Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutations

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Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutations is …
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scholarly articleQ13442814

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P356DOI10.1128/AAC.45.5.1515-1521.2001
P932PMC publication ID90498
P698PubMed publication ID11302820

P2093author name stringH Wang
M Chen
S B Levy
J L Dzink-Fox
P2860cites workCLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choiceQ24286950
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Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coliQ33698034
Topoisomerase IV is a target of quinolones in Escherichia coliQ33724600
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Impact of gyrA and parC mutations on quinolone resistance, doubling time, and supercoiling degree of Escherichia coli.Q33976675
Ineffectiveness of topoisomerase mutations in mediating clinically significant fluoroquinolone resistance in Escherichia coli in the absence of the AcrAB efflux pumpQ33978398
Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coliQ33979064
AcrAB efflux pump plays a major role in the antibiotic resistance phenotype of Escherichia coli multiple-antibiotic-resistance (Mar) mutantsQ34370243
Relationship between quinolone use and emergence of ciprofloxacin-resistant Escherichia coli in bloodstream infectionsQ35111896
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Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.Q35123629
Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from humans and animals.Q35128319
Development of resistance to nalidixic acid and the fluoroquinolones after the introduction of norfloxacin and ofloxacinQ35319641
Cross-resistance to fluoroquinolones in multiple-antibiotic-resistant (Mar) Escherichia coli selected by tetracycline or chloramphenicol: decreased drug accumulation associated with membrane changes in addition to OmpF reductionQ35343881
Activation of multiple antibiotic resistance and binding of stress-inducible promoters by Escherichia coli Rob proteinQ35581659
Role of the acrAB locus in organic solvent tolerance mediated by expression of marA, soxS, or robA in Escherichia coliQ35631010
Mutations in the gyrA gene of a highly fluoroquinolone-resistant clinical isolate of Escherichia coliQ35811107
Characterization of fluoroquinolone-resistant mutants of escherichia coli selected in vitroQ35821472
Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coliQ35912437
Two divergently transcribed genes, soxR and soxS, control a superoxide response regulon of Escherichia coliQ36145766
marA locus causes decreased expression of OmpF porin in multiple-antibiotic-resistant (Mar) mutants of Escherichia coliQ36223906
Amplifiable resistance to tetracycline, chloramphenicol, and other antibiotics in Escherichia coli: involvement of a non-plasmid-determined efflux of tetracyclineQ36331626
Overexpression of the robA gene increases organic solvent tolerance and multiple antibiotic and heavy metal ion resistance in Escherichia coli.Q36709289
Association with prior fluoroquinolone therapy of widespread ciprofloxacin resistance among gram-negative isolates in a Veterans Affairs medical centerQ36752823
Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA.Q38311410
High-level fluoroquinolone-resistant clinical isolates of Escherichia coli overproduce multidrug efflux protein AcrA.Q39475770
AcrD of Escherichia coli is an aminoglycoside efflux pumpQ39499577
Multidrug resistance following expression of the Escherichia coli marA gene in Mycobacterium smegmatis.Q39566356
Detection of gyrA and gyrB mutations in quinolone-resistant clinical isolates of Escherichia coli by single-strand conformational polymorphism analysis and determination of levels of resistance conferred by two different single gyrA mutationsQ39780132
Quinolone-resistant mutants of escherichia coli DNA topoisomerase IV parC geneQ39781656
gyrA and gyrB mutations in quinolone-resistant strains of Escherichia coliQ39814986
Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coliQ39816339
Activation of oxidative stress genes by mutations at the soxQ/cfxB/marA locus of Escherichia coliQ39942365
Two complementation groups mediate tetracycline resistance determined by Tn10Q39984225
4-Quinolone resistance mutations in the DNA gyrase of Escherichia coli clinical isolates identified by using the polymerase chain reactionQ40085967
Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coliQ40087129
Quinolone Mode of Action - New Aspects†Q40489458
Molecular characterization of the soxRS genes of Escherichia coli: two genes control a superoxide stress regulonQ40506211
The emergence of highly fluoroquinolone-resistant Escherichia coli in community-acquired urinary tract infectionsQ44324064
Development of resistance in Pseudomonas aeruginosa to imipenem, norfloxacin, and ciprofloxacin during therapy: proof provided by typing with a DNA probeQ44662659
Nalidixic acid-resistant mutations of the gyrB gene of Escherichia coliQ46102812
The local repressor AcrR plays a modulating role in the regulation of acrAB genes of Escherichia coli by global stress signalsQ46280464
Quinolone-resistant mutations of the gyrA gene of Escherichia coliQ48332361
Association of organic solvent tolerance and fluoroquinolone resistance in clinical isolates of Escherichia coli.Q52247046
Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates.Q54069730
Construction and use of a new broad-host-range lacZ transcriptional fusion vector, pHRP309, for gram- bacteria.Q54228474
Rapid development of ciprofloxacin resistance in methicillin-susceptible and -resistant Staphylococcus aureus.Q54294777
gyrA mutations in high-level fluoroquinolone-resistant clinical isolates of Escherichia coli.Q54581647
Mechanisms of Resistance to QuinolonesQ72092628
Mechanisms of fluoroquinolone resistanceQ74371163
Molecular analysis of fluoroquinolone-resistance in Escherichia coli on the aspect of gyrase and multiple antibiotic resistance (mar) genesQ74654645
Analysis of the mutations involved in fluoroquinolone resistance of in vivo and in vitro mutants of Escherichia coliQ78166633
P433issue5
P407language of work or nameEnglishQ1860
P921main subjectPeople's Republic of ChinaQ148
Escherichia coliQ25419
P304page(s)1515-1521
P577publication date2001-05-01
P1433published inAntimicrobial Agents and ChemotherapyQ578004
P1476titleGenetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutations
P478volume45

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