Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway

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Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway is …
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scholarly articleQ13442814

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P356DOI10.1002/CBIC.201500239
P698PubMed publication ID26052818

P50authorPei-Yuan QianQ52372051
P2093author name stringYing Xu
Bin Wang
Yongxin Li
Guoqiang Zhu
Liang Lu
Jennifer Y H Lai
Zhong-Rui Li
Jianqiang Tang
Xiyang Wu
P2860cites workDirected natural product biosynthesis gene cluster capture and expression in the model bacterium Bacillus subtilisQ28552699
PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosminQ30764407
Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moietyQ33365728
Thiazole and oxazole peptides: biosynthesis and molecular machineryQ33636923
Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.Q33879227
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cellsQ33953217
The microbiome and cancerQ35019302
Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways.Q35024032
The colibactin warhead crosslinks DNA.Q35844576
Bleomycins: towards better therapeuticsQ36026763
Pyridin-2(1H)-ones: a promising class of HIV-1 non-nucleoside reverse transcriptase inhibitorsQ36810076
Intestinal inflammation targets cancer-inducing activity of the microbiota.Q36819342
Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.Q37410263
Direct cloning and refactoring of a silent lipopeptide biosynthetic gene cluster yields the antibiotic taromycin A.Q37571513
A natural prodrug activation mechanism in the biosynthesis of nonribosomal peptides.Q38172793
Practical and efficient synthesis of pyrano[3,2-c]pyridone, pyrano[4,3-b]pyran and their hybrids with nucleoside as potential antiviral and antileishmanial agentsQ39753559
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.Q40244785
The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosisQ41890619
Heterologous production of albicidin: a promising approach to overproducing and characterizing this potent inhibitor of DNA gyrase.Q41905085
Synthesis of 6-(2-thienyl)purine nucleoside derivatives that form unnatural base pairs with pyridin-2-one nucleosidesQ43713833
In vivo evidence for a prodrug activation mechanism during colibactin maturation.Q44140961
A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicityQ45678137
The gyrase inhibitor albicidin consists of p-aminobenzoic acids and cyanoalanine.Q48234455
The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli.Q53068393
A natural prodrug activation mechanism in nonribosomal peptide synthesis.Q53218701
Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.Q54272417
Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype.Q54292519
P433issue12
P921main subjectEscherichia coliQ25419
colibactinQ66363675
Precolibactin CQ77376283
Precolibactin BQ77483129
(R)-N1-((S)-7-((1-acetylcyclopropyl)amino)-5,7-dioxoheptan-2-yl)-2-tetradecanamidosuccinamideQ105224209
P304page(s)1715-1719
P577publication date2015-06-26
P1433published inChemBioChemQ634395
P1476titleCritical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin Pathway
P478volume16

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cites work (P2860)
Q46773646A Mechanistic Model for Colibactin-Induced Genotoxicity.
Q54250718Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.
Q36219549ClbM is a versatile, cation-promiscuous MATE transporter found in the colibactin biosynthetic gene cluster.
Q48349705ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.
Q57812436Clone of Plipastatin Biosynthesis Gene Cluster by Transformation-associated Recombination Technique and High Efficient Expression in Model Organism Bacillus subtilis
Q47263315Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.
Q85631345Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursor
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Q36108894Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactin
Q48190463Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin Biosynthesis
Q101566484Employing chemical synthesis to study the structure and function of colibactin, a "dark matter" metabolite
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Q35803008Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular Networking
Q39443565MATE transport of the E. coli-derived genotoxin colibactin.
Q90135219Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavage
Q58591398Model colibactins exhibit human cell genotoxicity in the absence of host bacteria
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Q91182894Refining and expanding nonribosomal peptide synthetase function and mechanism
Q90739257Signaling Natural Products from Human Pathogenic Bacteria
Q38605864Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic Pathway
Q96298063Structure and bioactivity of colibactin
Q66499217Structure elucidation of colibactin and its DNA cross-links
Q90242856Synthesis and reactivity of precolibactin 886
Q98569359Synthesis of Colibactin Pyrrolidono[3,4-d]pyridones via Regioselective C(sp3)-H Activation
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Q35694112The Microbes inside Us and the Race for Colibactin
Q86596654The human gut bacterial genotoxin colibactin alkylates DNA
Q38817999Transformation-associated recombination (TAR) cloning for genomics studies and synthetic biology

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