An essential role of the JAK-STAT pathway in ischemic preconditioning

scientific article

An essential role of the JAK-STAT pathway in ischemic preconditioning is …
instance of (P31):
scholarly articleQ13442814

External links are
P819ADS bibcode2001PNAS...98.9050X
P356DOI10.1073/PNAS.161283798
P932PMC publication ID55371
P698PubMed publication ID11481471
P5875ResearchGate publication ID11862487

P2093author name stringY Zhu
Y Guo
H Han
R Bolli
Y T Xuan
P2860cites workIschemic preconditioning induces selective translocation of protein kinase C isoforms epsilon and eta in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activityQ28248095
Interferon-gamma induces tyrosine phosphorylation of interferon-gamma receptor and regulated association of protein tyrosine kinases, Jak1 and Jak2, with its receptorQ28286076
STATs and gene regulationQ29547796
Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathwayQ29615968
The late phase of ischemic preconditioning is abrogated by targeted disruption of the inducible NO synthase geneQ30454405
Myocardial ischemia activates the JAK-STAT pathway through angiotensin II signaling in in vivo myocardium of ratsQ31853215
The Jak-STAT pathway: cytokine signalling from the receptor to the nucleusQ33539989
The late phase of preconditioningQ33926118
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitorQ34379342
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activityQ34532143
Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell linesQ36239779
Demonstration of an early and a late phase of ischemic preconditioning in miceQ36982103
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domainQ38296506
Promoter of the mouse gene encoding calcium-independent nitric oxide synthase confers inducibility by interferon gamma and bacterial lipopolysaccharideQ38318972
Signals through gp130 upregulate bcl-x gene expression via STAT1-binding cis-element in cardiac myocytes.Q38344974
An interferon-gamma-activated site (GAS) is necessary for full expression of the mouse iNOS gene in response to interferon-gamma and lipopolysaccharideQ38349380
Regulation of induction of nitric oxide synthase and the inhibitory actions of dexamethasone in the human intestinal epithelial cell line, Caco-2: influence of cell differentiationQ40923705
Myocardial adaptation, stress proteins, and the second window of protectionQ41200575
GAS elements: a few nucleotides with a major impact on cytokine-induced gene expression.Q41404184
Involvement of protein kinase C in the delayed cytoprotection following sublethal ischaemia in rabbit myocardiumQ41985628
Cardiotrophin 1 (CT-1) inhibition of cardiac myocyte apoptosis via a mitogen-activated protein kinase-dependent pathway. Divergence from downstream CT-1 signals for myocardial cell hypertrophyQ46517609
Ischemia-induced STAT-1 Expression and Activation Play a Critical Role in Cardiomyocyte ApoptosisQ62011116
Regulation of cytokine-inducible nitric oxide synthase in cardiac myocytes and microvascular endothelial cells. Role of extracellular signal-regulated kinases 1 and 2 (ERK1/ERK2) and STAT1 alphaQ70889898
Activation of JAK-STAT and MAP kinases by leukemia inhibitory factor through gp130 in cardiac myocytesQ71785177
Demonstration of selective protein kinase C-dependent activation of Src and Lck tyrosine kinases during ischemic preconditioning in conscious rabbitsQ72993656
Biphasic response of cardiac NO synthase isoforms to ischemic preconditioning in conscious rabbitsQ73112776
Bifunctional role of protein tyrosine kinases in late preconditioning against myocardial stunning in conscious rabbitsQ73254506
Evidence that late preconditioning against myocardial stunning in conscious rabbits is triggered by the generation of nitric oxideQ73454262
Genistein, a tyrosine kinase inhibitor, blocks the "second window of protection" 48 h after ischemic preconditioning in the rabbitQ73542326
The type I angiotensin II receptor couples to Stat1 and Stat3 activation through Jak2 kinase in neonatal rat cardiac myocytesQ73702843
The protective effect of late preconditioning against myocardial stunning in conscious rabbits is mediated by nitric oxide synthase. Evidence that nitric oxide acts both as a trigger and as a mediator of the late phase of ischemic preconditioningQ73944504
Activation of JAK/STAT pathway transduces cytoprotective signal in rat acute myocardial infarctionQ74271653
Nitric oxide synthase is the mediator of late preconditioning against myocardial infarction in conscious rabbitsQ77133031
Nuclear factor-kappaB plays an essential role in the late phase of ischemic preconditioning in conscious rabbitsQ77744396
P433issue16
P407language of work or nameEnglishQ1860
P304page(s)9050-9055
P577publication date2001-07-01
P1433published inProceedings of the National Academy of Sciences of the United States of AmericaQ1146531
P1476titleAn essential role of the JAK-STAT pathway in ischemic preconditioning
P478volume98

