Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies

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Serum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

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P356DOI10.1136/BMJ.J2376
P932PMC publication ID5461476
P698PubMed publication ID28592419

P50authorIoanna TzoulakiQ63378793
Maria TimofeevaQ64609845
Evropi TheodoratouQ30438198
P2093author name stringXue Li
Harry Campbell
Konstantinos K Tsilidis
Xiangrui Meng
P A Ioannidis
P2860cites workCommon polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery diseaseQ21091170
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Genome-wide association analyses identify 18 new loci associated with serum urate concentrationsQ24620065
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Serum uric acid and coronary heart disease in 9,458 incident cases and 155,084 controls: prospective study and meta-analysisQ24805426
Serum Uric Acid Increases Risk of Cancer Incidence and Mortality: A Systematic Review and Meta-AnalysisQ26778698
Uric acid as a predictor of in-hospital mortality in acute myocardial infarction: a meta-analysisQ38228496
Serum Uric Acid Levels and Diabetic Peripheral Neuropathy in Type 2 Diabetes: a Systematic Review and Meta-analysisQ38314588
Serum Uric Acid Levels and Outcomes After Acute Ischemic StrokeQ38368304
Serum uric acid levels and risk of prehypertension: a meta-analysisQ38379314
High serum uric acid and risk of nonalcoholic fatty liver disease: A systematic review and meta-analysisQ38383877
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No causal effect of serum urate on bone-related outcomes among a population of postmenopausal women and elderly men of Chinese Han ethnicity--a Mendelian randomization studyQ40296281
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Uric acid and risk of myocardial infarction, stroke and congestive heart failure in 417,734 men and women in the Apolipoprotein MOrtality RISk study (AMORIS).Q45948035
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Significance of serum uric acid levels on the risk of all-cause and cardiovascular mortalityQ51352316
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Association of Uric Acid Genetic Risk Score With Blood PressureQ57366493
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Serum Uric Acid and Risk for Cardiovascular Disease and Death: The Framingham Heart StudyQ57740599
Uric acid and cardiovascular riskQ79689991
Serum urate and the risk of Parkinson's disease: results from a meta-analysisQ85723240
A genetic marker of uric acid level, carotid atherosclerosis, and arterial stiffness: a family-based studyQ85736032
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Association between serum uric acid and atrial fibrillation recurrence following catheter ablation: A meta-analysisQ86887249
Hyperuricemia is independently associated with increased risk of atrial fibrillation: A meta-analysis of cohort studiesQ86939556
Serum uric acid as a predictor for cardiovascular and all-cause mortality in women versus menQ86960562
A polymorphism in the major gene regulating serum uric acid associates with clinic SBP and the white-coat effect in a family-based studyQ87829165
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Gout, hyperuricemia, and Parkinson's disease: a protective effect?Q37738123
Uric acid and the development of hypertensionQ37795545
Is there anything good in uric acid?Q37930298
Serum uric acid levels in patients with multiple sclerosis: a meta-analysisQ37983970
Uric acid and the origins of hypertensionQ38081007
Oxidative stress in blood in Alzheimer's disease and mild cognitive impairment: a meta-analysisQ38122527
Effects of uric acid-lowering therapy on renal outcomes: a systematic review and meta-analysisQ38138322
Baseline serum uric acid level as a predictor of cardiovascular disease related mortality and all-cause mortality: a meta-analysis of prospective studiesQ38152501
Hyperuricemia and risk of stroke: a systematic review and meta-analysis of prospective studiesQ38182215
Association between serum uric acid and atrial fibrillation: a systematic review and meta-analysisQ38202745
Uric acid and risk of heart failure: a systematic review and meta‐analysisQ26852555
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Common variants related to serum uric acid concentrations are associated with glucose metabolism and insulin secretion in a Chinese populationQ28543082
Serum uric acid and adiposity: deciphering causality using a bidirectional Mendelian randomization approachQ28728265
Serum uric acid and mortality in chronic kidney disease: A systematic review and meta-analysisQ30248550
2016 updated EULAR evidence-based recommendations for the management of goutQ30248787
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Serum uric acid and cardiovascular disease: recent developments, and where do they leave us?Q33221221
Accuracy of serum uric acid determination in predicting pre-eclampsia: a systematic reviewQ33245845
The GRADE system for rating clinical guidelinesQ33503214
Meta-Analysis of Oxidative Stress in SchizophreniaQ33601360
Hyperuricemia and incident hypertension: a systematic review and meta-analysis.Q33687506
Association of a polymorphism in a gene encoding a urate transporter with CKD progressionQ33715840
Replication of the effect of SLC2A9 genetic variation on serum uric acid levels in American IndiansQ33765218
Uric acid as one of the important factors in multifactorial disorders – facts and controversiesQ33773142
Serum uric acid is associated with incident chronic kidney disease in middle-aged populations: a meta-analysis of 15 cohort studiesQ33800813
