Autocrine netrin function inhibits glioma cell motility and promotes focal adhesion formation

scientific article (publication date: 2011)

Autocrine netrin function inhibits glioma cell motility and promotes focal adhesion formation is …
instance of (P31):
scholarly articleQ13442814

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P819ADS bibcode2011PLoSO...625408J
P356DOI10.1371/JOURNAL.PONE.0025408
P3181OpenCitations bibliographic resource ID2204199
P932PMC publication ID3182204
P698PubMed publication ID21980448
P5875ResearchGate publication ID51700113

P50authorAndrew A JarjourQ56481272
P2093author name stringTimothy E Kennedy
Masoud Shekarabi
Margaret Durko
Nathalie Marçal
Tamarah L Luk
P2860cites workThe netrin protein familyQ21183890
FAK and Src kinases are required for netrin-induced tyrosine phosphorylation of UNC5Q24645421
The netrin-1 receptors UNC5H are putative tumor suppressors controlling cell death commitmentQ24683182
Phenotype of mice lacking functional Deleted in colorectal cancer (Dcc) geneQ28236533
Stimulation of extracellular matrix components in the normal brain by invading glioma cellsQ28264917
Identification of a chromosome 18q gene that is altered in colorectal cancersQ28274172
Genetic alterations during colorectal-tumor developmentQ28281200
Focal adhesion kinase in netrin-1 signalingQ28288747
Opposing roles of netrin-1 and the dependence receptor DCC in cancer cell invasion, tumor growth and metastasisQ28291163
Netrin-1: interaction with deleted in colorectal cancer (DCC) and alterations in brain tumors and neuroblastomasQ28296709
The DCC gene suppresses the malignant phenotype of transformed human epithelial cellsQ28300570
Netrin-1 is required for the normal development of spinal cord oligodendrocytesQ28506848
Novel role for Netrins in regulating epithelial behavior during lung branching morphogenesisQ28512524
Widespread expression of netrin-1 by neurons and oligodendrocytes in the adult mammalian spinal cordQ28572756
Deleted in colorectal cancer binding netrin-1 mediates cell substrate adhesion and recruits Cdc42, Rac1, Pak1, and N-WASP into an intracellular signaling complex that promotes growth cone expansionQ28577458
Netrin-3, a mouse homolog of human NTN2L, is highly expressed in sensory ganglia and shows differential binding to netrin receptorsQ28594844
Focal adhesion kinase: in command and control of cell motilityQ29615192
Required role of focal adhesion kinase (FAK) for integrin-stimulated cell migrationQ30175391
A ligand-gated association between cytoplasmic domains of UNC5 and DCC family receptors converts netrin-induced growth cone attraction to repulsionQ33867499
Growth-cone attraction to netrin-1 is converted to repulsion by laminin-1.Q33873943
Netrin-4 induces lymphangiogenesis in vivoQ33985154
Short- and long-range repulsion by the Drosophila Unc5 netrin receptor.Q34102812
Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activationQ34126386
Netrin-1/neogenin interaction stabilizes multipotent progenitor cap cells during mammary gland morphogenesisQ34183568
Netrin-1 is a chemorepellent for oligodendrocyte precursor cells in the embryonic spinal cord.Q34195453
Long term culture of normal and neoplastic human glia.Q51199195
Rho inhibition recruits DCC to the neuronal plasma membrane and enhances axon chemoattraction to netrin 1.Q52588292
Evidence for progressional changes in the human malignant glioma line U-343 MGa: analysis of karyotype and expression of genes encoding the subunit chains of platelet-derived growth factor.Q53437398
Functional implication of Netrin expression in malignant melanoma.Q54452958
Endothelial capillaries chemotactically attract tumour cells.Q55474554
Loss of DCC expression and glioma progression.Q55478778
Epidermal growth factor and laminin receptors contribute to migratory and invasive properties of gliomas.Q55478829
Netrin 1 and Dcc regulate oligodendrocyte process branching and membrane extension via Fyn and RhoAQ57041642
Expression of the UNC-5 guidance receptor in the touch neurons of C. elegans steers their axons dorsallyQ58493889
Migration pathways of human glioblastoma cells xenografted into the immunosuppressed rat brainQ74418569
High-density single nucleotide polymorphism array defines novel stage and location-dependent allelic imbalances in human bladder tumorsQ81307007
Recognition of the neural chemoattractant Netrin-1 by integrins alpha6beta4 and alpha3beta1 regulates epithelial cell adhesion and migrationQ34274897
