Mammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phase

scientific article

Mammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phase is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2009PLoSO...4.5462M
P356DOI10.1371/JOURNAL.PONE.0005462
P932PMC publication ID2674209
P698PubMed publication ID19421323
P5875ResearchGate publication ID24407361

P2093author name stringMark G Alexandrow
Sherry L Winter
Thinh V Cao
Piyali Mukherjee
P2860cites workInhibition of eukaryotic DNA replication by geminin binding to Cdt1Q24290664
Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosisQ24515107
Cell cycle-regulated expression of mammalian CDC6 is dependent on E2F.Q24522801
Cdc6 protein causes premature entry into S phase in a mammalian cell-free systemQ24533451
Stability, chromatin association and functional activity of mammalian pre-replication complex proteins during the cell cycleQ24550181
A requirement for MCM7 and Cdc45 in chromosome unwinding during eukaryotic DNA replicationQ24561565
The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2Q24561705
Hypo-phosphorylation of the retinoblastoma protein (pRb) by cyclin D:Cdk4/6 complexes results in active pRbQ24656289
Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cellsQ24682117
Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform ExtractionQ25938986
Uninterrupted MCM2-7 function required for DNA replication fork progressionQ27929772
CDK-dependent phosphorylation of Sld2 and Sld3 initiates DNA replication in budding yeastQ27932774
Phosphorylation of Sld2 and Sld3 by cyclin-dependent kinases promotes DNA replication in budding yeast.Q27935340
Cdc6p-dependent loading of Mcm proteins onto pre-replicative chromatin in budding yeastQ27936236
Interdependent nuclear accumulation of budding yeast Cdt1 and Mcm2-7 during G1 phase.Q27940280
DNA replication in eukaryotic cellsQ28131747
Initiation of eukaryotic DNA replication: origin unwinding and sequential chromatin association of Cdc45, RPA, and DNA polymerase alphaQ28140031
Cdk phosphorylation triggers sequential intramolecular interactions that progressively block Rb functions as cells move through G1Q28145116
Differential regulation of retinoblastoma tumor suppressor protein by G(1) cyclin-dependent kinase complexes in vivoQ28202769
Distinct roles for cyclins E and A during DNA replication complex assembly and activationQ28206467
ATP-dependent recognition of eukaryotic origins of DNA replication by a multiprotein complexQ28241786
Retinoblastoma protein recruits histone deacetylase to repress transcriptionQ28262144
Physical interaction of the retinoblastoma protein with human D cyclinsQ28269103
G1 phase progression: cycling on cueQ29615162
Evidence for sequential action of cdc7 and cdk2 protein kinases during initiation of DNA replication in Xenopus egg extracts.Q50723158
Essential role of E2F recognition sites in regulation of the proliferating cell nuclear antigen gene promoter during Drosophila development.Q52536778
The inhibition of DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cellsQ54605923
Modulation of retinoblastoma protein activity during the cell cycleQ67893102
Inhibition of RNA synthesis by actinomycin D: Characteristic dose-response of different RNA speciesQ71647340
Transforming growth factor beta and cell cycle regulationQ72611053
Active transcriptional repression by the Rb-E2F complex mediates G1 arrest triggered by p16INK4a, TGFbeta, and contact inhibitionQ77310904
Regulation of retinoblastoma protein functions by ectopic expression of human cyclinsQ29618320
Cdc6 chromatin affinity is unaffected by serine-54 phosphorylation, S-phase progression, and overexpression of cyclin A.Q30312052
Chromatin decondensation in S-phase involves recruitment of Cdk2 by Cdc45 and histone H1 phosphorylationQ30436174
An Rb-Skp2-p27 pathway mediates acute cell cycle inhibition by Rb and is retained in a partial-penetrance Rb mutantQ34356567
Regulation of cyclin E transcription by E2Fs and retinoblastoma proteinQ34382483
Overexpression of the c-Myc oncoprotein blocks the growth-inhibitory response but is required for the mitogenic effects of transforming growth factor beta 1.Q34425853
CDKs promote DNA replication origin licensing in human cells by protecting Cdc6 from APC/C-dependent proteolysisQ34449803
Transcriptional repressor functions of Drosophila E2F1 and E2F2 cooperate to inhibit genomic DNA synthesis in ovarian follicle cellsQ34741039
ORC localization in Drosophila follicle cells and the effects of mutations in dE2F and dDP.Q35193528
The action of alpha-amanitin on RNA synthesis in Chinese hamster ovary cells. Ultrastructural and biochemical studiesQ36196727
The role of Cdc6 in ensuring complete genome licensing and S phase checkpoint activationQ36321891
Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phaseQ36377671
Cell cycle regulation of the murine cyclin E gene depends on an E2F binding site in the promoter.Q36560592
The Rb family contains a conserved cyclin-dependent-kinase-regulated transcriptional repressor motifQ36564503
The replication origin decision point is a mitogen-independent, 2-aminopurine-sensitive, G1-phase event that precedes restriction point controlQ36569595
Differential stability of c-myc mRNAS in a cell-free systemQ36791935
Post-transcriptional control of the onset of DNA synthesis by an insulin-like growth factorQ36947555
Products of RNA polymerases in HeLa cell nucleiQ37492309
Distinct action of the retinoblastoma pathway on the DNA replication machinery defines specific roles for cyclin-dependent kinase complexes in prereplication complex assembly and S-phase progressionQ39129632
Functional inactivation of the retinoblastoma protein requires sequential modification by at least two distinct cyclin-cdk complexesQ39574223
?-Amanitin and 5-fluorouridine inhibition of serumstimulated DNA synthesis in quiescent AKR-2B mouse embryo cellsQ39902501
Retinoblastoma protein and anaphase-promoting complex physically interact and functionally cooperate during cell-cycle exitQ40190904
Expression of cyclin E renders cyclin D-CDK4 dispensable for inactivation of the retinoblastoma tumor suppressor protein, activation of E2F, and G1-S phase progressionQ40612848
Cyclins and cyclin-dependent kinases: take your partnersQ40832090
Ras enhances Myc protein stability.Q40967066
pRB phosphorylation mutants reveal role of pRB in regulating S phase completion by a mechanism independent of E2F.Q40995683
Transforming growth factor beta 1 inhibits mouse keratinocytes late in G1 independent of effects on gene transcriptionQ41303450
Role of the Rb/E2F pathway in cell growth controlQ41640467
Novel DNA microarray system for analysis of nascent mRNAsQ42123171
Metazoan origin selection: origin recognition complex chromatin binding is regulated by CDC6 recruitment and ATP hydrolysis.Q44594153
DNA replication control through interaction of E2F-RB and the origin recognition complexQ47071555
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue5
P407language of work or nameEnglishQ1860
P304page(s)e5462
P577publication date2009-01-01
P1433published inPLOS OneQ564954
P1476titleMammalian MCM loading in late-G(1) coincides with Rb hyperphosphorylation and the transition to post-transcriptional control of progression into S-phase
P478volume4

