The AT2 receptor: fact, fancy and fantasy

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The AT2 receptor: fact, fancy and fantasy is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1016/S0167-0115(99)00023-3
P698PubMed publication ID10395404

P2093author name stringSiragy HM
de Gasparo M
P2860cites workBehavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in miceQ24303396
Preliminary biochemical characterization of two angiotensin II receptor subtypesQ24339567
Angiotensin II type 2 receptor mediates programmed cell deathQ28272739
The AT2 receptor selectively associates with Gialpha2 and Gialpha3 in the rat fetusQ28281919
Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptorQ28283897
Possible role of P-450 metabolite of arachidonic acid in vasodilator mechanism of angiotensin II type 2 receptor in the isolated microperfused rabbit afferent arterioleQ28379250
Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effectsQ28505671
Angiotensin type 2 receptor dephosphorylates Bcl-2 by activating mitogen-activated protein kinase phosphatase-1 and induces apoptosisQ28569536
Angiotensin II and NGF differentially influence microtubule proteins in PC12W cells: role of the AT2 receptorQ28577645
Protective role of the angiotensin AT2 receptor in a renal wrap hypertension modelQ30304002
The subtype 2 (AT2) angiotensin receptor mediates renal production of nitric oxide in conscious ratsQ30448817
The subtype-2 (AT2) angiotensin receptor regulates renal cyclic guanosine 3', 5'-monophosphate and AT1 receptor-mediated prostaglandin E2 production in conscious ratsQ30448844
Expression of the subtype 2 angiotensin (AT2) receptor protein in rat kidneyQ30471269
Immunolocalization of subtype 2 angiotensin II (AT2) receptor protein in rat heartQ30472368
The angiotensin II type 2 (AT2) receptor antagonizes the growth effects of the AT1 receptor: gain-of-function study using gene transferQ33792965
Apoptosis of human vascular smooth muscle cells derived from normal vessels and coronary atherosclerotic plaquesQ34218450
Stretch-induced programmed myocyte cell deathQ35766096
Angiotensin II induces apoptosis of adult ventricular myocytes in vitroQ73342683
The angiotensin AT2 receptor down-regulates neurofilament M in PC12W cellsQ73404389
Angiotensin II-mediated growth and antigrowth effects in cultured neonatal rat cardiac myocytes and fibroblastsQ73661346
Growth-dependent induction of angiotensin II type 2 receptor in rat mesangial cellsQ73741462
ANG II AT1 and AT2 receptors both inhibit bFGF-induced proliferation of bovine adrenocortical cellsQ73847643
Angiotensin type 2 receptors are reexpressed by cardiac fibroblasts from failing myopathic hamster hearts and inhibit cell growth and fibrillar collagen metabolismQ73951516
Angiotensin II type 2 receptor stimulation of neuronal delayed-rectifier potassium current involves phospholipase A2 and arachidonic acidQ74023758
Local application of angiotensin II to the rat carotid artery induces adventitial thickeningQ74027393
Angiotensin II inhibits growth of cultured embryonic renomedullary interstitial cells through the AT2 receptorQ74130608
AT2 receptor stimulation increases aortic cyclic GMP in SHRSP by a kinin-dependent mechanismQ74132672
Effects of AT1 and AT2 angiotensin receptor antagonists in angiotensin II-infused ratsQ74132779
AT2 receptor blockade reduces cardiac interstitial cell DNA synthesis and cardiac function after rat myocardial infarctionQ74353363
Angiotensin II potentiates vascular endothelial growth factor-induced angiogenic activity in retinal microcapillary endothelial cellsQ74405505
Nitrosative and oxidative stress induced heme oxygenase-1 accumulation in rat mesangial cellsQ74449673
Apoptosis in restenosis versus stable-angina atherosclerosis: implications for the pathogenesis of restenosisQ74794174
Vascular remodeling--the emerging paradigm of programmed cell death (apoptosis): the Francis B. Parker lectureshipQ74805121
Tissue-specific expression of human angiotensin II AT1 and AT2 receptors and cellular localization of subtype mRNAs in adult human renal cortex using in situ hybridizationQ77216279
