Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock

scientific journal article

Periodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1101/GAD.1092303
P3181OpenCitations bibliographic resource ID3888953
P932PMC publication ID196074
P698PubMed publication ID12783854
P5875ResearchGate publication ID7097085

P50authorHiromi HirataQ90316635
P2093author name stringRyoichiro Kageyama
Yasumasa Bessho
Yoshito Masamizu
P2860cites workHes7: a bHLH-type repressor gene regulated by Notch and expressed in the presomitic mesodermQ24290956
Progression of the cell cycle through mitosis leads to abortion of nascent transcriptsQ24642939
Transcriptional oscillation of lunatic fringe is essential for somitogenesisQ24672577
Vertebrate somitogenesisQ28202951
Oscillatory expression of the bHLH factor Hes1 regulated by a negative feedback loopQ28210742
Axial skeletal defects caused by mutation in the spondylocostal dysplasia/pudgy gene Dll3 are associated with disruption of the segmentation clock within the presomitic mesodermQ28211424
Oscillating expression of c-Hey2 in the presomitic mesoderm suggests that the segmentation clock may use combinatorial signaling through multiple interacting bHLH factorsQ28510928
Wnt3a plays a major role in the segmentation clock controlling somitogenesisQ28587356
Mammalian achaete-scute and atonal homologs regulate neuronal versus glial fate determination in the central nervous systemQ28591759
Dynamic expression and essential functions of Hes7 in somite segmentationQ28593057
Notch signalling is required for cyclic expression of the hairy-like gene HES1 in the presomitic mesodermQ28594325
Cofactor dynamics and sufficiency in estrogen receptor-regulated transcriptionQ29547846
A clock-work somiteQ33825400
Notch signalling and the synchronization of the somite segmentation clockQ33926876
Clock regulatory elements control cyclic expression of Lunatic fringe during somitogenesisQ34137887
The making of the somite: molecular events in vertebrate segmentationQ34443564
Two linked hairy/Enhancer of split-related zebrafish genes, her1 and her7, function together to refine alternating somite boundaries.Q39608214
Control of her1 expression during zebrafish somitogenesis by a delta-dependent oscillator and an independent wave-front activityQ40443832
A gene that resuscitates a theory--somitogenesis and a molecular oscillatorQ41737710
her1 and the notch pathway function within the oscillator mechanism that regulates zebrafish somitogenesisQ43903112
Zebrafish Mesp family genes, mesp-a and mesp-b are segmentally expressed in the presomitic mesoderm, and Mesp-b confers the anterior identity to the developing somites.Q47073326
lunatic fringe is an essential mediator of somite segmentation and patterningQ47741550
Defects in somite formation in lunatic fringe-deficient miceQ47741558
Avian hairy gene expression identifies a molecular clock linked to vertebrate segmentation and somitogenesisQ48041941
Periodic Lunatic fringe expression is controlled during segmentation by a cyclic transcriptional enhancer responsive to notch signaling.Q48294316
A nomenclature for prospective somites and phases of cyclic gene expression in the presomitic mesodermQ48736832
Periodic notch inhibition by lunatic fringe underlies the chick segmentation clock.Q52110194
Hairy/E(spl)-related (Her) genes are central components of the segmentation oscillator and display redundancy with the Delta/Notch signaling pathway in the formation of anterior segmental boundaries in the zebrafish.Q52118960
Dynamic expression of lunatic fringe suggests a link between notch signaling and an autonomous cellular oscillator driving somite segmentation.Q52179113
The lunatic fringe gene is a target of the molecular clock linked to somite segmentation in avian embryos.Q52184463
Waves of mouse Lunatic fringe expression, in four-hour cycles at two-hour intervals, precede somite boundary formation.Q52184506
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectHes family bHLH transcription factor 7Q21495819
Notch 1Q21986193
P304page(s)1451–1456
P577publication date2003-06-15
P1433published inGenes & DevelopmentQ1524533
P1476titlePeriodic repression by the bHLH factor Hes7 is an essential mechanism for the somite segmentation clock
P478volume17

Reverse relations

cites work (P2860)
Q440965603'-UTR-dependent regulation of mRNA turnover is critical for differential distribution patterns of cyclic gene mRNAs.
