The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.

scientific article published on 20 March 2018

The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells. is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1128/MBIO.02393-17
P932PMC publication ID5874909
P698PubMed publication ID29559578

P50authorGladys MireyQ57021845
Jean-Philippe NougayredeQ64670688
Julien VignardQ83954800
Eric OswaldQ88360513
Damien DuboisQ115032525
Nadège Bossuet-GreifQ117256398
Frédéric TaiebQ117256399
P2093author name stringClaude Petit
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Alkaline gel electrophoresis of deoxyribonucleic acid photoreacted with trimethylpsoralen: rapid and sensitive detection of interstrand cross-linksQ30463502
Human RPA phosphorylation by ATR stimulates DNA synthesis and prevents ssDNA accumulation during DNA-replication stressQ33511571
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Clonogenic assay of cells in vitro.Q34615431
Interplay between siderophores and colibactin genotoxin biosynthetic pathways in Escherichia coliQ34819487
Mechanism of replication-coupled DNA interstrand crosslink repairQ34832238
Gut symbionts from distinct hosts exhibit genotoxic activity via divergent colibactin biosynthesis pathways.Q35024032
ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptidesQ35371319
Mitotic block and delayed lethality in HeLa epithelial cells exposed to Escherichia coli BM2-1 producing cytotoxic necrotizing factor type 1.Q35490054
The colibactin warhead crosslinks DNA.Q35844576
The Genotoxin Colibactin Is a Determinant of Virulence in Escherichia coli K1 Experimental Neonatal Systemic InfectionQ35947396
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactinQ36108894
DNA interstrand crosslink repair and cancerQ36576047
High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancerQ36611515
Intestinal inflammation targets cancer-inducing activity of the microbiota.Q36819342
Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic islandQ36994573
Cell resistance to the Cytolethal Distending Toxin involves an association of DNA repair mechanisms.Q37360355
Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.Q37410263
Prevalence and characteristics of pks genotoxin gene cluster-positive clinical Klebsiella pneumoniae isolates in TaiwanQ37663020
Colibactin Contributes to the Hypervirulence of pks+ K1 CC23 Klebsiella pneumoniae in Mouse Meningitis Infections.Q37730929
Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic PathwayQ38605864
The essential kinase ATR: ensuring faithful duplication of a challenging genome.Q38622938
The structure-specific endonuclease Mus81-Eme1 promotes conversion of interstrand DNA crosslinks into double-strands breaksQ38774142
Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assayQ39088426
MATE transport of the E. coli-derived genotoxin colibactin.Q39443565
Selective killing of ATM- or p53-deficient cancer cells through inhibition of ATR.Q39559122
ATR couples FANCD2 monoubiquitination to the DNA-damage responseQ39941293
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.Q40244785
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.Q40248146
Repair kinetics of genomic interstrand DNA cross-links: evidence for DNA double-strand break-dependent activation of the Fanconi anemia/BRCA pathwayQ40376906
Escherichia coli ClbS is a colibactin resistance protein.Q40913066
The genus Pseudovibrio contains metabolically versatile bacteria adapted for symbiosisQ41890619
In vivo evidence for a prodrug activation mechanism during colibactin maturation.Q44140961
Colonization of the human gut by E. coli and colorectal cancer riskQ44752814
Regulated interaction of the Fanconi anemia protein, FANCD2, with chromatinQ45083320
A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicityQ45678137
An adherent mucus layer attenuates the genotoxic effect of colibactinQ46257981
A Mechanistic Model for Colibactin-Induced Genotoxicity.Q46773646
Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.Q47263315
Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective.Q48286824
ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.Q48349705
The genotoxin colibactin exacerbates lymphopenia and decreases survival rate in mice infected with septicemic Escherichia coli.Q53068393
Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype.Q54292519
Escherichia coli strains with the capacity for long-term persistence in the bowel microbiota carry the potentially genotoxic pks island.Q54334232
Acute Escherichia coli prostatitis in previously health young men: bacterial virulence factors, antimicrobial resistance, and clinical outcomes.Q54364099
P433issue2
P921main subjectDNAQ7430
colibactinQ66363675
P577publication date2018-03-20
P1433published inmBioQ15817061
P1476titleThe Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.
P478volume9

Reverse relations

cites work (P2860)
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Q97568133ClbR Is the Key Transcriptional Activator of Colibactin Gene Expression in Escherichia coli
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