Genetic deletion of AT2 receptor antagonizes angiotensin II-induced apoptosis in fibroblasts of the mouse embryoQ77293344
Effects of angiotensin II on sexual function, blood pressure, and fluid intake are differentially affected by AT-1 receptor blockadeQ77332640
Apoptosis and the pathogenesis of IDDM: a question of life and deathQ77349126
Influence of the angiotensin II antagonist valsartan on left ventricular hypertrophy in patients with essential hypertensionQ77531896
Interaction of biphenylimidazole and imidazoleacrylic acid nonpeptide antagonists with valine 108 in TM III of the AT1 angiotensin receptorQ35884589
Phospholipase A2-mediated activation of mitogen-activated protein kinase by angiotensin IIQ36167444
The angiotensin II type 2 (AT2) receptor promotes axonal regeneration in the optic nerve of adult ratsQ36404036
Arachidonic acid mediates angiotensin II effects on p21ras in renal proximal tubular cells via the tyrosine kinase-Shc-Grb2-Sos pathwayQ36489750
Chronic blockade of AT2-subtype receptors prevents the effect of angiotensin II on the rat vascular structure.Q37357707
Effects of angiotensin-converting enzyme inhibitors and angiotensin II type 1 receptor antagonists in rats with heart failure. Role of kinins and angiotensin II type 2 receptorsQ37365932
Stretch-mediated release of angiotensin II induces myocyte apoptosis by activating p53 that enhances the local renin-angiotensin system and decreases the Bcl-2-to-Bax protein ratio in the cellQ37380055
Apoptosis and congestive heart failureQ37828669
The angiotensin AT2-receptor mediates inhibition of cell proliferation in coronary endothelial cellsQ38299038
Interferon regulatory factor-1 up-regulates angiotensin II type 2 receptor and induces apoptosisQ38346150
Regulation of gene transcription of angiotensin II receptor subtypes in myocardial infarctionQ40341321
Role of angiotensin II and prostaglandin E2 in regulating cardiac fibroblast collagen turnoverQ40380110
Angiotensin II receptor subtypes and cardiac function.Q40504829
Effects of growth factors on cell proliferation and angiotensin II type 2 receptor number and mRNA in PC12W and R3T3 cellsQ41016414
Repression of c-fos and c-jun gene expression is not part of AT2 receptor coupled signal transductionQ41052137
The angiotensin II AT2 receptor inhibits proliferation and promotes differentiation in PC12W cellsQ41173259
Sequential development of angiotensin receptors and angiotensin I converting enzyme during angiogenesis in the rat subcutaneous sponge granuloma.Q41973411
Angiotensin II receptors: localization of type I and type II in rat epididymides of different developmental stagesQ42438056
Different signaling pathways mediate stimulated secretions of endogenous ouabain and aldosterone from bovine adrenocortical cellsQ42450361
The angiotensin AT2 receptor stimulates protein tyrosine phosphatase activity and mediates inhibition of particulate guanylate cyclaseQ42452991
Ca2+ mobilization in adult rat cardiomyocytes by angiotensin type 1 and 2 receptorsQ42469011
Regulation of protease nexin-1 expression in cultured Schwann cells is mediated by angiotensin II receptors.Q42488014
Interaction of mRNAs for angiotensin II type 1 and type 2 receptors to vascular remodeling in spontaneously hypertensive ratsQ42539666
Smooth muscle apoptosis during vascular regression in spontaneously hypertensive ratsQ42551100
The angiotensin II type 2 receptor primarily inhibits cell growth via pertussis toxin-sensitive G proteinsQ42807182
Angiotensin II type 2 receptors mediate inhibition of mitogen-activated protein kinase cascade and functional activation of SHP-1 tyrosine phosphataseQ42987208
Mapping of angiotensin II receptor subtype heterogeneity in rat brainQ43685939
Angiotensin II AT2 receptors do not interact with guanine nucleotide binding proteinsQ44747015
Role of angiotensin subtype 2 receptor in neointima formation after vascular injuryQ44979985
Expression of angiotensin II AT2 receptors in the rat skin during experimental wound healingQ45073640
Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular functionQ46137769