Q35617198A Notch feeling of somite segmentation and beyond
Q36146536A balance of positive and negative regulators determines the pace of the segmentation clock
Q37902096A fluorescence spotlight on the clockwork development and metabolism of bone.
Q35679141A new mib allele with a chromosomal deletion covering foxc1a exhibits anterior somite specification defect
Q92957605An In Vitro Human Segmentation Clock Model Derived from Embryonic Stem Cells
Q28587304Analysis of Ripply1/2-deficient mouse embryos reveals a mechanism underlying the rostro-caudal patterning within a somite
Q34314148Analysis of her1 and her7 mutants reveals a spatio temporal separation of the somite clock module
Q51994121Appropriate suppression of Notch signaling by Mesp factors is essential for stripe pattern formation leading to segment boundary formation.
Q52010517Autoinhibition with transcriptional delay: a simple mechanism for the zebrafish somitogenesis oscillator.
Q37141071Building the spine: the vertebrate segmentation clock.
Q35058303Canine disorder mirrors human disease: exonic deletion in HES7 causes autosomal recessive spondylocostal dysostosis in miniature Schnauzer dogs.
Q33290478Chick Hairy1 protein interacts with Sap18, a component of the Sin3/HDAC transcriptional repressor complex.
Q35265333Circadian genes, xBmal1 and xNocturnin, modulate the timing and differentiation of somites in Xenopus laevis
Q35943690Clock genes in cell clocks: roles, actions, and mysteries
Q48796148Cloning, characterization and promoter analysis of common carp hairy/Enhancer-of-split-related gene, her6.
Q52023087Comparative analysis of her genes during fish somitogenesis suggests a mouse/chick-like mode of oscillation in medaka.
Q47128143Comparative cell cycle transcriptomics reveals synchronization of developmental transcription factor networks in cancer cells
Q40245530Completing the set of h/E(spl) cyclic genes in zebrafish: her12 and her15 reveal novel modes of expression and contribute to the segmentation clock.
Q31053995Complex dynamics of transcription regulation
Q27322328Control of Hes7 expression by Tbx6, the Wnt pathway and the chemical Gsk3 inhibitor LiCl in the mouse segmentation clock
Q34568331Cooperative Mesp activity is required for normal somitogenesis along the anterior-posterior axis
Q42055406Cooperative function of deltaC and her7 in anterior segment formation
Q47073624Coordination of symmetric cyclic gene expression during somitogenesis by Suppressor of Hairless involves regulation of retinoic acid catabolism
Q36786579Coupling cellular oscillators: a mechanism that maintains synchrony against developmental noise in the segmentation clock
Q37592411Cyclic Nrarp mRNA expression is regulated by the somitic oscillator but Nrarp protein levels do not oscillate.
Q36792682Deciphering the somite segmentation clock: beyond mutants and morphants
Q43941194Delay-managed tradeoff in the molecular dynamics of the segmentation clock
Q28069407Delta-Notch signalling in segmentation
Q39532078Different types of oscillations in Notch and Fgf signaling regulate the spatiotemporal periodicity of somitogenesis
Q30945648Differential axial requirements for lunatic fringe and Hes7 transcription during mouse somitogenesis
Q98184223Dynamical gene regulatory networks are tuned by transcriptional autoregulation with microRNA feedback
Q35635073Dynamics of the slowing segmentation clock reveal alternating two-segment periodicity.
Q50043698ES cell-derived presomitic mesoderm-like tissues for analysis of synchronized oscillations in the segmentation clock
Q51986088Editorial on segmentation focus.
Q34190763Evolutionary plasticity of segmentation clock networks.
