The utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry

scientific article

The utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry is …
instance of (P31):
scholarly articleQ13442814

External links are
P356DOI10.1002/PMIC.201300406
P932PMC publication ID4017854
P698PubMed publication ID24453194

P50authorAngus C GreyQ52845630
Jeffrey M. SpragginsQ55979545
P2093author name stringRosalie K Crouch
Yiannis Koutalos
Zsolt Ablonczy
Kevin L Schey
David M Anderson
Noah Smith
P2860cites workIn vivo fluorescence of the ocular fundus exhibits retinal pigment epithelium lipofuscin characteristicsQ72631037
The biosynthesis of A2E, a fluorophore of aging retina, involves the formation of the precursor, A2-PE, in the photoreceptor outer segment membraneQ73971779
Cyclin-dependent kinase-5 is associated with lipofuscin in motor neurones in amyotrophic lateral sclerosisQ74576356
Isolation and one-step preparation of A2E and iso-A2E, fluorophores from human retinal pigment epitheliumQ28610021
Blue light-induced singlet oxygen generation by retinal lipofuscin in non-polar mediaQ32061135
Phospholipid meets all-trans-retinal: the making of RPE bisretinoidsQ33577803
Oxidative damage and age-related macular degenerationQ33774187
Spatial localization of A2E in the retinal pigment epitheliumQ33831456
Biosynthesis of a major lipofuscin fluorophore in mice and humans with ABCR-mediated retinal and macular degenerationQ33905581
Mass spectrometry provides accurate and sensitive quantitation of A2EQ34452853
Lack of correlation between the spatial distribution of A2E and lipofuscin fluorescence in the human retinal pigment epitheliumQ34814102
Similar molecules spatially correlate with lipofuscin and N-retinylidene-N-retinylethanolamine in the mouse but not in the human retinal pigment epithelium.Q34967125
A novel bisretinoid of retina is an adduct on glycerophosphoethanolamineQ35595752
The bisretinoids of retinal pigment epitheliumQ35785390
Lipofuscin and N-retinylidene-N-retinylethanolamine (A2E) accumulate in retinal pigment epithelium in absence of light exposure: their origin is 11-cis-retinalQ36052545
RPE lipofuscin and its role in retinal pathobiologyQ36111032
Primary amines protect against retinal degeneration in mouse models of retinopathiesQ36455469
Retinal pigment epithelium lipofuscin proteomics.Q36804690
New insights into retinoid metabolism and cycling within the retinaQ37101460
Combination of sustained off-resonance irradiation and on-resonance excitation in FT-ICR.Q41991437
Photocytotoxicity of lipofuscin in human retinal pigment epithelial cellsQ42506829
The role of A2E in prevention or enhancement of light damage in human retinal pigment epithelial cellsQ43908836
Photoreactivity of aged human RPE melanosomes: a comparison with lipofuscin.Q44045967
Formation of a nonaoxirane from A2E, a lipofuscin fluorophore related to macular degeneration, and evidence of singlet oxygen involvementQ44255419
Altered lipofuscin pigmentation in the basal nucleus (Meynert) in Parkinson's diseaseQ45290238
Pin1 protein associates with neuronal lipofuscin: potential consequences in age-related neurodegeneration.Q48648932
Increased expression of cathepsins E and D in neurons of the aged rat brain and their colocalization with lipofuscin and carboxy-terminal fragments of Alzheimer amyloid precursor protein.Q53215870
Ocular Age Pigment “A2-E”: An Unprecedented Pyridinium BisretinoidQ57903209
Retinal age pigments generated by self-assembling lysosomotropic detergentsQ59071585
Lipofuscin and melanin of human retinal pigment epithelium. Fluorescence, enzyme cytochemical, and ultrastructural studiesQ67355359
The topography and age relationship of lipofuscin concentration in the retinal pigment epitheliumQ67355361
Age-related changes in the lipofuscin accumulation of brain and heartQ71567657
P433issue7-8
P304page(s)936-944
P577publication date2014-03-05
P1433published inProteomicsQ15614164
P1476titleThe utilization of fluorescence to identify the components of lipofuscin by imaging mass spectrometry
P478volume14

Reverse relations

cites work (P2860)
Q41555677A2E and lipofuscin distributions in macaque retinal pigment epithelium are similar to human
Q46243402Bis(monoacylglycero)phosphate lipids in the retinal pigment epithelium implicate lysosomal/endosomal dysfunction in a model of Stargardt disease and human retinas
Q36225789Determination of N-retinylidene-N-retinylethanolamine (A2E) levels in central and peripheral areas of human retinal pigment epithelium
Q98613380Fundus Autofluorescence Lifetimes and Spectral Features of Soft Drusen and Hyperpigmentation in Age-Related Macular Degeneration
Q35174717Fundus Autofluorescence and RPE Lipofuscin in Age-Related Macular Degeneration
Q35846688Imaging mass spectrometry of the visual system: Advancing the molecular understanding of retina degenerations
Q56515728Mass Spectrometry Imaging and Integration with Other Imaging Modalities for Greater Molecular Understanding of Biological Tissues
Q64084759Myocardial lipofuscin accumulation in ageing and sudden cardiac death
Q30883767Simultaneous decomposition of multiple hyperspectral data sets: signal recovery of unknown fluorophores in the retinal pigment epithelium
Q36921058Spatial and Spectral Characterization of Human Retinal Pigment Epithelium Fluorophore Families by Ex Vivo Hyperspectral Autofluorescence Imaging
Q51579843Time-of-flight secondary ion mass spectrometry to assess spatial distribution of A2E and its oxidized forms within lipofuscin granules isolated from human retinal pigment epithelium.

Search more.