A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal

scientific article published on December 1, 1990

A uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1128/MCB.10.12.6397
10.1128/MCB.10.12.6397-6407.1990
P953full work available at URLhttp://mcb.asm.org/cgi/content/abstract/10/12/6397
https://europepmc.org/articles/PMC362916
https://europepmc.org/articles/PMC362916?pdf=render
https://journals.asm.org/doi/pdf/10.1128/mcb.10.12.6397-6407.1990
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1701018/?tool=EBI
https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/1701018/pdf/?tool=EBI
P932PMC publication ID362916
P698PubMed publication ID1701018

P2093author name stringT. Shenk
J. Wilusz
P2860cites workA common RNA recognition motif identified within a defined U1 RNA binding domain of the 70K U1 snRNP proteinQ24293251
Primary structures of the heterogeneous nuclear ribonucleoprotein A2, B1, and C2 proteins: a diversity of RNA binding proteins is generated by small peptide insertsQ24313459
Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applicationsQ24561689
Primary structure differences between proteins C1 and C2 of HeLa 40S nuclear ribonucleoprotein particlesQ24623242
Primary structure of human nuclear ribonucleoprotein particle C proteins: conservation of sequence and domain structures in heterogeneous nuclear RNA, mRNA, and pre-rRNA-binding proteinsQ24628498
Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nucleiQ27860728
Efficientin vitrosynthesis of biologically active RNA and RNA hybridization probes from plasmids containing a bacteriophage SP6 promoterQ27861016
Characterization of Heterogeneous Nuclear RNA-Protein Complexes In Vivo with Monoclonal AntibodiesQ28262939
Mammalian heterogeneous nuclear ribonucleoprotein complex protein A1. Large-scale overproduction in Escherichia coli and cooperative binding to single-stranded nucleic acidsQ28338531
Structure of rodent helix-destabilizing protein revealed by cDNA cloningQ28577324
Accurate cleavage and polyadenylation of exogenous RNA substrateQ28646786
A multicomponent complex is required for the AAUAAA-dependent cross-linking of a 64-kilodalton protein to polyadenylation substratesQ28776198
mRNA polyadenylate-binding protein: gene isolation and sequencing and identification of a ribonucleoprotein consensus sequenceQ29620264
Isolation and characterization of a Xenopus laevis C protein cDNA: structure and expression of a heterogeneous nuclear ribonucleoprotein core proteinQ33687217
Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formationQ34048852
Purification and domain structure of core hnRNP proteins A1 and A2 and their relationship to single-stranded DNA-binding proteinsQ34188801
Non-random localization of ribonucleoprotein (RNP) structures within an adenovirus mRNA precursorQ35509757
Two proteins crosslinked to RNA containing the adenovirus L3 poly(A) site require the AAUAAA sequence for bindingQ35989261
RNA binding specificity of hnRNP proteins: a subset bind to the 3' end of intronsQ35993725
The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3' terminiQ36136653
General organization of protein in HeLa 40S nuclear ribonucleoprotein particlesQ36213420
High pressure liquid chromatography purification of UP1 and UP2, two related single-stranded nucleic acid-binding proteins from calf thymus.Q36492076
Reconstitution of nucleoprotein complexes with mammalian heterogeneous nuclear ribonucleoprotein (hnRNP) core proteinsQ36588362
In vitro reconstitution of 35S ribonucleoprotein complexesQ36617902
Sequences downstream of AAUAAA signals affect pre-mRNA cleavage and polyadenylation in vitro both directly and indirectlyQ36764593
The C proteins of HeLa 40S nuclear ribonucleoprotein particles exist as anisotropic tetramers of (C1)3 C2.Q36765616
Classification and purification of proteins of heterogeneous nuclear ribonucleoprotein particles by RNA-binding specificitiesQ36789207
Ribonucleoproteins package 700 nucleotides of pre-mRNA into a repeating array of regular particlesQ36792033
The C proteins of heterogeneous nuclear ribonucleoprotein complexes interact with RNA sequences downstream of polyadenylation cleavage sitesQ36847550
Identification of sequences in the herpes simplex virus thymidine kinase gene required for efficient processing and polyadenylationQ36892344
Identification of a sequence element on the 3' side of AAUAAA which is necessary for simian virus 40 late mRNA 3'-end processing.Q36894844
Sequences on the 3' side of hexanucleotide AAUAAA affect efficiency of cleavage at the polyadenylation site.Q36946265
Definition of essential sequences and functional equivalence of elements downstream of the adenovirus E2A and the early simian virus 40 polyadenylation sitesQ36951086
Arrangement of 30S Heterogeneous Nuclear Ribonucleoprotein on Polyoma Virus Late Nuclear TranscriptsQ36956300
Transcription and replication of rhabdoviruses.Q37063165