Q38018288Experiments, measurements, and mathematical modeling to decipher time signals in development
Q34145324Expression of the oscillating gene her1 is directly regulated by Hairy/Enhancer of Split, T-box, and Suppressor of Hairless proteins in the zebrafish segmentation clock
Q27321015Fast synchronization of ultradian oscillators controlled by delta-notch signaling with cis-inhibition
Q28651646From dinosaurs to birds: a tail of evolution
Q21090160From dynamic expression patterns to boundary formation in the presomitic mesoderm
Q33346156From signals to patterns: space, time, and mathematics in developmental biology
Q37288471Genetic aspects of congenital and idiopathic scoliosis
Q36318161Genetic association analysis between polymorphisms of HAIRY-AND-ENHANCER-OF SPLIT-7 and congenital scoliosis
Q34234902Hes7 3'UTR is required for somite segmentation function
Q60046998Hybrids Provide Insight Into Cell and Organism Size Control
Q42738593Identification of oscillatory genes in somitogenesis from functional genomic analysis of a human mesenchymal stem cell model
Q28505422Instability of Hes7 protein is crucial for the somite segmentation clock
Q37201732Interfering with Wnt signalling alters the periodicity of the segmentation clock.
Q34602627Intronic delay is essential for oscillatory expression in the segmentation clock
Q27315061Jagged2a-notch signaling mediates cell fate choice in the zebrafish pronephric duct
Q28510335Lfng regulates the synchronized oscillation of the mouse segmentation clock via trans-repression of Notch signalling
Q26865201Life rhythm as a symphony of oscillatory patterns: electromagnetic energy and sound vibration modulates gene expression for biological signaling and healing
Q33779631Modeling the zebrafish segmentation clock's gene regulatory network constrained by expression data suggests evolutionary transitions between oscillating and nonoscillating transcription
Q35238701Modelling coupled oscillations in the Notch, Wnt, and FGF signaling pathways during somitogenesis: a comprehensive mathematical model
Q51975063Mouse Ripply2 is downstream of Wnt3a and is dynamically expressed during somitogenesis.
Q32874834Negative feedback loop formed by Lunatic fringe and Hes7 controls their oscillatory expression during somitogenesis
Q34535986Noise-resistant and synchronized oscillation of the segmentation clock.
Q34809773Noncyclic Notch activity in the presomitic mesoderm demonstrates uncoupling of somite compartmentalization and boundary formation
Q28590793Notch is a critical component of the mouse somitogenesis oscillator and is essential for the formation of the somites
Q37503775Notch signaling, the segmentation clock, and the patterning of vertebrate somites
Q41964871Notch signalling regulates the contribution of progenitor cells from the chick Hensen's node to the floor plate and notochord.
Q25255507Number of active transcription factor binding sites is essential for the Hes7 oscillator
Q36762222Oscillator mechanism of Notch pathway in the segmentation clock
Q27322653Oscillatory control of Delta-like1 in cell interactions regulates dynamic gene expression and tissue morphogenesis.
Q38116917Oscillatory gene expression and somitogenesis.
Q38770518PAPC couples the segmentation clock to somite morphogenesis by regulating N-cadherin-dependent adhesion
Q24563952Papillomavirus-mediated neoplastic progression is associated with reciprocal changes in JAGGED1 and manic fringe expression linked to notch activation
Q46713018Pnrc2 regulates 3'UTR-mediated decay of segmentation clock-associated transcripts during zebrafish segmentation
Q40286298Posterior-anterior gradient of zebrafish hes6 expression in the presomitic mesoderm is established by the combinatorial functions of the downstream enhancer and 3'UTR.
Q42579695Practical lessons from theoretical models about the somitogenesis
Q89081045Presomitic mesoderm-specific expression of the transcriptional repressor Hes7 is controlled by E-box, T-box, and Notch signaling pathways
Q51989566Priming, initiation and synchronization of the segmentation clock by deltaD and deltaC.
