When are pro-inflammatory cytokines SAFE in heart failure?

scientific article published on 07 February 2011

When are pro-inflammatory cytokines SAFE in heart failure? is …
instance of (P31):
review articleQ7318358
scholarly articleQ13442814

External links are
P356DOI10.1093/EURHEARTJ/EHQ484
P698PubMed publication ID21303780

P2093author name stringSandrine Lecour
Richard W James
P2860cites workOmega-3 polyunsaturated fatty acids and cardiovascular diseasesQ27863409
Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stressQ28142513
Decrease of serum levels of the anti-inflammatory cytokine interleukin-10 in patients with advanced chronic heart failureQ28195394
Signal transducer and activator of transcription 3 in the heart transduces not only a hypertrophic signal but a protective signal against doxorubicin-induced cardiomyopathyQ28343848
The complex of ciliary neurotrophic factor-ciliary neurotrophic factor receptor alpha up-regulates connexin43 and intercellular coupling in astrocytes via the Janus tyrosine kinase/signal transducer and activator of transcription pathwayQ28565647
Dual activation of STAT-3 and Akt is required during the trigger phase of ischaemic preconditioningQ28771386
Regulation of matrix metalloproteinase activity in ischemic tissue by interleukin-10: role in ischemia-induced angiogenesisQ30697267
Atorvastatin enhances interleukin-10 levels and improves cardiac function in rats after acute myocardial infarctionQ33331962
Interleukin-10 improves left ventricular function in rats with heart failure subsequent to myocardial infarctionQ33348902
Increased concentrations of tumour necrosis factor in "cachectic" patients with severe chronic heart failureQ33611681
The Jak-STAT pathwayQ33899139
Classic ischemic but not pharmacologic preconditioning is abrogated following genetic ablation of the TNFalpha geneQ44088296
Therapy of ischemic cardiomyopathy with the immunomodulating agent pentoxifylline: results of a randomized study.Q44768384
Tumor necrosis factor-alpha receptor 1 is a major predictor of mortality and new-onset heart failure in patients with acute myocardial infarction: the Cytokine-Activation and Long-Term Prognosis in Myocardial Infarction (C-ALPHA) studyQ44799903
Mechanism of cardiac depression after trauma-hemorrhage: increased cardiomyocyte IL-6 and effect of sex steroids on IL-6 regulation and cardiac functionQ45099421
Free radicals trigger TNF alpha-induced cardioprotectionQ45203259
Native and reconstituted HDL activate Stat3 in ventricular cardiomyocytes via ERK1/2: role of sphingosine-1-phosphateQ46158490
TNFalpha is required to confer protection in an in vivo model of classical ischaemic preconditioningQ46224947
Effect of high-dose atorvastatin on hospitalizations for heart failure: subgroup analysis of the Treating to New Targets (TNT) studyQ46489522
Physical exercise improves plasmatic levels of IL-10, left ventricular end-diastolic pressure, and muscle lipid peroxidation in chronic heart failure ratsQ46651733
Pharmacological preconditioning with tumor necrosis factor-alpha activates signal transducer and activator of transcription-3 at reperfusion without involving classic prosurvival kinases (Akt and extracellular signal-regulated kinase).Q46847925
Oxidative modification of tropomyosin and myocardial dysfunction following coronary microembolizationQ46909913
Tumor necrosis factor-alpha does not modulate ischemia/reperfusion injury in naïve myocardium but is essential for the development of late preconditioningQ47226424
Randomised investigation of effects of pentoxifylline on left-ventricular performance in idiopathic dilated cardiomyopathyQ47860383
Results of a non-specific immunomodulation therapy in chronic heart failure (ACCLAIM trial): a placebo-controlled randomised trialQ47968070
Tumor necrosis factor-alpha confers resistance to hypoxic injury in the adult mammalian cardiac myocyte.Q50524441
Bidirectional role of tumor necrosis factor-alpha in coronary microembolization: progressive contractile dysfunction versus delayed protection against infarction.Q51093781
Multiple protective pathways against reperfusion injury: a SAFE path without Aktion?Q51752588
A cathepsin D-cleaved 16 kDa form of prolactin mediates postpartum cardiomyopathy.Q51767309
Tumor necrosis factor-alpha and its receptors 1 and 2: Yin and Yang in myocardial infarction?Q51789753
Safety and efficacy of a soluble P75 tumor necrosis factor receptor (Enbrel, etanercept) in patients with advanced heart failure.Q53547618
Therapeutic activation of signal transducer and activator of transcription 3 by interleukin-11 ameliorates cardiac fibrosis after myocardial infarction.Q54444876
Decreased expression of thrombospondin-1 in failing hearts may favor ventricular remodeling.Q54467496
Inhibition of tumor necrosis factor receptor-1-mediated pathways has beneficial effects in a murine model of postischemic remodeling.Q54705304
Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial InfarctionQ57339890
