A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates

scientific article (publication date: March 1990)

A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.10.3.1244
P932PMC publication ID361011
P698PubMed publication ID2304466

P2093author name stringT Shenk
J L Manley
J Wilusz
Y Takagaki
P2860cites work3' non-coding region sequences in eukaryotic messenger RNAQ27860858
U1, U2, and U4/U6 small nuclear ribonucleoproteins are required for in vitro splicing but not polyadenylationQ28302647
Accurate cleavage and polyadenylation of exogenous RNA substrateQ28646786
Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresisQ29547747
Transcription termination and 3' processing: the end is in site!Q29618288
Cleavage and polyadenylation of messenger RNA precursors in vitro occurs within large and specific 3' processing complexes.Q33930140
Complex transcriptional units: diversity in gene expression by alternative RNA processingQ34048629
Functional analysis of point mutations in the AAUAAA motif of the SV40 late polyadenylation signalQ35228128
Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for bindingQ35989261
Components required for in vitro cleavage and polyadenylation of eukaryotic mRNA.Q36009672
The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3' terminiQ36136653
Multiple forms of poly(A) polymerases purified from HeLa cells function in specific mRNA 3'-end formationQ36761870
Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectlyQ36764593
Sedimentation analysis of polyadenylation-specific complexesQ36780246
Assembly of a polyadenylation-specific 25S ribonucleoprotein complex in vitroQ36788795
The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sitesQ36847550
Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylationQ36892344
Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing.Q36894844
Identification of a complex associated with processing and polyadenylation in vitro of herpes simplex virus type 1 thymidine kinase precursor RNAQ36921323
Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.Q36946265
Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sitesQ36951086
A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytesQ37691120
Polyadenylation of mRNA precursorsQ39467361
snRNP mediators of 3' end processing: functional fossils?Q39473317
Poly(A) polymerase purified from HeLa cell nuclear extract is required for both cleavage and polyadenylation of pre-mRNA in vitroQ40644140
Specific pre-cleavage and post-cleavage complexes involved in the formation of SV40 late mRNA 3' termini in vitroQ41360882
A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motifQ41862487
Four factors are required for 3'-end cleavage of pre-mRNAsQ43727383
The sequence 5'-AAUAAA-3'forms parts of the recognition site for polyadenylation of late SV40 mRNAsQ48410195
Alpha-thalassaemia caused by a polyadenylation signal mutation.Q55062701
Inhibition of RNA cleavage but not polyadenylation by a point mutation in mRNA 3′ consensus sequence AAUAAAQ58451156
3' cleavage and polyadenylation of mRNA precursors in vitro requires a poly(A) polymerase, a cleavage factor, and a snRNPQ64379456
Multiple factors are required for specific RNA cleavage at a poly(A) addition siteQ64379503
Electrophoretic separation of polyadenylation-specific complexesQ64379710
A small nuclear ribonucleoprotein associates with the AAUAAA polyadenylation signal in vitroQ64380127
Requirement of a downstream sequence for generation of a poly(A) addition siteQ64380598
Multiple factors are required for poly(A) addition to a mRNA 3' endQ68413214
Separation and characterization of a poly(A) polymerase and a cleavage/specificity factor required for pre-mRNA polyadenylationQ69820089
Mutations downstream of the polyadenylation site of a Xenopus beta-globin mRNA affect the position but not the efficiency of 3' processingQ69882952
Accurate and specific polyadenylation of mRNA precursors in a soluble whole-cell lysateQ72555182
Role of the Conserved AAUAAA Sequence: Four AAUAAA Point Mutants Prevent Messenger RNA 3′ End FormationQ72749074
P433issue3
P407language of work or nameEnglishQ1860
P304page(s)1244-8
P577publication date1990-03-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleA multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substrates
P478volume10

Reverse relations

cites work (P2860)
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Q41569819mRNA 3' end processing factors: a phylogenetic comparison
Q34366770p54nrb is a component of the snRNP-free U1A (SF-A) complex that promotes pre-mRNA cleavage during polyadenylation

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