The unc-5, unc-6, and unc-40 genes guide circumferential migrations of pioneer axons and mesodermal cells on the epidermis in C. elegansQ34308728
Netrin-1 controls colorectal tumorigenesis by regulating apoptosisQ34345335
Developmental shift in expression of netrin receptors in the rat spinal cord: predominance of UNC-5 homologues in adulthoodQ34346266
Netrin requires focal adhesion kinase and Src family kinases for axon outgrowth and attractionQ34360468
Activation of FAK and Src are receptor-proximal events required for netrin signalingQ34360478
Identification and characterization of neogenin, a DCC-related geneQ34423537
Axon guidance by diffusible chemoattractants: a gradient of netrin protein in the developing spinal cord.Q34559992
Where the rubber meets the road: netrin expression and function in developing and adult nervous systemsQ35002876
The dependence receptors DCC and UNC5H as a link between neuronal guidance and survivalQ35575340
Focal adhesion regulation of cell behavior.Q35832734
The versatile roles of "axon guidance" cues in tissue morphogenesis.Q35967879
Phosphorylation of DCC by Fyn mediates Netrin-1 signaling in growth cone guidanceQ36322746
When a diffusible axon guidance cue stops diffusing: roles for netrins in adhesion and morphogenesisQ36578669
The axonal attractant Netrin-1 is an angiogenic factor.Q37621662
The netrin-1 receptor DCC promotes filopodia formation and cell spreading by activating Cdc42 and Rac1.Q39454809
Netrin 1 mediates spinal cord oligodendrocyte precursor dispersalQ40659705
Antisense RNA to the putative tumor-suppressor gene DCC transforms Rat-1 fibroblastsQ41637055
A study of the expression of laminin in the spinal cord of the frog during development and regenerationQ41818610
Netrin receptor deficient mice exhibit functional reorganization of dopaminergic systems and do not sensitize to amphetamine.Q42470321
Netrin stimulates tyrosine phosphorylation of the UNC-5 family of netrin receptors and induces Shp2 binding to the RCM cytodomain.Q43726475
The netrin receptor UNC5B mediates guidance events controlling morphogenesis of the vascular systemQ44216042
Early molecular events in the assembly of matrix adhesions at the leading edge of migrating cells.Q44630472
Critical role of Ena/VASP proteins for filopodia formation in neurons and in function downstream of netrin-1.Q44831766
The Abelson tyrosine kinase, the Trio GEF and Enabled interact with the Netrin receptor Frazzled in DrosophilaQ46404564
Suppressors of ectopic UNC-5 growth cone steering identify eight genes involved in axon guidance in Caenorhabditis elegans.Q47069022
DCC expression is altered by multiple mechanisms in brain tumours.Q48068595
A central role for RhoA during oligodendroglial maturation in the switch from netrin-1-mediated chemorepulsion to process elaborationQ48248550
Expression of s-laminin and laminin in the developing rat central nervous systemQ48432524
Laminin--developmental expression and role in axonal outgrowth in the peripheral nervous system of the chickQ48454102
Maintenance of axo-oligodendroglial paranodal junctions requires DCC and netrin-1.Q48869811
Graded expression of netrin-1 by specific neuronal subtypes in the adult mammalian striatumQ48871725
P275copyright licenseCreative Commons Attribution 4.0 InternationalQ20007257
P6216copyright statuscopyrightedQ50423863
P433issue9
P407language of work or nameEnglishQ1860
P304page(s)e25408
P577publication date2011-01-01
P1433published inPLOS OneQ564954
P1476titleAutocrine netrin function inhibits glioma cell motility and promotes focal adhesion formation
P478volume6

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cites work (P2860)
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Q34292791Down-regulation of neogenin accelerated glioma progression through promoter Methylation and its overexpression in SHG-44 Induced Apoptosis
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Q41612676Netrin-1 promotes gastric cancer cell proliferation and invasion via the receptor neogenin through PI3K/AKT signaling pathway
Q36561939Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein
Q90699174Netrin-1-like-immunoreactivity Coexpresses With DCC and Has a Differential Level in the Myenteric Cholinergic and Nitrergic Neurons of the Adult Mouse Colon
Q58593569Serine protease modulation of Dependence Receptors and EMT protein expression
Q48372089Signaling switch of the urotensin II vasosactive peptide GPCR: prototypic chemotaxic mechanism in glioma.
Q36289377The role of semaphorins and their receptors in gliomas

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