Q37636813Progress and perspective of TBX6 gene in congenital vertebral malformations
Q91562404Pumilio response and AU-rich elements drive rapid decay of Pnrc2-regulated cyclic gene transcripts
Q30476642Real-time imaging of the somite segmentation clock: revelation of unstable oscillators in the individual presomitic mesoderm cells
Q36382727Regulation of intrathymic T-cell development by Lunatic Fringe- Notch1 interactions
Q34585462Roles of O-fucose glycans in notch signaling revealed by mutant mice.
Q34353557Scoliosis and segmentation defects of the vertebrae
Q50603451Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2.
Q36774083Segmental border is defined by the key transcription factor Mesp2, by means of the suppression of Notch activity
Q34770048Segmental patterning of the vertebrate embryonic axis
Q33286066Setting the tempo in development: an investigation of the zebrafish somite clock mechanism
Q38261780Signalling dynamics in vertebrate segmentation
Q30528453Single-cell-resolution imaging of the impact of Notch signaling and mitosis on segmentation clock dynamics
Q28269656Somitogenesis
Q35550763Somitogenesis: breaking new boundaries.
Q42174470Sprouty4, an FGF inhibitor, displays cyclic gene expression under the control of the notch segmentation clock in the mouse PSM.
Q27318039Stochastic Regulation of her1/7 Gene Expression Is the Source of Noise in the Zebrafish Somite Clock Counteracted by Notch Signalling
Q50473575Supt20 is required for development of the axial skeleton.
Q34574452Tbx6-mediated Notch signaling controls somite-specific Mesp2 expression
Q35741905The Her7 node modulates the network topology of the zebrafish segmentation clock via sequestration of the Hes6 hub.
Q28505901The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity
Q47820612The TAF10-containing TFIID and SAGA transcriptional complexes are dispensable for early somitogenesis in the mouse embryo.
Q28511944The Wnt3a/β-catenin target gene Mesogenin1 controls the segmentation clock by activating a Notch signalling program
Q47074205The characterization of zebrafish antimorphic mib alleles reveals that Mib and Mind bomb-2 (Mib2) function redundantly
Q36488814The long and short of it: somite formation in mice
Q28506772The period of the somite segmentation clock is sensitive to Notch activity
Q43010260The precise timeline of transcriptional regulation reveals causation in mouse somitogenesis network
Q37781196The segmentation clock mechanism moves up a notch.
Q35853789The synchrony and cyclicity of developmental events
Q50010676Timing of neuronal plasticity in development and aging
Q28481517Topology and dynamics of the zebrafish segmentation clock core circuit
Q37319464Transcript processing and export kinetics are rate-limiting steps in expressing vertebrate segmentation clock genes.
Q35513267Travelling and splitting of a wave of hedgehog expression involved in spider-head segmentation
Q33364683Turn It Down a Notch
Q34329197Two novel missense mutations in HAIRY-AND-ENHANCER-OF-SPLIT-7 in a family with spondylocostal dysostosis
Q37785200Ultradian Oscillations in Notch Signaling Regulate Dynamic Biological Events
Q34341432Ultradian oscillations and pulses: coordinating cellular responses and cell fate decisions
Q37141076Ultradian oscillators in somite segmentation and other biological events
Q98394731Understanding paraxial mesoderm development and sclerotome specification for skeletal repair
Q41492486Unraveling the nature of the segmentation clock: Intrinsic disorder of clock proteins and their interaction map.
Q37881028Vertebrate segmentation: from cyclic gene networks to scoliosis
Q91852566What are you synching about? Emerging complexity of Notch signaling in the segmentation clock
Q34538497Whole Genome Sequencing Identifies a Missense Mutation in HES7 Associated with Short Tails in Asian Domestic Cats
Q38349987Xenopus Rnd1 and Rnd3 GTP-binding proteins are expressed under the control of segmentation clock and required for somite formation
Q33826911Zebrafish hairy/enhancer of split protein links FGF signaling to cyclic gene expression in the periodic segmentation of somites.
Q47073807beamter/deltaC and the role of Notch ligands in the zebrafish somite segmentation, hindbrain neurogenesis and hypochord differentiation
Q45017372her11 is involved in the somitogenesis clock in zebrafish

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