The human gut bacterial genotoxin colibactin alkylates DNA

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The human gut bacterial genotoxin colibactin alkylates DNA is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.AAR7785
P932PMC publication ID6407708
P698PubMed publication ID30765538

P50authorPeter W VillaltaQ59200418
Alessia StornettaQ60323332
Leona D SamsonQ88942379
Bevin P EngelwardQ89179270
Wendy S GarrettQ91152376
Matthew R. WilsonQ91595149
Yindi JiangQ91595150
Paul D BoudreauQ91595153
Andrea CarráQ91595158
Eunyoung ChunQ91595163
Lizzie NgoQ91595165
Silvia BalboQ37341127
Caitlin A BrennanQ56460453
Emily BalskusQ57449135
P2860cites workCritical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin PathwayQ30967654
Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moietyQ33365728
Genomic and epigenetic instability in colorectal cancer pathogenesisQ33836026
Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.Q33879227
Single cell trapping and DNA damage analysis using microwell arraysQ33933241
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cellsQ33953217
Characterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring OpeningQ58582133
Assigning stereochemistry to single diastereoisomers by GIAO NMR calculation: the DP4 probabilityQ84959297
1H and 13C NMR scaling factors for the calculation of chemical shifts in commonly used solvents using density functional theoryQ87935695
E. coli and colorectal cancer: a complex relationship that deserves a critical mindsetQ89128002
Microbial genomic analysis reveals the essential role of inflammation in bacteria-induced colorectal cancerQ34137586
Prokaryotic nucleotide excision repair: the UvrABC system.Q34492374
Micropatterned comet assay enables high throughput and sensitive DNA damage quantificationQ34743485
ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptidesQ35371319
The colibactin warhead crosslinks DNA.Q35844576
Chemical-induced DNA damage and human cancer riskQ35852323
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactinQ36108894
The Human Intestinal Microbiome in Health and DiseaseQ36224014
High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancerQ36611515
Balancing repair and tolerance of DNA damage caused by alkylating agentsQ36651488
Intestinal inflammation targets cancer-inducing activity of the microbiota.Q36819342
Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.Q37309140
Quantification of acylfulvene- and illudin S-DNA adducts in cells with variable bioactivation capacities.Q37381349
Screening for DNA Alkylation Mono and Cross-Linked Adducts with a Comprehensive LC-MS(3) Adductomic ApproachQ37450078
Chemical and biological explorations of the family of CC-1065 and the duocarmycin natural products.Q37630689
Application of a high-resolution mass-spectrometry-based DNA adductomics approach for identification of DNA adducts in complex mixtures.Q37696819
Chemistry and biology of acylfulvenes: sesquiterpene-derived antitumor agents.Q38000617
Cancer associated faecal microbial markers in colorectal cancer detectionQ38638269
Kinetics of H2AX phosphorylation after exposure to cisplatinQ39947163
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.Q40244785
Escherichia coli ClbS is a colibactin resistance protein.Q40913066
In vivo evidence for a prodrug activation mechanism during colibactin maturation.Q44140961
A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicityQ45678137
A Mechanistic Model for Colibactin-Induced Genotoxicity.Q46773646
ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.Q48349705
Patients with familial adenomatous polyposis harbor colonic biofilms containing tumorigenic bacteria.Q50115606
The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.Q52646141
Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.Q54250718
Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.Q54272417
P433issue6428
P407language of work or nameEnglishQ1860
P921main subjectintestineQ9639
mutagenQ221696
colibactinQ66363675
P304page(s)eaar7785
P577publication date2019-02-01
2019-02-14
P1433published inScienceQ192864
P1476titleThe human gut bacterial genotoxin colibactin alkylates DNA
P478volume363

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