | An enormous potential for niche construction through bacterial cross-feeding in a homogeneous environment |
Q38695026 | Biomass composition: the "elephant in the room" of metabolic modelling |
Q47131680 | Coarse-graining as a downward causation mechanism. |
Q46323402 | Constraint and Contingency Pervade the Emergence of Novel Phenotypes in Complex Metabolic Systems |
Q28480927 | Design Constraints on a Synthetic Metabolism |
Q33781543 | Diet shifts provoke complex and variable changes in the metabolic networks of the ruminal microbiome. |
Q30401203 | Distribution of genotype network sizes in sequence-to-structure genotype-phenotype maps |
Q51627623 | Enhancing effect of phenotype mutational robustness on adaptation in Escherichia coli. |
Q34001801 | Environmental versatility promotes modularity in genome-scale metabolic networks |
Q36349637 | Erroneous energy-generating cycles in published genome scale metabolic networks: Identification and removal |
Q34775302 | Evolution on neutral networks accelerates the ticking rate of the molecular clock |
Q28744539 | Evolutionary Innovations and the Organization of Protein Functions in Genotype Space |
Q38028398 | Evolutionary Systems Biology: Historical and Philosophical Perspectives on an Emerging Synthesis |
Q28743510 | Evolutionary plasticity determination by orthologous groups distribution |
Q35740048 | Exhaustive Analysis of a Genotype Space Comprising 10(15 )Central Carbon Metabolisms Reveals an Organization Conducive to Metabolic Innovation. |
Q33543376 | Genotype networks in metabolic reaction spaces |
Q37917100 | Genotype networks shed light on evolutionary constraints |
Q33840085 | Genotype networks, innovation, and robustness in sulfur metabolism |
Q36905240 | Growth Temperature and Genome Size in Bacteria Are Negatively Correlated, Suggesting Genomic Streamlining During Thermal Adaptation |
Q33615814 | Historical contingency and the gradual evolution of metabolic properties in central carbon and genome-scale metabolisms |
Q33728106 | Human genome variation and the concept of genotype networks |
Q34835690 | Impact of gene expression noise on organismal fitness and the efficacy of natural selection |
Q52455675 | Information theory, evolutionary innovations and evolvability. |
Q39312670 | Integration of Metabolic Modeling with Gene Co-expression Reveals Transcriptionally Programmed Reactions Explaining Robustness in Mycobacterium tuberculosis. |
Q84597241 | Metabolic Networks and Their Evolution |
Q57797074 | Metabolic determinants of enzyme evolution in a genome-scale bacterial metabolic network |
Q48141979 | Metabolic plasticity in synthetic lethal mutants: Viability at higher cost. |
Q38287802 | Modeling the evolution of complex genetic systems: the gene network family tree |
Q42864380 | Mutation rates and evolution of multiple coding in RNA-based protocells |
Q57465829 | On the deformability of an empirical fitness landscape by microbial evolution |
Q57002762 | On the networked architecture of genotype spaces and its critical effects on molecular evolution |
Q34268582 | Out of fuzzy chemistry: from prebiotic chemistry to metabolic networks |
Q31119186 | Parallel or convergent evolution in human population genomic data revealed by genotype networks |
Q48268065 | Phenotypes can be robust and evolvable if mutations have non-local effects on sequence constraints |
Q50867326 | Phenotypic constraints promote latent versatility and carbon efficiency in metabolic networks. |
Q55061666 | Phenotypic innovation through recombination in genome-scale metabolic networks. |
Q33787403 | Phenotypic plasticity can facilitate adaptive evolution in gene regulatory circuits |
Q51875929 | Phenotypic robustness can increase phenotypic variability after nongenetic perturbations in gene regulatory circuits |
Q55379339 | RNA-mediated gene regulation is less evolvable than transcriptional regulation. |
Q28479041 | Randomizing Genome-Scale Metabolic Networks |
Q24634833 | Robustness and evolvability |
Q39416093 | Structural properties of genotype-phenotype maps |
Q35935855 | Superessential reactions in metabolic networks |
Q50909695 | Surviving evolutionary escape on complex genotype-phenotype networks. |
Q30276470 | Systems level analysis of the Chlamydomonas reinhardtii metabolic network reveals variability in evolutionary co-conservation |
Q37909892 | Systems-biology approaches for predicting genomic evolution |
Q28482439 | The Emergence and Early Evolution of Biological Carbon-Fixation |
Q34539751 | The Underlying Molecular and Network Level Mechanisms in the Evolution of Robustness in Gene Regulatory Networks |
Q52314365 | The architecture of an empirical genotype-phenotype map. |
Q38067007 | The compositional and evolutionary logic of metabolism |
Q35137906 | The decoupling between genetic structure and metabolic phenotypes in Escherichia coli leads to continuous phenotypic diversity |
Q30390157 | The evolvability of programmable hardware |
Q36291540 | The genotype-phenotype map of an evolving digital organism. |
Q37923164 | The molecular origins of evolutionary innovations |
Q35792955 | The players may change but the game remains: network analyses of ruminal microbiomes suggest taxonomic differences mask functional similarity |
Q36171483 | The potential for non-adaptive origins of evolutionary innovations in central carbon metabolism. |
Q33362515 | The problems of biological information |
Q37978978 | Towards understanding how molecular networks evolve in plants |
Q42023667 | toyLIFE: a computational framework to study the multi-level organisation of the genotype-phenotype map. |
Search more.