Reverse relations

cites work (P2860)
Q4431335015d-PGJ2 and rosiglitazone suppress Janus kinase-STAT inflammatory signaling through induction of suppressor of cytokine signaling 1 (SOCS1) and SOCS3 in glia
Q36001255A novel protective effect of erythropoietin in the infarcted heart
Q50215120A soluble receptor for advanced glycation end-products inhibits myocardial apoptosis induced by ischemia/reperfusion via the JAK2/STAT3 pathway
Q54568438Activation of STAT1 in neurons following spinal cord injury in mice.
Q38827605Activation of mitochondrial STAT-3 and reduced mitochondria damage during hypothermia treatment for post-cardiac arrest myocardial dysfunction
Q34974091Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?
Q44027012Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway
Q38125624Adiponectin: mechanisms and new therapeutic approaches for restoring diabetic heart sensitivity to ischemic post-conditioning
Q35425229Administration of a CO-releasing molecule induces late preconditioning against myocardial infarction
Q43170086An important role of increase in tetrahydrobiopterin via H2O2-JAK2 signalling pathway in late phase of ischaemic preconditioning
Q33292191CCL3, acting via the chemokine receptor CCR5, leads to independent activation of Janus kinase 2 (JAK2) and Gi proteins
Q36921100Carbon monoxide induces a late preconditioning-mimetic cardioprotective and antiapoptotic milieu in the myocardium
Q33995071Cardiac preconditioning with sphingosine-1-phosphate requires activation of signal transducer and activator of transcription-3.
Q35641335Cardiac-Specific SOCS3 Deletion Prevents In Vivo Myocardial Ischemia Reperfusion Injury through Sustained Activation of Cardioprotective Signaling Molecules
Q41371396Cardioprotective Effects of Transfusion of Late-Phase Preconditioned Plasma May Be Induced by Activating the Reperfusion Injury Salvage Kinase Pathway but Not the Survivor Activating Factor Enhancement Pathway in Rats.
Q57298518Clinical manifestations and basic mechanisms of myocardial ischemia/reperfusion injury
Q57283582Context-enriched interactome powered by proteomics helps the identification of novel regulators of macrophage activation
Q39613493Convergence of protein kinase C and JAK-STAT signaling on transcription factor GATA-4.
Q46915202Coronary effluent from a preconditioned heart activates the JAK-STAT pathway and induces cardioprotection in a donor heart
Q34583556Critical role of the STAT3 pathway in the cardioprotective efficacy of zoniporide in a model of myocardial preservation – the rat isolated working heart
Q38143956Dancing rhinos in stilettos: The amazing saga of the genomic and nongenomic actions of STAT3 in the heart
Q37008467Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways
Q35622774Delayed adaptation of the heart to stress: late preconditioning
Q34357976Deletion of the innate immune NLRP3 receptor abolishes cardiac ischemic preconditioning and is associated with decreased Il-6/STAT3 signaling
Q36549642Disease mechanisms and emerging therapies: protein kinases and their inhibitors in myocardial disease
Q59810242Effects of Cardiovascular Risk Factors on Cardiac STAT3
Q35107929Endoplasmic reticulum stress-dependent activation of ATF3 mediates the late phase of ischemic preconditioning
Q38769588Endothelial nitric oxide synthase is not necessary for the early phase of ischemic preconditioning in the mouse
Q35622787Endothelial nitric oxide synthase plays an obligatory role in the late phase of ischemic preconditioning by activating the protein kinase C epsilon p44/42 mitogen-activated protein kinase pSer-signal transducers and activators of transcription1/3 pa
Q92703023Energy Metabolism in Cancer: The Roles of STAT3 and STAT5 in the Regulation of Metabolism-Related Genes
Q36142638Erythropoietin mimics ischemic preconditioning
Q52926879Erythropoietin reduces ischemia-reperfusion injury in the rat liver.
Q42861824Ethanolamine is a novel STAT-3 dependent cardioprotective agent
Q36569863Gadolinium limits myocardial infarction in the rat: dose-response, temporal relations and mechanisms
Q84732981Genetic background, gender, age, body temperature, and arterial blood pH have a major impact on myocardial infarct size in the mouse and need to be carefully measured and/or taken into account: results of a comprehensive analysis of determinants of
