Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli

scientific article published on 17 August 2017

Fitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli is …
instance of (P31):
scholarly articleQ13442814

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P356DOI10.1093/JAC/DKX270
P8608Fatcat IDrelease_edqa7fddcjgidj5dhrini5ophm
P932PMC publication ID5890708
P698PubMed publication ID28962020

P50authorGerrit BrandisQ56442332
P2093author name stringDiarmaid Hughes
Douglas L Huseby
Lisa Praski Alzrigat
P2860cites workPlasmid-mediated quinolone resistance: a multifaceted threatQ24645356
The crystal structure of MarR, a regulator of multiple antibiotic resistance, at 2.3 A resolutionQ27633696
The complete genome sequence of Escherichia coli K-12Q27860542
Interplay in the selection of fluoroquinolone resistance and bacterial fitnessQ28475870
An efficient recombination system for chromosome engineering in Escherichia coliQ29615038
Structure and function of TolC: the bacterial exit duct for proteins and drugs.Q30164023
Overexpression of the marA or soxS regulatory gene in clinical topoisomerase mutants of Escherichia coliQ33698034
Mechanisms of fluoroquinolone resistance: an update 1994-1998.Q33770066
Novel reference genes for quantifying transcriptional responses of Escherichia coli to protein overexpression by quantitative PCRQ33879869
High efficiency mutagenesis, repair, and engineering of chromosomal DNA using single-stranded oligonucleotidesQ33948878
Non-target gene mutations in the development of fluoroquinolone resistance in Escherichia coliQ33979064
Genetic characterization of highly fluoroquinolone-resistant clinical Escherichia coli strains from China: role of acrR mutationsQ33982113
Genome-wide transcriptional profiling of the Escherichia coli responses to superoxide stress and sodium salicylateQ33996373
Overproduction of AcrR increases organic solvent tolerance mediated by modulation of SoxS regulon in Escherichia coli.Q53023688
Can phylogenetic type predict resistance development?Q54365709
MarA, SoxS and Rob function as virulence factors in an Escherichia coli murine model of ascending pyelonephritis.Q54450584
DNA gyrase and topoisomerase IV on the bacterial chromosome: quinolone-induced DNA cleavage.Q54588445
Mechanism of action of and resistance to quinolonesQ58057075
Structural requirements for marbox function in transcriptional activation of mar/sox/rob regulon promoters in Escherichia coli: sequence, orientation and spatial relationship to the core promoterQ73189454
Mutational analysis of MarR, the negative regulator of marRAB expression in Escherichia coli, suggests the presence of two regions required for DNA bindingQ73665041
Binding of purified multiple antibiotic-resistance repressor protein (MarR) to mar operator sequencesQ34225580
Quinolone resistance in Escherichia coli.Q34296637
Regulation of bacterial drug export systemsQ34300836
Genetic evidence for a role of parC mutations in development of high-level fluoroquinolone resistance in Escherichia coli.Q35123629
The challenge of efflux-mediated antibiotic resistance in Gram-negative bacteriaQ35482558
Autoactivation of the marRAB multiple antibiotic resistance operon by the MarA transcriptional activator in Escherichia coliQ35605343
Genetic and functional analysis of the multiple antibiotic resistance (mar) locus in Escherichia coliQ35912437
Mutation rate and evolution of fluoroquinolone resistance in Escherichia coli isolates from patients with urinary tract infections.Q36048167
Positive selection procedure for entrapment of insertion sequence elements in gram-negative bacteriaQ36279805
Multidrug-resistance efflux pumps - not just for resistanceQ36538111
Fluoroquinolone resistance mechanisms in an Escherichia coli isolate, HUE1, without quinolone resistance-determining region mutationsQ36871802
Structural and functional aspects of the multidrug efflux pump AcrB.Q37488259
Broad-specificity efflux pumps and their role in multidrug resistance of Gram-negative bacteriaQ37894832
Medicinal potential of ciprofloxacin and its derivativesQ38068970
Multidrug efflux pumps in Gram-negative bacteria and their role in antibiotic resistanceQ38269145
Molecular mechanisms of antibiotic resistance.Q38272908
Differential expression of over 60 chromosomal genes in Escherichia coli by constitutive expression of MarA.Q38311410
The assembly and disassembly of the AcrAB-TolC three-component multidrug efflux pumpQ38523823
Tackling antimicrobial resistance in lower urinary tract infections: treatment optionsQ38833839
Mutation Supply and Relative Fitness Shape the Genotypes of Ciprofloxacin-Resistant Escherichia coliQ39020968
Duplication-Insertion Recombineering: a fast and scar-free method for efficient transfer of multiple mutations in bacteria.Q40450325
Effect of the efflux pump QepA2 combined with chromosomally mediated mechanisms on quinolone resistance and bacterial fitness in Escherichia coliQ41186835
Expression of multidrug efflux pump genes acrAB-tolC, mdfA, and norE in Escherichia coli clinical isolates as a function of fluoroquinolone and multidrug resistanceQ42111161
Bile salts and fatty acids induce the expression of Escherichia coli AcrAB multidrug efflux pump through their interaction with Rob regulatory protein.Q44468465
E. coli genome manipulation by P1 transductionQ46760894
Transcriptional and translational regulation of the marRAB multiple antibiotic resistance operon in Escherichia coliQ47269280
P275copyright licenseCreative Commons Attribution-NonCommercial 4.0 InternationalQ34179348
P6216copyright statuscopyrightedQ50423863
P433issue11
P407language of work or nameEnglishQ1860
P921main subjectEscherichia coliQ25419
P304page(s)3016-3024
P577publication date2017-11-01
P1433published inJournal of Antimicrobial ChemotherapyQ6294770
P1476titleFitness cost constrains the spectrum of marR mutations in ciprofloxacin-resistant Escherichia coli
P478volume72

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cites work (P2860)
Q96022501Development and selection of low-level multi-drug resistance over an extended range of sub-inhibitory ciprofloxacin concentrations in Escherichia coli
Q61448427Evaluation of Acquired Antibiotic Resistance in Exposed to Long-Term Low-Shear Modeled Microgravity and Background Antibiotic Exposure
Q50097364Methods to Determine Mutational Trajectories After Experimental Evolution of Antibiotic Resistance
Q89591629Population bottlenecks strongly influence the evolutionary trajectory to fluoroquinolone resistance in Escherichia coli
Q83230169Rapid decline of bacterial drug-resistance in an antibiotic-free environment through phenotypic reversion
Q90038371The SNAP hypothesis: Chromosomal rearrangements could emerge from positive Selection during Niche Adaptation

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