Molecular insights into angiotensin II type 1 and type 2 receptors: expression, signaling and physiological function and clinical application of its antagonistsQ47700424
Localization of the mRNA for the angiotensin II receptor subtype 2 (AT2) in follicular granulosa cells of the rat ovary by nonradioactive in situ hybridizationQ47813946
Mutational analysis of the angiotensin II type 2 receptor: contribution of conserved extracellular amino acidsQ47885770
Angiotensin receptors and norepinephrine neuromodulation: implications of functional couplingQ47885872
p53 Induces myocyte apoptosis via the activation of the renin-angiotensin system.Q48047369
Down-regulation by cAMP of angiotensin II type 2 receptor gene expression in PC12 cellsQ48057217
Insulin and insulin-like growth factors induce expression of angiotensin type-2 receptor in vascular-smooth-muscle cellsQ48061654
Expression, genomic organization, and transcription of the mouse angiotensin II type 2 receptor geneQ48074029
Angiotensin II type 2 receptor is upregulated in human heart with interstitial fibrosis, and cardiac fibroblasts are the major cell type for its expressionQ48350568
Pituitary-dependent expression of the testicular angiotensin II receptor and its subtypes in ratsQ48389554
Up-regulation of angiotensin type 2 receptor mRNA by angiotensin II in rat cortical cellsQ48606807
Functional interactions between neuronal AT1 and AT2 receptorsQ48722995
Proposed update of angiotensin receptor nomenclatureQ48791533
Angiotensin II decreases cGMP levels in neuronal cultures from rat brainQ48822986
Angiotensin II type 2 receptor-mediated regulation of rat neuronal K+ channelsQ48958400
Involvement of angiotensin II in the process of gonadotropin-induced ovulation in rabbitsQ48974556
Angiotensin II induces ovulation and oocyte maturation in rabbit ovaries via the AT2 receptor subtypeQ49016095
Angiotensin II directly induces follicle rupture and oocyte maturation in the rabbit.Q50790858
Type 2 angiotensin II receptor is expressed in human myometrium and uterine leiomyoma and is down-regulated during pregnancy.Q50986840
A G protein is involved in the angiotensin AT2 receptor inhibition of the T-type calcium current in non-differentiated NG108-15 cells.Q55481180
Calcium - a life and death signalQ56836038
Regulated Expression of Testis Angiotensin-Converting Enzyme during Spermatogenesis in Mice1Q57630638
DIFFERENTIAL GENE EXPRESSION OF ANGIOTENSIN II RECEPTOR SUBTYPES IN THE EPIDIDYMIDES OF MATURE AND IMMATURE RATSQ60585310
Overexpression of Bax Protein and Enhanced Apoptosis in the Left Ventricle of Spontaneously Hypertensive RatsQ61984453
Angiotensin II activates programmed myocyte cell death in vitroQ64389256
Localization of angiotensin II receptor subtypes in the rabbit adrenal and kidneyQ68019375
Identification and characterization of angiotensin II receptor subtypes in rabbit ventricular myocardiumQ68629226
Angiotensin II interferes with steroidogenesis in porcine granulosa cellsQ70862936
Regulation of angiotensin II type 2 receptor gene by the protein kinase C-calcium pathwayQ71036648
Opposing actions of angiotensin II on microvascular growth and arterial blood pressureQ71036830
Mitogen-activated protein kinases in rat brain neuronal cultures are activated by angiotensin II type 1 receptors and inhibited by angiotensin II type 2 receptorsQ71143758
Angiotensin II type 1 receptor modulation of neuronal K+ and Ca2+ currents: intracellular mechanismsQ71404374
Angiotensin II induction of neurite outgrowth by AT2 receptors in NG108-15 cells. Effect counteracted by the AT1 receptorsQ71514657
Programmed myocyte cell death affects the viable myocardium after infarction in ratsQ71530031
Angiotensin II-receptor subtypes in human atria and evidence for alterations in patients with cardiac dysfunctionQ71538365
Vasoactive substances regulate vascular smooth muscle cell apoptosis. Countervailing influences of nitric oxide and angiotensin IIQ71590987
Role of type 1 and type 2 angiotensin receptors in angiotensin II-induced cardiomyocyte hypertrophyQ71620642
Cycloheximide enhances ACTH-receptor mRNA through transcriptional and post-transcriptional mechanisms in bovine adrenocortical cellsQ71671105