Q36015677H11 kinase/heat shock protein 22 deletion impairs both nuclear and mitochondrial functions of STAT3 and accelerates the transition into heart failure on cardiac overload
Q36895483High density lipoprotein/sphingosine-1-phosphate-induced cardioprotection: Role of STAT3 as part of the SAFE pathway
Q41707207Homocysteine exaggerates microglia activation and neuroinflammation through microglia localized STAT3 overactivation following ischemic stroke
Q36952776IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2.
Q44418962Impact of eight weeks of repeated ischaemic preconditioning on brachial artery and cutaneous microcirculatory function in healthy males.
Q35850254Induction of heme oxygenase-1 shifts the balance from proinjury to prosurvival in the placentas of pregnant rats with reduced uterine perfusion pressure
Q40897166Inhibition of Janus kinases by tyrosine phosphorylation inhibitor, Tyrphostin AG-490.
Q45012762Inhibition of mammalian target of rapamycin protects against reperfusion injury in diabetic heart through STAT3 signaling
Q46742743Inhibition of matrix metalloproteinase-9 by interferons and TGF-beta1 through distinct signalings accounts for reduced monocyte invasiveness
Q34300508Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusion
Q98623397Inhibition of the long non-coding RNA NEAT1 protects cardiomyocytes from hypoxia in vitro via decreased pri-miRNA processing
Q36099027Intestinal Microbial Metabolites Are Linked to Severity of Myocardial Infarction in Rats
Q54463873Intestinal ischemic preconditioning after ischemia/reperfusion injury in rat intestine: profiling global gene expression patterns.
Q36732584Ischemic preconditioning in solid organ transplantation: from experimental to clinics
Q45113852JAK and STAT proteins are expressed and activated by IFN-gamma in rat pancreatic acinar cells
Q37430884JAK redux: a second look at the regulation and role of JAKs in the heart
Q36301907JAK-STAT pathway in cardiac ischemic stress
Q37421817JAK-STAT signaling and myocardial glucose metabolism
Q28584039JAK-STAT signaling mediates gangliosides-induced inflammatory responses in brain microglial cells
Q41394648JAK-STAT: Getting to the heart of the matter
Q35119530Karyopherins: potential biological elements involved in the delayed graft function in renal transplant recipients.
Q36923776Kir6.2 is not the mitochondrial KATP channel but is required for cardioprotection by ischemic preconditioning
Q36907315LIF and the heart: just another brick in the wall?
Q34212278Leptin-induced cardioprotection involves JAK/STAT signaling that may be linked to the mitochondrial permeability transition pore
Q37379567Loss of cardioprotection with ageing.
Q51102345Low-Dose Endotoxin Induces Late Preconditioning, Increases Peroxynitrite Formation, and Activates STAT3 in the Rat Heart.
Q35037331MG53 participates in ischaemic postconditioning through the RISK signalling pathway
Q35535211Mechanism of cyclooxygenase-2 upregulation in late preconditioning
Q97069866Myocardial ischaemia-reperfusion injury and cardioprotection in perspective
Q54485726Nesfatin-1 as a novel cardiac peptide: identification, functional characterization, and protection against ischemia/reperfusion injury.
Q37522854Occult cardiotoxicity--toxic effects on cardiac ischemic tolerance
Q46065905Osteopontin protects against cardiac ischemia-reperfusion injury through late preconditioning
Q54570243Paeoniflorin attenuates schistosomiasis japonica-associated liver fibrosis through inhibiting alternative activation of macrophages.
Q37361794Pharmacologic and pharmacokinetic profile of repifermin (KGF-2) in monkeys and comparative pharmacokinetics in humans
Q38018190Phosphoproteomics and molecular cardiology: techniques, applications and challenges
Q45959541Postinfarct active cardiac-targeted delivery of erythropoietin by liposomes with sialyl Lewis X repairs infarcted myocardium in rabbits.
Q54731678Potentiation of flagellin responses in gut epithelial cells by interferon-gamma is associated with STAT-independent regulation of MyD88 expression.
Q37238435Pretreatment with bone morphogenetic protein-7 (BMP-7) mimics ischemia preconditioning following intestinal ischemia/reperfusion injury in the intestine and liver
Q43439841Protective effect of carbamazepine on kainic acid-induced neuronal cell death through activation of signal transducer and activator of transcription-3.