Specific regions of the intervening sequences of beta-globin RNA are resistant to nuclease in 50S heterogeneous nuclear RNA-protein complexesQ37539252
Isolation of the heterogeneous nuclear RNA-ribonucleoprotein complex (hnRNP): a unique supramolecular assemblyQ37578982
Structure of nuclear ribonucleoprotein: heterogeneous nuclear RNA is complexed with a major sextet of proteins in vivoQ37606427
A sequence downstream of A-A-U-A-A-A is required for formation of simian virus 40 late mRNA 3' termini in frog oocytesQ37691120
A protein that specifically recognizes the 3' splice site of mammalian pre-mRNA introns is associated with a small nuclear ribonucleoproteinQ38350103
Structure and function of nuclear and cytoplasmic ribonucleoprotein particlesQ39760617
Antibodies to hnRNP core proteins inhibit in vitro splicing of human beta-globin pre-mRNA.Q40417404
Sequence dependent interaction of hnRNP proteins with late adenoviral transcriptsQ40497272
Ultrastructure of free ribonucleoprotein complexes in spread mammalian nucleiQ41384221
A 64 kd nuclear protein binds to RNA segments that include the AAUAAA polyadenylation motifQ41862487
Sequences capable of restoring poly(A) site function define two distinct downstream elements.Q42574256
Mild nuclease treatment as a probe for a non-random distribution of adenovirus-specific RNA sequences and of cellular RNA in nuclear ribonucleoprotein fibrilsQ44749414
The structure of nuclear ribonucleoprotein of amphibian oocytesQ45360621
Sex-specific alternative splicing of RNA from the transformer gene results from sequence-dependent splice site blockageQ46493195
A dot-immunobinding assay for monoclonal and other antibodiesQ49056624
An ordered pathway of assembly of components required for polyadenylation site recognition and processing.Q51172966
Ultrastructural patterns of RNA synthesis during early embryogenesis of Drosophila melanogaster.Q52432940
RNP particles at splice junction sequences on Drosophila chorion transcripts.Q52466521
Correlation of hnRNP structure and nascent transcript cleavageQ52516604
Ribonucleoprotein structure in nascent hnRNA is nonrandom and sequence-dependent.Q52525912
Immunopurification of heterogeneous nuclear ribonucleoprotein particles reveals an assortment of RNA-binding proteins.Q54389649
The core proteins of 35S hnRNP complexes. Characterization of nine different species.Q54456349
Poly(A) site cleavage in a HeLa nuclear extract is dependent on downstream sequences.Q55060176
Requirement of a downstream sequence for generation of a poly(A) addition siteQ64380598
Protected nucleotide sequences in nuclear ribonucleoproteinQ66921127
Proteins of nuclear ribonucleoprotein subcomplexesQ67397150
Identification and characterization of the packaging proteins of core 40S hnRNP particlesQ67585131
Position-dependent sequence elements downstream of AAUAAA are required for efficient rabbit beta-globin mRNA 3' end formationQ68985721
A functionally redundant downstream sequence in SV40 late pre-mRNA is required for mRNA 3'-end formation and for assembly of a precleavage complex in vitroQ69823612
Mutations downstream of the polyadenylation site of a Xenopus beta-globin mRNA affect the position but not the efficiency of 3' processingQ69882952
A protein associated with small nuclear ribonucleoprotein particles recognizes the 3' splice site of premessenger RNAQ70016576
Heterogeneous nuclear ribonucleoproteins: role in RNA splicingQ70022506
A factor, U2AF, is required for U2 snRNP binding and splicing complex assemblyQ70046647
Structure of complexes between a major protein of heterogeneous nuclear ribonucleoprotein particles and polyribonucleotidesQ70186324
Phosphorylation of the C-proteins of HeLa cell hnRNP particles. Involvement of a casein kinase II-type enzymeQ70471341
P433issue12
P407language of work or nameEnglishQ1860
P921main subjectribonucleoprotein complexQ417662
cell biologyQ7141
P304page(s)6397-6407
P577publication date1990-12-01
P1433published inMolecular and Cellular BiologyQ3319478
P1476titleA uridylate tract mediates efficient heterogeneous nuclear ribonucleoprotein C protein-RNA cross-linking and functionally substitutes for the downstream element of the polyadenylation signal
P478volume10

Reverse relations

cites work (P2860)
Q36697599A 32-kilodalton protein binds to AU-rich domains in the 3' untranslated regions of rapidly degraded mRNAs
Q24519069A 57-nucleotide upstream early polyadenylation element in human papillomavirus type 16 interacts with hFip1, CstF-64, hnRNP C1/C2, and polypyrimidine tract binding protein
Q33236766A multispecies comparison of the metazoan 3'-processing downstream elements and the CstF-64 RNA recognition motif
Q48061041A plant poly(A) polymerase requires a novel RNA-binding protein for activity
Q24317545AUH, a gene encoding an AU-specific RNA binding protein with intrinsic enoyl-CoA hydratase activity
Q34630891Alternative poly(A) site selection in complex transcription units: means to an end?