Tumor Necrosis Factor Soluble Receptors in Patients With Various Degrees of Congestive Heart FailureQ57951046
Expression of proinflammatory cytokines in the failing human heart: comparison of recent-onset and end-stage congestive heart failureQ59192155
Cellular basis for the negative inotropic effects of tumor necrosis factor-alpha in the adult mammalian heartQ33907789
An essential role of the JAK-STAT pathway in ischemic preconditioningQ33929635
The cytoprotective effects of tumor necrosis factor are conveyed through tumor necrosis factor receptor-associated factor 2 in the heartQ34022068
Inhibition of permeability transition pore opening by mitochondrial STAT3 and its role in myocardial ischemia/reperfusionQ34300508
Innate immunity and cardiac preconditioning: a putative intrinsic cardioprotective programQ34772373
Activation of the protective Survivor Activating Factor Enhancement (SAFE) pathway against reperfusion injury: Does it go beyond the RISK pathway?Q34974091
Left ventricular systolic and diastolic dysfunction after infusion of tumor necrosis factor-alpha in conscious dogsQ35604862
Gender differences in injury induced mesenchymal stem cell apoptosis and VEGF, TNF, IL-6 expression: role of the 55 kDa TNF receptor (TNFR1).Q35606632
TNFα protects cardiac mitochondria independently of its cell surface receptorsQ36148170
Role of gp130-mediated signalling pathways in the heart and its impact on potential therapeutic aspectsQ36497007
Cardiomyocyte-restricted knockout of STAT3 results in higher sensitivity to inflammation, cardiac fibrosis, and heart failure with advanced ageQ36689956
Connexin 43 in ischemic pre- and postconditioning.Q36827888
Can the protective actions of JAK-STAT in the heart be exploited therapeutically? Parsing the regulation of interleukin-6-type cytokine signalingQ36912096
IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2.Q36952776
Endogenous tumor necrosis factor protects the adult cardiac myocyte against ischemic-induced apoptosis in a murine model of acute myocardial infarctionQ36977754
Cytokines and acute heart failureQ37044902
Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trialQ37213020
Regulation of Mn-superoxide dismutase activity and neuroprotection by STAT3 in mice after cerebral ischemiaQ37265505
The myocardial JAK/STAT pathway: from protection to failureQ37266843
Immunological mechanisms of pentoxifylline in chronic heart failureQ37377105
Function of mitochondrial Stat3 in cellular respirationQ37378567
Transforming growth factor-beta receptor antagonism attenuates myocardial fibrosis in mice with cardiac-restricted overexpression of tumor necrosis factorQ37412421
JAK redux: a second look at the regulation and role of JAKs in the heartQ37430884
TNFalpha in atherosclerosis, myocardial ischemia/reperfusion and heart failureQ37771751
Autophagic cardiomyocyte death in cardiomyopathic hamsters and its prevention by granulocyte colony-stimulating factorQ38622547
The JAK/STAT pathway is essential for opioid-induced cardioprotection: JAK2 as a mediator of STAT3, Akt, and GSK-3 betaQ40308442
Pro- versus anti-inflammatory cytokine profile in patients with severe sepsis: a marker for prognosis and future therapeutic optionsQ40785303
Interleukin-6 spillover in the peripheral circulation increases with the severity of heart failure, and the high plasma level of interleukin-6 is an important prognostic predictor in patients with congestive heart failureQ40870003
Immunomodulating agents for the management of heart failure with myocarditis and cardiomyopathy--lessons from animal experimentsQ41016937
Basic mechanisms in heart failure: the cytokine hypothesisQ41188647
New insights into the pathological role of TNF-alpha in early cardiac dysfunction and subsequent heart failure after infarction in ratsQ42463523
Ethanolamine is a novel STAT-3 dependent cardioprotective agentQ42861824
Divergent tumor necrosis factor receptor-related remodeling responses in heart failure: role of nuclear factor-kappaB and inflammatory activationQ43065625
High-density lipoprotein cholesterol levels and prognosis in advanced heart failureQ43283941
Native and reconstituted HDL protect cardiomyocytes from doxorubicin-induced apoptosisQ43287633
Ischaemic postconditioning protects against reperfusion injury via the SAFE pathwayQ43295255
Cytokines and cytokine receptors in advanced heart failure: an analysis of the cytokine database from the Vesnarinone trial (VEST).Q43586296
Role of STAT3 in ischemic preconditioningQ43799529
Myocardial dysfunction with coronary microembolization: signal transduction through a sequence of nitric oxide, tumor necrosis factor-alpha, and sphingosineQ43966261
Identification of a novel role for sphingolipid signaling in TNF alpha and ischemic preconditioning mediated cardioprotectionQ44022447
P433issue6
P921main subjectinflammationQ101991
heart failureQ181754
P304page(s)680-685
P577publication date2011-02-07
P1433published inEuropean Heart JournalQ2286839
P1476titleWhen are pro-inflammatory cytokines SAFE in heart failure?
P478volume32