Localization of the angiotensin II receptor subtypes in the human atriumQ71699203
Apoptosis in target organs of hypertensionQ71740108
Angiotensin II induces cardiac phenotypic modulation and remodeling in vivo in ratsQ72282322
Down regulation of the angiotensin II receptor subtype AT2 in human myometrium during pregnancyQ72358282
Angiotensin II type 2 receptor-modulated changes in potassium currents in cultured neuronsQ72542289
Characterization of angiotensin II receptor type 2 during differentiation and apoptosis of rat ovarian cultured granulosa cellsQ72566492
Regulation of adrenal cell-differentiated functions by growth factorsQ72802715
Collagen metabolism in cultured adult rat cardiac fibroblasts: response to angiotensin II and aldosteroneQ72819723
Angiotensin II type 2 receptor stimulation of neuronal K+ currents involves an inhibitory GTP binding proteinQ72850342
Differential effects of kinins on cardiomyocyte hypertrophy and interstitial collagen matrix in the surviving myocardium after myocardial infarction in the ratQ73233103
Transforming growth factor beta 1 and renal injury following subtotal nephrectomy in the rat: role of the renin-angiotensin systemQ73338092
P433issue1-3
P407language of work or nameEnglishQ1860
P304page(s)11-24
P577publication date1999-05-01
P1433published inRegulatory PeptidesQ15762717
P1476titleThe AT2 receptor: fact, fancy and fantasy
P478volume81

Reverse relations

cites work (P2860)
Q37269304A peripherally administered, centrally acting angiotensin II AT2 antagonist selectively increases brain AT1 receptors and decreases brain tyrosine hydroxylase transcription, pituitary vasopressin and ACTH.
Q44210986ANG II AT2 receptor modulates AT1 receptor-mediated descending vasa recta endothelial Ca2+ signaling
Q30434317ANG II type 2 receptor regulates smooth muscle growth and force generation in late fetal mouse development
Q44490998AT1 and AT2 receptors in human glomerular endothelial cells at different passages
Q54765190Activated human hepatic stellate cells express the renin-angiotensin system and synthesize angiotensin II.
Q34238307Addressing those two that go together: the angiotensin II receptors and their role in blood-flow regulation
Q35045801Angiotensin AT2 receptors: cardiovascular hope or hype?
Q37342730Angiotensin II AT(1) receptor blockade selectively enhances brain AT(2) receptor expression, and abolishes the cold-restraint stress-induced increase in tyrosine hydroxylase mRNA in the locus coeruleus of spontaneously hypertensive rats
Q35827935Angiotensin II AT(1) receptor blockers ameliorate inflammatory stress: a beneficial effect for the treatment of brain disorders
Q36410269Angiotensin II AT(1) receptor blockers as treatments for inflammatory brain disorders
Q42439825Angiotensin II AT1 and AT2 Receptors Contribute to Maintain Basal Adrenomedullary Norepinephrine Synthesis and Tyrosine Hydroxylase Transcription
Q48106483Angiotensin II AT2 Receptors Contribute to Regulate the Sympathoadrenal and Hormonal Reaction to Stress Stimuli.
Q34963306Angiotensin II and nitric oxide interaction.
Q50508773Angiotensin II does not induce apoptosis but rather prevents apoptosis in cardiomyocytes.
Q45049892Angiotensin II increases differentiation of dopaminergic neurons from mesencephalic precursors via angiotensin type 2 receptors
Q41195003Angiotensin II receptors and peritoneal dialysis-induced peritoneal fibrosis
Q58764102Angiotensin II upregulates cyclophilin A by enhancing ROS production in rat cardiomyocytes
Q34209423Angiotensin receptor blockers: evidence for preserving target organs.
Q37045324Angiotensin receptor subtype mediated physiologies and behaviors: new discoveries and clinical targets
Q38275879Angiotensin type 1 and type 2 receptors during ontogeny: cardiovascular and renal effects
Q36827283Brain and peripheral angiotensin II play a major role in stress
Q36216393Brain angiotensin II: new developments, unanswered questions and therapeutic opportunities
Q43080218Brain renin-angiotensin system modifies the blood pressure response to intracerebroventricular cadmium in rats.