Q24798039Alternative polyadenylation of cyclooxygenase-2.
Q40641554An RNA-binding protein specifically interacts with a functionally important domain of the downstream element of the simian virus 40 late polyadenylation signal
Q35070406Bipartite structure of the downstream element of the mouse beta globin (major) poly(A) signal
Q24630724Characterization and primary structure of the poly(C)-binding heterogeneous nuclear ribonucleoprotein complex K protein
Q27939401Characterization of nuclear polyadenylated RNA-binding proteins in Saccharomyces cerevisiae.
Q34282553Characterization of specific protein-RNA complexes associated with the coupling of polyadenylation and last-intron removal
Q28594012Characterization of two nuclear proteins that interact with cytochrome P-450 1A2 mRNA. Regulation of RNA binding and possible role in the expression of the Cyp1a2 gene
Q52569258Chemical shift perturbation studies of the interactions of the second RNA-binding domain of the Drosophila sex-lethal protein with the transformer pre-mRNA polyuridine tract and 3' splice-site sequences.
Q34762164Cleavage site determinants min the mammalian polydenylation signal
Q36886468Common double- and single-stranded DNA binding factor for a sterol regulatory element
Q36706227Definition of the upstream efficiency element of the simian virus 40 late polyadenylation signal by using in vitro analyses
Q38293504Disruption of base-paired U4.U6 small nuclear RNAs induced by mammalian heterogeneous nuclear ribonucleoprotein C protein
Q34759787Downstream elements of mammalian pre-mRNA polyadenylation signals: primary, secondary and higher-order structures.
Q35187019ELAV proteins stabilize deadenylated intermediates in a novel in vitro mRNA deadenylation/degradation system
Q24601682Elements upstream of the AAUAAA within the human immunodeficiency virus polyadenylation signal are required for efficient polyadenylation in vitro
Q41169359Evidence that heteronuclear proteins interact with XIST RNA in vitro.
Q40123601Expression of RNA virus proteins by RNA polymerase II dependent expression plasmids is hindered at multiple steps.
Q28609911Formation of mRNA 3' ends in eukaryotes: mechanism, regulation, and interrelationships with other steps in mRNA synthesis
Q39452272Functionally significant secondary structure of the simian virus 40 late polyadenylation signal
Q24314952GRSF-1: a poly(A)+ mRNA binding protein which interacts with a conserved G-rich element
Q92480797Genome-wide profiling reveals alternative polyadenylation of mRNA in human non-small cell lung cancer
Q33741982GraphProt: modeling binding preferences of RNA-binding proteins.
Q28265649Grb2 and its apoptotic isoform Grb3-3 associate with heterogeneous nuclear ribonucleoprotein C, and these interactions are modulated by poly(U) RNA
Q73428264Heterogeneous nuclear ribonucleoprotein C binds exclusively to the functionally important UUUUU-motifs in the human papillomavirus type-1 AU-rich inhibitory element
Q33966749Heterogeneous nuclear ribonucleoproteins C1 and C2 associate with the RNA component of human telomerase
Q42157210Identification of S1 proteins B2, C1 and D1 as AUF1 isoforms and their major role as heterogeneous nuclear ribonucleoprotein proteins
Q40018485Identification of two RNA-binding proteins in Balbiani ring premessenger ribonucleoprotein granules and presence of these proteins in specific subsets of heterogeneous nuclear ribonucleoprotein particles
Q24555670Interaction of the RNA-binding domain of the hnRNP C proteins with RNA
Q34362676Isolation and characterization of polyadenylation complexes assembled in vitro.
