Structure elucidation of colibactin and its DNA cross-links

scientific article

Structure elucidation of colibactin and its DNA cross-links is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1126/SCIENCE.AAX2685
P932PMC publication ID6820679
P698PubMed publication ID31395743

P50authorZhixun WangQ63430307
Alan R HealyQ64219003
Seth B. HerzonQ87707879
Jason M CrawfordQ88262532
Kevin M WernkeQ90242852
Emilee ShineQ91089475
Mengzhao XueQ92508218
Madeline C FrischlingQ92508222
Weiwei WangQ92508223
Chung Sub KimQ57053662
P2093author name stringWeiwei Wang
Mengzhao Xue
Emilee E. Shine
Jason M. Crawford
Kevin M. Wernke
Madeline C. Frischling
Seth B. Herzon
P2860cites workCharacterization of Natural Colibactin-Nucleobase Adducts by Tandem Mass Spectrometry and Isotopic Labeling. Support for DNA Alkylation by Cyclopropane Ring OpeningQ58582133
Model colibactins exhibit human cell genotoxicity in the absence of host bacteriaQ58591398
Colibactin biosynthesis and biological activity depend on the rare aminomalonyl polyketide precursorQ85631345
The human gut bacterial genotoxin colibactin alkylates DNAQ86596654
Macrocyclic colibactin induces DNA double-strand breaks via copper-mediated oxidative cleavageQ90135219
Synthesis and reactivity of precolibactin 886Q90242856
Microbiome: Focus on Causation and MechanismQ90872233
Reactivity of an Unusual Amidase May Explain Colibactin's DNA Cross-Linking ActivityQ93099442
Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collectionQ22122301
Analysis of structure-function relationships in the colibactin-maturating enzyme ClbPQ27682692
Critical Intermediates Reveal New Biosynthetic Events in the Enigmatic Colibactin PathwayQ30967654
Two more pieces of the colibactin genotoxin puzzle from Escherichia coli show incorporation of an unusual 1-aminocyclopropanecarboxylic acid moietyQ33365728
Comparative metabolomics and structural characterizations illuminate colibactin pathway-dependent small molecules.Q33879227
Escherichia coli induces DNA damage in vivo and triggers genomic instability in mammalian cellsQ33953217
Colibactin: understanding an elusive gut bacterial genotoxinQ34495096
ClbP is a prototype of a peptidase subgroup involved in biosynthesis of nonribosomal peptidesQ35371319
Linking Biosynthetic Gene Clusters to their Metabolites via Pathway- Targeted Molecular NetworkingQ35803008
The colibactin warhead crosslinks DNA.Q35844576
Divergent biosynthesis yields a cytotoxic aminomalonate-containing precolibactinQ36108894
High prevalence of mucosa-associated E. coli producing cyclomodulin and genotoxin in colon cancerQ36611515
Intestinal inflammation targets cancer-inducing activity of the microbiota.Q36819342
Molecular epidemiology and phylogenetic distribution of the Escherichia coli pks genomic islandQ36994573
Convergent and Modular Synthesis of Candidate Precolibactins. Structural Revision of Precolibactin A.Q37309140
Genetic structure and distribution of the colibactin genomic island among members of the family Enterobacteriaceae.Q37410263
Structure and Functional Analysis of ClbQ, an Unusual Intermediate-Releasing Thioesterase from the Colibactin Biosynthetic PathwayQ38605864
The Enterobacterial Genotoxins: Cytolethal Distending Toxin and ColibactinQ38897671
Escherichia coli induces DNA double-strand breaks in eukaryotic cells.Q40244785
Locoregional Effects of Microbiota in a Preclinical Model of Colon Carcinogenesis.Q40248146
Escherichia coli ClbS is a colibactin resistance protein.Q40913066
In vivo evidence for a prodrug activation mechanism during colibactin maturation.Q44140961
A prodrug resistance mechanism is involved in colibactin biosynthesis and cytotoxicityQ45678137
Moving beyond microbiome-wide associations to causal microbe identificationQ46246834
A Mechanistic Model for Colibactin-Induced Genotoxicity.Q46773646
Colibactin assembly line enzymes use S-adenosylmethionine to build a cyclopropane ring.Q47263315
Domain-Targeted Metabolomics Delineates the Heterocycle Assembly Steps of Colibactin BiosynthesisQ48190463
Molecular Basis of Gut Microbiome-Associated Colorectal Cancer: A Synthetic Perspective.Q48286824
ClbS Is a Cyclopropane Hydrolase That Confers Colibactin Resistance.Q48349705
Colibactin: More Than a New Bacterial Toxin.Q52593550
The Colibactin Genotoxin Generates DNA Interstrand Cross-Links in Infected Cells.Q52646141
Characterization of Polyketide Synthase Machinery from the pks Island Facilitates Isolation of a Candidate Precolibactin.Q54250718
Isolation of a metabolite from the pks island provides insights into colibactin biosynthesis and activity.Q54272417
Bacterial genotoxin colibactin promotes colon tumour growth by inducing a senescence-associated secretory phenotype.Q54292519
P433issue6457
P407language of work or nameEnglishQ1860
P921main subjectcolibactinQ66363675
P304page(s)eaax2685
P577publication date2019-08-08
P1433published inScienceQ192864
P1476titleStructure elucidation of colibactin and its DNA cross-links
P478volume365

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