Q48967197Candesartan decreases the sympatho-adrenal and hormonal response to isolation stress
Q34809342Commercially available angiotensin II At₂ receptor antibodies are nonspecific.
Q34117878Comparative analysis of amphibian and mammalian angiotensin receptors
Q44217775Conversion of brain angiotensin II to angiotensin III is critical for pressor response in rats
Q39012575Crosstalk between angiotensin and the nonamyloidogenic pathway of Alzheimer's amyloid precursor protein
Q43756594Day-night variation in the in vitro contractility of aorta and mesenteric and renal arteries in transgenic hypertensive rats.
Q35572277Demographics, Treatment Regimens and the Use of Angiotensin-Receptor Blockers in Heart Failure: Findings from the Valsartan Heart Failure Trial
Q28344420Differential effect of angiotensin II on blood circulation in the renal medulla and cortex of anaesthetised rats
Q35046246Differential regulation by AT(1) and AT(2) receptors of angiotensin II-stimulated cyclic GMP production in rat uterine artery and aorta.
Q30417907Dopamine and angiotensin type 2 receptors cooperatively inhibit sodium transport in human renal proximal tubule cells
Q33568455Eprosartan improves cardiac function in swine working heart model of ischemia-reperfusion injury
Q44174214Estrogen upregulates renal angiotensin II AT(2) receptors
Q34508369Extracellular matrix molecules, long-term potentiation, memory consolidation and the brain angiotensin system
Q34099679Functional cross-talk between the cyclic AMP and Jak/STAT signaling pathways in vascular smooth muscle cells
Q35045808Functional role of angiotensin II AT2 receptor in modulation of AT1 receptor‐mediated contraction in rat uterine artery: involvement of bradykinin and nitric oxide
Q41953838High blood pressure reduction reverses angiotensin II type 2 receptor-mediated vasoconstriction into vasodilation in spontaneously hypertensive rats
Q43766131Increased AT(1) receptors in adrenal gland of AT(2) receptor gene-disrupted mice
Q37461915Increased angiotensin II AT1 receptor mRNA and binding in spleen and lung of AT2 receptor gene disrupted mice
Q37138957Increased vascular angiotensin type 2 receptor expression and NOS-mediated mechanisms of vascular relaxation in pregnant rats
Q30496299Intraneuronal angiotensinergic system in rat and human dorsal root ganglia
Q34942174Neural plasticity and the brain renin-angiotensin system
Q38264237Neuroprotective effects of angiotensin receptor blockers.
Q36996244New insights into the importance of aminopeptidase A in hypertension
Q35097995Persistent proteinuria up-regulates angiotensin II type 2 receptor and induces apoptosis in proximal tubular cells
Q39091992Review: Lessons on renal function from transgenic mice lacking different angiotensin II receptors
Q37739210Role of the angiotensin II receptor blocker valsartan in heart failure.
Q51817293Sarcosine1, glycine8 angiotensin II is a functional AT1 angiotensin receptor antagonist.
Q93108344Structural alterations and markers of endothelial activation in pulmonary and bronchial arteries in fatal asthma
Q36019970Telmisartan Modulates Glial Activation: In Vitro and In Vivo Studies
Q44635561The Serotonin Transporter is Required for Stress-Evoked Increases in Adrenal Catecholamine Synthesis and Angiotensin II AT<sub>2</sub> Receptor Expression
Q40853213The interaction of nitric oxide, bradykinin, and the angiotensin II type 2 receptor: lessons learned from transgenic mice
Q40756560The renin-angiotensin system in Barrett's esophagus.
Q36421051The role of angiotensin II type 1 receptor antagonists in elderly patients with hypertension
Q36909521The role of angiotensin II type 1 receptor blockers in the prevention and management of diabetes mellitus
Q38253635The role of local renin-angiotensin system in arterial chemoreceptors in sleep-breathing disorders
Q39185363Transforming growth factor type beta 1 increases the expression of angiotensin II receptor type 2 by a SMAD- and p38 MAPK-dependent mechanism in skeletal muscle.
Q28577142Upregulation of a local renin-angiotensin system in the rat carotid body during chronic intermittent hypoxia

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