Q39826764Protective mechanisms of NO preconditioning against NO-induced apoptosis in H9c2 cells: role of PKC and COX-2.
Q44490744Protein Alpha Shape Similarity Analysis (PASSA): a new method for mapping protein binding sites. Application in the design of a selective inhibitor of tyrosine kinase 2.
Q46765499ROS generated during early reperfusion contribute to intermittent hypobaric hypoxia-afforded cardioprotection against postischemia-induced Ca(2+) overload and contractile dysfunction via the JAK2/STAT3 pathway
Q36392865Rapamycin protects against myocardial ischemia-reperfusion injury through JAK2-STAT3 signaling pathway.
Q46891023Reducing effect of IL-32α in the development of stroke through blocking of NF-κB, but enhancement of STAT3 pathways
Q36995201Regulating RISK: a role for JAK-STAT signaling in postconditioning?
Q42704632Regulation of signal transducer and activator of transcription 3 and apoptotic pathways by betaine attenuates isoproterenol-induced acute myocardial injury in rats
Q28573076Role of JAK/STAT pathway in IL-6-induced activation of vascular smooth muscle cells
Q35985573Role of STAT-1 and STAT-3 in ischaemia/reperfusion injury.
Q44068471Role of Src protein tyrosine kinases in late preconditioning against myocardial infarction
Q91598194Role of interleukins in heart failure with reduced ejection fraction
Q36943612Role of signal transducer and activator of transcription-3 in estradiol-mediated neuroprotection
Q48953467Role of signal transducer and activator of transcription-3 in up-regulation of GFAP after epilepsy
Q40550480Role of the protein kinase C-epsilon-Raf-1-MEK-1/2-p44/42 MAPK signaling cascade in the activation of signal transducers and activators of transcription 1 and 3 and induction of cyclooxygenase-2 after ischemic preconditioning
Q36895471Roles of STATs signaling in cardiovascular diseases
Q44513055STAT signaling in ischemic heart: a role of STAT5A in ischemic preconditioning
Q34600271STAT subtype specificity and ischemic preconditioning in mice: is STAT-3 enough?
Q36895468STAT transcription in the ischemic heart
Q37734934STAT3 and cardiac remodeling
Q33883642STAT3 balances myocyte hypertrophy vis-à-vis autophagy in response to Angiotensin II by modulating the AMPKα/mTOR axis.
Q36099739Signal transducer and activator of transcription 3 is involved in the cardioprotective signalling pathway activated by insulin therapy at reperfusion
Q34805921Signal transducers and activators of transcription: STATs-mediated mitochondrial neuroprotection
Q34150633Stress signaling by Tec tyrosine kinase in the ischemic myocardium
Q92305799Systems Network Genomic Analysis Reveals Cardioprotective Effect of MURC/Cavin-4 Deletion Against Ischemia/Reperfusion Injury
Q35635261Tadalafil, a Phosphodiesterase Inhibitor Protects Stem Cells over Longer Period Against Hypoxia/Reoxygenation Injury Through STAT3/PKG-I Signaling
Q40308442The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta
Q65002701The Role of the Microbiota in the Diabetic Peripheral Artery Disease.
Q44132497The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytes
Q92077691The critical role of the zinc transporter Zip2 (SLC39A2) in ischemia/reperfusion injury in mouse hearts
Q54519859The effects of curcumin post-treatment against myocardial ischemia and reperfusion by activation of the JAK2/STAT3 signaling pathway.
Q89871237The inhibition of miR-17-5p promotes cortical neuron neurite growth via STAT3/GAP-43 pathway
Q35987663The late phase of ischemic preconditioning induces a prosurvival genetic program that results in marked attenuation of apoptosis
Q36352011The role of erythropoietin in myocardial protection: potential mechanisms and applications
Q40719951The second window of desflurane-induced preconditioning is mediated by STAT3: role of Pim-1 kinase
Q38790211Understanding STAT3 signaling in cardiac ischemia.
Q37838085When are pro-inflammatory cytokines SAFE in heart failure?
Q48123240Whole-body hypoxic preconditioning protects mice against acute hypoxia by improving lung function
Q52335565Zinc improves mitochondrial respiratory function and prevents mitochondrial ROS generation at reperfusion by phosphorylating STAT3 at Ser727.
Q37608600gp130-mediated pathway and heart failure

Search more.