Reverse relations

cites work (P2860)
Q33349206Arabidopsis RETINOBLASTOMA-RELATED is required for stem cell maintenance, cell differentiation, and lateral organ production
Q35878894C. elegans MCM-4 is a general DNA replication and checkpoint component with an epidermis-specific requirement for growth and viability
Q33614054Cell cycle arrest by transforming growth factor beta1 near G1/S is mediated by acute abrogation of prereplication complex activation involving an Rb-MCM interaction
Q30429899Chromatin unfolding by Cdt1 regulates MCM loading via opposing functions of HBO1 and HDAC11-geminin
Q35870692Curcumin: a novel Stat3 pathway inhibitor for chemoprevention of lung cancer
Q33557789Cytometry of chromatin bound Mcm6 and PCNA identifies two states in G1 that are separated functionally by the G1 restriction point
Q33655591Granzyme G is expressed in the two-cell stage mouse embryo and is required for the maternal-zygotic transition
Q24306661Histone H3 lysine 56 methylation regulates DNA replication through its interaction with PCNA
Q64060260Myc-driven chromatin accessibility regulates Cdc45 assembly into CMG helicases
Q35083440Proteomic analysis of proton beam irradiated human melanoma cells
Q38845745Simultaneous measurement of passage through the restriction point and MCM loading in single cells
Q38865133Suppression of Reserve MCM Complexes Chemosensitizes to Gemcitabine and 5-Fluorouracil
Q91784010TGFβ1 Cell Cycle Arrest Is Mediated by Inhibition of MCM Assembly in Rb-Deficient Conditions