Bayesian methods for instrumental variable analysis with genetic instruments ('Mendelian randomization'): example with urate transporter SLC2A9 as an instrumental variable for effect of urate levels on metabolic syndromeQ33884926
Causal Assessment of Serum Urate Levels in Cardiometabolic Diseases Through a Mendelian Randomization StudyQ33887961
Uric acid: a novel mediator and marker of risk in chronic kidney disease?Q33913892
Is hyperuricemia an independent risk factor for new-onset chronic kidney disease?: A systematic review and meta-analysis based on observational cohort studiesQ34042891
A simple method for converting an odds ratio to effect size for use in meta-analysisQ34103097
Effects of Hyperuricemia on Renal Function of Renal Transplant Recipients: A Systematic Review and Meta-Analysis of Cohort StudiesQ34321410
Medical management to prevent recurrent nephrolithiasis in adults: a systematic review for an American College of Physicians Clinical GuidelineQ34336412
A causal role for uric acid in fructose-induced metabolic syndromeQ34460827
Effects of Urate-Lowering Therapy in Hyperuricemia on Slowing the Progression of Renal Function: A Meta-AnalysisQ34468472
Mendelian randomization of serum urate and parkinson disease progressionQ34576895
Uric acid and oxidative stress: relative impact on cardiovascular risk?Q34581253
High Serum Uric Acid and Increased Risk of Type 2 Diabetes: A Systemic Review and Meta-Analysis of Prospective Cohort StudiesQ34599618
Hyperuricemia and risk of incident hypertension: a systematic review and meta-analysis of observational studiesQ34601785
Mendelian randomization provides no evidence for a causal role of serum urate in increasing serum triglyceride levelsQ34734573
Urate as a physiological substrate for myeloperoxidase: implications for hyperuricemia and inflammationQ34787028
The role of uric acid in stroke: the issue remains unresolved.Q34794610
Associations of serum uric acid and SLC2A9 variant with depressive and anxiety disorders: a population-based studyQ35034635
Hyperuricemia as an independent predictor of vascular complications and mortality in type 2 diabetes patients: a meta-analysisQ35036205
Associations of the uric acid related genetic variants in SLC2A9 and ABCG2 loci with coronary heart disease riskQ35041324
Power and instrument strength requirements for Mendelian randomization studies using multiple genetic variantsQ35137931
Serum uric acid levels in patients with Alzheimer's disease: a meta-analysisQ35143061
Effects of allopurinol on endothelial dysfunction: a meta-analysisQ35153967
Hyperuricemia and coronary heart disease: a systematic review and meta-analysis.Q35166411
Effect of uric-acid-lowering therapy on progression of chronic kidney disease: a meta-analysisQ35227649
Network Mendelian randomization: using genetic variants as instrumental variables to investigate mediation in causal pathwaysQ35230437
Plasma Urate and Risk of a Hospital Stay with AKI: The Atherosclerosis Risk in Communities StudyQ35576084
Xanthine oxidase inhibitors in heart failure: where do we go from here?Q35627837
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On-admission serum uric acid predicts outcomes after acute myocardial infarction: systematic review and meta-analysis of prognostic studiesQ35929324
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factorsQ36020848
Low serum uric acid levels in patients with multiple sclerosis and neuromyelitis optica: An updated meta-analysisQ36137434
Birth weight in relation to health and disease in later life: an umbrella review of systematic reviews and meta-analysesQ36146180
Observations on Certain Pathological Conditions of the Blood and Urine in Gout, Rheumatism and Bright's DiseaseQ36182898
Uric Acid and Cardiovascular Events: A Mendelian Randomization StudyQ36223277
Unearthing uric acid: an ancient factor with recently found significance in renal and cardiovascular diseaseQ36441852
Genomics and metabolomics of muscular mass in a community-based sample of UK femalesQ36475044
Hyperuricemia and the risk for coronary heart disease morbidity and mortality a systematic review and dose-response meta-analysisQ36506786
Plasma urate and risk of Parkinson's diseaseQ36667290
Short communication: genetic variations of SLC2A9 in relation to Parkinson's diseaseQ36686805
Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysisQ36724236
Genotype-based changes in serum uric acid affect blood pressureQ36808243
Serum urate and the risk of major coronary heart disease eventsQ36846981
Association of Serum Uric Acid Levels in Psoriasis: A Systematic Review and Meta-AnalysisQ36993602
Association of plasma uric acid with ischaemic heart disease and blood pressure: mendelian randomisation analysis of two large cohortsQ37023991
Potential role of uric acid in metabolic syndrome, hypertension, kidney injury, and cardiovascular diseases: is it time for reappraisal?Q37078795
Hyperuricaemia--where nephrology meets rheumatologyQ37149663
Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stressQ37167578
P275copyright licenseCreative Commons Attribution-NonCommercialQ6936496
P407language of work or nameEnglishQ1860
P921main subjecturic acidQ105522
goutQ133087
heterocyclic compoundQ193430
nephrolithiasisQ18557037
P5008on focus list of Wikimedia projectScienceSourceQ55439927
P304page(s)j2376
P577publication date2017-06-07
P1433published inThe BMJQ546003
P1476titleSerum uric acid levels and multiple health outcomes: umbrella review of evidence from observational studies, randomised controlled trials, and Mendelian randomisation studies
P478volume357

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