Q36691462Molecular analyses of two poly(A) site-processing factors that determine the recognition and efficiency of cleavage of the pre-mRNA.
Q30632677Mutational definition of RNA-binding and protein-protein interaction domains of heterogeneous nuclear RNP C1.
Q38335922Oligonucleotide binding specificities of the hnRNP C protein tetramer
Q41888633Polyadenylation proteins CstF-64 and tauCstF-64 exhibit differential binding affinities for RNA polymers.
Q35850283Polypyrimidine tract-binding protein and heterogeneous nuclear ribonucleoprotein A1 bind to human T-cell leukemia virus type 2 RNA regulatory elements
Q33957005Polypyrimidine tract-binding protein positively regulates inclusion of an alternative 3'-terminal exon
Q24629236Purification, characterization, and cDNA cloning of an AU-rich element RNA-binding protein, AUF1
Q64379521RNA polymerase II-dependent positional effects on mRNA 3' end processing in the adenovirus major late transcription unit
Q24646013RNA recognition by the human polyadenylation factor CstF
Q74781345RNA-Binding Characteristics of a Ribonucleoprotein from Spinach Chloroplast
Q40402003RNA-binding activities of the different domains of a spinach chloroplast ribonucleoprotein
Q40045524RNA-binding properties of a translational activator, the adenovirus L4 100-kilodalton protein
Q43182216RNA-protein interactions in the nuclei of Xenopus oocytes: complex formation and processing activity on the regulatory intron of ribosomal protein gene L1.
Q36555995Regulation of poly(A) site use during mouse B-cell development involves a change in the binding of a general polyadenylation factor in a B-cell stage-specific manner
Q40795616S1 proteins C2 and D2 are novel hnRNPs similar to the transcriptional repressor, CArG box motif-binding factor A.
Q24599827Secondary structure as a functional feature in the downstream region of mammalian polyadenylation signals
Q34852725Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals
Q41882662Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites
Q38297910The 30-kDa protein binding to the "initiator" of the baculovirus polyhedrin promoter also binds specifically to the coding strand
Q36667262The 64-kilodalton subunit of the CstF polyadenylation factor binds to pre-mRNAs downstream of the cleavage site and influences cleavage site location
Q34222991The Ebola virus VP24 protein prevents hnRNP C1/C2 binding to karyopherin α1 and partially alters its nuclear import.
Q33785161The Epstein-Barr virus (EBV) SM protein enhances pre-mRNA processing of the EBV DNA polymerase transcript
Q34749544The G-rich auxiliary downstream element has distinct sequence and position requirements and mediates efficient 3' end pre-mRNA processing through a trans-acting factor
Q36559866The cap and the 3' splice site similarly affect polyadenylation efficiency
Q47723898The heterogeneous nuclear ribonucleoprotein C protein tetramer binds U1, U2, and U6 snRNAs through its high affinity RNA binding domain (the bZIP-like motif).
Q34462937The internal ribosome entry site-mediated translation of antiapoptotic protein XIAP is modulated by the heterogeneous nuclear ribonucleoproteins C1 and C2.
Q40020766The poly(A) tail inhibits the assembly of a 3'-to-5' exonuclease in an in vitro RNA stability system
Q36110142The regulation of AβPP expression by RNA-binding proteins
Q47362591The size heterogeneity of human lysyl oxidase mRNA is due to alternate polyadenylation site and not alternate exon usage
Q35207740The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3' end formation by two distinct mechanisms.
Q34973737Three new members of the RNP protein family in Xenopus
Q37059501Transcription termination and polyadenylation in retroviruses
Q34070133Uridylate-containing RNA sequences determine specificity for binding and polyadenylation by the catalytic subunit of vaccinia virus poly(A) polymerase.
Q33958705Utilization of splicing elements and polyadenylation signal elements in the coupling of polyadenylation and last-intron removal

Search more.