The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta

scientific article published on 3 March 2006

The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1152/AJPHEART.00003.2006
P698PubMed publication ID16517948

P2093author name stringAnna K Hsu
Eric R Gross
Garrett J Gross
P2860cites workGlycogen synthase kinase3 beta phosphorylates serine 33 of p53 and activates p53's transcriptional activityQ21284181
Direct, activating interaction between glycogen synthase kinase-3beta and p53 after DNA damageQ24534352
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathyQ28343848
Jaks and STATs: biological implicationsQ29619657
Up-regulation of endothelial nitric-oxide synthase promoter by the phosphatidylinositol 3-kinase gamma /Janus kinase 2/MEK-1-dependent pathwayQ31478590
An essential role of the JAK-STAT pathway in ischemic preconditioningQ33929635
Induction of apoptosis and Fas receptor/Fas ligand expression by ischemia/reperfusion in cardiac myocytes requires serine 727 of the STAT-1 transcription factor but not tyrosine 701.Q33942943
Glycogen synthase kinase-3beta mediates convergence of protection signaling to inhibit the mitochondrial permeability transition poreQ34327908
Glycogen Synthase Kinase-3β (GSK3β) Binds to and Promotes the Actions of p53Q34338748
Inhibition of acute lymphoblastic leukaemia by a Jak-2 inhibitorQ34379342
Interplay between the cardiac renin angiotensin system and JAK-STAT signaling: role in cardiac hypertrophy, ischemia/reperfusion dysfunction, and heart failureQ34996826
Role of the JAK-STAT pathway in protection against myocardial ischemia/reperfusion injuryQ35066240
Jak family of kinases in cancerQ35186465
Interleukin 3-dependent survival by the Akt protein kinaseQ36593239
Up-regulation of mitochondrial transcription factor 1 mRNA levels by GH in VSMC.Q40589003
TEL-JAK2 mediates constitutive activation of the phosphatidylinositol 3'-kinase/protein kinase B signaling pathwayQ40795252
STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptorQ41109044
Activation of signal transducer and activator of transcription 3 protects cardiomyocytes from hypoxia/reoxygenation-induced oxidative stress through the upregulation of manganese superoxide dismutaseQ43721242
Role of STAT3 in ischemic preconditioningQ43799529
The carboxyl-terminal activation domain of the STAT-1 transcription factor enhances ischemia/reperfusion-induced apoptosis in cardiac myocytesQ44132497
Novel signal transduction pathway for luteinizing hormone and its interaction with insulin: activation of Janus kinase/signal transducer and activator of transcription and phosphoinositol 3-kinase/Akt pathways.Q44285380
Opioid-induced cardioprotection occurs via glycogen synthase kinase beta inhibition during reperfusion in intact rat heartsQ44344567
Signal transducer and activator of transcription 3 activation by the delta-opioid receptor via Galpha14 involves multiple intermediatesQ44345537
Morphine suppresses lymphocyte apoptosis by blocking p53-mediated death signalingQ44555485
p53 down-regulation: a new molecular mechanism involved in ischaemic preconditioningQ44673386
Postconditioning: a form of "modified reperfusion" protects the myocardium by activating the phosphatidylinositol 3-kinase-Akt pathwayQ44970377
Signal transducer and activator of transcription 3 is required for myocardial capillary growth, control of interstitial matrix deposition, and heart protection from ischemic injuryQ47359646
Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injuryQ47881997
Induction of phosphorylated-Stat3 following focal cerebral ischemia in miceQ48900686
Opposing actions of STAT-1 and STAT-3 on the Bcl-2 and Bcl-x promoters.Q55033997
P433issue2
P304page(s)H827-34
P577publication date2006-03-03
P1433published inAmerican Journal of Physiology Heart and Circulatory PhysiologyQ3193662
P1476titleThe JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 beta
P478volume291

Reverse relations

cites work (P2860)
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